-
1
-
-
84920116915
-
Targeting the insulin-like growth factor-I receptor in cancer therapy
-
In: Leroith D, editor. New York, NY: Springer
-
Clemmons DR. Targeting the insulin-like growth factor-I receptor in cancer therapy. In: Leroith D, editor. Insulin-Like Growth Factors and Cancer: From Basic Biology to Therapeutics. New York, NY: Springer (2012). p. 193-213.
-
(2012)
Insulin-Like Growth Factors and Cancer: From Basic Biology to Therapeutics
, pp. 193-213
-
-
Clemmons, D.R.1
-
2
-
-
0036970842
-
The role of the IGF system in cancer: from basic to clinical studies and clinical applications
-
Moschos SJ, Mantzoros CS. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology (2002) 63:317-32. doi: 10.1159/000066230
-
(2002)
Oncology
, vol.63
, pp. 317-332
-
-
Moschos, S.J.1
Mantzoros, C.S.2
-
3
-
-
0024550730
-
Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer
-
Yee D, Paik S, Lebovic GS, Marcus RR, Favoni RE, Cullen KJ, et al. Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol (1989) 3:509-17. doi:10.1210/mend-3-3-509
-
(1989)
Mol Endocrinol
, vol.3
, pp. 509-517
-
-
Yee, D.1
Paik, S.2
Lebovic, G.S.3
Marcus, R.R.4
Favoni, R.E.5
Cullen, K.J.6
-
4
-
-
0043198265
-
Serum levels of insulin-like growth factor I and its binding proteins in health and disease
-
Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res (2003) 13:113-70. doi:10.1016/S1096-6374(03)00038-8
-
(2003)
Growth Horm IGF Res
, vol.13
, pp. 113-170
-
-
Juul, A.1
-
5
-
-
0028958031
-
Insulin-like growth factors and their binding proteins: biological actions
-
Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev (1995) 16:3-34. doi:10.1210/edrv-16-1-3
-
(1995)
Endocr Rev
, vol.16
, pp. 3-34
-
-
Jones, J.I.1
Clemmons, D.R.2
-
6
-
-
0018929433
-
Somatogenic receptors of rat liver: regulation by insulin
-
Baxter RC, Bryson JM, Turtle JR. Somatogenic receptors of rat liver: regulation by insulin. Endocrinology (1980) 107:1176-81. doi:10.1210/endo-107-4-1176
-
(1980)
Endocrinology
, vol.107
, pp. 1176-1181
-
-
Baxter, R.C.1
Bryson, J.M.2
Turtle, J.R.3
-
7
-
-
0142152633
-
Polycystic ovary syndrome (PCOS), insulin resistance and insulin-like growth factors (IGfs)/IGF-binding proteins (IGFBPs)
-
Wang HS, Wang TH. Polycystic ovary syndrome (PCOS), insulin resistance and insulin-like growth factors (IGfs)/IGF-binding proteins (IGFBPs). Chang Gung Med J (2003) 26:540-53.
-
(2003)
Chang Gung Med J
, vol.26
, pp. 540-553
-
-
Wang, H.S.1
Wang, T.H.2
-
8
-
-
83455236504
-
Insulin-like growth factor: current concepts and new developments in cancer therapy
-
King ER, Wong KK. Insulin-like growth factor: current concepts and new developments in cancer therapy. Recent Pat Anticancer Drug Discov (2012) 7:14-30. doi:10.2174/157489212798357930
-
(2012)
Recent Pat Anticancer Drug Discov
, vol.7
, pp. 14-30
-
-
King, E.R.1
Wong, K.K.2
-
9
-
-
84867429597
-
Insulin and its analogues and their affinities for the IGF1 receptor
-
Varewijck AJ, Janssen JA. Insulin and its analogues and their affinities for the IGF1 receptor. Endocr Relat Cancer (2012) 19:F63-75. doi:10.1530/ERC-12-0026
-
(2012)
Endocr Relat Cancer
, vol.19
, pp. F63-F75
-
-
Varewijck, A.J.1
Janssen, J.A.2
-
10
-
-
0021924895
-
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling
-
Ebina Y, Ellis L, Jarnagin K, Edery M, Graf L, Clauser E, et al. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell (1985) 40:747-58. doi:10.1016/0092-8674(85)90334-4
-
(1985)
Cell
, vol.40
, pp. 747-758
-
-
Ebina, Y.1
Ellis, L.2
Jarnagin, K.3
Edery, M.4
Graf, L.5
Clauser, E.6
-
11
-
-
0024548162
-
Structure of the human insulin receptor gene and characterization of its promoter
-
Seino S, Seino M, Nishi S, Bell GI. Structure of the human insulin receptor gene and characterization of its promoter. Proc Natl Acad Sci U S A (1989) 86:114-8. doi:10.1073/pnas.86.1.114
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 114-118
-
-
Seino, S.1
Seino, M.2
Nishi, S.3
Bell, G.I.4
-
12
-
-
0024403208
-
Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man
-
Moller DE, Yokota A, Caro JF, Flier JS. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol Endocrinol (1989) 3:1263-9. doi:10.1210/mend-3-8-1263
-
(1989)
Mol Endocrinol
, vol.3
, pp. 1263-1269
-
-
Moller, D.E.1
Yokota, A.2
Caro, J.F.3
Flier, J.S.4
-
13
-
-
0032932822
-
Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
-
Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, et al. Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol (1999) 19:3278-88.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3278-3288
-
-
Frasca, F.1
Pandini, G.2
Scalia, P.3
Sciacca, L.4
Mineo, R.5
Costantino, A.6
-
14
-
-
70849120946
-
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
-
Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev (2009) 30:586-623. doi:10.1210/er.2008-0047
-
(2009)
Endocr Rev
, vol.30
, pp. 586-623
-
-
Belfiore, A.1
Frasca, F.2
Pandini, G.3
Sciacca, L.4
Vigneri, R.5
-
15
-
-
40749128979
-
IGF2: epigenetic regulation and role in development and disease
-
Chao W, D'Amore PA. IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev (2008) 19:111-20. doi:10.1016/j.cytogfr.2008.01.005
-
(2008)
Cytokine Growth Factor Rev
, vol.19
, pp. 111-120
-
-
Chao, W.1
D'Amore, P.A.2
-
16
-
-
0025362295
-
Functionally distinct insulin receptors generated by tissue-specific alternative splicing
-
Mosthaf L, Grako K, Dull TJ, Coussens L, Ullrich A, Mcclain DA. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J (1990) 9:2409-13.
-
(1990)
EMBO J
, vol.9
, pp. 2409-2413
-
-
Mosthaf, L.1
Grako, K.2
Dull, T.J.3
Coussens, L.4
Ullrich, A.5
Mcclain, D.A.6
-
17
-
-
0025801714
-
Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients
-
Mosthaf L, Vogt B, Haring HU, Ullrich A. Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc Natl Acad Sci U S A (1991) 88:4728-30. doi:10.1073/pnas.88.11.4728
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 4728-4730
-
-
Mosthaf, L.1
Vogt, B.2
Haring, H.U.3
Ullrich, A.4
-
18
-
-
0026348452
-
Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients
-
Sesti G, Marini MA, Tullio AN, Montemurro A, Borboni P, Fusco A, et al. Altered expression of the two naturally occurring human insulin receptor variants in isolated adipocytes of non-insulin-dependent diabetes mellitus patients. Biochem Biophys Res Commun (1991) 181:1419-24. doi:10.1016/0006-291X(91)92097-4
-
(1991)
Biochem Biophys Res Commun
, vol.181
, pp. 1419-1424
-
-
Sesti, G.1
Marini, M.A.2
Tullio, A.N.3
Montemurro, A.4
Borboni, P.5
Fusco, A.6
-
19
-
-
0033920612
-
Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities
-
Baxter RC. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol Endocrinol Metab (2000) 278:E967-76.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.278
, pp. E967-E976
-
-
Baxter, R.C.1
-
20
-
-
0032126714
-
Regulatory actions of insulin-like growth factor-binding proteins
-
Rechler MM, Clemmons DR. Regulatory actions of insulin-like growth factor-binding proteins. Trends Endocrinol Metab (1998) 9:176-83. doi:10.1016/S1043-2760(98)00047-2
-
(1998)
Trends Endocrinol Metab
, vol.9
, pp. 176-183
-
-
Rechler, M.M.1
Clemmons, D.R.2
-
21
-
-
0030693249
-
Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting
-
Bailyes EM, Nave BT, Soos MA, Orr SR, Hayward AC, Siddle K. Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J (1997) 327(Pt 1):209-15.
-
(1997)
Biochem J
, vol.327
, pp. 209-215
-
-
Bailyes, E.M.1
Nave, B.T.2
Soos, M.A.3
Orr, S.R.4
Hayward, A.C.5
Siddle, K.6
-
22
-
-
0037131385
-
Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
-
Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem (2002) 277:39684-95. doi:10.1074/jbc. M202766200
-
(2002)
J Biol Chem
, vol.277
, pp. 39684-39695
-
-
Pandini, G.1
Frasca, F.2
Mineo, R.3
Sciacca, L.4
Vigneri, R.5
Belfiore, A.6
-
23
-
-
33748744723
-
Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
-
Slaaby R, Schaffer L, Lautrup-Larsen I, Andersen AS, Shaw AC, Mathiasen IS, et al. Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J Biol Chem (2006) 281:25869-74. doi:10.1074/jbc. M605189200
-
(2006)
J Biol Chem
, vol.281
, pp. 25869-25874
-
-
Slaaby, R.1
Schaffer, L.2
Lautrup-Larsen, I.3
Andersen, A.S.4
Shaw, A.C.5
Mathiasen, I.S.6
-
24
-
-
25844468319
-
Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
-
Gee JM, Robertson JF, Gutteridge E, Ellis IO, Pinder SE, Rubini M, et al. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocr Relat Cancer (2005) 12(Suppl 1):S99-111. doi:10.1677/erc.1.01005
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. S99-S111
-
-
Gee, J.M.1
Robertson, J.F.2
Gutteridge, E.3
Ellis, I.O.4
Pinder, S.E.5
Rubini, M.6
-
25
-
-
16444367879
-
Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells
-
Pandini G, Mineo R, Frasca F, Roberts CT Jr, Marcelli M, Vigneri R, et al. Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells. Cancer Res (2005) 65:1849-57. doi:10.1158/0008-5472.CAN-04-1837
-
(2005)
Cancer Res
, vol.65
, pp. 1849-1857
-
-
Pandini, G.1
Mineo, R.2
Frasca, F.3
Roberts Jr., C.T.4
Marcelli, M.5
Vigneri, R.6
-
26
-
-
61349161849
-
Crosstalk between growth hormone and insulin signaling
-
Xu J, Messina JL. Crosstalk between growth hormone and insulin signaling. Vitam Horm (2009) 80:125-53. doi:10.1016/S0083-6729(08)00606-7
-
(2009)
Vitam Horm
, vol.80
, pp. 125-153
-
-
Xu, J.1
Messina, J.L.2
-
27
-
-
84897879220
-
Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling
-
Malaguarnera R, Sacco A, Morcavallo A, Squatrito S, Migliaccio A, Morrione A, et al. Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling. Endocrinology (2014) 155:1207-21. doi:10.1210/en.2013-1925
-
(2014)
Endocrinology
, vol.155
, pp. 1207-1221
-
-
Malaguarnera, R.1
Sacco, A.2
Morcavallo, A.3
Squatrito, S.4
Migliaccio, A.5
Morrione, A.6
-
28
-
-
0028362024
-
A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
-
Coppola D, Ferber A, Miura M, Sell C, D'Ambrosio C, Rubin R, et al. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol (1994) 14:4588-95.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4588-4595
-
-
Coppola, D.1
Ferber, A.2
Miura, M.3
Sell, C.4
D'Ambrosio, C.5
Rubin, R.6
-
29
-
-
33750571170
-
Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
-
Morgillo F, Woo JK, Kim ES, Hong WK, Lee HY. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res (2006) 66:10100-11. doi:10.1158/0008-5472.CAN-06-1684
-
(2006)
Cancer Res
, vol.66
, pp. 10100-10111
-
-
Morgillo, F.1
Woo, J.K.2
Kim, E.S.3
Hong, W.K.4
Lee, H.Y.5
-
30
-
-
46749156706
-
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
-
Guix M, Faber AC, Wang SE, Olivares MG, Song Y, Qu S, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest (2008) 118:2609-19. doi:10.1172/JCI34588
-
(2008)
J Clin Invest
, vol.118
, pp. 2609-2619
-
-
Guix, M.1
Faber, A.C.2
Wang, S.E.3
Olivares, M.G.4
Song, Y.5
Qu, S.6
-
31
-
-
70349148288
-
Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy
-
van der Veeken J, Oliveira S, Schiffelers RM, Storm G, Van Bergen En Henegouwen PM, Roovers RC. Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy. Curr Cancer Drug Targets (2009) 9:748-60. doi:10.2174/156800909789271495
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 748-760
-
-
van der Veeken, J.1
Oliveira, S.2
Schiffelers, R.M.3
Storm, G.4
Van Bergen En Henegouwen, P.M.5
Roovers, R.C.6
-
32
-
-
84913536390
-
Drug resistance to targeted therapies: Deja vu all over again
-
Groenendijk FH, Bernards R. Drug resistance to targeted therapies: Deja vu all over again. Mol Oncol (2014) 8(6):1067-83. doi:10.1016/j.molonc.2014.05.004
-
(2014)
Mol Oncol
, vol.8
, Issue.6
, pp. 1067-1083
-
-
Groenendijk, F.H.1
Bernards, R.2
-
33
-
-
84877313224
-
IGF-1R as an anti-cancer target - trials and tribulations
-
Chen HX, Sharon E. IGF-1R as an anti-cancer target - trials and tribulations. Chin J Cancer (2013) 32:242-52. doi:10.5732/cjc.012.10263
-
(2013)
Chin J Cancer
, vol.32
, pp. 242-252
-
-
Chen, H.X.1
Sharon, E.2
-
34
-
-
0037308651
-
A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I
-
Sachdev D, Li SL, Hartell JS, Fujita-Yamaguchi Y, Miller JS, Yee D. A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res (2003) 63:627-35.
-
(2003)
Cancer Res
, vol.63
, pp. 627-635
-
-
Sachdev, D.1
Li, S.L.2
Hartell, J.S.3
Fujita-Yamaguchi, Y.4
Miller, J.S.5
Yee, D.6
-
35
-
-
84857640868
-
The insulin and insulin-like growth factor receptor family in neoplasia: an update
-
Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer (2012) 12:159-69. doi:10.1038/nrc3215
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 159-169
-
-
Pollak, M.1
-
36
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions
-
Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene (2009) 28:3009-21. doi:10.1038/onc.2009.172
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
37
-
-
84928758281
-
Can we unlock the potential of IGF-1R inhibition in cancer therapy?
-
King H, Aleksic T, Haluska P, Macaulay VM. Can we unlock the potential of IGF-1R inhibition in cancer therapy? Cancer Treat Rev (2014) 40(9):1096-105. doi:10.1016/j.ctrv.2014.07.004
-
(2014)
Cancer Treat Rev
, vol.40
, Issue.9
, pp. 1096-1105
-
-
King, H.1
Aleksic, T.2
Haluska, P.3
Macaulay, V.M.4
-
38
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol (2009) 27:2516-22. doi:10.1200/JCO.2008.19.9331
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
Haluska, P.4
Garland, L.5
Cardenal, F.6
-
39
-
-
75249097799
-
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
-
Olmos D, Postel-Vinay S, Molife LR, Okuno SH, Schuetze SM, Paccagnella ML, et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol (2010) 11:129-35. doi:10.1016/S1470-2045(09)70354-7
-
(2010)
Lancet Oncol
, vol.11
, pp. 129-135
-
-
Olmos, D.1
Postel-Vinay, S.2
Molife, L.R.3
Okuno, S.H.4
Schuetze, S.M.5
Paccagnella, M.L.6
-
40
-
-
80053525113
-
A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors
-
Atzori F, Tabernero J, Cervantes A, Prudkin L, Andreu J, Rodriguez-Braun E, et al. A phase I pharmacokinetic and pharmacodynamic study of dalotuzumab (MK-0646), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res (2011) 17:6304-12. doi:10.1158/1078-0432.CCR-10-3336
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6304-6312
-
-
Atzori, F.1
Tabernero, J.2
Cervantes, A.3
Prudkin, L.4
Andreu, J.5
Rodriguez-Braun, E.6
-
41
-
-
84881523535
-
Targeting the insulin-like growth factor-1 receptor in human cancer
-
Arcaro A. Targeting the insulin-like growth factor-1 receptor in human cancer. Front Pharmacol (2013) 4:30. doi:10.3389/fphar.2013.00030
-
(2013)
Front Pharmacol
, vol.4
, pp. 30
-
-
Arcaro, A.1
-
42
-
-
84903308286
-
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
-
Girnita L, Worrall C, Takahashi S, Seregard S, Girnita A. Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci (2014) 71:2403-27. doi:10.1007/s00018-013-1514-y
-
(2014)
Cell Mol Life Sci
, vol.71
, pp. 2403-2427
-
-
Girnita, L.1
Worrall, C.2
Takahashi, S.3
Seregard, S.4
Girnita, A.5
-
43
-
-
9144234724
-
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
-
Burtrum D, Zhu Z, Lu D, Anderson DM, Prewett M, Pereira DS, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res (2003) 63:8912-21.
-
(2003)
Cancer Res
, vol.63
, pp. 8912-8921
-
-
Burtrum, D.1
Zhu, Z.2
Lu, D.3
Anderson, D.M.4
Prewett, M.5
Pereira, D.S.6
-
44
-
-
20144386856
-
Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
-
Cohen BD, Baker DA, Soderstrom C, Tkalcevic G, Rossi AM, Miller PE, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res (2005) 11:2063-73. doi:10.1158/1078-0432.CCR-04-1070
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2063-2073
-
-
Cohen, B.D.1
Baker, D.A.2
Soderstrom, C.3
Tkalcevic, G.4
Rossi, A.M.5
Miller, P.E.6
-
45
-
-
84900841645
-
Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells
-
Weinstein D, Sarfstein R, Laron Z, Werner H. Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells. Endocr Connect (2014) 3:24-35. doi:10.1530/EC-13-0086
-
(2014)
Endocr Connect
, vol.3
, pp. 24-35
-
-
Weinstein, D.1
Sarfstein, R.2
Laron, Z.3
Werner, H.4
-
46
-
-
33846458639
-
Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
-
Zhang H, Pelzer AM, Kiang DT, Yee D. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res (2007) 67:391-7. doi:10.1158/0008-5472.CAN-06-1712
-
(2007)
Cancer Res
, vol.67
, pp. 391-397
-
-
Zhang, H.1
Pelzer, A.M.2
Kiang, D.T.3
Yee, D.4
-
47
-
-
84871706981
-
The decline and fall of the IGF-I receptor
-
Baserga R. The decline and fall of the IGF-I receptor. J Cell Physiol (2013) 228:675-9. doi:10.1002/jcp.24217
-
(2013)
J Cell Physiol
, vol.228
, pp. 675-679
-
-
Baserga, R.1
-
48
-
-
84904410600
-
Dynamics of IGF-1R expression during endocrine breast cancer treatment
-
Heskamp S, Boerman OC, Molkenboer-Kuenen JD, Koornstra RH, Linn SC, Oyen WJ, et al. Dynamics of IGF-1R expression during endocrine breast cancer treatment. Mol Imaging Biol (2014) 16:529-37. doi:10.1007/s11307-014-0723-6
-
(2014)
Mol Imaging Biol
, vol.16
, pp. 529-537
-
-
Heskamp, S.1
Boerman, O.C.2
Molkenboer-Kuenen, J.D.3
Koornstra, R.H.4
Linn, S.C.5
Oyen, W.J.6
-
49
-
-
84863378814
-
Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody
-
Kim JG, Kang MJ, Yoon YK, Kim HP, Park J, Song SH, et al. Heterodimerization of glycosylated insulin-like growth factor-1 receptors and insulin receptors in cancer cells sensitive to anti-IGF1R antibody. PLoS One (2012) 7:e33322. doi:10.1371/journal.pone.0033322
-
(2012)
PLoS One
, vol.7
-
-
Kim, J.G.1
Kang, M.J.2
Yoon, Y.K.3
Kim, H.P.4
Park, J.5
Song, S.H.6
-
50
-
-
84867574623
-
Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas
-
Asmane I, Watkin E, Alberti L, Duc A, Marec-Berard P, Ray-Coquard I, et al. Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. Eur J Cancer (2012) 48:3027-35. doi:10.1016/j.ejca.2012.05.009
-
(2012)
Eur J Cancer
, vol.48
, pp. 3027-3035
-
-
Asmane, I.1
Watkin, E.2
Alberti, L.3
Duc, A.4
Marec-Berard, P.5
Ray-Coquard, I.6
-
51
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell (2010) 141:1117-34. doi:10.1016/j.cell.2010.06.011
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
52
-
-
83355163331
-
Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody
-
Shin DH, Min HY, El-Naggar AK, Lippman SM, Glisson B, Lee HY. Akt/mTOR counteract the antitumor activities of cixutumumab, an anti-insulin-like growth factor I receptor monoclonal antibody. Mol Cancer Ther (2011) 10:2437-48. doi:10.1158/1535-7163.MCT-11-0235
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2437-2448
-
-
Shin, D.H.1
Min, H.Y.2
El-Naggar, A.K.3
Lippman, S.M.4
Glisson, B.5
Lee, H.Y.6
-
53
-
-
79961015442
-
Igf-I signaling in response to hyperglycemia and the development of diabetic complications
-
Clemmons D, Maile L, Xi G, Shen X, Radhakrishnan Y. Igf-I signaling in response to hyperglycemia and the development of diabetic complications. Curr Diabetes Rev (2011) 7:235-45. doi:10.2174/157339911796397848
-
(2011)
Curr Diabetes Rev
, vol.7
, pp. 235-245
-
-
Clemmons, D.1
Maile, L.2
Xi, G.3
Shen, X.4
Radhakrishnan, Y.5
-
54
-
-
84905498813
-
Insulin analogs and cancer: a note of caution
-
Janssen JA, Varewijck AJ. Insulin analogs and cancer: a note of caution. Front Endocrinol (2014) 5:79. doi:10.3389/fendo.2014.00079
-
(2014)
Front Endocrinol
, vol.5
, pp. 79
-
-
Janssen, J.A.1
Varewijck, A.J.2
-
55
-
-
84894289173
-
Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells
-
Baricevic I, Roberts DL, Renehan AG. Chronic insulin exposure does not cause insulin resistance but is associated with chemo-resistance in colon cancer cells. Horm Metab Res (2014) 46:85-93. doi:10.1055/s-0033-1354414
-
(2014)
Horm Metab Res
, vol.46
, pp. 85-93
-
-
Baricevic, I.1
Roberts, D.L.2
Renehan, A.G.3
-
56
-
-
84880312858
-
Growth hormone and cancer: an update on progress
-
Perry JK, Liu DX, Wu ZS, Zhu T, Lobie PE. Growth hormone and cancer: an update on progress. Curr Opin Endocrinol Diabetes Obes (2013) 20:307-13. doi:10.1097/MED.0b013e328363183a
-
(2013)
Curr Opin Endocrinol Diabetes Obes
, vol.20
, pp. 307-313
-
-
Perry, J.K.1
Liu, D.X.2
Wu, Z.S.3
Zhu, T.4
Lobie, P.E.5
-
57
-
-
84899736575
-
Insulin-like growth factor 1 receptor (IGF-1R) as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic cancer
-
Xu JW, Wang TX, You L, Zheng LF, Shu H, Zhang TP, et al. Insulin-like growth factor 1 receptor (IGF-1R) as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic cancer. PLoS One (2014) 9:e92847. doi:10.1371/journal.pone.0092847
-
(2014)
PLoS One
, vol.9
-
-
Xu, J.W.1
Wang, T.X.2
You, L.3
Zheng, L.F.4
Shu, H.5
Zhang, T.P.6
-
58
-
-
33846215917
-
Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors
-
Beckman RA, Weiner LM, Davis HM. Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors. Cancer (2007) 109:170-9. doi:10.1002/cncr.22402
-
(2007)
Cancer
, vol.109
, pp. 170-179
-
-
Beckman, R.A.1
Weiner, L.M.2
Davis, H.M.3
-
59
-
-
56749110996
-
The type 1 insulin-like growth factor receptor pathway
-
Chitnis MM, Yuen JS, Protheroe AS, Pollak M, Macaulay VM. The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res (2008) 14:6364-70. doi:10.1158/1078-0432.CCR-07-4879
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6364-6370
-
-
Chitnis, M.M.1
Yuen, J.S.2
Protheroe, A.S.3
Pollak, M.4
Macaulay, V.M.5
-
60
-
-
84868465951
-
Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling
-
Varewijck AJ, Brugts MP, Frystyk J, Goudzwaard JA, Uitterlinden P, Waaijers AM, et al. Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling. Mol Cell Endocrinol (2013) 365:17-24. doi:10.1016/j.mce.2012.08.021
-
(2013)
Mol Cell Endocrinol
, vol.365
, pp. 17-24
-
-
Varewijck, A.J.1
Brugts, M.P.2
Frystyk, J.3
Goudzwaard, J.A.4
Uitterlinden, P.5
Waaijers, A.M.6
-
61
-
-
79951873316
-
Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors
-
Davies PC, Lineweaver CH. Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors. Phys Biol (2011) 8:015001. doi:10.1088/1478-3975/8/1/015001
-
(2011)
Phys Biol
, vol.8
-
-
Davies, P.C.1
Lineweaver, C.H.2
-
62
-
-
84919327487
-
Theranostic applications of antibodies in oncology
-
Fleuren ED, Versleijen-Jonkers YM, Heskamp S, Van Herpen CM, Oyen WJ, Van Der Graaf WT, et al. Theranostic applications of antibodies in oncology. Mol Oncol (2014) 8:799-812. doi:10.1016/j.molonc.2014.03.010
-
(2014)
Mol Oncol
, vol.8
, pp. 799-812
-
-
Fleuren, E.D.1
Versleijen-Jonkers, Y.M.2
Heskamp, S.3
Van Herpen, C.M.4
Oyen, W.J.5
Van Der Graaf, W.T.6
-
63
-
-
84055176504
-
Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507
-
Fleuren ED, Versleijen-Jonkers YM, Van De Luijtgaarden AC, Molkenboer-Kuenen JD, Heskamp S, Roeffen MH, et al. Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507. Clin Cancer Res (2011) 17:7693-703. doi:10.1158/1078-0432.CCR-11-1488
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7693-7703
-
-
Fleuren, E.D.1
Versleijen-Jonkers, Y.M.2
Van De Luijtgaarden, A.C.3
Molkenboer-Kuenen, J.D.4
Heskamp, S.5
Roeffen, M.H.6
-
64
-
-
84871368849
-
BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer
-
Awasthi N, Zhang C, Ruan W, Schwarz MA, Schwarz RE. BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer. Mol Cancer Ther (2012) 11:2644-53. doi:10.1158/1535-7163.MCT-12-0447
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2644-2653
-
-
Awasthi, N.1
Zhang, C.2
Ruan, W.3
Schwarz, M.A.4
Schwarz, R.E.5
|