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Volumn 39, Issue 12, 2016, Pages 1365-1376

Insulin, insulin receptors, and cancer

Author keywords

Diabetes and cancer; Hybrid receptors; Insulin; Insulin receptor; IR isoforms

Indexed keywords

INSULIN; INSULIN RECEPTOR; MEMBRANE RECEPTOR; PROTEIN TYROSINE KINASE; SOMATOMEDIN C RECEPTOR;

EID: 84994872058     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-016-0508-7     Document Type: Review
Times cited : (174)

References (99)
  • 1
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • COI: 1:CAS:528:DC%2BD28XhtlWnsLw%3D
    • Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7(2):85–96
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 2
    • 0021924895 scopus 로고
    • The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling
    • COI: 1:CAS:528:DyaL2MXktFOltLw%3D
    • Ebina Y et al (1985) The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 40(4):747–758
    • (1985) Cell , vol.40 , Issue.4 , pp. 747-758
    • Ebina, Y.1
  • 3
    • 65449168837 scopus 로고    scopus 로고
    • Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor
    • COI: 1:CAS:528:DC%2BD1MXltVOrtLc%3D
    • Ward CW, Lawrence MC (2009) Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor. BioEssays 31(4):422–434
    • (2009) BioEssays , vol.31 , Issue.4 , pp. 422-434
    • Ward, C.W.1    Lawrence, M.C.2
  • 4
    • 0035916357 scopus 로고    scopus 로고
    • An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    • COI: 1:CAS:528:DC%2BD3MXhsFWhtLo%3D
    • Brogiolo W et al (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11(4):213–221
    • (2001) Curr Biol , vol.11 , Issue.4 , pp. 213-221
    • Brogiolo, W.1
  • 5
    • 0032932822 scopus 로고    scopus 로고
    • Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
    • COI: 1:CAS:528:DyaK1MXislSltLk%3D
    • Frasca F et al (1999) Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 19(5):3278–3288
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3278-3288
    • Frasca, F.1
  • 6
    • 0026799458 scopus 로고
    • Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA
    • COI: 1:CAS:528:DyaK38XmsVGrtL0%3D
    • Giddings SJ, Carnaghi LR (1992) Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA. Mol Endocrinol 6(10):1665–1672
    • (1992) Mol Endocrinol , vol.6 , Issue.10 , pp. 1665-1672
    • Giddings, S.J.1    Carnaghi, L.R.2
  • 7
    • 34047174592 scopus 로고    scopus 로고
    • The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    • COI: 1:CAS:528:DC%2BD2sXlsVagtr8%3D
    • Belfiore A (2007) The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 13(7):671–686
    • (2007) Curr Pharm Des , vol.13 , Issue.7 , pp. 671-686
    • Belfiore, A.1
  • 8
    • 0027730575 scopus 로고
    • Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification
    • COI: 1:CAS:528:DyaK3sXms1alur4%3D
    • Kasuya J et al (1993) Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification. Biochemistry 32(49):13531–13536
    • (1993) Biochemistry , vol.32 , Issue.49 , pp. 13531-13536
    • Kasuya, J.1
  • 9
    • 34247872895 scopus 로고    scopus 로고
    • Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
    • COI: 1:CAS:528:DC%2BD2sXltVejsb8%3D
    • Benyoucef S et al (2007) Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation. Biochem J 403(3):603–613
    • (2007) Biochem J , vol.403 , Issue.3 , pp. 603-613
    • Benyoucef, S.1
  • 10
    • 0034877139 scopus 로고    scopus 로고
    • Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors
    • COI: 1:CAS:528:DC%2BD3MXms1Sltro%3D
    • Siddle K et al (2001) Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors. Biochem Soc Trans 29(Pt 4):513–525
    • (2001) Biochem Soc Trans , vol.29 , pp. 513-525
    • Siddle, K.1
  • 11
    • 0024358801 scopus 로고
    • Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains
    • COI: 1:CAS:528:DyaL1MXktFyjtbw%3D
    • Lammers R et al (1989) Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains. EMBO J 8(5):1369–1375
    • (1989) EMBO J , vol.8 , Issue.5 , pp. 1369-1375
    • Lammers, R.1
  • 12
    • 5044227353 scopus 로고    scopus 로고
    • Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR
    • COI: 1:CAS:528:DC%2BD2cXotFamsbg%3D
    • Denley A et al (2004) Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR. Mol Endocrinol 18(10):2502–2512
    • (2004) Mol Endocrinol , vol.18 , Issue.10 , pp. 2502-2512
    • Denley, A.1
  • 13
    • 80052143150 scopus 로고    scopus 로고
    • Insulin receptor and cancer
    • COI: 1:CAS:528:DC%2BC3MXhtlShsb%2FK
    • Belfiore A, Malaguarnera R (2011) Insulin receptor and cancer. Endocr Relat Cancer 18(4):R125–R147
    • (2011) Endocr Relat Cancer , vol.18 , Issue.4 , pp. R125-R147
    • Belfiore, A.1    Malaguarnera, R.2
  • 14
    • 84860340287 scopus 로고    scopus 로고
    • Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway
    • COI: 1:CAS:528:DC%2BC38XmsVKntb4%3D
    • Malaguarnera R et al (2012) Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway. Endocrinology 153(5):2152–2163
    • (2012) Endocrinology , vol.153 , Issue.5 , pp. 2152-2163
    • Malaguarnera, R.1
  • 15
    • 0842303519 scopus 로고    scopus 로고
    • Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells
    • COI: 1:CAS:528:DC%2BD2cXnsFGkuw%3D%3D
    • Frasca F et al (2003) Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells. Breast Dis 17:73–89
    • (2003) Breast Dis , vol.17 , pp. 73-89
    • Frasca, F.1
  • 16
    • 0342657181 scopus 로고    scopus 로고
    • Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use
    • COI: 1:CAS:528:DC%2BD3cXjvFylu7w%3D
    • Kurtzhals P et al (2000) Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. Diabetes 49(6):999–1005
    • (2000) Diabetes , vol.49 , Issue.6 , pp. 999-1005
    • Kurtzhals, P.1
  • 18
    • 72549116243 scopus 로고    scopus 로고
    • Diabetes and cancer
    • COI: 1:CAS:528:DC%2BC3cXhtFOgu7w%3D
    • Vigneri P et al (2009) Diabetes and cancer. Endocr Relat Cancer 16(4):1103–1123
    • (2009) Endocr Relat Cancer , vol.16 , Issue.4 , pp. 1103-1123
    • Vigneri, P.1
  • 19
    • 84869207897 scopus 로고    scopus 로고
    • The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression
    • COI: 1:CAS:528:DC%2BC3sXhsFCitL0%3D
    • Rose DP, Vona-Davis L (2012) The cellular and molecular mechanisms by which insulin influences breast cancer risk and progression. Endocr Relat Cancer 19(6):R225–R241
    • (2012) Endocr Relat Cancer , vol.19 , Issue.6 , pp. R225-R241
    • Rose, D.P.1    Vona-Davis, L.2
  • 20
    • 77955517441 scopus 로고    scopus 로고
    • Diabetes and cancer: a consensus report
    • Giovannucci E et al (2010) Diabetes and cancer: a consensus report. Diabetes Care 33(7):1674–1685
    • (2010) Diabetes Care , vol.33 , Issue.7 , pp. 1674-1685
    • Giovannucci, E.1
  • 21
    • 0030693249 scopus 로고    scopus 로고
    • Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting
    • COI: 1:CAS:528:DyaK2sXmvVGktrw%3D
    • Bailyes EM et al (1997) Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J 327(Pt 1):209–215
    • (1997) Biochem J , vol.327 , pp. 209-215
    • Bailyes, E.M.1
  • 22
    • 0031918624 scopus 로고    scopus 로고
    • The IRS-signalling system: a network of docking proteins that mediate insulin action
    • COI: 1:CAS:528:DyaK1cXjtlOnsr4%3D
    • White MF (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 182(1–2):3–11
    • (1998) Mol Cell Biochem , vol.182 , Issue.1-2 , pp. 3-11
    • White, M.F.1
  • 23
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • COI: 1:CAS:528:DC%2BD1MXhsVyhsrbK
    • Belfiore A et al (2009) Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 30(6):586–623
    • (2009) Endocr Rev , vol.30 , Issue.6 , pp. 586-623
    • Belfiore, A.1
  • 24
    • 0026710682 scopus 로고
    • Insulin receptor expression and function in human breast cancer cell lines
    • COI: 1:CAS:528:DyaK38XlsVyhsbw%3D
    • Milazzo G et al (1992) Insulin receptor expression and function in human breast cancer cell lines. Cancer Res 52(14):3924–3930
    • (1992) Cancer Res , vol.52 , Issue.14 , pp. 3924-3930
    • Milazzo, G.1
  • 25
    • 0030880432 scopus 로고    scopus 로고
    • The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice
    • COI: 1:CAS:528:DyaK2sXmvFygur4%3D
    • Frittitta L et al (1997) The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice. Breast Cancer Res Treat 45(2):141–147
    • (1997) Breast Cancer Res Treat , vol.45 , Issue.2 , pp. 141-147
    • Frittitta, L.1
  • 26
    • 0017806494 scopus 로고
    • Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture
    • COI: 1:CAS:528:DyaE1cXmtV2ltw%3D%3D
    • Osborne CK et al (1978) Correlation among insulin binding, degradation, and biological activity in human breast cancer cells in long-term tissue culture. Cancer Res 38(1):94–102
    • (1978) Cancer Res , vol.38 , Issue.1 , pp. 94-102
    • Osborne, C.K.1
  • 27
    • 0027409865 scopus 로고
    • Structural and functional studies of insulin receptors in human breast cancer
    • COI: 1:STN:280:DyaK3s3pvV2guw%3D%3D
    • Frittitta L et al (1993) Structural and functional studies of insulin receptors in human breast cancer. Breast Cancer Res Treat 25(1):73–82
    • (1993) Breast Cancer Res Treat , vol.25 , Issue.1 , pp. 73-82
    • Frittitta, L.1
  • 28
    • 0025066641 scopus 로고
    • Elevated insulin receptor content in human breast cancer
    • COI: 1:STN:280:DyaK3M%2Fls1Wmsg%3D%3D
    • Papa V et al (1990) Elevated insulin receptor content in human breast cancer. J Clin Invest 86(5):1503–1510
    • (1990) J Clin Invest , vol.86 , Issue.5 , pp. 1503-1510
    • Papa, V.1
  • 29
    • 0034967179 scopus 로고    scopus 로고
    • The IGF system in thyroid cancer: new concepts
    • COI: 1:CAS:528:DC%2BD3MXltVOisr4%3D
    • Vella V et al (2001) The IGF system in thyroid cancer: new concepts. Mol Pathol 54(3):121–124
    • (2001) Mol Pathol , vol.54 , Issue.3 , pp. 121-124
    • Vella, V.1
  • 30
    • 77953292060 scopus 로고    scopus 로고
    • HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene
    • COI: 1:CAS:528:DC%2BC3cXntlajur0%3D
    • Aiello A et al (2010) HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene. Eur J Cancer 46(10):1919–1926
    • (2010) Eur J Cancer , vol.46 , Issue.10 , pp. 1919-1926
    • Aiello, A.1
  • 31
    • 84875795546 scopus 로고    scopus 로고
    • A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components
    • Chiefari E et al (2013) A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components. Sci Rep 3:1491
    • (2013) Sci Rep , vol.3 , pp. 1491
    • Chiefari, E.1
  • 32
    • 36448992338 scopus 로고    scopus 로고
    • Roles of HMGA proteins in cancer
    • COI: 1:CAS:528:DC%2BD2sXhtlCrsLbO
    • Fusco A, Fedele M (2007) Roles of HMGA proteins in cancer. Nat Rev Cancer 7(12):899–910
    • (2007) Nat Rev Cancer , vol.7 , Issue.12 , pp. 899-910
    • Fusco, A.1    Fedele, M.2
  • 33
    • 0037191919 scopus 로고    scopus 로고
    • In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A
    • COI: 1:CAS:528:DC%2BD38XovVGmsL0%3D
    • Sciacca L et al (2002) In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene 21(54):8240–8250
    • (2002) Oncogene , vol.21 , Issue.54 , pp. 8240-8250
    • Sciacca, L.1
  • 34
    • 0036148531 scopus 로고    scopus 로고
    • A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer
    • COI: 1:CAS:528:DC%2BD38XntVymtQ%3D%3D
    • Vella V et al (2002) A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Metab 87(1):245–254
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.1 , pp. 245-254
    • Vella, V.1
  • 35
    • 0036721496 scopus 로고    scopus 로고
    • Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling
    • COI: 1:CAS:528:DC%2BD38XmsVSgt7g%3D
    • Kalli KR et al (2002) Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling. Endocrinology 143(9):3259–3267
    • (2002) Endocrinology , vol.143 , Issue.9 , pp. 3259-3267
    • Kalli, K.R.1
  • 36
    • 0025131648 scopus 로고
    • Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells
    • COI: 1:CAS:528:DyaK3cXlt1KrtLk%3D
    • Soos MA et al (1990) Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells. Biochem J 270(2):383–390
    • (1990) Biochem J , vol.270 , Issue.2 , pp. 383-390
    • Soos, M.A.1
  • 37
    • 0034527601 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects
    • COI: 1:CAS:528:DC%2BD3cXotlWnu7Y%3D
    • Spampinato D et al (2000) Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects. J Clin Endocrinol Metab 85(11):4219–4223
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.11 , pp. 4219-4223
    • Spampinato, D.1
  • 38
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling
    • COI: 1:CAS:528:DyaK1MXltVCqtL8%3D
    • Pandini G et al (1999) Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 5(7):1935–1944
    • (1999) Clin Cancer Res , vol.5 , Issue.7 , pp. 1935-1944
    • Pandini, G.1
  • 39
    • 34248170187 scopus 로고    scopus 로고
    • Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    • COI: 1:CAS:528:DC%2BD2sXlt1ahtr0%3D
    • Pandini G et al (2007) Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer 43(8):1318–1327
    • (2007) Eur J Cancer , vol.43 , Issue.8 , pp. 1318-1327
    • Pandini, G.1
  • 40
    • 0037131385 scopus 로고    scopus 로고
    • Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    • COI: 1:CAS:528:DC%2BD38XnvVeiu74%3D
    • Pandini G et al (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 277(42):39684–39695
    • (2002) J Biol Chem , vol.277 , Issue.42 , pp. 39684-39695
    • Pandini, G.1
  • 41
    • 12144287363 scopus 로고    scopus 로고
    • Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women
    • COI: 1:CAS:528:DC%2BD2cXitVWltbo%3D
    • Lukanova A et al (2004) Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women. Eur J Endocrinol 150(2):161–171
    • (2004) Eur J Endocrinol , vol.150 , Issue.2 , pp. 161-171
    • Lukanova, A.1
  • 42
    • 34250321324 scopus 로고    scopus 로고
    • Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition
    • COI: 1:CAS:528:DC%2BD2sXmslOlt7Y%3D
    • Jenab M et al (2007) Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 121(2):368–376
    • (2007) Int J Cancer , vol.121 , Issue.2 , pp. 368-376
    • Jenab, M.1
  • 43
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: scientific review
    • COI: 1:CAS:528:DC%2BD38XksVClsA%3D%3D
    • Inzucchi SE (2002) Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA 287(3):360–372
    • (2002) JAMA , vol.287 , Issue.3 , pp. 360-372
    • Inzucchi, S.E.1
  • 44
    • 84862857629 scopus 로고    scopus 로고
    • Does use of metformin protect against cancer in Type 2 diabetes mellitus?
    • COI: 1:CAS:528:DC%2BC38XoslCgtLk%3D
    • Bo S et al (2012) Does use of metformin protect against cancer in Type 2 diabetes mellitus? J Endocrinol Invest 35(2):231–235
    • (2012) J Endocrinol Invest , vol.35 , Issue.2 , pp. 231-235
    • Bo, S.1
  • 45
    • 84942088910 scopus 로고    scopus 로고
    • Expanding the therapeutic spectrum of metformin: from diabetes to cancer
    • COI: 1:CAS:528:DC%2BC28XhvFSisrY%3D
    • Coperchini F et al (2015) Expanding the therapeutic spectrum of metformin: from diabetes to cancer. J Endocrinol Invest 38(10):1047–1055
    • (2015) J Endocrinol Invest , vol.38 , Issue.10 , pp. 1047-1055
    • Coperchini, F.1
  • 46
    • 0025865344 scopus 로고
    • Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype
    • COI: 1:CAS:528:DyaK3MXitVSqs7w%3D
    • Giorgino F et al (1991) Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype. Mol Endocrinol 5(3):452–459
    • (1991) Mol Endocrinol , vol.5 , Issue.3 , pp. 452-459
    • Giorgino, F.1
  • 47
    • 84884145031 scopus 로고    scopus 로고
    • Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients
    • COI: 1:CAS:528:DC%2BC3sXht1eksrvL
    • Sciacca L et al (2013) Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients. Nutr Metab Cardiovasc Dis 23(9):808–815
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , Issue.9 , pp. 808-815
    • Sciacca, L.1
  • 48
    • 0028906841 scopus 로고
    • Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype
    • COI: 1:CAS:528:DyaK2MXltFaqsro%3D
    • Frittitta L et al (1995) Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype. J Cell Biochem 57(4):666–669
    • (1995) J Cell Biochem , vol.57 , Issue.4 , pp. 666-669
    • Frittitta, L.1
  • 49
    • 0019419891 scopus 로고
    • Role of hormones in the growth and regression of human breast cancer cells (MCF-7) transplanted into athymic nude mice
    • COI: 1:CAS:528:DyaL3MXlt1KntLc%3D
    • Shafie SM, Grantham FH (1981) Role of hormones in the growth and regression of human breast cancer cells (MCF-7) transplanted into athymic nude mice. J Natl Cancer Inst 67(1):51–56
    • (1981) J Natl Cancer Inst , vol.67 , Issue.1 , pp. 51-56
    • Shafie, S.M.1    Grantham, F.H.2
  • 50
    • 84994899949 scopus 로고    scopus 로고
    • Targeting the Warburg effect for leukemia therapy: magnitude matters
    • Wang YH, Scadden DT (2015) Targeting the Warburg effect for leukemia therapy: magnitude matters. Mol Cell Oncol 2(3):e981988
    • (2015) Mol Cell Oncol , vol.2 , Issue.3
    • Wang, Y.H.1    Scadden, D.T.2
  • 51
    • 84994874107 scopus 로고    scopus 로고
    • Mitochondrial respiratory defects promote the Warburg effect and cancer progression
    • Srinivasan S, Guha M, Avadhani NG (2016) Mitochondrial respiratory defects promote the Warburg effect and cancer progression. Mol Cell Oncol 3(2):e1085120
    • (2016) Mol Cell Oncol , vol.3 , Issue.2
    • Srinivasan, S.1    Guha, M.2    Avadhani, N.G.3
  • 52
    • 0036845537 scopus 로고    scopus 로고
    • Fasting glucose is a risk factor for breast cancer: a prospective study
    • COI: 1:CAS:528:DC%2BD38XpsVyksrg%3D
    • Muti P et al (2002) Fasting glucose is a risk factor for breast cancer: a prospective study. Cancer Epidemiol Biomark Prev 11(11):1361–1368
    • (2002) Cancer Epidemiol Biomark Prev , vol.11 , Issue.11 , pp. 1361-1368
    • Muti, P.1
  • 53
    • 13844273241 scopus 로고    scopus 로고
    • Controlling hyperglycemia as an adjunct to cancer therapy
    • Krone CA, Ely JT (2005) Controlling hyperglycemia as an adjunct to cancer therapy. Integr Cancer Ther 4(1):25–31
    • (2005) Integr Cancer Ther , vol.4 , Issue.1 , pp. 25-31
    • Krone, C.A.1    Ely, J.T.2
  • 54
    • 84880846482 scopus 로고    scopus 로고
    • Blood glucose concentrations and breast cancer risk in women without diabetes: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXhtFGrsLbK
    • Boyle P et al (2013) Blood glucose concentrations and breast cancer risk in women without diabetes: a meta-analysis. Eur J Nutr 52(5):1533–1540
    • (2013) Eur J Nutr , vol.52 , Issue.5 , pp. 1533-1540
    • Boyle, P.1
  • 55
    • 84962925971 scopus 로고    scopus 로고
    • Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals
    • COI: 1:CAS:528:DC%2BC28Xjs1altbw%3D
    • Carstensen B et al (2016) Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals. Diabetologia 59(5):980–988
    • (2016) Diabetologia , vol.59 , Issue.5 , pp. 980-988
    • Carstensen, B.1
  • 56
    • 84916614291 scopus 로고    scopus 로고
    • Prediabetes and the risk of cancer: a meta-analysis
    • COI: 1:CAS:528:DC%2BC2cXhsFeksLrI
    • Huang Y et al (2014) Prediabetes and the risk of cancer: a meta-analysis. Diabetologia 57(11):2261–2269
    • (2014) Diabetologia , vol.57 , Issue.11 , pp. 2261-2269
    • Huang, Y.1
  • 57
    • 84908233394 scopus 로고    scopus 로고
    • Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: the Korean Cancer Prevention Study-II
    • COI: 1:CAS:528:DC%2BC2cXhtlamsbzL
    • Shin HY et al (2014) Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: the Korean Cancer Prevention Study-II. Metabolism 63(10):1250–1256
    • (2014) Metabolism , vol.63 , Issue.10 , pp. 1250-1256
    • Shin, H.Y.1
  • 58
    • 84886407673 scopus 로고    scopus 로고
    • Metabolic dysregulation of the insulin-glucose axis and risk of obesity-related cancers in the Framingham heart study-offspring cohort (1971-2008)
    • Parekh N et al (2013) Metabolic dysregulation of the insulin-glucose axis and risk of obesity-related cancers in the Framingham heart study-offspring cohort (1971-2008). Cancer Epidemiol Biomark Prev 22(10):1825–1836
    • (2013) Cancer Epidemiol Biomark Prev , vol.22 , Issue.10 , pp. 1825-1836
    • Parekh, N.1
  • 59
    • 84925485218 scopus 로고    scopus 로고
    • Prediabetes and associated disorders
    • COI: 1:CAS:528:DC%2BC2cXhslahurbO
    • Buysschaert M et al (2015) Prediabetes and associated disorders. Endocrine 48(2):371–393
    • (2015) Endocrine , vol.48 , Issue.2 , pp. 371-393
    • Buysschaert, M.1
  • 60
    • 84930913485 scopus 로고    scopus 로고
    • Metabolic components and recurrence in early-stage cervical cancer
    • COI: 1:CAS:528:DC%2BC2cXhvFGgt77F
    • Ahn HK et al (2015) Metabolic components and recurrence in early-stage cervical cancer. Tumour Biol 36(3):2201–2207
    • (2015) Tumour Biol , vol.36 , Issue.3 , pp. 2201-2207
    • Ahn, H.K.1
  • 61
    • 33947653911 scopus 로고    scopus 로고
    • The metabolic syndrome: a high-risk state for cancer?
    • COI: 1:CAS:528:DC%2BD28Xht12isr7K
    • Cowey S, Hardy RW (2006) The metabolic syndrome: a high-risk state for cancer? Am J Pathol 169(5):1505–1522
    • (2006) Am J Pathol , vol.169 , Issue.5 , pp. 1505-1522
    • Cowey, S.1    Hardy, R.W.2
  • 62
    • 84921024951 scopus 로고    scopus 로고
    • Metabolic syndrome and risk of endometrial cancer in the united states: a study in the SEER-medicare linked database
    • Trabert B et al (2015) Metabolic syndrome and risk of endometrial cancer in the united states: a study in the SEER-medicare linked database. Cancer Epidemiol Biomark Prev 24(1):261–267
    • (2015) Cancer Epidemiol Biomark Prev , vol.24 , Issue.1 , pp. 261-267
    • Trabert, B.1
  • 63
    • 84922498435 scopus 로고    scopus 로고
    • Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort
    • COI: 1:CAS:528:DC%2BC2cXivF2ns7Y%3D
    • Bhindi B et al (2015) Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort. Eur Urol 67(1):64–70
    • (2015) Eur Urol , vol.67 , Issue.1 , pp. 64-70
    • Bhindi, B.1
  • 64
    • 33646016264 scopus 로고    scopus 로고
    • Obesity and cancer
    • COI: 1:STN:280:DC%2BD28%2FhsVWlsQ%3D%3D
    • Vigneri P et al (2006) Obesity and cancer. Nutr Metab Cardiovasc Dis 16(1):1–7
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , Issue.1 , pp. 1-7
    • Vigneri, P.1
  • 65
    • 18944373410 scopus 로고    scopus 로고
    • Visceral fat accumulation as a risk factor for prostate cancer
    • von Hafe P et al (2004) Visceral fat accumulation as a risk factor for prostate cancer. Obes Res 12(12):1930–1935
    • (2004) Obes Res , vol.12 , Issue.12 , pp. 1930-1935
    • von Hafe, P.1
  • 66
    • 0036270579 scopus 로고    scopus 로고
    • Upper abdominal obesity, insulin resistance and breast cancer risk
    • COI: 1:STN:280:DC%2BD383ps1Kmsw%3D%3D
    • Stoll BA (2002) Upper abdominal obesity, insulin resistance and breast cancer risk. Int J Obes Relat Metab Disord 26(6):747–753
    • (2002) Int J Obes Relat Metab Disord , vol.26 , Issue.6 , pp. 747-753
    • Stoll, B.A.1
  • 67
    • 84863576934 scopus 로고    scopus 로고
    • A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer
    • COI: 1:CAS:528:DC%2BC38Xht1WltLrM
    • Weichhaus M et al (2012) A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer. Int J Oncol 41(2):745–752
    • (2012) Int J Oncol , vol.41 , Issue.2 , pp. 745-752
    • Weichhaus, M.1
  • 68
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE et al (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–1638
    • (2003) N Engl J Med , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1
  • 69
    • 84937630982 scopus 로고    scopus 로고
    • Insulin receptor variants and obesity-related cancers in the Framingham Heart Study
    • Parekh N et al (2015) Insulin receptor variants and obesity-related cancers in the Framingham Heart Study. Cancer Causes Control 26(8):1189–1195
    • (2015) Cancer Causes Control , vol.26 , Issue.8 , pp. 1189-1195
    • Parekh, N.1
  • 70
    • 79952260576 scopus 로고    scopus 로고
    • Diabetes mellitus, fasting glucose, and risk of cause-specific death
    • Emerging Risk Factors Collaboration et al (2011) Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med 364(9):829–841
    • (2011) N Engl J Med , vol.364 , Issue.9 , pp. 829-841
    • Emerging Risk Factors Collaboration1
  • 71
    • 84925096868 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and insulin: our understanding in the past, present and future
    • COI: 1:CAS:528:DC%2BC2MXksVOkt7k%3D
    • Mayer SB, Evans WS, Nestler JE (2015) Polycystic ovary syndrome and insulin: our understanding in the past, present and future. Womens Health 11(2):137–149
    • (2015) Womens Health , vol.11 , Issue.2 , pp. 137-149
    • Mayer, S.B.1    Evans, W.S.2    Nestler, J.E.3
  • 72
    • 84945378389 scopus 로고    scopus 로고
    • Metabolic syndrome: polycystic ovary syndrome
    • Mortada R, Williams T (2015) Metabolic syndrome: polycystic ovary syndrome. FP Essent 435:30–42
    • (2015) FP Essent , vol.435 , pp. 30-42
    • Mortada, R.1    Williams, T.2
  • 73
    • 84907266329 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and risk of endometrial cancer: a mini-review
    • Tokmak A et al (2014) Polycystic ovary syndrome and risk of endometrial cancer: a mini-review. Asian Pac J Cancer Prev 15(17):7011–7014
    • (2014) Asian Pac J Cancer Prev , vol.15 , Issue.17 , pp. 7011-7014
    • Tokmak, A.1
  • 74
    • 84940470586 scopus 로고    scopus 로고
    • Complications and challenges associated with polycystic ovary syndrome: current perspectives
    • COI: 1:CAS:528:DC%2BC28Xns1Ggsb4%3D
    • Palomba S et al (2015) Complications and challenges associated with polycystic ovary syndrome: current perspectives. Int J Womens Health 7:745–763
    • (2015) Int J Womens Health , vol.7 , pp. 745-763
    • Palomba, S.1
  • 75
    • 84905082203 scopus 로고    scopus 로고
    • Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis
    • Barry JA, Azizia MM, Hardiman PJ (2014) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 20(5):748–758
    • (2014) Hum Reprod Update , vol.20 , Issue.5 , pp. 748-758
    • Barry, J.A.1    Azizia, M.M.2    Hardiman, P.J.3
  • 76
    • 0346888536 scopus 로고    scopus 로고
    • Cancer incidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden
    • Zendehdel K et al (2003) Cancer incidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden. J Natl Cancer Inst 95(23):1797–1800
    • (2003) J Natl Cancer Inst , vol.95 , Issue.23 , pp. 1797-1800
    • Zendehdel, K.1
  • 77
    • 0030054231 scopus 로고    scopus 로고
    • Insulin analogues and carcinoma of the breast
    • COI: 1:CAS:528:DyaK28Xhtlyms78%3D
    • Ebeling P, Tuominen JA, Koivisto VA (1996) Insulin analogues and carcinoma of the breast. Diabetologia 39(1):124–125
    • (1996) Diabetologia , vol.39 , Issue.1 , pp. 124-125
    • Ebeling, P.1    Tuominen, J.A.2    Koivisto, V.A.3
  • 78
    • 84924905128 scopus 로고    scopus 로고
    • Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/(+)WAPCre mouse model
    • ter Braak B et al (2015) Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/(+)WAPCre mouse model. Breast Cancer Res 17:14
    • (2015) Breast Cancer Res , vol.17 , pp. 14
    • ter Braak, B.1
  • 79
    • 0030614323 scopus 로고    scopus 로고
    • ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor
    • COI: 1:CAS:528:DyaK2sXhtVWrs7k%3D
    • Milazzo G et al (1997) ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: evidence for enhanced interactions with the insulin-like growth factor-I receptor. Mol Carcinog 18(1):19–25
    • (1997) Mol Carcinog , vol.18 , Issue.1 , pp. 19-25
    • Milazzo, G.1
  • 80
    • 77955515434 scopus 로고    scopus 로고
    • Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
    • COI: 1:CAS:528:DC%2BC3cXotVKgsL4%3D
    • Sciacca L et al (2010) Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling. Diabetologia 53(8):1743–1753
    • (2010) Diabetologia , vol.53 , Issue.8 , pp. 1743-1753
    • Sciacca, L.1
  • 81
    • 68449104156 scopus 로고    scopus 로고
    • Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
    • COI: 1:CAS:528:DC%2BD1MXpsFyrsL0%3D
    • Hemkens LG et al (2009) Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia 52(9):1732–1744
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1732-1744
    • Hemkens, L.G.1
  • 82
    • 68449094354 scopus 로고    scopus 로고
    • Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group
    • Colhoun, H.M. and S.E. Group (2009) Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group. Diabetologia 52(9):1755–1765
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1755-1765
    • Colhoun, H.M. and S.E. Group,1
  • 83
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1MXpsFyrsLo%3D
    • Currie CJ, Poole CD, Gale EA (2009) The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 52(9):1766–1777
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 84
    • 68449104625 scopus 로고    scopus 로고
    • Insulin glargine use and short-term incidence of malignancies-a population-based follow-up study in Sweden
    • COI: 1:STN:280:DC%2BD1MrktlygtQ%3D%3D
    • Jonasson JM et al (2009) Insulin glargine use and short-term incidence of malignancies-a population-based follow-up study in Sweden. Diabetologia 52(9):1745–1754
    • (2009) Diabetologia , vol.52 , Issue.9 , pp. 1745-1754
    • Jonasson, J.M.1
  • 85
    • 77954832956 scopus 로고    scopus 로고
    • Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BC3cXht1OmurnO
    • Mannucci E et al (2010) Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care 33(9):1997–2003
    • (2010) Diabetes Care , vol.33 , Issue.9 , pp. 1997-2003
    • Mannucci, E.1
  • 86
    • 68349148204 scopus 로고    scopus 로고
    • Insulin glargine and malignancy: an unwarranted alarm
    • Pocock SJ, Smeeth L (2009) Insulin glargine and malignancy: an unwarranted alarm. Lancet 374(9689):511–513
    • (2009) Lancet , vol.374 , Issue.9689 , pp. 511-513
    • Pocock, S.J.1    Smeeth, L.2
  • 87
    • 69949174459 scopus 로고    scopus 로고
    • Insulin glargine and cancer—an unsubstantiated allegation
    • COI: 1:CAS:528:DC%2BD1MXhtVGjtbvK
    • Garg SK, Hirsch IB, Skyler JS (2009) Insulin glargine and cancer—an unsubstantiated allegation. Diabetes Technol Ther 11(8):473–476
    • (2009) Diabetes Technol Ther , vol.11 , Issue.8 , pp. 473-476
    • Garg, S.K.1    Hirsch, I.B.2    Skyler, J.S.3
  • 88
    • 80054700909 scopus 로고    scopus 로고
    • Long-term effects of insulin glargine on the risk of breast cancer
    • COI: 1:CAS:528:DC%2BC3MXpvVKjsr4%3D
    • Suissa S et al (2011) Long-term effects of insulin glargine on the risk of breast cancer. Diabetologia 54(9):2254–2262
    • (2011) Diabetologia , vol.54 , Issue.9 , pp. 2254-2262
    • Suissa, S.1
  • 89
    • 84856715759 scopus 로고    scopus 로고
    • Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study
    • COI: 1:CAS:528:DC%2BC3MXhsFOqu7%2FE
    • Ruiter R et al (2012) Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study. Diabetologia 55(1):51–62
    • (2012) Diabetologia , vol.55 , Issue.1 , pp. 51-62
    • Ruiter, R.1
  • 90
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dysglycemia
    • Investigators OT et al (2012) Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 367(4):319–328
    • (2012) N Engl J Med , vol.367 , Issue.4 , pp. 319-328
    • Investigators, O.T.1
  • 91
    • 84868257500 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes
    • (author reply 1763-4)
    • Vigneri R, Vigneri P, Frittitta L (2012) Basal insulin and cardiovascular and other outcomes. N Engl J Med 367(18):1761–1762 (author reply 1763-4)
    • (2012) N Engl J Med , vol.367 , Issue.18 , pp. 1761-1762
    • Vigneri, R.1    Vigneri, P.2    Frittitta, L.3
  • 92
    • 0030679620 scopus 로고    scopus 로고
    • Insulin receptor expression and clinical outcome in node-negative breast cancer
    • COI: 1:CAS:528:DyaK2sXns1Omu7Y%3D
    • Mathieu MC et al (1997) Insulin receptor expression and clinical outcome in node-negative breast cancer. Proc Assoc Am Physicians 109(6):565–571
    • (1997) Proc Assoc Am Physicians , vol.109 , Issue.6 , pp. 565-571
    • Mathieu, M.C.1
  • 93
    • 57749089652 scopus 로고    scopus 로고
    • Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival
    • COI: 1:CAS:528:DC%2BD1cXhsV2itL7K
    • Law JH et al (2008) Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res 68(24):10238–10246
    • (2008) Cancer Res , vol.68 , Issue.24 , pp. 10238-10246
    • Law, J.H.1
  • 94
    • 84857380018 scopus 로고    scopus 로고
    • Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer
    • COI: 1:CAS:528:DC%2BC38Xlslyitbs%3D
    • Kim JS et al (2012) Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer. Cancer 118(9):2454–2465
    • (2012) Cancer , vol.118 , Issue.9 , pp. 2454-2465
    • Kim, J.S.1
  • 95
    • 1442344925 scopus 로고    scopus 로고
    • The insulin-like growth factor system in advanced breast cancer
    • COI: 1:CAS:528:DC%2BD3sXpvVWmurY%3D
    • Helle SI (2004) The insulin-like growth factor system in advanced breast cancer. Best Pract Res Clin Endocrinol Metab 18(1):67–79
    • (2004) Best Pract Res Clin Endocrinol Metab , vol.18 , Issue.1 , pp. 67-79
    • Helle, S.I.1
  • 96
    • 84920165976 scopus 로고    scopus 로고
    • IGF-IR Targeted Therapy: past, present and future
    • Janssen JA, Varewijck AJ (2014) IGF-IR Targeted Therapy: past, present and future. Front Endocrinol 5:224
    • (2014) Front Endocrinol , vol.5 , pp. 224
    • Janssen, J.A.1    Varewijck, A.J.2
  • 97
    • 84929337178 scopus 로고    scopus 로고
    • Highly specific role of the insulin receptor in breast cancer progression
    • COI: 1:CAS:528:DC%2BC2MXosV2ktbc%3D
    • Rostoker R et al (2015) Highly specific role of the insulin receptor in breast cancer progression. Endocr Relat Cancer 22(2):145–157
    • (2015) Endocr Relat Cancer , vol.22 , Issue.2 , pp. 145-157
    • Rostoker, R.1
  • 98
    • 84904906540 scopus 로고    scopus 로고
    • Biological effects of insulin and its analogs on cancer cells with different insulin family receptor expression
    • COI: 1:CAS:528:DC%2BC2cXht1alu7nJ
    • Sciacca L et al (2014) Biological effects of insulin and its analogs on cancer cells with different insulin family receptor expression. J Cell Physiol 229(11):1817–1821
    • (2014) J Cell Physiol , vol.229 , Issue.11 , pp. 1817-1821
    • Sciacca, L.1
  • 99
    • 77953286864 scopus 로고    scopus 로고
    • Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey
    • Parekh N et al (2010) Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey. Cancer Causes Control 21(4):631–642
    • (2010) Cancer Causes Control , vol.21 , Issue.4 , pp. 631-642
    • Parekh, N.1


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