-
1
-
-
80052376956
-
The size and burden of mental disorders and other disorders of the brain in Europe 2010
-
COI: 1:CAS:528:DC%2BC3MXhtFaqsrbE, PID: 21896369
-
Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21(9):655–79. DOI: 10.1016/j.euroneuro.2011.07.018
-
(2011)
Eur Neuropsychopharmacol
, vol.21
, Issue.9
, pp. 655-679
-
-
Wittchen, H.U.1
Jacobi, F.2
Rehm, J.3
Gustavsson, A.4
Svensson, M.5
Jonsson, B.6
-
2
-
-
0037831023
-
The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)
-
PID: 12813115
-
Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095–105. DOI: 10.1001/jama.289.23.3095
-
(2003)
JAMA
, vol.289
, Issue.23
, pp. 3095-3105
-
-
Kessler, R.C.1
Berglund, P.2
Demler, O.3
Jin, R.4
Koretz, D.5
Merikangas, K.R.6
-
3
-
-
79960044482
-
Grand challenges in global mental health
-
COI: 1:CAS:528:DC%2BC3MXosFehurs%3D, PID: 21734685
-
Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, et al. Grand challenges in global mental health. Nature. 2011;475(7354):27–30. DOI: 10.1038/475027a
-
(2011)
Nature
, vol.475
, Issue.7354
, pp. 27-30
-
-
Collins, P.Y.1
Patel, V.2
Joestl, S.S.3
March, D.4
Insel, T.R.5
Daar, A.S.6
-
4
-
-
49549119585
-
Treatment-resistant depression: critique of current approaches
-
PID: 18696279
-
Wijeratne C, Sachdev P. Treatment-resistant depression: critique of current approaches. Aust N Z J Psychiatry. 2008;42(9):751–62. DOI: 10.1080/00048670802277206
-
(2008)
Aust N Z J Psychiatry
, vol.42
, Issue.9
, pp. 751-762
-
-
Wijeratne, C.1
Sachdev, P.2
-
5
-
-
0025157918
-
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
-
COI: 1:CAS:528:DyaK3cXls1Gqtbk%3D, PID: 2171955
-
Trullas R, Skolnick P. Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur J Pharmacol. 1990;185(1):1–10. DOI: 10.1016/0014-2999(90)90204-J
-
(1990)
Eur J Pharmacol
, vol.185
, Issue.1
, pp. 1-10
-
-
Trullas, R.1
Skolnick, P.2
-
6
-
-
0033969685
-
Antidepressant effects of ketamine in depressed patients
-
COI: 1:CAS:528:DC%2BD3cXht1KqtrY%3D, PID: 10686270
-
Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47(4):351–4. DOI: 10.1016/S0006-3223(99)00230-9
-
(2000)
Biol Psychiatry
, vol.47
, Issue.4
, pp. 351-354
-
-
Berman, R.M.1
Cappiello, A.2
Anand, A.3
Oren, D.A.4
Heninger, G.R.5
Charney, D.S.6
-
7
-
-
33746896935
-
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
-
COI: 1:CAS:528:DC%2BD28XovF2lsLo%3D, PID: 16894061
-
Zarate Jr CA, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006;63(8):856–64. DOI: 10.1001/archpsyc.63.8.856
-
(2006)
Arch Gen Psychiatry
, vol.63
, Issue.8
, pp. 856-864
-
-
Zarate, C.A.1
Singh, J.B.2
Carlson, P.J.3
Brutsche, N.E.4
Ameli, R.5
Luckenbaugh, D.A.6
-
8
-
-
84855549573
-
Overview of glutamatergic neurotransmission in the nervous system
-
COI: 1:CAS:528:DC%2BC38XltVehtw%3D%3D, PID: 21889952
-
Niciu MJ, Kelmendi B, Sanacora G. Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behav. 2012;100(4):656–64. DOI: 10.1016/j.pbb.2011.08.008
-
(2012)
Pharmacol Biochem Behav
, vol.100
, Issue.4
, pp. 656-664
-
-
Niciu, M.J.1
Kelmendi, B.2
Sanacora, G.3
-
9
-
-
84878396787
-
Glutamate-based antidepressants: Preclinical psychopharmacology
-
The article concisely summarizes glutamate-based antidepressants in pre-clinical studies and focuses on major concepts and mechanisms
-
Pilc A, Wieronska JM, Skolnick P. Glutamate-based antidepressants: preclinical psychopharmacology. Biol Psychiatry. 2013;73(12):1125–32. The article concisely summarizes glutamate-based antidepressants in pre-clinical studies and focuses on major concepts and mechanisms.
-
(2013)
Biol Psychiatry
, vol.73
, Issue.12
, pp. 1125-1132
-
-
Pilc, A.1
Wieronska, J.M.2
Skolnick, P.3
-
10
-
-
84920279509
-
Antidepressant actions of ketamine: from molecular mechanisms to clinical practice
-
COI: 1:CAS:528:DC%2BC2cXitV2msLzJ, PID: 25562451
-
Monteggia LM, Zarate Jr C. Antidepressant actions of ketamine: from molecular mechanisms to clinical practice. Curr Opin Neurobiol. 2015;30:139–43. DOI: 10.1016/j.conb.2014.12.004
-
(2015)
Curr Opin Neurobiol
, vol.30
, pp. 139-143
-
-
Monteggia, L.M.1
Zarate, C.2
-
11
-
-
84930516190
-
Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review
-
COI: 1:CAS:528:DC%2BC2MXptlKqt74%3D, PID: 25954495
-
Iadarola ND, Niciu MJ, Richards EM, Vande Voort JL, Ballard ED, Lundin NB, et al. Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther Adv Chronic Dis. 2015;6(3):97–114. DOI: 10.1177/2040622315579059
-
(2015)
Ther Adv Chronic Dis
, vol.6
, Issue.3
, pp. 97-114
-
-
Iadarola, N.D.1
Niciu, M.J.2
Richards, E.M.3
Vande Voort, J.L.4
Ballard, E.D.5
Lundin, N.B.6
-
12
-
-
84929619652
-
Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders
-
COI: 1:CAS:528:DC%2BC2MXosVGgurk%3D, PID: 25817855
-
Ohgi Y, Futamura T, Hashimoto K. Glutamate signaling in synaptogenesis and NMDA receptors as potential therapeutic targets for psychiatric disorders. Curr Mol Med. 2015;15(3):206–21. DOI: 10.2174/1566524015666150330143008
-
(2015)
Curr Mol Med
, vol.15
, Issue.3
, pp. 206-221
-
-
Ohgi, Y.1
Futamura, T.2
Hashimoto, K.3
-
13
-
-
79953166373
-
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
-
COI: 1:CAS:528:DC%2BC3MXkt1GmsLg%3D, PID: 21292242
-
Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, et al. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry. 2011;69(8):754–61. DOI: 10.1016/j.biopsych.2010.12.015
-
(2011)
Biol Psychiatry
, vol.69
, Issue.8
, pp. 754-761
-
-
Li, N.1
Liu, R.J.2
Dwyer, J.M.3
Banasr, M.4
Lee, B.5
Son, H.6
-
14
-
-
84890446708
-
Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3beta
-
COI: 1:CAS:528:DC%2BC3sXhvFCqsrfN, PID: 24317309
-
Duman RS, Aghajanian GK. Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3beta. Neuropsychopharmacology. 2014;39(1):233. DOI: 10.1038/npp.2013.217
-
(2014)
Neuropsychopharmacology
, vol.39
, Issue.1
, pp. 233
-
-
Duman, R.S.1
Aghajanian, G.K.2
-
15
-
-
18944406852
-
Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
-
COI: 1:CAS:528:DC%2BD2MXktVGls7c%3D, PID: 15893584
-
Karege F, Vaudan G, Schwald M, Perroud N, La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res. 2005;136(1–2):29–37. DOI: 10.1016/j.molbrainres.2004.12.020
-
(2005)
Brain Res Mol Brain Res
, vol.136
, Issue.1-2
, pp. 29-37
-
-
Karege, F.1
Vaudan, G.2
Schwald, M.3
Perroud, N.4
La Harpe, R.5
-
16
-
-
73349135323
-
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
-
COI: 1:CAS:528:DC%2BD1MXhsVGru77M, PID: 19777221
-
Gottmann K, Mittmann T, Lessmann V. BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses. Exp Brain Res. 2009;199(3–4):203–34. DOI: 10.1007/s00221-009-1994-z
-
(2009)
Exp Brain Res
, vol.199
, Issue.3-4
, pp. 203-234
-
-
Gottmann, K.1
Mittmann, T.2
Lessmann, V.3
-
17
-
-
84885214350
-
Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site randomized controlled trial
-
This is the largest clinical trial of ketamine to date. It validated the antidepressant effects of ketamine and used an active placebo, midazolam
-
Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CE, Perez AM, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013;170(10):1134–42. This is the largest clinical trial of ketamine to date. It validated the antidepressant effects of ketamine and used an active placebo, midazolam.
-
(2013)
Am J Psychiatry
, vol.170
, Issue.10
, pp. 1134-1142
-
-
Murrough, J.W.1
Iosifescu, D.V.2
Chang, L.C.3
Al Jurdi, R.K.4
Green, C.E.5
Perez, A.M.6
-
18
-
-
84880767967
-
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
-
This is the largest trial of repeated ketamine infusion
-
Murrough JW, Perez AM, Pillemer S, Stern J, Parides MK, aan het Rot M, et al. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry. 2013;74(4):250–6. This is the largest trial of repeated ketamine infusion.
-
(2013)
Biol Psychiatry
, vol.74
, Issue.4
, pp. 250-256
-
-
Murrough, J.W.1
Perez, A.M.2
Pillemer, S.3
Stern, J.4
Parides, M.K.5
Aan Het Rot, M.6
-
19
-
-
84925650392
-
Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression
-
COI: 1:CAS:528:DC%2BC2cXhs1Cns7zE, PID: 24963561
-
Shiroma PR, Albott CS, Johns B, Thuras P, Wels J, Lim KO. Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression. Int J Neuropsychopharmacol. 2014;17(11):1805–13. DOI: 10.1017/S1461145714001011
-
(2014)
Int J Neuropsychopharmacol
, vol.17
, Issue.11
, pp. 1805-1813
-
-
Shiroma, P.R.1
Albott, C.S.2
Johns, B.3
Thuras, P.4
Wels, J.5
Lim, K.O.6
-
20
-
-
84876531468
-
Serial infusions of low-dose ketamine for major depression
-
COI: 1:CAS:528:DC%2BC2cXhs1OltrfP, PID: 23428794
-
Rasmussen KG, Lineberry TW, Galardy CW, Kung S, Lapid MI, Palmer BA, et al. Serial infusions of low-dose ketamine for major depression. J Psychopharmacol. 2013;27(5):444–50. DOI: 10.1177/0269881113478283
-
(2013)
J Psychopharmacol
, vol.27
, Issue.5
, pp. 444-450
-
-
Rasmussen, K.G.1
Lineberry, T.W.2
Galardy, C.W.3
Kung, S.4
Lapid, M.I.5
Palmer, B.A.6
-
21
-
-
84898003445
-
Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic
-
PID: 24699062
-
Diamond PR, Farmery AD, Atkinson S, Haldar J, Williams N, Cowen PJ, et al. Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic. J Psychopharmacol. 2014;28(6):536–44. DOI: 10.1177/0269881114527361
-
(2014)
J Psychopharmacol
, vol.28
, Issue.6
, pp. 536-544
-
-
Diamond, P.R.1
Farmery, A.D.2
Atkinson, S.3
Haldar, J.4
Williams, N.5
Cowen, P.J.6
-
22
-
-
84907260750
-
Pilot dose–response trial of i.v. ketamine in treatment-resistant depression
-
PID: 24910102
-
Lai R, Katalinic N, Glue P, Somogyi AA, Mitchell PB, Leyden J, et al. Pilot dose–response trial of i.v. ketamine in treatment-resistant depression. World J Biol Psychiatry. 2014;15(7):579–84. DOI: 10.3109/15622975.2014.922697
-
(2014)
World J Biol Psychiatry
, vol.15
, Issue.7
, pp. 579-584
-
-
Lai, R.1
Katalinic, N.2
Glue, P.3
Somogyi, A.A.4
Mitchell, P.B.5
Leyden, J.6
-
23
-
-
84919398586
-
A randomized controlled trial of intranasal ketamine in major depressive disorder
-
This is the first controlled study of intranasal ketamine
-
Lapidus KA, Levitch CF, Perez AM, Brallier JW, Parides MK, Soleimani L, et al. A randomized controlled trial of intranasal ketamine in major depressive disorder. Biol Psychiatry. 2014;76(12):970–6. This is the first controlled study of intranasal ketamine.
-
(2014)
Biol Psychiatry
, vol.76
, Issue.12
, pp. 970-976
-
-
Lapidus, K.A.1
Levitch, C.F.2
Perez, A.M.3
Brallier, J.W.4
Parides, M.K.5
Soleimani, L.6
-
24
-
-
84864807084
-
Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression
-
PID: 22854933
-
Cusin C, Hilton GQ, Nierenberg AA, Fava M. Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression. Am J Psychiatry. 2012;169(8):868–9. DOI: 10.1176/appi.ajp.2012.12020219
-
(2012)
Am J Psychiatry
, vol.169
, Issue.8
, pp. 868-869
-
-
Cusin, C.1
Hilton, G.Q.2
Nierenberg, A.A.3
Fava, M.4
-
25
-
-
84883324216
-
Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression
-
This is the first clinical trial to report the robust and rapid antidepressant effect of sublingual ketamine
-
Lara DR, Bisol LW, Munari LR. Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression. Int J Neuropsychopharmacol. 2013;16(9):2111–7. This is the first clinical trial to report the robust and rapid antidepressant effect of sublingual ketamine.
-
(2013)
Int J Neuropsychopharmacol
, vol.16
, Issue.9
, pp. 2111-2117
-
-
Lara, D.R.1
Bisol, L.W.2
Munari, L.R.3
-
26
-
-
77954950428
-
Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care
-
PID: 20636166
-
Irwin SA, Iglewicz A. Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care. J Palliat Med. 2010;13(7):903–8. DOI: 10.1089/jpm.2010.9808
-
(2010)
J Palliat Med
, vol.13
, Issue.7
, pp. 903-908
-
-
Irwin, S.A.1
Iglewicz, A.2
-
27
-
-
76349084738
-
Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series
-
COI: 1:CAS:528:DC%2BC3cXksVyms78%3D, PID: 20013614
-
Paslakis G, Gilles M, Meyer-Lindenberg A, Deuschle M. Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series. Pharmacopsychiatry. 2010;43(1):33–5. DOI: 10.1055/s-0029-1237375
-
(2010)
Pharmacopsychiatry
, vol.43
, Issue.1
, pp. 33-35
-
-
Paslakis, G.1
Gilles, M.2
Meyer-Lindenberg, A.3
Deuschle, M.4
-
28
-
-
84880852239
-
Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial
-
PID: 23805864
-
Irwin SA, Iglewicz A, Nelesen RA, Lo JY, Carr CH, Romero SD, et al. Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial. J Palliat Med. 2013;16(8):958–65. DOI: 10.1089/jpm.2012.0617
-
(2013)
J Palliat Med
, vol.16
, Issue.8
, pp. 958-965
-
-
Irwin, S.A.1
Iglewicz, A.2
Nelesen, R.A.3
Lo, J.Y.4
Carr, C.H.5
Romero, S.D.6
-
29
-
-
84903543431
-
Oral ketamine augmentation for chronic suicidality in treatment-resistant depression
-
PID: 24452289
-
De Gioannis A, De Leo D. Oral ketamine augmentation for chronic suicidality in treatment-resistant depression. Aust N Z J Psychiatry. 2014;48(7):686. DOI: 10.1177/0004867414520754
-
(2014)
Aust N Z J Psychiatry
, vol.48
, Issue.7
, pp. 686
-
-
De Gioannis, A.1
De Leo, D.2
-
30
-
-
79960757856
-
Dose- and exposure-response to ketamine in depression
-
PID: 21481846, author reply e11-2
-
Glue P, Gulati A, Le Nedelec M, Duffull S. Dose- and exposure-response to ketamine in depression. Biol Psychiatry. 2011;70(4):e9–10. author reply e11-2. DOI: 10.1016/j.biopsych.2010.11.031
-
(2011)
Biol Psychiatry
, vol.70
, Issue.4
, pp. e9-e10
-
-
Glue, P.1
Gulati, A.2
Le Nedelec, M.3
Duffull, S.4
-
31
-
-
77957008254
-
Taming the ketamine tiger. 1965
-
PID: 20693870
-
Domino EF. Taming the ketamine tiger. 1965. Anesthesiology. 2010;113(3):678–84.
-
(2010)
Anesthesiology
, vol.113
, Issue.3
, pp. 678-684
-
-
Domino, E.F.1
-
32
-
-
84939803581
-
Nitrous oxide for treatment-resistant major depression: A proof-of-concept trial
-
This study showed that nitrous oxide, a non-ketamine NMDA receptor antagonist, had rapid antidepressant effects. This finding implicates NMDA receptor antagonism in the mechanism of antidepressant activity
-
Nagele P, Duma A, et al. Nitrous oxide for treatment-resistant major depression: a proof-of-concept trial. Soc Biol Psychiatry. 2015. This study showed that nitrous oxide, a non-ketamine NMDA receptor antagonist, had rapid antidepressant effects. This finding implicates NMDA receptor antagonism in the mechanism of antidepressant activity.
-
(2015)
Soc Biol Psychiatry
-
-
Nagele, P.1
Duma, A.2
-
33
-
-
54749137815
-
Biologic effects of nitrous oxide: a mechanistic and toxicologic review
-
COI: 1:CAS:528:DC%2BD1cXhtFCkt7bP, PID: 18813051
-
Sanders RD, Weimann J, Maze M. Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Anesthesiology. 2008;109(4):707–22. DOI: 10.1097/ALN.0b013e3181870a17
-
(2008)
Anesthesiology
, vol.109
, Issue.4
, pp. 707-722
-
-
Sanders, R.D.1
Weimann, J.2
Maze, M.3
-
34
-
-
84862808862
-
The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder
-
COI: 1:CAS:528:DC%2BC38Xjs1altrw%3D, PID: 22326841
-
Lee SY, Chen SL, Chang YH, Chen SH, Chu CH, Huang SY, et al. The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder. J Affect Disord. 2012;138(3):295–300. DOI: 10.1016/j.jad.2012.01.024
-
(2012)
J Affect Disord
, vol.138
, Issue.3
, pp. 295-300
-
-
Lee, S.Y.1
Chen, S.L.2
Chang, Y.H.3
Chen, S.H.4
Chu, C.H.5
Huang, S.Y.6
-
35
-
-
0027970898
-
Interactions of dextromethorphan with the N-methyl-D-aspartate receptor-channel complex: single channel recordings
-
COI: 1:CAS:528:DyaK2MXisFars7o%3D, PID: 7533633
-
Church J, Sawyer D, McLarnon JG. Interactions of dextromethorphan with the N-methyl-D-aspartate receptor-channel complex: single channel recordings. Brain Res. 1994;666(2):189–94. DOI: 10.1016/0006-8993(94)90771-4
-
(1994)
Brain Res
, vol.666
, Issue.2
, pp. 189-194
-
-
Church, J.1
Sawyer, D.2
McLarnon, J.G.3
-
36
-
-
84904291457
-
The utility of the combination of dextromethorphan and quinidine in the treatment of bipolar II and bipolar NOS
-
COI: 1:CAS:528:DC%2BC2cXhtlWrs7vM, PID: 25016490
-
Kelly TF, Lieberman DZ. The utility of the combination of dextromethorphan and quinidine in the treatment of bipolar II and bipolar NOS. J Affect Disord. 2014;167:333–5. DOI: 10.1016/j.jad.2014.05.050
-
(2014)
J Affect Disord
, vol.167
, pp. 333-335
-
-
Kelly, T.F.1
Lieberman, D.Z.2
-
37
-
-
30044450251
-
A double-blind, placebo-controlled study of memantine in the treatment of major depression
-
PID: 16390905
-
Zarate Jr CA, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, et al. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry. 2006;163(1):153–5. DOI: 10.1176/appi.ajp.163.1.153
-
(2006)
Am J Psychiatry
, vol.163
, Issue.1
, pp. 153-155
-
-
Zarate, C.A.1
Singh, J.B.2
Quiroz, J.A.3
De Jesus, G.4
Denicoff, K.K.5
Luckenbaugh, D.A.6
-
38
-
-
84887043337
-
Antidepressant augmentation using the N-methyl-D-aspartate antagonist memantine: a randomized, double-blind, placebo-controlled trial
-
COI: 1:CAS:528:DC%2BC3sXhvVamurfK, PID: 24229746
-
Smith EG, Deligiannidis KM, Ulbricht CM, Landolin CS, Patel JK, Rothschild AJ. Antidepressant augmentation using the N-methyl-D-aspartate antagonist memantine: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2013;74(10):966–73. DOI: 10.4088/JCP.12m08252
-
(2013)
J Clin Psychiatry
, vol.74
, Issue.10
, pp. 966-973
-
-
Smith, E.G.1
Deligiannidis, K.M.2
Ulbricht, C.M.3
Landolin, C.S.4
Patel, J.K.5
Rothschild, A.J.6
-
39
-
-
84925372786
-
Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder
-
This article suggests that although memantine may not be an effective augmenting agent for major depressive disorder, it may be effective in bipolar depression
-
Serra G, Koukopoulos A, De Chiara L, Koukopoulos AE, Tondo L, Girardi P, et al. Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder. J Clin Psychiatry. 2015;76(1):e91–7. This article suggests that although memantine may not be an effective augmenting agent for major depressive disorder, it may be effective in bipolar depression.
-
(2015)
J Clin Psychiatry
, vol.76
, Issue.1
, pp. e91-e97
-
-
Serra, G.1
Koukopoulos, A.2
de Chiara, L.3
Koukopoulos, A.E.4
Tondo, L.5
Girardi, P.6
-
40
-
-
84902184667
-
Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
-
COI: 1:CAS:528:DC%2BC2cXos1aqurY%3D, PID: 24912158
-
Gideons ES, Kavalali ET, Monteggia LM. Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses. Proc Natl Acad Sci U S A. 2014;111(23):8649–54. DOI: 10.1073/pnas.1323920111
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.23
, pp. 8649-8654
-
-
Gideons, E.S.1
Kavalali, E.T.2
Monteggia, L.M.3
-
41
-
-
84880829258
-
A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression
-
COI: 1:CAS:528:DC%2BC38Xhslynur7K, PID: 23206319
-
Zarate Jr CA, Mathews D, Ibrahim L, Chaves JF, Marquardt C, Ukoh I, et al. A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biol Psychiatry. 2013;74(4):257–64. DOI: 10.1016/j.biopsych.2012.10.019
-
(2013)
Biol Psychiatry
, vol.74
, Issue.4
, pp. 257-264
-
-
Zarate, C.A.1
Mathews, D.2
Ibrahim, L.3
Chaves, J.F.4
Marquardt, C.5
Ukoh, I.6
-
42
-
-
84908572031
-
Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
-
COI: 1:CAS:528:DC%2BC3sXhs1CiurvE, PID: 24126931
-
Sanacora G, Smith MA, Pathak S, Su HL, Boeijinga PH, McCarthy DJ, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol Psychiatry. 2014;19(9):978–85. DOI: 10.1038/mp.2013.130
-
(2014)
Mol Psychiatry
, vol.19
, Issue.9
, pp. 978-985
-
-
Sanacora, G.1
Smith, M.A.2
Pathak, S.3
Su, H.L.4
Boeijinga, P.H.5
McCarthy, D.J.6
-
43
-
-
85090131502
-
Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: Primary results from a randomized
-
Hollywood, FL, USA
-
Sanacora G, Johnson M, Khan A, Atkinson S, Riesenberg R, Schronen J. Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: primary results from a randomized, placebo-controlled study (PURSUIT). 53rd Meeting of the ACNP. 2014. Hollywood, FL, USA.
-
(2014)
Placebo-Controlled Study (PURSUIT). 53Rd Meeting of the ACNP
-
-
Sanacora, G.1
Johnson, M.2
Khan, A.3
Atkinson, S.4
Riesenberg, R.5
Schronen, J.6
-
44
-
-
66649086928
-
Mechanism of differential control of NMDA receptor activity by NR2 subunits
-
COI: 1:CAS:528:DC%2BD1MXlt1Sku7s%3D, PID: 19404260
-
Gielen M, Siegler RB, Mony L, Johnson JW, Paoletti P. Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature. 2009;459(7247):703–7. DOI: 10.1038/nature07993
-
(2009)
Nature
, vol.459
, Issue.7247
, pp. 703-707
-
-
Gielen, M.1
Siegler, R.B.2
Mony, L.3
Johnson, J.W.4
Paoletti, P.5
-
45
-
-
27744500994
-
Subunit arrangement and function in NMDA receptors
-
COI: 1:CAS:528:DC%2BD2MXhtF2nsrjI, PID: 16281028
-
Furukawa H, Singh SK, Mancusso R, Gouaux E. Subunit arrangement and function in NMDA receptors. Nature. 2005;438(7065):185–92. DOI: 10.1038/nature04089
-
(2005)
Nature
, vol.438
, Issue.7065
, pp. 185-192
-
-
Furukawa, H.1
Singh, S.K.2
Mancusso, R.3
Gouaux, E.4
-
46
-
-
33646849232
-
Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A
-
COI: 1:CAS:528:DC%2BD28XksFWqtbg%3D, PID: 16641235
-
Yao Y, Mayer ML. Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A. J Neurosci. 2006;26(17):4559–66. DOI: 10.1523/JNEUROSCI.0560-06.2006
-
(2006)
J Neurosci
, vol.26
, Issue.17
, pp. 4559-4566
-
-
Yao, Y.1
Mayer, M.L.2
-
47
-
-
84920270347
-
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
-
PID: 25340958
-
Miller OH, Yang L, Wang CC, Hargroder EA, Zhang Y, Delpire E, et al. GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine. Elife. 2014;3:e03581.
-
(2014)
Elife
, vol.3
-
-
Miller, O.H.1
Yang, L.2
Wang, C.C.3
Hargroder, E.A.4
Zhang, Y.5
Delpire, E.6
-
48
-
-
84893956740
-
A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression
-
COI: 1:CAS:528:DC%2BC3sXhs1SnsLbJ
-
Zhang C, Li Z, Wu Z, Chen J, Wang Z, Peng D, et al. A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression. Psychopharmacology (Berl). 2014;231(4):685–93. DOI: 10.1007/s00213-013-3297-0
-
(2014)
Psychopharmacology (Berl)
, vol.231
, Issue.4
, pp. 685-693
-
-
Zhang, C.1
Li, Z.2
Wu, Z.3
Chen, J.4
Wang, Z.5
Peng, D.6
-
49
-
-
59049098262
-
An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder
-
COI: 1:CAS:528:DC%2BD1cXhtlyqu7zE, PID: 19011431
-
Preskorn SH, Baker B, Kolluri S, Menniti FS, Krams M, Landen JW. An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol. 2008;28(6):631–7. DOI: 10.1097/JCP.0b013e31818a6cea
-
(2008)
J Clin Psychopharmacol
, vol.28
, Issue.6
, pp. 631-637
-
-
Preskorn, S.H.1
Baker, B.2
Kolluri, S.3
Menniti, F.S.4
Krams, M.5
Landen, J.W.6
-
50
-
-
35948933040
-
The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys
-
COI: 1:CAS:528:DC%2BD2sXht1KrsrfO, PID: 17989511
-
Nicholson KL, Mansbach RS, Menniti FS, Balster RL. The phencyclidine-like discriminative stimulus effects and reinforcing properties of the NR2B-selective N-methyl-D-aspartate antagonist CP-101 606 in rats and rhesus monkeys. Behav Pharmacol. 2007;18(8):731–43. DOI: 10.1097/FBP.0b013e3282f14ed6
-
(2007)
Behav Pharmacol
, vol.18
, Issue.8
, pp. 731-743
-
-
Nicholson, K.L.1
Mansbach, R.S.2
Menniti, F.S.3
Balster, R.L.4
-
51
-
-
84863719297
-
A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder
-
COI: 1:CAS:528:DC%2BC38XhtVWjtrjO, PID: 22722512
-
Ibrahim L, Diaz GN, Jolkovsky L, Brutsche N, Luckenbaugh DA, Herring WJ, et al. A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder. J Clin Psychopharmacol. 2012;32(4):551–7. DOI: 10.1097/JCP.0b013e31825d70d6
-
(2012)
J Clin Psychopharmacol
, vol.32
, Issue.4
, pp. 551-557
-
-
Ibrahim, L.1
Diaz, G.N.2
Jolkovsky, L.3
Brutsche, N.4
Luckenbaugh, D.A.5
Herring, W.J.6
-
52
-
-
0013085913
-
N-methyl-D-aspartate receptor-coupled glycineB receptors in the pathogenesis and treatment of schizophrenia: a critical review
-
COI: 1:CAS:528:DC%2BD38XjvV2nu70%3D, PID: 12769627
-
Millan MJ. N-methyl-D-aspartate receptor-coupled glycineB receptors in the pathogenesis and treatment of schizophrenia: a critical review. Curr Drug Targets CNS Neurol Disord. 2002;1(2):191–213. DOI: 10.2174/1568007024606258
-
(2002)
Curr Drug Targets CNS Neurol Disord
, vol.1
, Issue.2
, pp. 191-213
-
-
Millan, M.J.1
-
53
-
-
33744549976
-
Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder
-
COI: 1:CAS:528:DC%2BD28Xltl2hsbw%3D, PID: 16677714
-
Heresco-Levy U, Javitt DC, Gelfin Y, Gorelik E, Bar M, Blanaru M, et al. Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder. J Affect Disord. 2006;93(1–3):239–43. DOI: 10.1016/j.jad.2006.03.004
-
(2006)
J Affect Disord
, vol.93
, Issue.1-3
, pp. 239-243
-
-
Heresco-Levy, U.1
Javitt, D.C.2
Gelfin, Y.3
Gorelik, E.4
Bar, M.5
Blanaru, M.6
-
54
-
-
84874654554
-
A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression
-
COI: 1:CAS:528:DC%2BC3sXjtlWlu7c%3D, PID: 23174090
-
Heresco-Levy U, Gelfin G, Bloch B, Levin R, Edelman S, Javitt DC, et al. A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression. Int J Neuropsychopharmacol. 2013;16(3):501–6. DOI: 10.1017/S1461145712000910
-
(2013)
Int J Neuropsychopharmacol
, vol.16
, Issue.3
, pp. 501-506
-
-
Heresco-Levy, U.1
Gelfin, G.2
Bloch, B.3
Levin, R.4
Edelman, S.5
Javitt, D.C.6
-
55
-
-
1942539345
-
Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms
-
COI: 1:CAS:528:DC%2BD2cXhtlKgs7s%3D, PID: 14720317
-
Sumiyoshi T, Anil AE, Jin D, Jayathilake K, Lee M, Meltzer HY. Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms. Int J Neuropsychopharmacol. 2004;7(1):1–8. DOI: 10.1017/S1461145703003900
-
(2004)
Int J Neuropsychopharmacol
, vol.7
, Issue.1
, pp. 1-8
-
-
Sumiyoshi, T.1
Anil, A.E.2
Jin, D.3
Jayathilake, K.4
Lee, M.5
Meltzer, H.Y.6
-
56
-
-
84892403784
-
GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
-
This article provides a quick overview of GLYX-13, including its mechanism of action, preclinical results, and clinical data
-
Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, et al. GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists. Expert Opin Investig Drugs. 2014;23(2):243–54. This article provides a quick overview of GLYX-13, including its mechanism of action, preclinical results, and clinical data.
-
(2014)
Expert Opin Investig Drugs
, vol.23
, Issue.2
, pp. 243-254
-
-
Moskal, J.R.1
Burch, R.2
Burgdorf, J.S.3
Kroes, R.A.4
Stanton, P.K.5
Disterhoft, J.F.6
-
57
-
-
85090138251
-
-
Naurex Inc. NRX-1074. 2015. http://www.naurex.com/pipeline/nrx-1074.
-
(2015)
NRX-1074
-
-
-
58
-
-
84891713774
-
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
-
PID: 24409146
-
Browne CA, Lucki I. Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants. Front Pharmacol. 2013;4:161. DOI: 10.3389/fphar.2013.00161
-
(2013)
Front Pharmacol
, vol.4
, pp. 161
-
-
Browne, C.A.1
Lucki, I.2
-
59
-
-
38349186799
-
Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
-
COI: 1:CAS:528:DC%2BD1cXhsVShs7g%3D, PID: 17643398
-
Maeng S, Zarate Jr CA, Du J, Schloesser RJ, McCammon J, Chen G, et al. Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry. 2008;63(4):349–52. DOI: 10.1016/j.biopsych.2007.05.028
-
(2008)
Biol Psychiatry
, vol.63
, Issue.4
, pp. 349-352
-
-
Maeng, S.1
Zarate, C.A.2
Du, J.3
Schloesser, R.J.4
McCammon, J.5
Chen, G.6
-
60
-
-
84878916836
-
Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests
-
COI: 1:CAS:528:DC%2BC3sXotlGitL4%3D, PID: 23643996
-
Andreasen JT, Gynther M, Rygaard A, Bogelund T, Nielsen SD, Clausen RP, et al. Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests. Neurosci Lett. 2013;546:6–10. DOI: 10.1016/j.neulet.2013.04.045
-
(2013)
Neurosci Lett
, vol.546
, pp. 6-10
-
-
Andreasen, J.T.1
Gynther, M.2
Rygaard, A.3
Bogelund, T.4
Nielsen, S.D.5
Clausen, R.P.6
-
61
-
-
84902687924
-
Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats
-
COI: 1:CAS:528:DC%2BC2cXht1SlsbjL, PID: 24909673
-
Koike H, Chaki S. Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats. Behav Brain Res. 2014;271:111–5. DOI: 10.1016/j.bbr.2014.05.065
-
(2014)
Behav Brain Res
, vol.271
, pp. 111-115
-
-
Koike, H.1
Chaki, S.2
-
62
-
-
34249098796
-
AMPA receptor potentiators: application for depression and Parkinson’s disease
-
PID: 17504104
-
O’Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson’s disease. Curr Drug Targets. 2007;8(5):603–20. DOI: 10.2174/138945007780618517
-
(2007)
Curr Drug Targets
, vol.8
, Issue.5
, pp. 603-620
-
-
O’Neill, M.J.1
Witkin, J.M.2
-
63
-
-
34247620902
-
AMPA receptors in the therapeutic management of depression
-
COI: 1:CAS:528:DC%2BD2sXltValtbw%3D, PID: 17430149
-
Bleakman D, Alt A, Witkin JM. AMPA receptors in the therapeutic management of depression. CNS Neurol Disord Drug Targets. 2007;6(2):117–26. DOI: 10.2174/187152707780363258
-
(2007)
CNS Neurol Disord Drug Targets
, vol.6
, Issue.2
, pp. 117-126
-
-
Bleakman, D.1
Alt, A.2
Witkin, J.M.3
-
64
-
-
77951694715
-
Challenges for and current status of research into positive modulators of AMPA receptors
-
COI: 1:CAS:528:DC%2BC3cXpslyqs74%3D, PID: 20423333
-
Ward SE, Bax BD, Harries M. Challenges for and current status of research into positive modulators of AMPA receptors. Br J Pharmacol. 2010;160(2):181–90. DOI: 10.1111/j.1476-5381.2010.00726.x
-
(2010)
Br J Pharmacol
, vol.160
, Issue.2
, pp. 181-190
-
-
Ward, S.E.1
Bax, B.D.2
Harries, M.3
-
65
-
-
84865858577
-
Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection
-
COI: 1:CAS:528:DC%2BC3sXotVCrug%3D%3D, PID: 22852579
-
Nations KR, Bursi R, Dogterom P, Ereshefsky L, Gertsik L, Mant T, et al. Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection. Drugs R D. 2012;12(3):127–39. DOI: 10.2165/11634360-000000000-00000
-
(2012)
Drugs R D
, vol.12
, Issue.3
, pp. 127-139
-
-
Nations, K.R.1
Bursi, R.2
Dogterom, P.3
Ereshefsky, L.4
Gertsik, L.5
Mant, T.6
-
66
-
-
84919681704
-
Dynamics and modulation of metabotropic glutamate receptors
-
COI: 1:CAS:528:DC%2BC2cXitVyktbfK, PID: 25529199
-
Rondard P, Pin JP. Dynamics and modulation of metabotropic glutamate receptors. Curr Opin Pharmacol. 2015;20:95–101. DOI: 10.1016/j.coph.2014.12.001
-
(2015)
Curr Opin Pharmacol
, vol.20
, pp. 95-101
-
-
Rondard, P.1
Pin, J.P.2
-
67
-
-
0033166537
-
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
-
COI: 1:CAS:528:DyaK1MXltVynurc%3D, PID: 10433269
-
Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23(3):583–92. DOI: 10.1016/S0896-6273(00)80810-7
-
(1999)
Neuron
, vol.23
, Issue.3
, pp. 583-592
-
-
Tu, J.C.1
Xiao, B.2
Naisbitt, S.3
Yuan, J.P.4
Petralia, R.S.5
Brakeman, P.6
-
68
-
-
0033360182
-
Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
-
COI: 1:CAS:528:DyaK1MXhsl2gu78%3D, PID: 10195215
-
Alagarsamy S, Marino MJ, Rouse ST, Gereau RW, Heinemann SF, Conn PJ. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nat Neurosci. 1999;2(3):234–40. DOI: 10.1038/6338
-
(1999)
Nat Neurosci
, vol.2
, Issue.3
, pp. 234-240
-
-
Alagarsamy, S.1
Marino, M.J.2
Rouse, S.T.3
Gereau, R.W.4
Heinemann, S.F.5
Conn, P.J.6
-
69
-
-
79960539531
-
Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study
-
PID: 21498461
-
Deschwanden A, Karolewicz B, Feyissa AM, Treyer V, Ametamey SM, Johayem A, et al. Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am J Psychiatry. 2011;168(7):727–34. DOI: 10.1176/appi.ajp.2011.09111607
-
(2011)
Am J Psychiatry
, vol.168
, Issue.7
, pp. 727-734
-
-
Deschwanden, A.1
Karolewicz, B.2
Feyissa, A.M.3
Treyer, V.4
Ametamey, S.M.5
Johayem, A.6
-
70
-
-
34848890329
-
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
-
COI: 1:CAS:528:DC%2BD2sXhtFajt7fK, PID: 17881561
-
Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A. 2007;104(39):15537–42. DOI: 10.1073/pnas.0707484104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.39
, pp. 15537-15542
-
-
Nakamoto, M.1
Nalavadi, V.2
Epstein, M.P.3
Narayanan, U.4
Bassell, G.J.5
Warren, S.T.6
-
71
-
-
0035069188
-
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
-
COI: 1:CAS:528:DC%2BD3MXivVahs70%3D, PID: 11264235
-
Tatarczynska E, Klodzinska A, Chojnacka-Wojcik E, Palucha A, Gasparini F, Kuhn R, et al. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br J Pharmacol. 2001;132(7):1423–30. DOI: 10.1038/sj.bjp.0703923
-
(2001)
Br J Pharmacol
, vol.132
, Issue.7
, pp. 1423-1430
-
-
Tatarczynska, E.1
Klodzinska, A.2
Chojnacka-Wojcik, E.3
Palucha, A.4
Gasparini, F.5
Kuhn, R.6
-
72
-
-
84865832806
-
Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: role of brain-derived neurotrophic factor
-
COI: 1:CAS:528:DC%2BC38XhsVSnsLjO, PID: 22890078
-
Liu CY, Jiang XX, Zhu YH, Wei DN. Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: role of brain-derived neurotrophic factor. Neuroscience. 2012;223:219–24. DOI: 10.1016/j.neuroscience.2012.08.010
-
(2012)
Neuroscience
, vol.223
, pp. 219-224
-
-
Liu, C.Y.1
Jiang, X.X.2
Zhu, Y.H.3
Wei, D.N.4
-
73
-
-
33746351511
-
Effect of MPEP treatment on brain-derived neurotrophic factor gene expression
-
COI: 1:CAS:528:DC%2BD28XhtVKrtbbN, PID: 16845218
-
Legutko B, Szewczyk B, Pomierny-Chamiolo L, Nowak G, Pilc A. Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. Pharmacol Rep. 2006;58(3):427–30.
-
(2006)
Pharmacol Rep
, vol.58
, Issue.3
, pp. 427-430
-
-
Legutko, B.1
Szewczyk, B.2
Pomierny-Chamiolo, L.3
Nowak, G.4
Pilc, A.5
-
74
-
-
23944453080
-
Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist
-
COI: 1:CAS:528:DC%2BD2MXos1Wrurw%3D, PID: 16040106
-
Palucha A, Branski P, Szewczyk B, Wieronska JM, Klak K, Pilc A. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005;81(4):901–6. DOI: 10.1016/j.pbb.2005.06.015
-
(2005)
Pharmacol Biochem Behav
, vol.81
, Issue.4
, pp. 901-906
-
-
Palucha, A.1
Branski, P.2
Szewczyk, B.3
Wieronska, J.M.4
Klak, K.5
Pilc, A.6
-
75
-
-
79551487430
-
NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice
-
COI: 1:CAS:528:DC%2BC3MXltlCjsrs%3D, PID: 21273676
-
Pomierny-Chamiolo L, Poleszak E, Pilc A, Nowak G. NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice. Pharmacol Rep. 2010;62(6):1186–90. DOI: 10.1016/S1734-1140(10)70381-9
-
(2010)
Pharmacol Rep
, vol.62
, Issue.6
, pp. 1186-1190
-
-
Pomierny-Chamiolo, L.1
Poleszak, E.2
Pilc, A.3
Nowak, G.4
-
76
-
-
84905225358
-
Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression
-
COI: 1:CAS:528:DC%2BC2cXhtlejur3I, PID: 25043733
-
Domin H, Szewczyk B, Wozniak M, Wawrzak-Wlecial A, Smialowska M. Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression. Behav Brain Res. 2014;273:23–33. DOI: 10.1016/j.bbr.2014.07.019
-
(2014)
Behav Brain Res
, vol.273
, pp. 23-33
-
-
Domin, H.1
Szewczyk, B.2
Wozniak, M.3
Wawrzak-Wlecial, A.4
Smialowska, M.5
-
77
-
-
84973231974
-
The efficacy and safety of basimglurant as adjunctive therapy in major depression: A randomized, double-blind, placebo-controlled study
-
This article discusses the difficulties associated with clinical trials when placebo rates are high and explores possible solutions
-
Quiroz J, Tamburri P, Deptula D, Banken L, Beyer U, Fontoura P, et al. The efficacy and safety of basimglurant as adjunctive therapy in major depression: a randomized, double-blind, placebo-controlled study. Neuropsychopharmacology. 2014;39:S376–7. This article discusses the difficulties associated with clinical trials when placebo rates are high and explores possible solutions.
-
(2014)
Neuropsychopharmacology
, vol.39
, pp. S376-S377
-
-
Quiroz, J.1
Tamburri, P.2
Deptula, D.3
Banken, L.4
Beyer, U.5
Fontoura, P.6
-
78
-
-
0345707603
-
Meta-analysis of placebo rates in major depressive disorder trials
-
PID: 14632596
-
Stolk P, Ten Berg MJ, Hemels ME, Einarson TR. Meta-analysis of placebo rates in major depressive disorder trials. Ann Pharmacother. 2003;37(12):1891–9. DOI: 10.1345/aph.1D172
-
(2003)
Ann Pharmacother
, vol.37
, Issue.12
, pp. 1891-1899
-
-
Stolk, P.1
Ten Berg, M.J.2
Hemels, M.E.3
Einarson, T.R.4
-
79
-
-
0035960059
-
Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites
-
COI: 1:CAS:528:DC%2BD3MXntlOrtL4%3D, PID: 11591452
-
Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Neuroscience. 2001;106(3):481–503. DOI: 10.1016/S0306-4522(01)00305-0
-
(2001)
Neuroscience
, vol.106
, Issue.3
, pp. 481-503
-
-
Tamaru, Y.1
Nomura, S.2
Mizuno, N.3
Shigemoto, R.4
-
80
-
-
10744233803
-
MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity
-
COI: 1:CAS:528:DC%2BD2cXht1Kjurs%3D, PID: 14975669
-
Chaki S, Yoshikawa R, Hirota S, Shimazaki T, Maeda M, Kawashima N, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004;46(4):457–67. DOI: 10.1016/j.neuropharm.2003.10.009
-
(2004)
Neuropharmacology
, vol.46
, Issue.4
, pp. 457-467
-
-
Chaki, S.1
Yoshikawa, R.2
Hirota, S.3
Shimazaki, T.4
Maeda, M.5
Kawashima, N.6
-
81
-
-
84862669286
-
mTOR activation is required for the antidepressant effects of mGluR(2)/(3) blockade
-
COI: 1:CAS:528:DC%2BC38XnvVOgsLs%3D, PID: 22114864
-
Dwyer JM, Lepack AE, Duman RS. mTOR activation is required for the antidepressant effects of mGluR(2)/(3) blockade. Int J Neuropsychopharmacol. 2012;15(4):429–34. DOI: 10.1017/S1461145711001702
-
(2012)
Int J Neuropsychopharmacol
, vol.15
, Issue.4
, pp. 429-434
-
-
Dwyer, J.M.1
Lepack, A.E.2
Duman, R.S.3
-
82
-
-
81555205690
-
Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression
-
COI: 1:CAS:528:DC%2BC3MXhsV2hs7fI, PID: 22091727
-
Campo B, Kalinichev M, Lambeng N, El Yacoubi M, Royer-Urios I, Schneider M, et al. Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011;25(4):152–66. DOI: 10.3109/01677063.2011.627485
-
(2011)
J Neurogenet
, vol.25
, Issue.4
, pp. 152-166
-
-
Campo, B.1
Kalinichev, M.2
Lambeng, N.3
El Yacoubi, M.4
Royer-Urios, I.5
Schneider, M.6
-
83
-
-
84866401521
-
Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
-
COI: 1:CAS:528:DC%2BC38Xht1OjsLfK, PID: 22992331
-
Goeldner C, Ballard TM, Knoflach F, Wichmann J, Gatti S, Umbricht D. Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target. Neuropharmacology. 2013;64:337–46. DOI: 10.1016/j.neuropharm.2012.08.001
-
(2013)
Neuropharmacology
, vol.64
, pp. 337-346
-
-
Goeldner, C.1
Ballard, T.M.2
Knoflach, F.3
Wichmann, J.4
Gatti, S.5
Umbricht, D.6
-
84
-
-
0029863890
-
Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies
-
COI: 1:CAS:528:DyaK28XhvVGnsrg%3D, PID: 8604049
-
Bradley SR, Levey AI, Hersch SM, Conn PJ. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. J Neurosci. 1996;16(6):2044–56.
-
(1996)
J Neurosci
, vol.16
, Issue.6
, pp. 2044-2056
-
-
Bradley, S.R.1
Levey, A.I.2
Hersch, S.M.3
Conn, P.J.4
-
85
-
-
0038391169
-
Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7
-
PID: 12814372
-
Cryan JF, Kelly PH, Neijt HC, Sansig G, Flor PJ, van Der Putten H. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci. 2003;17(11):2409–17. DOI: 10.1046/j.1460-9568.2003.02667.x
-
(2003)
Eur J Neurosci
, vol.17
, Issue.11
, pp. 2409-2417
-
-
Cryan, J.F.1
Kelly, P.H.2
Neijt, H.C.3
Sansig, G.4
Flor, P.J.5
van Der Putten, H.6
-
86
-
-
77955768871
-
Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression
-
PID: 20638442
-
O’Mahony CM, Bravo JA, Dinan TG, Cryan JF. Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression. Neurosci Lett. 2010;482(2):137–41. DOI: 10.1016/j.neulet.2010.07.018
-
(2010)
Neurosci Lett
, vol.482
, Issue.2
, pp. 137-141
-
-
O’Mahony, C.M.1
Bravo, J.A.2
Dinan, T.G.3
Cryan, J.F.4
-
87
-
-
83455229501
-
The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling
-
COI: 1:CAS:528:DC%2BC38XhvFagurk%3D, PID: 22138407
-
Bradley SR, Uslaner JM, Flick RB, Lee A, Groover KM, Hutson PH. The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling. Pharmacol Biochem Behav. 2012;101(1):35–40. DOI: 10.1016/j.pbb.2011.11.006
-
(2012)
Pharmacol Biochem Behav
, vol.101
, Issue.1
, pp. 35-40
-
-
Bradley, S.R.1
Uslaner, J.M.2
Flick, R.B.3
Lee, A.4
Groover, K.M.5
Hutson, P.H.6
-
88
-
-
84897994660
-
Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
-
COI: 1:CAS:528:DC%2BC2cXotFynt7k%3D, PID: 24631968
-
Palucha-Poniewiera A, Szewczyk B, Pilc A. Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats. Neuropharmacology. 2014;82:59–68. DOI: 10.1016/j.neuropharm.2014.03.001
-
(2014)
Neuropharmacology
, vol.82
, pp. 59-68
-
-
Palucha-Poniewiera, A.1
Szewczyk, B.2
Pilc, A.3
-
89
-
-
79959527317
-
The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?
-
PID: 21508084
-
Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, et al. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? J Pharmacol Exp Ther. 2011;338(1):345–52. DOI: 10.1124/jpet.110.177378
-
(2011)
J Pharmacol Exp Ther
, vol.338
, Issue.1
, pp. 345-352
-
-
Sukoff Rizzo, S.J.1
Leonard, S.K.2
Gilbert, A.3
Dollings, P.4
Smith, D.L.5
Zhang, M.Y.6
-
90
-
-
77956257563
-
The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N′-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent
-
COI: 1:CAS:528:DC%2BC3cXhtFyksLrP, PID: 20562216
-
Palucha-Poniewiera A, Branski P, Lenda T, Pilc A. The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N′-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent. J Pharmacol Exp Ther. 2010;334(3):1066–74. DOI: 10.1124/jpet.110.169730
-
(2010)
J Pharmacol Exp Ther
, vol.334
, Issue.3
, pp. 1066-1074
-
-
Palucha-Poniewiera, A.1
Branski, P.2
Lenda, T.3
Pilc, A.4
-
91
-
-
84926658459
-
Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?
-
COI: 1:CAS:528:DC%2BC2cXhvVWntbjI, PID: 25257213
-
Sanacora G, Schatzberg AF. Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology. 2015;40(2):259–67. DOI: 10.1038/npp.2014.261
-
(2015)
Neuropsychopharmacology
, vol.40
, Issue.2
, pp. 259-267
-
-
Sanacora, G.1
Schatzberg, A.F.2
|