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Volumn 6, Issue 3, 2015, Pages 97-114

Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: A perspective review

Author keywords

Antagonist; Bipolar depression; Bipolar disorder; Glutamate; Ketamine; Major depressive disorder; N methyl D aspartate receptor; NR2B; Treatment resistant depression

Indexed keywords

AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

EID: 84930516190     PISSN: 20406223     EISSN: 20406231     Source Type: Journal    
DOI: 10.1177/2040622315579059     Document Type: Review
Times cited : (175)

References (103)
  • 1
    • 71649098114 scopus 로고    scopus 로고
    • Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression
    • aan het Rot M. Collins K. Murrough J. Perez A. Reich D. Charney D. et al. (2010) Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. Biol Psychiatry 67: 139–145.
    • (2010) Biol Psychiatry , vol.67 , pp. 139-145
    • aan het Rot, M.1    Collins, K.2    Murrough, J.3    Perez, A.4    Reich, D.5    Charney, D.6
  • 2
    • 84865777512 scopus 로고    scopus 로고
    • Rapid antidepressant effect of ketamine in the electroconvulsive therapy setting
    • Abdallah C. Fasula M. Kelmendi B. Sanacora G. Ostroff R. (2012) Rapid antidepressant effect of ketamine in the electroconvulsive therapy setting. J ECT 28: 157–161.
    • (2012) J ECT , vol.28 , pp. 157-161
    • Abdallah, C.1    Fasula, M.2    Kelmendi, B.3    Sanacora, G.4    Ostroff, R.5
  • 3
    • 84930685065 scopus 로고    scopus 로고
    • Hippocampal volume and the rapid antidepressant effect of ketamine
    • Epub ahead of print 13 August 2014. doi: 10.1177/0269881114544776
    • Abdallah C. Salas R. Jackowski A. Baldwin P. Sato J. Mathew S. (2014) Hippocampal volume and the rapid antidepressant effect of ketamine. J Psychopharmacol. Epub ahead of print 13 August 2014. doi: 10.1177/0269881114544776.
    • (2014) J Psychopharmacol
    • Abdallah, C.1    Salas, R.2    Jackowski, A.3    Baldwin, P.4    Sato, J.5    Mathew, S.6
  • 4
    • 84856875518 scopus 로고    scopus 로고
    • Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial
    • Anand A. Gunn A. Barkay G. Karne H. Nurnberger J. Mathew S. et al. (2012) Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar Disord 14: 64–70.
    • (2012) Bipolar Disord , vol.14 , pp. 64-70
    • Anand, A.1    Gunn, A.2    Barkay, G.3    Karne, H.4    Nurnberger, J.5    Mathew, S.6
  • 5
    • 84878916836 scopus 로고    scopus 로고
    • Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests
    • Andreasen J. Gynther M. Rygaard A. Bøgelund T. Nielsen S. Clausen R. et al. (2013) Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests. Neurosci Lett 546: 6–10.
    • (2013) Neurosci Lett , vol.546 , pp. 6-10
    • Andreasen, J.1    Gynther, M.2    Rygaard, A.3    Bøgelund, T.4    Nielsen, S.5    Clausen, R.6
  • 6
    • 79960057257 scopus 로고    scopus 로고
    • NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    • Autry A. Adachi M. Nosyreva E. Na E. Los M. Cheng P. et al. (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475: 91–95.
    • (2011) Nature , vol.475 , pp. 91-95
    • Autry, A.1    Adachi, M.2    Nosyreva, E.3    Na, E.4    Los, M.5    Cheng, P.6
  • 7
    • 84912075029 scopus 로고    scopus 로고
    • Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety
    • Ballard E. Ionescu D. Vande Voort J. Niciu M. Richards E. Luckenbaugh D. et al. (2014) Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety. J Psychiatr Res 58: 161–166.
    • (2014) J Psychiatr Res , vol.58 , pp. 161-166
    • Ballard, E.1    Ionescu, D.2    Vande Voort, J.3    Niciu, M.4    Richards, E.5    Luckenbaugh, D.6
  • 9
    • 85028117370 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice
    • Beurel E. Song L. Jope R. (2011) Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice. Mol Psychiatry 16: 1068–1070.
    • (2011) Mol Psychiatry , vol.16 , pp. 1068-1070
    • Beurel, E.1    Song, L.2    Jope, R.3
  • 10
    • 84864288609 scopus 로고    scopus 로고
    • On the safety and benefits of repeated intravenous injections of ketamine for depression
    • Blier P. Zigman D. Blier J. (2012) On the safety and benefits of repeated intravenous injections of ketamine for depression. Biol Psychiatry 72: e11–e12.
    • (2012) Biol Psychiatry , vol.72 , pp. e11-e12
    • Blier, P.1    Zigman, D.2    Blier, J.3
  • 13
    • 84861093240 scopus 로고    scopus 로고
    • 1H-[13C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism
    • Chowdhury G. Behar K. Cho W. Thomas M. Rothman D. Sanacora G. (2012) 1H-[13C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism. Biol Psychiatry 71: 1022–1025.
    • (2012) Biol Psychiatry , vol.71 , pp. 1022-1025
    • Chowdhury, G.1    Behar, K.2    Cho, W.3    Thomas, M.4    Rothman, D.5    Sanacora, G.6
  • 14
    • 84864807084 scopus 로고    scopus 로고
    • Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression
    • Cusin C. Hilton G. Nierenberg A. Fava M. (2012) Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression. Am J Psychiatry 169: 868–869.
    • (2012) Am J Psychiatry , vol.169 , pp. 868-869
    • Cusin, C.1    Hilton, G.2    Nierenberg, A.3    Fava, M.4
  • 15
    • 84903543431 scopus 로고    scopus 로고
    • Oral ketamine augmentation for chronic suicidality in treatment-resistant depression
    • de Gioannis A. de Leo D. (2014) Oral ketamine augmentation for chronic suicidality in treatment-resistant depression. Aust N Z J Psychiatry 48: 686.
    • (2014) Aust N Z J Psychiatry , vol.48 , pp. 686
    • de Gioannis, A.1    de Leo, D.2
  • 16
    • 84898003445 scopus 로고    scopus 로고
    • Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic
    • Diamond P. Farmery A. Atkinson S. Haldar J. Williams N. Cowen P. et al. (2014) Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic. J Psychopharmacol 28: 536–544.
    • (2014) J Psychopharmacol , vol.28 , pp. 536-544
    • Diamond, P.1    Farmery, A.2    Atkinson, S.3    Haldar, J.4    Williams, N.5    Cowen, P.6
  • 17
    • 78650371169 scopus 로고    scopus 로고
    • Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder
    • DiazGranados N. Ibrahim L. Brutsche N. Ameli R. Henter I. Luckenbaugh D. et al. (2010 a) Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J Clin Psychiatry 71: 1605–1611.
    • (2010) J Clin Psychiatry , vol.71 , pp. 1605-1611
    • DiazGranados, N.1    Ibrahim, L.2    Brutsche, N.3    Ameli, R.4    Henter, I.5    Luckenbaugh, D.6
  • 18
    • 77955891255 scopus 로고    scopus 로고
    • A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression
    • DiazGranados N. Ibrahim L. Brutsche N. Newberg A. Kronstein P. Khalife S. et al. (2010 b) A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry 67: 793–802.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 793-802
    • DiazGranados, N.1    Ibrahim, L.2    Brutsche, N.3    Newberg, A.4    Kronstein, P.5    Khalife, S.6
  • 19
    • 77957008254 scopus 로고    scopus 로고
    • Taming the ketamine tiger
    • Domino E. (2010) Taming the ketamine tiger. 1965. Anesthesiology 113: 678–684
    • (2010) Anesthesiology , vol.113 , pp. 678-684
    • Domino, E.1
  • 20
    • 84867227874 scopus 로고    scopus 로고
    • Synaptic dysfunction in depression: potential therapeutic targets
    • Duman R. Aghajanian G. (2012) Synaptic dysfunction in depression: potential therapeutic targets. Science 338: 68–72.
    • (2012) Science , vol.338 , pp. 68-72
    • Duman, R.1    Aghajanian, G.2
  • 21
    • 80054101849 scopus 로고    scopus 로고
    • Signaling pathways underlying the rapid antidepressant actions of ketamine
    • Duman R. Li N. Liu R. Duric V. Aghajanian G. (2012) Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology 62: 35–41.
    • (2012) Neuropharmacology , vol.62 , pp. 35-41
    • Duman, R.1    Li, N.2    Liu, R.3    Duric, V.4    Aghajanian, G.5
  • 22
    • 77950377037 scopus 로고    scopus 로고
    • NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test
    • Ghasemi M. Raza M. Dehpour A. (2010) NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. J Psychopharmacology 24: 585–594.
    • (2010) J Psychopharmacology , vol.24 , pp. 585-594
    • Ghasemi, M.1    Raza, M.2    Dehpour, A.3
  • 23
    • 84902184667 scopus 로고    scopus 로고
    • Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
    • Gideons E. Kavalali E. Monteggia L. (2014) Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses. Proc Natl Acad Sci USA 111: 8649–8654.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 8649-8654
    • Gideons, E.1    Kavalali, E.2    Monteggia, L.3
  • 24
    • 79960757856 scopus 로고    scopus 로고
    • Dose- and exposure-response to ketamine in depression
    • author reply e11–e12.
    • Glue P. Gulati A. Le Nedelec M. Duffull S. (2011) Dose- and exposure-response to ketamine in depression. Biol Psychiatry 70: e9–e10; author reply e11–e12.
    • (2011) Biol Psychiatry , vol.70 , pp. e9-e10
    • Glue, P.1    Gulati, A.2    Le Nedelec, M.3    Duffull, S.4
  • 25
    • 84891817325 scopus 로고    scopus 로고
    • Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression
    • Haile C. Murrough J. Iosifescu D. Chang L. Al Jurdi R. Foulkes A. et al. (2014) Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression. Int J Neuropsychopharmacol 17: 331–336.
    • (2014) Int J Neuropsychopharmacol , vol.17 , pp. 331-336
    • Haile, C.1    Murrough, J.2    Iosifescu, D.3    Chang, L.4    Al Jurdi, R.5    Foulkes, A.6
  • 26
    • 84887404798 scopus 로고    scopus 로고
    • SHANK 3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
    • Han K. Holder J. Schaaf C. Lu H. Chen H. Kang H. et al. (2013) SHANK 3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature 503: 72–77.
    • (2013) Nature , vol.503 , pp. 72-77
    • Han, K.1    Holder, J.2    Schaaf, C.3    Lu, H.4    Chen, H.5    Kang, H.6
  • 27
    • 84878459001 scopus 로고    scopus 로고
    • Intramuscular ketamine in acute depression: a report on two cases
    • Harihar C. Dasari P. Srinivas J. (2013) Intramuscular ketamine in acute depression: a report on two cases. Indian J Psychiatry 55: 186–188.
    • (2013) Indian J Psychiatry , vol.55 , pp. 186-188
    • Harihar, C.1    Dasari, P.2    Srinivas, J.3
  • 28
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N. Sonenberg N. (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926–1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 30
    • 33744549976 scopus 로고    scopus 로고
    • Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder
    • Heresco-Levy U. Javitt D. Gelfin Y. Gorelik E. Bar M. Blanaru M. et al. (2006) Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder. J Affect Disord 93: 239–243.
    • (2006) J Affect Disord , vol.93 , pp. 239-243
    • Heresco-Levy, U.1    Javitt, D.2    Gelfin, Y.3    Gorelik, E.4    Bar, M.5    Blanaru, M.6
  • 31
    • 75749114797 scopus 로고    scopus 로고
    • mTOR signaling: at the crossroads of plasticity, memory and disease
    • Hoeffer C. Klann E. (2010) mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci 33: 67–75.
    • (2010) Trends Neurosci , vol.33 , pp. 67-75
    • Hoeffer, C.1    Klann, E.2
  • 32
    • 84859777474 scopus 로고    scopus 로고
    • Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study
    • Ibrahim L. Diazgranados N. Franco-Chaves J. Brutsche N. Henter I. Kronstein P. et al. (2012 a) Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology 37: 1526–1533.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1526-1533
    • Ibrahim, L.1    Diazgranados, N.2    Franco-Chaves, J.3    Brutsche, N.4    Henter, I.5    Kronstein, P.6
  • 33
    • 84863719297 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder
    • Ibrahim L. DiazGranados N. Jolkovsky L. Brutsche N. Luckenbaugh D. Herring W. et al. (2012 b) A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder. J Clin Psychopharmacol 32: 551–557.
    • (2012) J Clin Psychopharmacol , vol.32 , pp. 551-557
    • Ibrahim, L.1    DiazGranados, N.2    Jolkovsky, L.3    Brutsche, N.4    Luckenbaugh, D.5    Herring, W.6
  • 34
    • 84867475329 scopus 로고    scopus 로고
    • Next-generation treatments for mental disorders
    • Insel T. (2012) Next-generation treatments for mental disorders. Sci Trans Med 4: 155–164.
    • (2012) Sci Trans Med , vol.4 , pp. 155-164
    • Insel, T.1
  • 35
    • 84922041650 scopus 로고    scopus 로고
    • Effect of baseline anxious depression on initial and sustained antidepressant response to ketamine
    • Ionescu D. Luckenbaugh D. Niciu M. Richards E. Slonena E. Vande Voort J. et al. (2014) Effect of baseline anxious depression on initial and sustained antidepressant response to ketamine. J Clin Psychiatry 75: e932–e938.
    • (2014) J Clin Psychiatry , vol.75 , pp. e932-e938
    • Ionescu, D.1    Luckenbaugh, D.2    Niciu, M.3    Richards, E.4    Slonena, E.5    Vande Voort, J.6
  • 36
    • 77954950428 scopus 로고    scopus 로고
    • Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care
    • Irwin S. Iglewicz A. (2010) Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care. J Palliat Med 13: 903–908.
    • (2010) J Palliat Med , vol.13 , pp. 903-908
    • Irwin, S.1    Iglewicz, A.2
  • 37
    • 84880852239 scopus 로고    scopus 로고
    • Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial
    • Irwin S. Iglewicz A. Nelesen R. Lo J. Carr C. Romero S. et al. (2013) Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial. J Palliat Med 16: 958–965.
    • (2013) J Palliat Med , vol.16 , pp. 958-965
    • Irwin, S.1    Iglewicz, A.2    Nelesen, R.3    Lo, J.4    Carr, C.5    Romero, S.6
  • 38
    • 84883555889 scopus 로고    scopus 로고
    • Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study
    • Järventausta K. Chrapek W. Kampman O. Tuohimaa K. Björkqvist M. Häkkinen H. et al. (2013) Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study. J ECT 29: 158–161.
    • (2013) J ECT , vol.29 , pp. 158-161
    • Järventausta, K.1    Chrapek, W.2    Kampman, O.3    Tuohimaa, K.4    Björkqvist, M.5    Häkkinen, H.6
  • 39
    • 84902687924 scopus 로고    scopus 로고
    • Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY 341495 during the forced swim test in rats
    • Koike H. Chaki S. (2014) Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY 341495 during the forced swim test in rats. Behav Brain Res 271: 111–115.
    • (2014) Behav Brain Res , vol.271 , pp. 111-115
    • Koike, H.1    Chaki, S.2
  • 41
    • 84868208976 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients
    • Laje G. Lally N. Mathews D. Brutsche N. Chemerinski A. Akula N. et al. (2012) Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients. Biol Psychiatry 72: e27–e28.
    • (2012) Biol Psychiatry , vol.72 , pp. e27-e28
    • Laje, G.1    Lally, N.2    Mathews, D.3    Brutsche, N.4    Chemerinski, A.5    Akula, N.6
  • 42
    • 85006269731 scopus 로고    scopus 로고
    • Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
    • Lally N. Nugent A. Luckenbaugh D. Ameli R. Roiser J. Zarate C. Jr (2014) Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression. Transl Psychiatry 4: e469.
    • (2014) Transl Psychiatry , vol.4 , pp. e469
    • Lally, N.1    Nugent, A.2    Luckenbaugh, D.3    Ameli, R.4    Roiser, J.5    Zarate, C.6
  • 43
  • 44
    • 84883324216 scopus 로고    scopus 로고
    • Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression
    • Lara D. Bisol L. Munari L. (2013) Antidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression. Int J Neuropsychopharmacol 16: 2111–2117.
    • (2013) Int J Neuropsychopharmacol , vol.16 , pp. 2111-2117
    • Lara, D.1    Bisol, L.2    Munari, L.3
  • 45
    • 80053025475 scopus 로고    scopus 로고
    • A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department
    • Larkin G. Beautrais A. (2011) A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department. Int J Neuropsychopharmacol 14: 1127–1131.
    • (2011) Int J Neuropsychopharmacol , vol.14 , pp. 1127-1131
    • Larkin, G.1    Beautrais, A.2
  • 46
    • 77955909841 scopus 로고    scopus 로고
    • mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    • Li N. Lee B. Liu R. Banasr M. Dwyer J. Iwata M. et al. (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329: 959–964.
    • (2010) Science , vol.329 , pp. 959-964
    • Li, N.1    Lee, B.2    Liu, R.3    Banasr, M.4    Dwyer, J.5    Iwata, M.6
  • 47
    • 79953166373 scopus 로고    scopus 로고
    • Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    • Li N. Liu R. Dwyer J. Banasr M. Lee B. Son H. et al. (2011) Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69: 754–761.
    • (2011) Biol Psychiatry , vol.69 , pp. 754-761
    • Li, N.1    Liu, R.2    Dwyer, J.3    Banasr, M.4    Lee, B.5    Son, H.6
  • 49
    • 84884288609 scopus 로고    scopus 로고
    • GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine
    • Liu R. Fuchikami M. Dwyer J. Lepack A. Duman R. Aghajanian G. (2013) GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology 38: 2268–2277.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2268-2277
    • Liu, R.1    Fuchikami, M.2    Dwyer, J.3    Lepack, A.4    Duman, R.5    Aghajanian, G.6
  • 51
    • 84904811380 scopus 로고    scopus 로고
    • Baseline vitamin B 12 and folate levels do not predict improvement in depression after a single infusion of ketamine
    • Lundin N. Niciu M. Luckenbaugh D. Ionescu D. Richards E. Vande Voort J. et al. (2014) Baseline vitamin B 12 and folate levels do not predict improvement in depression after a single infusion of ketamine. Pharmacopsychiatry 47: 141–144.
    • (2014) Pharmacopsychiatry , vol.47 , pp. 141-144
    • Lundin, N.1    Niciu, M.2    Luckenbaugh, D.3    Ionescu, D.4    Richards, E.5    Vande Voort, J.6
  • 52
    • 74549122218 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist
    • Machado-Vieira R. Yuan P. Brutsche N. DiazGranados N. Luckenbaugh D. Manji H. et al. (2009) Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist. J Clin Psychiatry 70: 1662–1666.
    • (2009) J Clin Psychiatry , vol.70 , pp. 1662-1666
    • Machado-Vieira, R.1    Yuan, P.2    Brutsche, N.3    DiazGranados, N.4    Luckenbaugh, D.5    Manji, H.6
  • 53
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • Maeng S. Zarate C. Jr Du J. Schloesser R. McCammon J. Chen G. et al. (2008) Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry 63: 349–352.
    • (2008) Biol Psychiatry , vol.63 , pp. 349-352
    • Maeng, S.1    Zarate, C.2    Du, J.3    Schloesser, R.4    McCammon, J.5    Chen, G.6
  • 55
    • 77949625234 scopus 로고    scopus 로고
    • Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
    • Mathew S. Murrough J. aan het Rot M. Collins K. Reich D. Charney D. (2010) Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial. Int J Neuropsychopharmacol 13: 71–82.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 71-82
    • Mathew, S.1    Murrough, J.2    aan het Rot, M.3    Collins, K.4    Reich, D.5    Charney, D.6
  • 56
    • 84856818407 scopus 로고    scopus 로고
    • Ketamine for treatment-resistant unipolar depression: current evidence
    • Mathew S. Shah A. Lapidus K. Clark C. Jarun N. Ostermeyer B. et al. (2012) Ketamine for treatment-resistant unipolar depression: current evidence. CNS Drugs 26: 189–204.
    • (2012) CNS Drugs , vol.26 , pp. 189-204
    • Mathew, S.1    Shah, A.2    Lapidus, K.3    Clark, C.4    Jarun, N.5    Ostermeyer, B.6
  • 57
    • 0033366383 scopus 로고    scopus 로고
    • Miniature synaptic events maintain dendritic spines via AMPA receptor activation
    • McKinney R. Capogna M. Dürr R. Gähwiler B. Thompson S. (1999) Miniature synaptic events maintain dendritic spines via AMPA receptor activation. Nat Neurosci 2: 44–49.
    • (1999) Nat Neurosci , vol.2 , pp. 44-49
    • McKinney, R.1    Capogna, M.2    Dürr, R.3    Gähwiler, B.4    Thompson, S.5
  • 58
    • 0032934209 scopus 로고    scopus 로고
    • Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block
    • Mealing G. Lanthorn T. Murray C. Small D. Morley P. (1999) Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block. J Pharmacol Exp Ther 288: 204–210.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 204-210
    • Mealing, G.1    Lanthorn, T.2    Murray, C.3    Small, D.4    Morley, P.5
  • 59
    • 84926454370 scopus 로고    scopus 로고
    • D-serine plasma concentration is a potential biomarker of (R, S)-ketamine antidepressant response in subjects with treatment-resistant depression
    • Moaddel R. Luckenbaugh D. Xie Y. Villaseñor A. Brutsche N. Machado-Vieira R. et al. (2014) D-serine plasma concentration is a potential biomarker of (R, S)-ketamine antidepressant response in subjects with treatment-resistant depression. Psychopharmacology (Berl) 232: 399–409.
    • (2014) Psychopharmacology (Berl) , vol.232 , pp. 399-409
    • Moaddel, R.1    Luckenbaugh, D.2    Xie, Y.3    Villaseñor, A.4    Brutsche, N.5    Machado-Vieira, R.6
  • 60
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B. Adams B. Verma A. Daly D. (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17: 2921–2927.
    • (1997) J Neurosci , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 61
    • 84869499270 scopus 로고    scopus 로고
    • Neurocognitive function and schizophrenia-proneness in individuals dependent on ketamine, on high potency cannabis (‘skunk’) or on cocaine
    • Morgan C. Duffin S. Hunt S. Monaghan L. Mason O. Curran H. (2012) Neurocognitive function and schizophrenia-proneness in individuals dependent on ketamine, on high potency cannabis (‘skunk’) or on cocaine. Pharmacopsychiatry 45: 269–274.
    • (2012) Pharmacopsychiatry , vol.45 , pp. 269-274
    • Morgan, C.1    Duffin, S.2    Hunt, S.3    Monaghan, L.4    Mason, O.5    Curran, H.6
  • 62
    • 57649115522 scopus 로고    scopus 로고
    • Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls
    • Morgan C. Muetzelfeldt L. Curran H. (2009) Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls. Addiction 104: 77–87.
    • (2009) Addiction , vol.104 , pp. 77-87
    • Morgan, C.1    Muetzelfeldt, L.2    Curran, H.3
  • 63
    • 72249099672 scopus 로고    scopus 로고
    • Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study
    • Morgan C. Muetzelfeldt L. Curran H. (2010) Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: a 1-year longitudinal study. Addiction 105: 121–133.
    • (2010) Addiction , vol.105 , pp. 121-133
    • Morgan, C.1    Muetzelfeldt, L.2    Curran, H.3
  • 64
    • 48749093469 scopus 로고    scopus 로고
    • Attentional bias to incentive stimuli in frequent ketamine users
    • Morgan C. Rees H. Curran H. (2008) Attentional bias to incentive stimuli in frequent ketamine users. Psychol Med 38: 1331–1340.
    • (2008) Psychol Med , vol.38 , pp. 1331-1340
    • Morgan, C.1    Rees, H.2    Curran, H.3
  • 65
    • 84873348026 scopus 로고    scopus 로고
    • 2012 FDA drug approvals
    • Mullard A. (2013) 2012 FDA drug approvals. Nat Rev Drug Discov 12: 87–90.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 87-90
    • Mullard, A.1
  • 67
    • 84885214350 scopus 로고    scopus 로고
    • Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
    • Murrough J. Iosifescu D. Chang L. Al Jurdi R. Green C. Perez A. et al. (2013 a) Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry 170: 1134–1142.
    • (2013) Am J Psychiatry , vol.170 , pp. 1134-1142
    • Murrough, J.1    Iosifescu, D.2    Chang, L.3    Al Jurdi, R.4    Green, C.5    Perez, A.6
  • 68
    • 84880767967 scopus 로고    scopus 로고
    • Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
    • Murrough J. Perez A. Pillemer S. Stern J. Parides M. aah het Rot M. et al. (2013 b) Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry 74: 250-256.
    • (2013) Biol Psychiatry , vol.74 , pp. 250-256
    • Murrough, J.1    Perez, A.2    Pillemer, S.3    Stern, J.4    Parides, M.5    aah het Rot, M.6
  • 69
    • 84879407498 scopus 로고    scopus 로고
    • Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder
    • Niciu M. Grunschel B. Corlett P. Pittenger C. Bloch M. (2013 a) Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder. J Psychopharmacol 27: 651–654.
    • (2013) J Psychopharmacol , vol.27 , pp. 651-654
    • Niciu, M.1    Grunschel, B.2    Corlett, P.3    Pittenger, C.4    Bloch, M.5
  • 70
    • 84891851738 scopus 로고    scopus 로고
    • Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds
    • Niciu M. Henter I. Luckenbaugh D. Zarate Jr, C. Charney D. (2014 a) Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds. Annu Rev Pharmacol Toxicol 54: 119–139.
    • (2014) Annu Rev Pharmacol Toxicol , vol.54 , pp. 119-139
    • Niciu, M.1    Henter, I.2    Luckenbaugh, D.3    Zarate, C.4    Charney, D.5
  • 71
    • 84884666321 scopus 로고    scopus 로고
    • Second messenger / signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part I: major depressive disorder
    • Niciu M. Ionescu D. Mathews D. Richards E. (2013 b) Second messenger / signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part I: major depressive disorder. CNS Spectr 18: 231–241.
    • (2013) CNS Spectr , vol.18 , pp. 231-241
    • Niciu, M.1    Ionescu, D.2    Mathews, D.3    Richards, E.4
  • 72
    • 84855549573 scopus 로고    scopus 로고
    • Overview of glutamatergic neurotransmission in the nervous system
    • Niciu M. Kelmendi B. Sanacora G. (2012) Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behav 100: 656–664.
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 656-664
    • Niciu, M.1    Kelmendi, B.2    Sanacora, G.3
  • 74
    • 84886696509 scopus 로고    scopus 로고
    • Subanesthetic dose ketamine does not induce an affective switch in three independent samples of treatment-resistant major depression
    • Niciu M. Luckenbaugh D. Ionescu D. Mathews D. Richards E. Zarate C. Jr (2013 c) Subanesthetic dose ketamine does not induce an affective switch in three independent samples of treatment-resistant major depression. Biol Psychiatry 74: e23–e24.
    • (2013) Biol Psychiatry , vol.74 , pp. e23-e24
    • Niciu, M.1    Luckenbaugh, D.2    Ionescu, D.3    Mathews, D.4    Richards, E.5    Zarate, C.6
  • 75
    • 84898826938 scopus 로고    scopus 로고
    • Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants
    • Niciu M. Mathews D. Nugent A. Ionescu D. Furey M. Richards E. et al. (2014 c) Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants. Depress Anxiety 31: 297–307.
    • (2014) Depress Anxiety , vol.31 , pp. 297-307
    • Niciu, M.1    Mathews, D.2    Nugent, A.3    Ionescu, D.4    Furey, M.5    Richards, E.6
  • 77
    • 84908425862 scopus 로고    scopus 로고
    • SHANK 3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression
    • Ortiz R. Niciu M. Lukkahati N. Saligan L. Nugent A. Luckenbaugh D. et al. (2014) SHANK 3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression. J Affect Disord 172C: 307–311.
    • (2014) J Affect Disord , vol.172C , pp. 307-311
    • Ortiz, R.1    Niciu, M.2    Lukkahati, N.3    Saligan, L.4    Nugent, A.5    Luckenbaugh, D.6
  • 78
    • 76349084738 scopus 로고    scopus 로고
    • Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series
    • Paslakis G. Gilles M. Meyer-Lindenberg A. Deuschle M. (2010) Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series. Pharmacopsychiatry 43: 33–35.
    • (2010) Pharmacopsychiatry , vol.43 , pp. 33-35
    • Paslakis, G.1    Gilles, M.2    Meyer-Lindenberg, A.3    Deuschle, M.4
  • 82
    • 58049211903 scopus 로고    scopus 로고
    • Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonists
    • Phelps L. Brutsche N. Moral J. Luckenbaugh D. Manji H. Zarate C. Jr (2009) Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonists. Biol Psychiatry 65: 181–184.
    • (2009) Biol Psychiatry , vol.65 , pp. 181-184
    • Phelps, L.1    Brutsche, N.2    Moral, J.3    Luckenbaugh, D.4    Manji, H.5    Zarate, C.6
  • 83
    • 59049098262 scopus 로고    scopus 로고
    • An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder
    • Preskorn S. Baker B. Kolluri S. Menniti F. Krams M. Landen J. (2008) An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol 28: 631–637.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 631-637
    • Preskorn, S.1    Baker, B.2    Kolluri, S.3    Menniti, F.4    Krams, M.5    Landen, J.6
  • 84
    • 84899072984 scopus 로고    scopus 로고
    • Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression
    • Price R. Iosifescu D. Murrough J. Chang L. Al Jurdi R. Iqbal S. et al. (2014) Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression. Depress Anxiety 31: 335–343.
    • (2014) Depress Anxiety , vol.31 , pp. 335-343
    • Price, R.1    Iosifescu, D.2    Murrough, J.3    Chang, L.4    Al Jurdi, R.5    Iqbal, S.6
  • 85
    • 68049121850 scopus 로고    scopus 로고
    • Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression
    • Price R. Nock M. Charney D. Mathew S. (2009) Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol Psychiatry 66: 522–526.
    • (2009) Biol Psychiatry , vol.66 , pp. 522-526
    • Price, R.1    Nock, M.2    Charney, D.3    Mathew, S.4
  • 86
    • 79955482647 scopus 로고    scopus 로고
    • Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model
    • Quan M. Zhang N. Wang Y. Zhang T. Yang Z. (2011) Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model. Neuroscience 182: 88–97.
    • (2011) Neuroscience , vol.182 , pp. 88-97
    • Quan, M.1    Zhang, N.2    Wang, Y.3    Zhang, T.4    Yang, Z.5
  • 88
    • 77049122009 scopus 로고    scopus 로고
    • Neurochemical and behavioural effects of acute and chronic memantine administration in rats: further support for NMDA as a new pharmacological target for the treatment of depression?
    • Réus G. Stringari R. Kirsch T. Fries G. Kapczinski F. Roesler R. et al. (2010) Neurochemical and behavioural effects of acute and chronic memantine administration in rats: further support for NMDA as a new pharmacological target for the treatment of depression? Brain Res Bull 81: 585–589.
    • (2010) Brain Res Bull , vol.81 , pp. 585-589
    • Réus, G.1    Stringari, R.2    Kirsch, T.3    Fries, G.4    Kapczinski, F.5    Roesler, R.6
  • 90
    • 84993814559 scopus 로고    scopus 로고
    • Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: primary results from a randomized, placebo-controlled study (PURSUIT)
    • Poster presented on 18 June at the 2014 American Society of Clinical Psychopharmacology Annual Meeting Hollywood, FL
    • Sanacora G. Johnson M. Khan A. Atkinson S. Risenberg R. Schronen J. et al. (2014 a) Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: primary results from a randomized, placebo-controlled study (PURSUIT). Poster presented on 18 June at the 2014 American Society of Clinical Psychopharmacology Annual Meeting in Hollywood, FL.
    • (2014)
    • Sanacora, G.1    Johnson, M.2    Khan, A.3    Atkinson, S.4    Risenberg, R.5    Schronen, J.6
  • 91
    • 84908572031 scopus 로고    scopus 로고
    • Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
    • Sanacora G. Smith M. Pathak S. Su H. Boeijinga P. McCarthy D. et al. (2014 b) Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol Psychiatry 19: 978–985.
    • (2014) Mol Psychiatry , vol.19 , pp. 978-985
    • Sanacora, G.1    Smith, M.2    Pathak, S.3    Su, H.4    Boeijinga, P.5    McCarthy, D.6
  • 92
    • 42949123365 scopus 로고    scopus 로고
    • Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    • Sanacora G. Zarate C. Jr Krystal J. Manji H. (2008) Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov 7: 426–437.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 426-437
    • Sanacora, G.1    Zarate, C.2    Krystal, J.3    Manji, H.4
  • 93
    • 84880555463 scopus 로고    scopus 로고
    • Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression
    • Sos P. Klirova M. Novak T. Kohutova B. Horacek J. Palenicek T. (2013) Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression. Neuro Endocrinol Lett 34: 287–293.
    • (2013) Neuro Endocrinol Lett , vol.34 , pp. 287-293
    • Sos, P.1    Klirova, M.2    Novak, T.3    Kohutova, B.4    Horacek, J.5    Palenicek, T.6
  • 94
    • 0025157918 scopus 로고
    • Functional antagonists at the NMDA receptor complex exhibit antidepressant actions
    • Trullas R. Skolnick P. (1990) Functional antagonists at the NMDA receptor complex exhibit antidepressant actions. Eur J Pharmacol 185: 1–10.
    • (1990) Eur J Pharmacol , vol.185 , pp. 1-10
    • Trullas, R.1    Skolnick, P.2
  • 95
    • 78751701060 scopus 로고    scopus 로고
    • The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [ (1) H]-MRS
    • Valentine G. Mason G. Gomez R. Fasula M. Watzl J. Pittman B. et al. (2011) The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [ (1)H]-MRS. Psychiatry Res 191: 122–127.
    • (2011) Psychiatry Res , vol.191 , pp. 122-127
    • Valentine, G.1    Mason, G.2    Gomez, R.3    Fasula, M.4    Watzl, J.5    Pittman, B.6
  • 96
    • 84897409537 scopus 로고    scopus 로고
    • A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks
    • Villaseñor A. Ramamoorthy A. Silva dos Santos M. Lorenzo M. Laje G. Zarate C. Jr et al. (2014) A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks. Br J Pharmacol 171: 2230–2242.
    • (2014) Br J Pharmacol , vol.171 , pp. 2230-2242
    • Villaseñor, A.1    Ramamoorthy, A.2    Silva dos Santos, M.3    Lorenzo, M.4    Laje, G.5    Zarate, C.6
  • 97
    • 84930510385 scopus 로고    scopus 로고
    • Ketamine safety and tolerability in clinical trials for treatment-resistant depression
    • September (epub ahead of print).
    • Wan L. Levitch C. Perez A. Brallier J. Iosifescu D. Chang L. et al. (2014) Ketamine safety and tolerability in clinical trials for treatment-resistant depression. J Clin Psychiatry 2 September (epub ahead of print).
    • (2014) J Clin Psychiatry
    • Wan, L.1    Levitch, C.2    Perez, A.3    Brallier, J.4    Iosifescu, D.5    Chang, L.6
  • 98
    • 0018898475 scopus 로고
    • Pharmacology of ketamine isomers in surgical patients
    • White P. Ham J. Way W. Trevor A. (1980) Pharmacology of ketamine isomers in surgical patients. Anesthesiology 52: 231–239.
    • (1980) Anesthesiology , vol.52 , pp. 231-239
    • White, P.1    Ham, J.2    Way, W.3    Trevor, A.4
  • 99
    • 84861099072 scopus 로고    scopus 로고
    • Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial
    • Zarate C. Jr Brutsche N. Ibrahim L. Franco-Chaves J. Diazgranados N. Cravchik A. et al. (2012) Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol Psychiatry 71: 939–946.
    • (2012) Biol Psychiatry , vol.71 , pp. 939-946
    • Zarate, C.1    Brutsche, N.2    Ibrahim, L.3    Franco-Chaves, J.4    Diazgranados, N.5    Cravchik, A.6
  • 100
    • 84880829258 scopus 로고    scopus 로고
    • A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression
    • Zarate C. Jr Mathews D. Ibrahim L. Chaves J. Marquardt C. Ukoh I. et al. (2013) A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression. Biol Psychiatry 74: 257–264.
    • (2013) Biol Psychiatry , vol.74 , pp. 257-264
    • Zarate, C.1    Mathews, D.2    Ibrahim, L.3    Chaves, J.4    Marquardt, C.5    Ukoh, I.6
  • 101
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    • Zarate C. Jr Singh J. Carlson P. Brutsche N. Ameli R. Luckenbaugh D. et al. (2006 a) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63: 856–864.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 856-864
    • Zarate, C.1    Singh, J.2    Carlson, P.3    Brutsche, N.4    Ameli, R.5    Luckenbaugh, D.6
  • 102
    • 30044450251 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of memantine in the treatment of major depression
    • Zarate C. Jr Singh J. Quiroz J. de Jesus G. Denicoff K. Luckenbaugh D. et al. (2006 b) A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry 163: 153–155.
    • (2006) Am J Psychiatry , vol.163 , pp. 153-155
    • Zarate, C.1    Singh, J.2    Quiroz, J.3    de Jesus, G.4    Denicoff, K.5    Luckenbaugh, D.6
  • 103
    • 84893686765 scopus 로고    scopus 로고
    • Akt mediates GSK-3β phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions
    • Zhou W. Dong L. Wang N. Shi J. Yang J. Zuo Z. et al. (2014) Akt mediates GSK-3β phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions. Neuroimmunomodulation 21: 183–188.
    • (2014) Neuroimmunomodulation , vol.21 , pp. 183-188
    • Zhou, W.1    Dong, L.2    Wang, N.3    Shi, J.4    Yang, J.5    Zuo, Z.6


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