Mitochondrial respiratory defects promote the Warburg effect and cancer progression

Molecular and Cellular Oncology

Volumn 3, Issue 2, 2016, Pages

  Srinivasan, Satish ^a   Guha, Manti ^a   Avadhani, Narayan G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cancer; cytochrome oxidase; mitochondrial dysfunction; retrograde signaling

Indexed keywords

EID: 84994874107     PISSN: None     EISSN: 23723556     Source Type: Journal    
DOI: 10.1080/23723556.2015.1085120     Document Type: Article

References (10)

1. Chatterjee A, Mambo E, Sidransky D. Mitochondrial DNA mutations in human cancer. Oncogene 2006; 25: 4663-74; PMID:16892080; http://dx.doi.org/10.1038/sj.onc.1209604
2. Wallace DC. Mitochondria and cancer. Nat Rev Cancer 2012; 12: 685-98; PMID:23001348; http://dx.doi.org/10.1038/nrc3365
3. Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet 2011; 20: 4605-16; PMID:21890492; http://dx.doi.org/10.1093/hmg/ddr395
4. Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 2008; 320: 661-4; PMID:18388260; http://dx.doi.org/10.1126/science.1156906
5. Butow RA, Avadhani NG. Mitochondrial signaling: the retrograde response. Mol Cell 2004; 14: 1-15; PMID:15068799; http://dx.doi.org/10.1016/S1097-2765(04)00179-0
6. Namslauer I, Brzezinski P. A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase. Proc Natl Acad Sci U S A 2009; 106: 3402-7; PMID:19218458; http://dx.doi.org/10.1073/pnas.0811450106
7. Srinivasan S, Avadhani NG. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med 2012; 53: 1252-63; PMID:22841758; http://dx.doi.org/10.1016/j.freeradbiomed.2012.07.021
8. Srinivasan S, Guha M, Dong DW, Whelan KA, Ruthel G, Uchikado Y, Natsugoe S, Nakagawa H, Avadhani NG. Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming. Oncogene 2015; http://dx.doi.org/10.1038/onc.2015.227
9. van WC, Sun Y, Cheung HS, Moraes CT. Oxidative phosphorylation dysfunction modulates expression of extracellular matrix–remodeling genes and invasion. Carcinogenesis 2006; 27: 409-18; PMID:16221732; http://dx.doi.org/10.1093/carcin/bgi242
10. Radde BN, Ivanova MM, Mai HX, Salabei JK, Hill BG, Klinge CM. Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen. Biochem J 2015; 465: 49-61; PMID:25279503; http://dx.doi.org/10.1042/BJ20131608