A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

Cell Reports

Volumn 9, Issue 6, 2014, Pages 2018-2026

  Liebscher, Ines ^a,c   Schön, Julia ^a   Petersen, Sarah C ^b   Fischer, Liane ^a   Auerbach, Nina ^a,b   Demberg, Lilian Marie ^a   Mogha, Amit ^b   Cöster, Maxi ^a   Simon, Kay Uwe ^a   Rothemund, Sven ^a   Monk, Kelly R ^b   Schöneberg, Torsten ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 126; G PROTEIN COUPLED RECEPTOR 133; UNCLASSIFIED DRUG; GPR126 PROTEIN, HUMAN; GPR133 PROTEIN, HUMAN; OLIGOPEPTIDE; PROTEIN BINDING;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; MUTANT; NONHUMAN; PEPTIDE SYNTHESIS; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; PROTEIN FUNCTION; STACHEL SEQUENCE; ZEBRA FISH; AGONISTS; ANIMAL; BINDING SITE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS;

DANIO RERIO;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; ZEBRAFISH;

EID: 84919876223     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.11.036     Document Type: Article

References (33)

1. Araç D., Boucard A.A., Bolliger M.F., Nguyen J., Soltis S.M., Südhof T.C., Brunger A.T. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J. 2012, 31:1364-1378.
2. Bjarnadóttir T.K., Fredriksson R., Höglund P.J., Gloriam D.E., Lagerström M.C., Schiöth H.B. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004, 84:23-33.
3. Bohnekamp J., Schöneberg T. Cell adhesion receptor GPR133 couples to Gs protein. J.Biol. Chem. 2011, 286:41912-41916.
4. Geng F.S., Abbas L., Baxendale S., Holdsworth C.J., Swanson A.G., Slanchev K., Hammerschmidt M., Topczewski J., Whitfield T.T. Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development 2013, 140:4362-4374.
5. Glenn T.D., Talbot W.S. Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin. Development 2013, 140:3167-3175.
6. Gupte J., Swaminath G., Danao J., Tian H., Li Y., Wu X. Signaling property study of adhesion G-protein-coupled receptors. FEBS Lett. 2012, 586:1214-1219.
7. Iguchi T., Sakata K., Yoshizaki K., Tago K., Mizuno N., Itoh H. Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. J.Biol. Chem. 2008, 283:14469-14478.
8. Karpus O.N., Veninga H., Hoek R.M., Flierman D., van Buul J.D., Vandenakker C.C., vanBavel E., Medof M.E., van Lier R.A., Reedquist K.A., Hamann J. Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. J.Immunol. 2013, 190:3740-3748.
9. Krause G., Kreuchwig A., Kleinau G. Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor. PLoS ONE 2012, 7:e52920.
10. Langenhan T., Aust G., Hamann J. Sticky signaling-adhesion class G protein-coupled receptors take the stage. Sci. Signal. 2013, 6:re3.
11. Lawrence P.A., Struhl G., Casal J. Planar cell polarity: one or two pathways?. Nat. Rev. Genet. 2007, 8:555-563.
12. Liebscher I., Schöneberg T., Prömel S. Progress in demystification of adhesion G protein-coupled receptors. Biol. Chem. 2013, 394:937-950.
13. McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C. Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J.Biol. Chem. 2002, 277:785-792.
14. Mogha A., Benesh A.E., Patra C., Engel F.B., Schöneberg T., Liebscher I., Monk K.R. Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J.Neurosci. 2013, 33:17976-17985.
15. Monk K.R., Naylor S.G., Glenn T.D., Mercurio S., Perlin J.R., Dominguez C., Moens C.B., Talbot W.S. A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science 2009, 325:1402-1405.
16. Monteclaro F.S., Charo I.F. The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation. J.Biol. Chem. 1996, 271:19084-19092.
17. Morash M.G., Douglas S.E., Robotham A., Ridley C.M., Gallant J.W., Soanes K.H. The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. Dis. Model. Mech. 2011, 4:622-633.
18. Moriguchi T., Haraguchi K., Ueda N., Okada M., Furuya T., Akiyama T. DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Genes Cells 2004, 9:549-560.
19. O'Sullivan M.L., de Wit J., Savas J.N., Comoletti D., Otto-Hitt S., Yates J.R., Ghosh A. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron 2012, 73:903-910.
20. Okajima D., Kudo G., Yokota H. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J.Recept. Signal Transduct. Res. 2010, 30:143-153.
21. Paavola K.J., Stephenson J.R., Ritter S.L., Alter S.P., Hall R.A. The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity. J.Biol. Chem. 2011, 286:28914-28921.
22. Paavola K.J., Sidik H., Zuchero J.B., Eckart M., Talbot W.S. Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126. Sci. Signal. 2014, 7:ra76.
23. Patra C., van Amerongen M.J., Ghosh S., Ricciardi F., Sajjad A., Novoyatleva T., Mogha A., Monk K.R., Mühlfeld C., Engel F.B. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc. Natl. Acad. Sci. USA 2013, 110:16898-16903.
24. Pogoda H.M., Sternheim N., Lyons D.A., Diamond B., Hawkins T.A., Woods I.G., Bhatt D.H., Franzini-Armstrong C., Dominguez C., Arana N., et al. A genetic screen identifies genes essential for development of myelinated axons in zebrafish. Dev. Biol. 2006, 298:118-131.
25. Prömel S., Frickenhaus M., Hughes S., Mestek L., Staunton D., Woollard A., Vakonakis I., Schöneberg T., Schnabel R., Russ A.P., Langenhan T. The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Cell Reports 2012, 2:321-331.
26. Sangkuhl K., Schulz A., Schultz G., Schöneberg T. Structural requirements for mutational lutropin/choriogonadotropin receptor activation. J.Biol. Chem. 2002, 277:47748-47755.
27. Schöneberg T., Schulz A., Biebermann H., Grüters A., Grimm T., Hübschmann K., Filler G., Gudermann T., Schultz G. V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms. Hum. Mutat. 1998, 12:196-205.
28. Schröder R., Janssen N., Schmidt J., Kebig A., Merten N., Hennen S., Müller A., Blättermann S., Mohr-Andrä M., Zahn S., et al. Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat. Biotechnol. 2010, 28:943-949.
29. Stäubert C., Böselt I., Bohnekamp J., Römpler H., Enard W., Schöneberg T. Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE 2010, 5:e11133.
30. Südhof T.C. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Annu. Rev. Neurosci. 2001, 24:933-962.
31. Thompson A.A., Liu W., Chun E., Katritch V., Wu H., Vardy E., Huang X.P., Trapella C., Guerrini R., Calo G., et al. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature 2012, 485:395-399.
32. Vu T.K., Hung D.T., Wheaton V.I., Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991, 64:1057-1068.
33. Yang L., Chen G., Mohanty S., Scott G., Fazal F., Rahman A., Begum S., Hynes R.O., Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res. 2011, 71:5558-5568.