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Volumn 2, Issue 4, 2015, Pages 198-208

Novel Glutamatergic Treatments for Severe Mood Disorders

Author keywords

Glutamate; Metabotropic positive allosteric modulator; Mood disorders; N methyl d aspartate (NMDA) antagonist; Negative allosteric modulator

Indexed keywords


EID: 84994859480     PISSN: None     EISSN: 21962979     Source Type: Journal    
DOI: 10.1007/s40473-015-0050-5     Document Type: Review
Times cited : (30)

References (91)
  • 1
    • 80052376956 scopus 로고    scopus 로고
    • The size and burden of mental disorders and other disorders of the brain in Europe 2010
    • COI: 1:CAS:528:DC%2BC3MXhtFaqsrbE, PID: 21896369
    • Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(9):655–79. DOI: 10.1016/j.euroneuro.2011.07.018
    • (2011) Eur Neuropsychopharmacol , vol.21 , Issue.9 , pp. 655-679
    • Wittchen, H.U.1    Jacobi, F.2    Rehm, J.3    Gustavsson, A.4    Svensson, M.5    Jonsson, B.6
  • 2
    • 0037831023 scopus 로고    scopus 로고
    • The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
    • PID: 12813115
    • Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095–105. DOI: 10.1001/jama.289.23.3095
    • (2003) JAMA , vol.289 , Issue.23 , pp. 3095-3105
    • Kessler, R.C.1    Berglund, P.2    Demler, O.3    Jin, R.4    Koretz, D.5    Merikangas, K.R.6
  • 3
    • 79960044482 scopus 로고    scopus 로고
    • Grand challenges in global mental health
    • COI: 1:CAS:528:DC%2BC3MXosFehurs%3D, PID: 21734685
    • Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, et al. Grand challenges in global mental health. Nature. 2011;475(7354):27–30. DOI: 10.1038/475027a
    • (2011) Nature , vol.475 , Issue.7354 , pp. 27-30
    • Collins, P.Y.1    Patel, V.2    Joestl, S.S.3    March, D.4    Insel, T.R.5    Daar, A.S.6
  • 4
    • 49549119585 scopus 로고    scopus 로고
    • Treatment-resistant depression: critique of current approaches
    • PID: 18696279
    • Wijeratne C, Sachdev P. Treatment-resistant depression: critique of current approaches. Aust N Z J Psychiatry. 2008;42(9):751–62. DOI: 10.1080/00048670802277206
    • (2008) Aust N Z J Psychiatry , vol.42 , Issue.9 , pp. 751-762
    • Wijeratne, C.1    Sachdev, P.2
  • 5
    • 0025157918 scopus 로고
    • Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
    • COI: 1:CAS:528:DyaK3cXls1Gqtbk%3D, PID: 2171955
    • Trullas R, Skolnick P. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur J Pharmacol. 1990;185(1):1–10. DOI: 10.1016/0014-2999(90)90204-J
    • (1990) Eur J Pharmacol , vol.185 , Issue.1 , pp. 1-10
    • Trullas, R.1    Skolnick, P.2
  • 6
    • 0033969685 scopus 로고    scopus 로고
    • Antidepressant effects of ketamine in depressed patients
    • COI: 1:CAS:528:DC%2BD3cXht1KqtrY%3D, PID: 10686270
    • Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47(4):351–4. DOI: 10.1016/S0006-3223(99)00230-9
    • (2000) Biol Psychiatry , vol.47 , Issue.4 , pp. 351-354
    • Berman, R.M.1    Cappiello, A.2    Anand, A.3    Oren, D.A.4    Heninger, G.R.5    Charney, D.S.6
  • 7
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    • COI: 1:CAS:528:DC%2BD28XovF2lsLo%3D, PID: 16894061
    • Zarate Jr CA, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006;63(8):856–64. DOI: 10.1001/archpsyc.63.8.856
    • (2006) Arch Gen Psychiatry , vol.63 , Issue.8 , pp. 856-864
    • Zarate, C.A.1    Singh, J.B.2    Carlson, P.J.3    Brutsche, N.E.4    Ameli, R.5    Luckenbaugh, D.A.6
  • 8
    • 84855549573 scopus 로고    scopus 로고
    • Overview of glutamatergic neurotransmission in the nervous system
    • COI: 1:CAS:528:DC%2BC38XltVehtw%3D%3D, PID: 21889952
    • Niciu MJ, Kelmendi B, Sanacora G. Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behav. 2012;100(4):656–64. DOI: 10.1016/j.pbb.2011.08.008
    • (2012) Pharmacol Biochem Behav , vol.100 , Issue.4 , pp. 656-664
    • Niciu, M.J.1    Kelmendi, B.2    Sanacora, G.3
  • 9
    • 84878396787 scopus 로고    scopus 로고
    • Glutamate-based antidepressants: Preclinical psychopharmacology
    • The article concisely summarizes glutamate-based antidepressants in pre-clinical studies and focuses on major concepts and mechanisms
    • Pilc A, Wieronska JM, Skolnick P. Glutamate-based antidepressants: preclinical psychopharmacology. Biol Psychiatry. 2013;73(12):1125–32. The article concisely summarizes glutamate-based antidepressants in pre-clinical studies and focuses on major concepts and mechanisms.
    • (2013) Biol Psychiatry , vol.73 , Issue.12 , pp. 1125-1132
    • Pilc, A.1    Wieronska, J.M.2    Skolnick, P.3
  • 10
    • 84920279509 scopus 로고    scopus 로고
    • Antidepressant actions of ketamine: from molecular mechanisms to clinical practice
    • COI: 1:CAS:528:DC%2BC2cXitV2msLzJ, PID: 25562451
    • Monteggia LM, Zarate Jr C. Antidepressant actions of ketamine: from molecular mechanisms to clinical practice. Curr Opin Neurobiol. 2015;30:139–43. DOI: 10.1016/j.conb.2014.12.004
    • (2015) Curr Opin Neurobiol , vol.30 , pp. 139-143
    • Monteggia, L.M.1    Zarate, C.2
  • 11
    • 84930516190 scopus 로고    scopus 로고
    • Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review
    • COI: 1:CAS:528:DC%2BC2MXptlKqt74%3D, PID: 25954495
    • Iadarola ND, Niciu MJ, Richards EM, Vande Voort JL, Ballard ED, Lundin NB, et al. Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther Adv Chronic Dis. 2015;6(3):97–114. DOI: 10.1177/2040622315579059
    • (2015) Ther Adv Chronic Dis , vol.6 , Issue.3 , pp. 97-114
    • Iadarola, N.D.1    Niciu, M.J.2    Richards, E.M.3    Vande Voort, J.L.4    Ballard, E.D.5    Lundin, N.B.6
  • 12
    • 84929619652 scopus 로고    scopus 로고
    • Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders
    • COI: 1:CAS:528:DC%2BC2MXosVGgurk%3D, PID: 25817855
    • Ohgi Y, Futamura T, Hashimoto K. Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders. Curr Mol Med. 2015;15(3):206–21. DOI: 10.2174/1566524015666150330143008
    • (2015) Curr Mol Med , vol.15 , Issue.3 , pp. 206-221
    • Ohgi, Y.1    Futamura, T.2    Hashimoto, K.3
  • 13
    • 79953166373 scopus 로고    scopus 로고
    • Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    • COI: 1:CAS:528:DC%2BC3MXkt1GmsLg%3D, PID: 21292242
    • Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, et al. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry. 2011;69(8):754–61. DOI: 10.1016/j.biopsych.2010.12.015
    • (2011) Biol Psychiatry , vol.69 , Issue.8 , pp. 754-761
    • Li, N.1    Liu, R.J.2    Dwyer, J.M.3    Banasr, M.4    Lee, B.5    Son, H.6
  • 14
    • 84890446708 scopus 로고    scopus 로고
    • Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3beta
    • COI: 1:CAS:528:DC%2BC3sXhvFCqsrfN, PID: 24317309
    • Duman RS, Aghajanian GK. Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3beta. Neuropsychopharmacology. 2014;39(1):233. DOI: 10.1038/npp.2013.217
    • (2014) Neuropsychopharmacology , vol.39 , Issue.1 , pp. 233
    • Duman, R.S.1    Aghajanian, G.K.2
  • 15
    • 18944406852 scopus 로고    scopus 로고
    • Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
    • COI: 1:CAS:528:DC%2BD2MXktVGls7c%3D, PID: 15893584
    • Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res. 2005;136(1–2):29–37. DOI: 10.1016/j.molbrainres.2004.12.020
    • (2005) Brain Res Mol Brain Res , vol.136 , Issue.1-2 , pp. 29-37
    • Karege, F.1    Vaudan, G.2    Schwald, M.3    Perroud, N.4    La Harpe, R.5
  • 16
    • 73349135323 scopus 로고    scopus 로고
    • BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
    • COI: 1:CAS:528:DC%2BD1MXhsVGru77M, PID: 19777221
    • Gottmann K, Mittmann T, Lessmann V. BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res. 2009;199(3–4):203–34. DOI: 10.1007/s00221-009-1994-z
    • (2009) Exp Brain Res , vol.199 , Issue.3-4 , pp. 203-234
    • Gottmann, K.1    Mittmann, T.2    Lessmann, V.3
  • 17
    • 84885214350 scopus 로고    scopus 로고
    • Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site randomized controlled trial
    • This is the largest clinical trial of ketamine to date. It validated the antidepressant effects of ketamine and used an active placebo, midazolam
    • Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CE, Perez AM, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013;170(10):1134–42. This is the largest clinical trial of ketamine to date. It validated the antidepressant effects of ketamine and used an active placebo, midazolam.
    • (2013) Am J Psychiatry , vol.170 , Issue.10 , pp. 1134-1142
    • Murrough, J.W.1    Iosifescu, D.V.2    Chang, L.C.3    Al Jurdi, R.K.4    Green, C.E.5    Perez, A.M.6
  • 18
    • 84880767967 scopus 로고    scopus 로고
    • Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
    • This is the largest trial of repeated ketamine infusion
    • Murrough JW, Perez AM, Pillemer S, Stern J, Parides MK, aan het Rot M, et al. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry. 2013;74(4):250–6. This is the largest trial of repeated ketamine infusion.
    • (2013) Biol Psychiatry , vol.74 , Issue.4 , pp. 250-256
    • Murrough, J.W.1    Perez, A.M.2    Pillemer, S.3    Stern, J.4    Parides, M.K.5    Aan Het Rot, M.6
  • 19
    • 84925650392 scopus 로고    scopus 로고
    • Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression
    • COI: 1:CAS:528:DC%2BC2cXhs1Cns7zE, PID: 24963561
    • Shiroma PR, Albott CS, Johns B, Thuras P, Wels J, Lim KO. Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression. Int J Neuropsychopharmacol. 2014;17(11):1805–13. DOI: 10.1017/S1461145714001011
    • (2014) Int J Neuropsychopharmacol , vol.17 , Issue.11 , pp. 1805-1813
    • Shiroma, P.R.1    Albott, C.S.2    Johns, B.3    Thuras, P.4    Wels, J.5    Lim, K.O.6
  • 20
    • 84876531468 scopus 로고    scopus 로고
    • Serial infusions of low-dose ketamine for major depression
    • COI: 1:CAS:528:DC%2BC2cXhs1OltrfP, PID: 23428794
    • Rasmussen KG, Lineberry TW, Galardy CW, Kung S, Lapid MI, Palmer BA, et al. Serial infusions of low-dose ketamine for major depression. J Psychopharmacol. 2013;27(5):444–50. DOI: 10.1177/0269881113478283
    • (2013) J Psychopharmacol , vol.27 , Issue.5 , pp. 444-450
    • Rasmussen, K.G.1    Lineberry, T.W.2    Galardy, C.W.3    Kung, S.4    Lapid, M.I.5    Palmer, B.A.6
  • 21
    • 84898003445 scopus 로고    scopus 로고
    • Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic
    • PID: 24699062
    • Diamond PR, Farmery AD, Atkinson S, Haldar J, Williams N, Cowen PJ, et al. Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic. J Psychopharmacol. 2014;28(6):536–44. DOI: 10.1177/0269881114527361
    • (2014) J Psychopharmacol , vol.28 , Issue.6 , pp. 536-544
    • Diamond, P.R.1    Farmery, A.D.2    Atkinson, S.3    Haldar, J.4    Williams, N.5    Cowen, P.J.6
  • 22
    • 84907260750 scopus 로고    scopus 로고
    • Pilot dose–response trial of i.v. ketamine in treatment-resistant depression
    • PID: 24910102
    • Lai R, Katalinic N, Glue P, Somogyi AA, Mitchell PB, Leyden J, et al. Pilot dose–response trial of i.v. ketamine in treatment-resistant depression. World J Biol Psychiatry. 2014;15(7):579–84. DOI: 10.3109/15622975.2014.922697
    • (2014) World J Biol Psychiatry , vol.15 , Issue.7 , pp. 579-584
    • Lai, R.1    Katalinic, N.2    Glue, P.3    Somogyi, A.A.4    Mitchell, P.B.5    Leyden, J.6
  • 23
    • 84919398586 scopus 로고    scopus 로고
    • A randomized controlled trial of intranasal ketamine in major depressive disorder
    • This is the first controlled study of intranasal ketamine
    • Lapidus KA, Levitch CF, Perez AM, Brallier JW, Parides MK, Soleimani L, et al. A randomized controlled trial of intranasal ketamine in major depressive disorder. Biol Psychiatry. 2014;76(12):970–6. This is the first controlled study of intranasal ketamine.
    • (2014) Biol Psychiatry , vol.76 , Issue.12 , pp. 970-976
    • Lapidus, K.A.1    Levitch, C.F.2    Perez, A.M.3    Brallier, J.W.4    Parides, M.K.5    Soleimani, L.6
  • 24
    • 84864807084 scopus 로고    scopus 로고
    • Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression
    • PID: 22854933
    • Cusin C, Hilton GQ, Nierenberg AA, Fava M. Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression. Am J Psychiatry. 2012;169(8):868–9. DOI: 10.1176/appi.ajp.2012.12020219
    • (2012) Am J Psychiatry , vol.169 , Issue.8 , pp. 868-869
    • Cusin, C.1    Hilton, G.Q.2    Nierenberg, A.A.3    Fava, M.4
  • 25
    • 84883324216 scopus 로고    scopus 로고
    • Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression
    • This is the first clinical trial to report the robust and rapid antidepressant effect of sublingual ketamine
    • Lara DR, Bisol LW, Munari LR. Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression. Int J Neuropsychopharmacol. 2013;16(9):2111–7. This is the first clinical trial to report the robust and rapid antidepressant effect of sublingual ketamine.
    • (2013) Int J Neuropsychopharmacol , vol.16 , Issue.9 , pp. 2111-2117
    • Lara, D.R.1    Bisol, L.W.2    Munari, L.R.3
  • 26
    • 77954950428 scopus 로고    scopus 로고
    • Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care
    • PID: 20636166
    • Irwin SA, Iglewicz A. Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care. J Palliat Med. 2010;13(7):903–8. DOI: 10.1089/jpm.2010.9808
    • (2010) J Palliat Med , vol.13 , Issue.7 , pp. 903-908
    • Irwin, S.A.1    Iglewicz, A.2
  • 27
    • 76349084738 scopus 로고    scopus 로고
    • Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series
    • COI: 1:CAS:528:DC%2BC3cXksVyms78%3D, PID: 20013614
    • Paslakis G, Gilles M, Meyer-Lindenberg A, Deuschle M. Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series. Pharmacopsychiatry. 2010;43(1):33–5. DOI: 10.1055/s-0029-1237375
    • (2010) Pharmacopsychiatry , vol.43 , Issue.1 , pp. 33-35
    • Paslakis, G.1    Gilles, M.2    Meyer-Lindenberg, A.3    Deuschle, M.4
  • 28
    • 84880852239 scopus 로고    scopus 로고
    • Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial
    • PID: 23805864
    • Irwin SA, Iglewicz A, Nelesen RA, Lo JY, Carr CH, Romero SD, et al. Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial. J Palliat Med. 2013;16(8):958–65. DOI: 10.1089/jpm.2012.0617
    • (2013) J Palliat Med , vol.16 , Issue.8 , pp. 958-965
    • Irwin, S.A.1    Iglewicz, A.2    Nelesen, R.A.3    Lo, J.Y.4    Carr, C.H.5    Romero, S.D.6
  • 29
    • 84903543431 scopus 로고    scopus 로고
    • Oral ketamine augmentation for chronic suicidality in treatment-resistant depression
    • PID: 24452289
    • De Gioannis A, De Leo D. Oral ketamine augmentation for chronic suicidality in treatment-resistant depression. Aust N Z J Psychiatry. 2014;48(7):686. DOI: 10.1177/0004867414520754
    • (2014) Aust N Z J Psychiatry , vol.48 , Issue.7 , pp. 686
    • De Gioannis, A.1    De Leo, D.2
  • 30
    • 79960757856 scopus 로고    scopus 로고
    • Dose- and exposure-response to ketamine in depression
    • PID: 21481846, author reply e11-2
    • Glue P, Gulati A, Le Nedelec M, Duffull S. Dose- and exposure-response to ketamine in depression. Biol Psychiatry. 2011;70(4):e9–10. author reply e11-2. DOI: 10.1016/j.biopsych.2010.11.031
    • (2011) Biol Psychiatry , vol.70 , Issue.4 , pp. e9-e10
    • Glue, P.1    Gulati, A.2    Le Nedelec, M.3    Duffull, S.4
  • 31
    • 77957008254 scopus 로고    scopus 로고
    • Taming the ketamine tiger. 1965
    • PID: 20693870
    • Domino EF. Taming the ketamine tiger. 1965. Anesthesiology. 2010;113(3):678–84.
    • (2010) Anesthesiology , vol.113 , Issue.3 , pp. 678-684
    • Domino, E.F.1
  • 32
    • 84939803581 scopus 로고    scopus 로고
    • Nitrous oxide for treatment-resistant major depression: A proof-of-concept trial
    • This study showed that nitrous oxide, a non-ketamine NMDA receptor antagonist, had rapid antidepressant effects. This finding implicates NMDA receptor antagonism in the mechanism of antidepressant activity
    • Nagele P, Duma A, et al. Nitrous oxide for treatment-resistant major depression: a proof-of-concept trial. Soc Biol Psychiatry. 2015. This study showed that nitrous oxide, a non-ketamine NMDA receptor antagonist, had rapid antidepressant effects. This finding implicates NMDA receptor antagonism in the mechanism of antidepressant activity.
    • (2015) Soc Biol Psychiatry
    • Nagele, P.1    Duma, A.2
  • 33
    • 54749137815 scopus 로고    scopus 로고
    • Biologic effects of nitrous oxide: a mechanistic and toxicologic review
    • COI: 1:CAS:528:DC%2BD1cXhtFCkt7bP, PID: 18813051
    • Sanders RD, Weimann J, Maze M. Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Anesthesiology. 2008;109(4):707–22. DOI: 10.1097/ALN.0b013e3181870a17
    • (2008) Anesthesiology , vol.109 , Issue.4 , pp. 707-722
    • Sanders, R.D.1    Weimann, J.2    Maze, M.3
  • 34
    • 84862808862 scopus 로고    scopus 로고
    • The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder
    • COI: 1:CAS:528:DC%2BC38Xjs1altrw%3D, PID: 22326841
    • Lee SY, Chen SL, Chang YH, Chen SH, Chu CH, Huang SY, et al. The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder. J Affect Disord. 2012;138(3):295–300. DOI: 10.1016/j.jad.2012.01.024
    • (2012) J Affect Disord , vol.138 , Issue.3 , pp. 295-300
    • Lee, S.Y.1    Chen, S.L.2    Chang, Y.H.3    Chen, S.H.4    Chu, C.H.5    Huang, S.Y.6
  • 35
    • 0027970898 scopus 로고
    • Interactions of dextromethorphan with the N-methyl-D-aspartate receptor-channel complex: single channel recordings
    • COI: 1:CAS:528:DyaK2MXisFars7o%3D, PID: 7533633
    • Church J, Sawyer D, McLarnon JG. Interactions of dextromethorphan with the N-methyl-D-aspartate receptor-channel complex: single channel recordings. Brain Res. 1994;666(2):189–94. DOI: 10.1016/0006-8993(94)90771-4
    • (1994) Brain Res , vol.666 , Issue.2 , pp. 189-194
    • Church, J.1    Sawyer, D.2    McLarnon, J.G.3
  • 36
    • 84904291457 scopus 로고    scopus 로고
    • The utility of the combination of dextromethorphan and quinidine in the treatment of bipolar II and bipolar NOS
    • COI: 1:CAS:528:DC%2BC2cXhtlWrs7vM, PID: 25016490
    • Kelly TF, Lieberman DZ. The utility of the combination of dextromethorphan and quinidine in the treatment of bipolar II and bipolar NOS. J Affect Disord. 2014;167:333–5. DOI: 10.1016/j.jad.2014.05.050
    • (2014) J Affect Disord , vol.167 , pp. 333-335
    • Kelly, T.F.1    Lieberman, D.Z.2
  • 37
    • 30044450251 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of memantine in the treatment of major depression
    • PID: 16390905
    • Zarate Jr CA, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, et al. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry. 2006;163(1):153–5. DOI: 10.1176/appi.ajp.163.1.153
    • (2006) Am J Psychiatry , vol.163 , Issue.1 , pp. 153-155
    • Zarate, C.A.1    Singh, J.B.2    Quiroz, J.A.3    De Jesus, G.4    Denicoff, K.K.5    Luckenbaugh, D.A.6
  • 38
    • 84887043337 scopus 로고    scopus 로고
    • Antidepressant augmentation using the N-methyl-D-aspartate antagonist memantine: a randomized, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC3sXhvVamurfK, PID: 24229746
    • Smith EG, Deligiannidis KM, Ulbricht CM, Landolin CS, Patel JK, Rothschild AJ. Antidepressant augmentation using the N-methyl-D-aspartate antagonist memantine: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2013;74(10):966–73. DOI: 10.4088/JCP.12m08252
    • (2013) J Clin Psychiatry , vol.74 , Issue.10 , pp. 966-973
    • Smith, E.G.1    Deligiannidis, K.M.2    Ulbricht, C.M.3    Landolin, C.S.4    Patel, J.K.5    Rothschild, A.J.6
  • 39
    • 84925372786 scopus 로고    scopus 로고
    • Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder
    • This article suggests that although memantine may not be an effective augmenting agent for major depressive disorder, it may be effective in bipolar depression
    • Serra G, Koukopoulos A, De Chiara L, Koukopoulos AE, Tondo L, Girardi P, et al. Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder. J Clin Psychiatry. 2015;76(1):e91–7. This article suggests that although memantine may not be an effective augmenting agent for major depressive disorder, it may be effective in bipolar depression.
    • (2015) J Clin Psychiatry , vol.76 , Issue.1 , pp. e91-e97
    • Serra, G.1    Koukopoulos, A.2    de Chiara, L.3    Koukopoulos, A.E.4    Tondo, L.5    Girardi, P.6
  • 40
    • 84902184667 scopus 로고    scopus 로고
    • Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
    • COI: 1:CAS:528:DC%2BC2cXos1aqurY%3D, PID: 24912158
    • Gideons ES, Kavalali ET, Monteggia LM. Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses. Proc Natl Acad Sci U S A. 2014;111(23):8649–54. DOI: 10.1073/pnas.1323920111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.23 , pp. 8649-8654
    • Gideons, E.S.1    Kavalali, E.T.2    Monteggia, L.M.3
  • 41
    • 84880829258 scopus 로고    scopus 로고
    • A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression
    • COI: 1:CAS:528:DC%2BC38Xhslynur7K, PID: 23206319
    • Zarate Jr CA, Mathews D, Ibrahim L, Chaves JF, Marquardt C, Ukoh I, et al. A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biol Psychiatry. 2013;74(4):257–64. DOI: 10.1016/j.biopsych.2012.10.019
    • (2013) Biol Psychiatry , vol.74 , Issue.4 , pp. 257-264
    • Zarate, C.A.1    Mathews, D.2    Ibrahim, L.3    Chaves, J.F.4    Marquardt, C.5    Ukoh, I.6
  • 42
    • 84908572031 scopus 로고    scopus 로고
    • Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
    • COI: 1:CAS:528:DC%2BC3sXhs1CiurvE, PID: 24126931
    • Sanacora G, Smith MA, Pathak S, Su HL, Boeijinga PH, McCarthy DJ, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol Psychiatry. 2014;19(9):978–85. DOI: 10.1038/mp.2013.130
    • (2014) Mol Psychiatry , vol.19 , Issue.9 , pp. 978-985
    • Sanacora, G.1    Smith, M.A.2    Pathak, S.3    Su, H.L.4    Boeijinga, P.H.5    McCarthy, D.J.6
  • 43
    • 85090131502 scopus 로고    scopus 로고
    • Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: Primary results from a randomized
    • Hollywood, FL, USA
    • Sanacora G, Johnson M, Khan A, Atkinson S, Riesenberg R, Schronen J. Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: primary results from a randomized, placebo-controlled study (PURSUIT). 53rd Meeting of the ACNP. 2014. Hollywood, FL, USA.
    • (2014) Placebo-Controlled Study (PURSUIT). 53Rd Meeting of the ACNP
    • Sanacora, G.1    Johnson, M.2    Khan, A.3    Atkinson, S.4    Riesenberg, R.5    Schronen, J.6
  • 44
    • 66649086928 scopus 로고    scopus 로고
    • Mechanism of differential control of NMDA receptor activity by NR2 subunits
    • COI: 1:CAS:528:DC%2BD1MXlt1Sku7s%3D, PID: 19404260
    • Gielen M, Siegler RB, Mony L, Johnson JW, Paoletti P. Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature. 2009;459(7247):703–7. DOI: 10.1038/nature07993
    • (2009) Nature , vol.459 , Issue.7247 , pp. 703-707
    • Gielen, M.1    Siegler, R.B.2    Mony, L.3    Johnson, J.W.4    Paoletti, P.5
  • 45
    • 27744500994 scopus 로고    scopus 로고
    • Subunit arrangement and function in NMDA receptors
    • COI: 1:CAS:528:DC%2BD2MXhtF2nsrjI, PID: 16281028
    • Furukawa H, Singh SK, Mancusso R, Gouaux E. Subunit arrangement and function in NMDA receptors. Nature. 2005;438(7065):185–92. DOI: 10.1038/nature04089
    • (2005) Nature , vol.438 , Issue.7065 , pp. 185-192
    • Furukawa, H.1    Singh, S.K.2    Mancusso, R.3    Gouaux, E.4
  • 46
    • 33646849232 scopus 로고    scopus 로고
    • Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A
    • COI: 1:CAS:528:DC%2BD28XksFWqtbg%3D, PID: 16641235
    • Yao Y, Mayer ML. Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A. J Neurosci. 2006;26(17):4559–66. DOI: 10.1523/JNEUROSCI.0560-06.2006
    • (2006) J Neurosci , vol.26 , Issue.17 , pp. 4559-4566
    • Yao, Y.1    Mayer, M.L.2
  • 47
    • 84920270347 scopus 로고    scopus 로고
    • GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
    • PID: 25340958
    • Miller OH, Yang L, Wang CC, Hargroder EA, Zhang Y, Delpire E, et al. GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. Elife. 2014;3:e03581.
    • (2014) Elife , vol.3
    • Miller, O.H.1    Yang, L.2    Wang, C.C.3    Hargroder, E.A.4    Zhang, Y.5    Delpire, E.6
  • 48
    • 84893956740 scopus 로고    scopus 로고
    • A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression
    • COI: 1:CAS:528:DC%2BC3sXhs1SnsLbJ
    • Zhang C, Li Z, Wu Z, Chen J, Wang Z, Peng D, et al. A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression. Psychopharmacology (Berl). 2014;231(4):685–93. DOI: 10.1007/s00213-013-3297-0
    • (2014) Psychopharmacology (Berl) , vol.231 , Issue.4 , pp. 685-693
    • Zhang, C.1    Li, Z.2    Wu, Z.3    Chen, J.4    Wang, Z.5    Peng, D.6
  • 49
    • 59049098262 scopus 로고    scopus 로고
    • An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder
    • COI: 1:CAS:528:DC%2BD1cXhtlyqu7zE, PID: 19011431
    • Preskorn SH, Baker B, Kolluri S, Menniti FS, Krams M, Landen JW. An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol. 2008;28(6):631–7. DOI: 10.1097/JCP.0b013e31818a6cea
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.6 , pp. 631-637
    • Preskorn, S.H.1    Baker, B.2    Kolluri, S.3    Menniti, F.S.4    Krams, M.5    Landen, J.W.6
  • 50
    • 35948933040 scopus 로고    scopus 로고
    • The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys
    • COI: 1:CAS:528:DC%2BD2sXht1KrsrfO, PID: 17989511
    • Nicholson KL, Mansbach RS, Menniti FS, Balster RL. The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys. Behav Pharmacol. 2007;18(8):731–43. DOI: 10.1097/FBP.0b013e3282f14ed6
    • (2007) Behav Pharmacol , vol.18 , Issue.8 , pp. 731-743
    • Nicholson, K.L.1    Mansbach, R.S.2    Menniti, F.S.3    Balster, R.L.4
  • 51
    • 84863719297 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder
    • COI: 1:CAS:528:DC%2BC38XhtVWjtrjO, PID: 22722512
    • Ibrahim L, Diaz GN, Jolkovsky L, Brutsche N, Luckenbaugh DA, Herring WJ, et al. A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder. J Clin Psychopharmacol. 2012;32(4):551–7. DOI: 10.1097/JCP.0b013e31825d70d6
    • (2012) J Clin Psychopharmacol , vol.32 , Issue.4 , pp. 551-557
    • Ibrahim, L.1    Diaz, G.N.2    Jolkovsky, L.3    Brutsche, N.4    Luckenbaugh, D.A.5    Herring, W.J.6
  • 52
    • 0013085913 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor-coupled glycineB receptors in the pathogenesis and treatment of schizophrenia: a critical review
    • COI: 1:CAS:528:DC%2BD38XjvV2nu70%3D, PID: 12769627
    • Millan MJ. N-methyl-D-aspartate receptor-coupled glycineB receptors in the pathogenesis and treatment of schizophrenia: a critical review. Curr Drug Targets CNS Neurol Disord. 2002;1(2):191–213. DOI: 10.2174/1568007024606258
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , Issue.2 , pp. 191-213
    • Millan, M.J.1
  • 53
    • 33744549976 scopus 로고    scopus 로고
    • Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder
    • COI: 1:CAS:528:DC%2BD28Xltl2hsbw%3D, PID: 16677714
    • Heresco-Levy U, Javitt DC, Gelfin Y, Gorelik E, Bar M, Blanaru M, et al. Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder. J Affect Disord. 2006;93(1–3):239–43. DOI: 10.1016/j.jad.2006.03.004
    • (2006) J Affect Disord , vol.93 , Issue.1-3 , pp. 239-243
    • Heresco-Levy, U.1    Javitt, D.C.2    Gelfin, Y.3    Gorelik, E.4    Bar, M.5    Blanaru, M.6
  • 54
    • 84874654554 scopus 로고    scopus 로고
    • A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression
    • COI: 1:CAS:528:DC%2BC3sXjtlWlu7c%3D, PID: 23174090
    • Heresco-Levy U, Gelfin G, Bloch B, Levin R, Edelman S, Javitt DC, et al. A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression. Int J Neuropsychopharmacol. 2013;16(3):501–6. DOI: 10.1017/S1461145712000910
    • (2013) Int J Neuropsychopharmacol , vol.16 , Issue.3 , pp. 501-506
    • Heresco-Levy, U.1    Gelfin, G.2    Bloch, B.3    Levin, R.4    Edelman, S.5    Javitt, D.C.6
  • 55
    • 1942539345 scopus 로고    scopus 로고
    • Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms
    • COI: 1:CAS:528:DC%2BD2cXhtlKgs7s%3D, PID: 14720317
    • Sumiyoshi T, Anil AE, Jin D, Jayathilake K, Lee M, Meltzer HY. Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms. Int J Neuropsychopharmacol. 2004;7(1):1–8. DOI: 10.1017/S1461145703003900
    • (2004) Int J Neuropsychopharmacol , vol.7 , Issue.1 , pp. 1-8
    • Sumiyoshi, T.1    Anil, A.E.2    Jin, D.3    Jayathilake, K.4    Lee, M.5    Meltzer, H.Y.6
  • 56
    • 84892403784 scopus 로고    scopus 로고
    • GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
    • This article provides a quick overview of GLYX-13, including its mechanism of action, preclinical results, and clinical data
    • Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, et al. GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists. Expert Opin Investig Drugs. 2014;23(2):243–54. This article provides a quick overview of GLYX-13, including its mechanism of action, preclinical results, and clinical data.
    • (2014) Expert Opin Investig Drugs , vol.23 , Issue.2 , pp. 243-254
    • Moskal, J.R.1    Burch, R.2    Burgdorf, J.S.3    Kroes, R.A.4    Stanton, P.K.5    Disterhoft, J.F.6
  • 57
    • 85090138251 scopus 로고    scopus 로고
    • Naurex Inc. NRX-1074. 2015. http://www.naurex.com/pipeline/nrx-1074.
    • (2015) NRX-1074
  • 58
    • 84891713774 scopus 로고    scopus 로고
    • Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
    • PID: 24409146
    • Browne CA, Lucki I. Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants. Front Pharmacol. 2013;4:161. DOI: 10.3389/fphar.2013.00161
    • (2013) Front Pharmacol , vol.4 , pp. 161
    • Browne, C.A.1    Lucki, I.2
  • 59
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • COI: 1:CAS:528:DC%2BD1cXhsVShs7g%3D, PID: 17643398
    • Maeng S, Zarate Jr CA, Du J, Schloesser RJ, McCammon J, Chen G, et al. Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry. 2008;63(4):349–52. DOI: 10.1016/j.biopsych.2007.05.028
    • (2008) Biol Psychiatry , vol.63 , Issue.4 , pp. 349-352
    • Maeng, S.1    Zarate, C.A.2    Du, J.3    Schloesser, R.J.4    McCammon, J.5    Chen, G.6
  • 60
    • 84878916836 scopus 로고    scopus 로고
    • Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests
    • COI: 1:CAS:528:DC%2BC3sXotlGitL4%3D, PID: 23643996
    • Andreasen JT, Gynther M, Rygaard A, Bogelund T, Nielsen SD, Clausen RP, et al. Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests. Neurosci Lett. 2013;546:6–10. DOI: 10.1016/j.neulet.2013.04.045
    • (2013) Neurosci Lett , vol.546 , pp. 6-10
    • Andreasen, J.T.1    Gynther, M.2    Rygaard, A.3    Bogelund, T.4    Nielsen, S.D.5    Clausen, R.P.6
  • 61
    • 84902687924 scopus 로고    scopus 로고
    • Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats
    • COI: 1:CAS:528:DC%2BC2cXht1SlsbjL, PID: 24909673
    • Koike H, Chaki S. Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats. Behav Brain Res. 2014;271:111–5. DOI: 10.1016/j.bbr.2014.05.065
    • (2014) Behav Brain Res , vol.271 , pp. 111-115
    • Koike, H.1    Chaki, S.2
  • 62
    • 34249098796 scopus 로고    scopus 로고
    • AMPA receptor potentiators: application for depression and Parkinson’s disease
    • PID: 17504104
    • O’Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson’s disease. Curr Drug Targets. 2007;8(5):603–20. DOI: 10.2174/138945007780618517
    • (2007) Curr Drug Targets , vol.8 , Issue.5 , pp. 603-620
    • O’Neill, M.J.1    Witkin, J.M.2
  • 63
    • 34247620902 scopus 로고    scopus 로고
    • AMPA receptors in the therapeutic management of depression
    • COI: 1:CAS:528:DC%2BD2sXltValtbw%3D, PID: 17430149
    • Bleakman D, Alt A, Witkin JM. AMPA receptors in the therapeutic management of depression. CNS Neurol Disord Drug Targets. 2007;6(2):117–26. DOI: 10.2174/187152707780363258
    • (2007) CNS Neurol Disord Drug Targets , vol.6 , Issue.2 , pp. 117-126
    • Bleakman, D.1    Alt, A.2    Witkin, J.M.3
  • 64
    • 77951694715 scopus 로고    scopus 로고
    • Challenges for and current status of research into positive modulators of AMPA receptors
    • COI: 1:CAS:528:DC%2BC3cXpslyqs74%3D, PID: 20423333
    • Ward SE, Bax BD, Harries M. Challenges for and current status of research into positive modulators of AMPA receptors. Br J Pharmacol. 2010;160(2):181–90. DOI: 10.1111/j.1476-5381.2010.00726.x
    • (2010) Br J Pharmacol , vol.160 , Issue.2 , pp. 181-190
    • Ward, S.E.1    Bax, B.D.2    Harries, M.3
  • 65
    • 84865858577 scopus 로고    scopus 로고
    • Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection
    • COI: 1:CAS:528:DC%2BC3sXotVCrug%3D%3D, PID: 22852579
    • Nations KR, Bursi R, Dogterom P, Ereshefsky L, Gertsik L, Mant T, et al. Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection. Drugs R D. 2012;12(3):127–39. DOI: 10.2165/11634360-000000000-00000
    • (2012) Drugs R D , vol.12 , Issue.3 , pp. 127-139
    • Nations, K.R.1    Bursi, R.2    Dogterom, P.3    Ereshefsky, L.4    Gertsik, L.5    Mant, T.6
  • 66
    • 84919681704 scopus 로고    scopus 로고
    • Dynamics and modulation of metabotropic glutamate receptors
    • COI: 1:CAS:528:DC%2BC2cXitVyktbfK, PID: 25529199
    • Rondard P, Pin JP. Dynamics and modulation of metabotropic glutamate receptors. Curr Opin Pharmacol. 2015;20:95–101. DOI: 10.1016/j.coph.2014.12.001
    • (2015) Curr Opin Pharmacol , vol.20 , pp. 95-101
    • Rondard, P.1    Pin, J.P.2
  • 67
    • 0033166537 scopus 로고    scopus 로고
    • Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    • COI: 1:CAS:528:DyaK1MXltVynurc%3D, PID: 10433269
    • Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23(3):583–92. DOI: 10.1016/S0896-6273(00)80810-7
    • (1999) Neuron , vol.23 , Issue.3 , pp. 583-592
    • Tu, J.C.1    Xiao, B.2    Naisbitt, S.3    Yuan, J.P.4    Petralia, R.S.5    Brakeman, P.6
  • 68
    • 0033360182 scopus 로고    scopus 로고
    • Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
    • COI: 1:CAS:528:DyaK1MXhsl2gu78%3D, PID: 10195215
    • Alagarsamy S, Marino MJ, Rouse ST, Gereau RW, Heinemann SF, Conn PJ. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nat Neurosci. 1999;2(3):234–40. DOI: 10.1038/6338
    • (1999) Nat Neurosci , vol.2 , Issue.3 , pp. 234-240
    • Alagarsamy, S.1    Marino, M.J.2    Rouse, S.T.3    Gereau, R.W.4    Heinemann, S.F.5    Conn, P.J.6
  • 69
    • 79960539531 scopus 로고    scopus 로고
    • Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study
    • PID: 21498461
    • Deschwanden A, Karolewicz B, Feyissa AM, Treyer V, Ametamey SM, Johayem A, et al. Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am J Psychiatry. 2011;168(7):727–34. DOI: 10.1176/appi.ajp.2011.09111607
    • (2011) Am J Psychiatry , vol.168 , Issue.7 , pp. 727-734
    • Deschwanden, A.1    Karolewicz, B.2    Feyissa, A.M.3    Treyer, V.4    Ametamey, S.M.5    Johayem, A.6
  • 70
    • 34848890329 scopus 로고    scopus 로고
    • Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    • COI: 1:CAS:528:DC%2BD2sXhtFajt7fK, PID: 17881561
    • Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A. 2007;104(39):15537–42. DOI: 10.1073/pnas.0707484104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.39 , pp. 15537-15542
    • Nakamoto, M.1    Nalavadi, V.2    Epstein, M.P.3    Narayanan, U.4    Bassell, G.J.5    Warren, S.T.6
  • 71
    • 0035069188 scopus 로고    scopus 로고
    • Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
    • COI: 1:CAS:528:DC%2BD3MXivVahs70%3D, PID: 11264235
    • Tatarczynska E, Klodzinska A, Chojnacka-Wojcik E, Palucha A, Gasparini F, Kuhn R, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001;132(7):1423–30. DOI: 10.1038/sj.bjp.0703923
    • (2001) Br J Pharmacol , vol.132 , Issue.7 , pp. 1423-1430
    • Tatarczynska, E.1    Klodzinska, A.2    Chojnacka-Wojcik, E.3    Palucha, A.4    Gasparini, F.5    Kuhn, R.6
  • 72
    • 84865832806 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: role of brain-derived neurotrophic factor
    • COI: 1:CAS:528:DC%2BC38XhsVSnsLjO, PID: 22890078
    • Liu CY, Jiang XX, Zhu YH, Wei DN. Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: role of brain-derived neurotrophic factor. Neuroscience. 2012;223:219–24. DOI: 10.1016/j.neuroscience.2012.08.010
    • (2012) Neuroscience , vol.223 , pp. 219-224
    • Liu, C.Y.1    Jiang, X.X.2    Zhu, Y.H.3    Wei, D.N.4
  • 73
    • 33746351511 scopus 로고    scopus 로고
    • Effect of MPEP treatment on brain-derived neurotrophic factor gene expression
    • COI: 1:CAS:528:DC%2BD28XhtVKrtbbN, PID: 16845218
    • Legutko B, Szewczyk B, Pomierny-Chamiolo L, Nowak G, Pilc A. Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. Pharmacol Rep. 2006;58(3):427–30.
    • (2006) Pharmacol Rep , vol.58 , Issue.3 , pp. 427-430
    • Legutko, B.1    Szewczyk, B.2    Pomierny-Chamiolo, L.3    Nowak, G.4    Pilc, A.5
  • 74
    • 23944453080 scopus 로고    scopus 로고
    • Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
    • COI: 1:CAS:528:DC%2BD2MXos1Wrurw%3D, PID: 16040106
    • Palucha A, Branski P, Szewczyk B, Wieronska JM, Klak K, Pilc A. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005;81(4):901–6. DOI: 10.1016/j.pbb.2005.06.015
    • (2005) Pharmacol Biochem Behav , vol.81 , Issue.4 , pp. 901-906
    • Palucha, A.1    Branski, P.2    Szewczyk, B.3    Wieronska, J.M.4    Klak, K.5    Pilc, A.6
  • 75
    • 79551487430 scopus 로고    scopus 로고
    • NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice
    • COI: 1:CAS:528:DC%2BC3MXltlCjsrs%3D, PID: 21273676
    • Pomierny-Chamiolo L, Poleszak E, Pilc A, Nowak G. NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice. Pharmacol Rep. 2010;62(6):1186–90. DOI: 10.1016/S1734-1140(10)70381-9
    • (2010) Pharmacol Rep , vol.62 , Issue.6 , pp. 1186-1190
    • Pomierny-Chamiolo, L.1    Poleszak, E.2    Pilc, A.3    Nowak, G.4
  • 76
    • 84905225358 scopus 로고    scopus 로고
    • Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression
    • COI: 1:CAS:528:DC%2BC2cXhtlejur3I, PID: 25043733
    • Domin H, Szewczyk B, Wozniak M, Wawrzak-Wlecial A, Smialowska M. Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression. Behav Brain Res. 2014;273:23–33. DOI: 10.1016/j.bbr.2014.07.019
    • (2014) Behav Brain Res , vol.273 , pp. 23-33
    • Domin, H.1    Szewczyk, B.2    Wozniak, M.3    Wawrzak-Wlecial, A.4    Smialowska, M.5
  • 77
    • 84973231974 scopus 로고    scopus 로고
    • The efficacy and safety of basimglurant as adjunctive therapy in major depression: A randomized, double-blind, placebo-controlled study
    • This article discusses the difficulties associated with clinical trials when placebo rates are high and explores possible solutions
    • Quiroz J, Tamburri P, Deptula D, Banken L, Beyer U, Fontoura P, et al. The efficacy and safety of basimglurant as adjunctive therapy in major depression: a randomized, double-blind, placebo-controlled study. Neuropsychopharmacology. 2014;39:S376–7. This article discusses the difficulties associated with clinical trials when placebo rates are high and explores possible solutions.
    • (2014) Neuropsychopharmacology , vol.39 , pp. S376-S377
    • Quiroz, J.1    Tamburri, P.2    Deptula, D.3    Banken, L.4    Beyer, U.5    Fontoura, P.6
  • 78
    • 0345707603 scopus 로고    scopus 로고
    • Meta-analysis of placebo rates in major depressive disorder trials
    • PID: 14632596
    • Stolk P, Ten Berg MJ, Hemels ME, Einarson TR. Meta-analysis of placebo rates in major depressive disorder trials. Ann Pharmacother. 2003;37(12):1891–9. DOI: 10.1345/aph.1D172
    • (2003) Ann Pharmacother , vol.37 , Issue.12 , pp. 1891-1899
    • Stolk, P.1    Ten Berg, M.J.2    Hemels, M.E.3    Einarson, T.R.4
  • 79
    • 0035960059 scopus 로고    scopus 로고
    • Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites
    • COI: 1:CAS:528:DC%2BD3MXntlOrtL4%3D, PID: 11591452
    • Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Neuroscience. 2001;106(3):481–503. DOI: 10.1016/S0306-4522(01)00305-0
    • (2001) Neuroscience , vol.106 , Issue.3 , pp. 481-503
    • Tamaru, Y.1    Nomura, S.2    Mizuno, N.3    Shigemoto, R.4
  • 80
    • 10744233803 scopus 로고    scopus 로고
    • MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity
    • COI: 1:CAS:528:DC%2BD2cXht1Kjurs%3D, PID: 14975669
    • Chaki S, Yoshikawa R, Hirota S, Shimazaki T, Maeda M, Kawashima N, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004;46(4):457–67. DOI: 10.1016/j.neuropharm.2003.10.009
    • (2004) Neuropharmacology , vol.46 , Issue.4 , pp. 457-467
    • Chaki, S.1    Yoshikawa, R.2    Hirota, S.3    Shimazaki, T.4    Maeda, M.5    Kawashima, N.6
  • 81
    • 84862669286 scopus 로고    scopus 로고
    • mTOR activation is required for the antidepressant effects of mGluR(2)/(3) blockade
    • COI: 1:CAS:528:DC%2BC38XnvVOgsLs%3D, PID: 22114864
    • Dwyer JM, Lepack AE, Duman RS. mTOR activation is required for the antidepressant effects of mGluR(2)/(3) blockade. Int J Neuropsychopharmacol. 2012;15(4):429–34. DOI: 10.1017/S1461145711001702
    • (2012) Int J Neuropsychopharmacol , vol.15 , Issue.4 , pp. 429-434
    • Dwyer, J.M.1    Lepack, A.E.2    Duman, R.S.3
  • 82
    • 81555205690 scopus 로고    scopus 로고
    • Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression
    • COI: 1:CAS:528:DC%2BC3MXhsV2hs7fI, PID: 22091727
    • Campo B, Kalinichev M, Lambeng N, El Yacoubi M, Royer-Urios I, Schneider M, et al. Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011;25(4):152–66. DOI: 10.3109/01677063.2011.627485
    • (2011) J Neurogenet , vol.25 , Issue.4 , pp. 152-166
    • Campo, B.1    Kalinichev, M.2    Lambeng, N.3    El Yacoubi, M.4    Royer-Urios, I.5    Schneider, M.6
  • 83
    • 84866401521 scopus 로고    scopus 로고
    • Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
    • COI: 1:CAS:528:DC%2BC38Xht1OjsLfK, PID: 22992331
    • Goeldner C, Ballard TM, Knoflach F, Wichmann J, Gatti S, Umbricht D. Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target. Neuropharmacology. 2013;64:337–46. DOI: 10.1016/j.neuropharm.2012.08.001
    • (2013) Neuropharmacology , vol.64 , pp. 337-346
    • Goeldner, C.1    Ballard, T.M.2    Knoflach, F.3    Wichmann, J.4    Gatti, S.5    Umbricht, D.6
  • 84
    • 0029863890 scopus 로고    scopus 로고
    • Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies
    • COI: 1:CAS:528:DyaK28XhvVGnsrg%3D, PID: 8604049
    • Bradley SR, Levey AI, Hersch SM, Conn PJ. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. J Neurosci. 1996;16(6):2044–56.
    • (1996) J Neurosci , vol.16 , Issue.6 , pp. 2044-2056
    • Bradley, S.R.1    Levey, A.I.2    Hersch, S.M.3    Conn, P.J.4
  • 85
    • 0038391169 scopus 로고    scopus 로고
    • Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7
    • PID: 12814372
    • Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci. 2003;17(11):2409–17. DOI: 10.1046/j.1460-9568.2003.02667.x
    • (2003) Eur J Neurosci , vol.17 , Issue.11 , pp. 2409-2417
    • Cryan, J.F.1    Kelly, P.H.2    Neijt, H.C.3    Sansig, G.4    Flor, P.J.5    van Der Putten, H.6
  • 86
    • 77955768871 scopus 로고    scopus 로고
    • Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression
    • PID: 20638442
    • O’Mahony CM, Bravo JA, Dinan TG, Cryan JF. Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression. Neurosci Lett. 2010;482(2):137–41. DOI: 10.1016/j.neulet.2010.07.018
    • (2010) Neurosci Lett , vol.482 , Issue.2 , pp. 137-141
    • O’Mahony, C.M.1    Bravo, J.A.2    Dinan, T.G.3    Cryan, J.F.4
  • 87
    • 83455229501 scopus 로고    scopus 로고
    • The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling
    • COI: 1:CAS:528:DC%2BC38XhvFagurk%3D, PID: 22138407
    • Bradley SR, Uslaner JM, Flick RB, Lee A, Groover KM, Hutson PH. The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling. Pharmacol Biochem Behav. 2012;101(1):35–40. DOI: 10.1016/j.pbb.2011.11.006
    • (2012) Pharmacol Biochem Behav , vol.101 , Issue.1 , pp. 35-40
    • Bradley, S.R.1    Uslaner, J.M.2    Flick, R.B.3    Lee, A.4    Groover, K.M.5    Hutson, P.H.6
  • 88
    • 84897994660 scopus 로고    scopus 로고
    • Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
    • COI: 1:CAS:528:DC%2BC2cXotFynt7k%3D, PID: 24631968
    • Palucha-Poniewiera A, Szewczyk B, Pilc A. Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats. Neuropharmacology. 2014;82:59–68. DOI: 10.1016/j.neuropharm.2014.03.001
    • (2014) Neuropharmacology , vol.82 , pp. 59-68
    • Palucha-Poniewiera, A.1    Szewczyk, B.2    Pilc, A.3
  • 89
    • 79959527317 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?
    • PID: 21508084
    • Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, et al. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? J Pharmacol Exp Ther. 2011;338(1):345–52. DOI: 10.1124/jpet.110.177378
    • (2011) J Pharmacol Exp Ther , vol.338 , Issue.1 , pp. 345-352
    • Sukoff Rizzo, S.J.1    Leonard, S.K.2    Gilbert, A.3    Dollings, P.4    Smith, D.L.5    Zhang, M.Y.6
  • 90
    • 77956257563 scopus 로고    scopus 로고
    • The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N′-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent
    • COI: 1:CAS:528:DC%2BC3cXhtFyksLrP, PID: 20562216
    • Palucha-Poniewiera A, Branski P, Lenda T, Pilc A. The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N′-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent. J Pharmacol Exp Ther. 2010;334(3):1066–74. DOI: 10.1124/jpet.110.169730
    • (2010) J Pharmacol Exp Ther , vol.334 , Issue.3 , pp. 1066-1074
    • Palucha-Poniewiera, A.1    Branski, P.2    Lenda, T.3    Pilc, A.4
  • 91
    • 84926658459 scopus 로고    scopus 로고
    • Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?
    • COI: 1:CAS:528:DC%2BC2cXhvVWntbjI, PID: 25257213
    • Sanacora G, Schatzberg AF. Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology. 2015;40(2):259–67. DOI: 10.1038/npp.2014.261
    • (2015) Neuropsychopharmacology , vol.40 , Issue.2 , pp. 259-267
    • Sanacora, G.1    Schatzberg, A.F.2


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