The DRD2/ANKK1 gene is associated with response to add-on dextromethorphan treatment in bipolar disorder

Journal of Affective Disorders

Volumn 138, Issue 3, 2012, Pages 295-300

  Lee, Sheng Yu ^a,b   Chen, Shiou Lan ^a,b   Chang, Yun Hsuan ^a   Chen, Shih Heng ^a,b   Chu, Chun Hsieh ^a,b   Huang, San Yuan ^c   Tzeng, Nian Sheng ^c   Wang, Chen Lin ^b   Lee, I Hui ^a   Yeh, Tzung Lieh ^a   Yang, Yen Kuang ^a   Lu, Ru Band ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Bipolar disorder; Dextromethorphan; DRD2; Polymorphism; Treatment

Indexed keywords

ANKYRIN; CHOLINERGIC RECEPTOR BLOCKING AGENT; DEXTROMETHORPHAN; DOPAMINE 2 RECEPTOR; FLUOXETINE; LORAZEPAM; PLACEBO; PROTEIN ANKK1; RISPERIDONE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADD ON THERAPY; ADULT; AGED; ARTICLE; BIPOLAR DISORDER; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; DNA POLYMORPHISM; DOUBLE BLIND PROCEDURE; EXTRAPYRAMIDAL SYNDROME; GENETIC ASSOCIATION; GENOTYPE; HAMILTON SCALE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MANIA; MONOTHERAPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TREATMENT RESPONSE; YOUNG MANIA RATING SCALE;

ADULT; ANTIMANIC AGENTS; BIPOLAR DISORDER; DEXTROMETHORPHAN; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; HUMANS; MALE; NEUROPROTECTIVE AGENTS; POLYMORPHISM, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DOPAMINE D2; RECEPTORS, N-METHYL-D-ASPARTATE; VALPROIC ACID; YOUNG ADULT;

EID: 84862808862     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.01.024     Document Type: Article

References (62)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorder-IV-TR 2000 American Psychiatric Association Washington
2. J.L. Beyer, and K.R. Krishnan Volumetric brain imaging findings in mood disorders Bipolar Disorders 4 2002 89 104 (Pubitemid 34411272)
3. E. Brugue, and E. Vieta Atypical antipsychotics in bipolar depression: neurobiological basis and clinical implications Progress in Neuro- Psychopharmacology & Biological Psychiatry 31 2007 275 282 (Pubitemid 44959242)
4. A. Buchner, F. Faul, and E. Erdfelder G-power: A Priori, Post Hoc, and Compromise Power Analyses for the Macintosh, Version 2.1.1 1996 University of Trier Trier, Germany
5. W.J. Burke, S.W. Li, E.A. Williams, R. Nonneman, and D.S. Zahm 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis Brain Research 989 2003 205 213 (Pubitemid 37211424)
6. J.J. Chen Pharmacologic safety concerns in Parkinson's disease: facts and insights The International Journal of Neuroscience 121 2011 45 52
7. P.S. Chen, G.S. Peng, G. Li, S. Yang, X. Wu, C.C. Wang, B. Wilson, R.B. Lu, P.W. Gean, D.M. Chuang, and J.S. Hong Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes Molecular Psychiatry 11 2006 1116 1125 (Pubitemid 44867481)
8. W.C. Drevets Neuroimaging studies of mood disorders Biological Psychiatry 48 2000 813 829
9. W.C. Drevets, J.L. Price, J.R. Simpson Jr.; R.D. Todd, T. Reich, M. Vannier, and M.E. Raichle Subgenual prefrontal cortex abnormalities in mood disorders Nature 386 1997 824 827 (Pubitemid 27181254)
10. B.W. Dunlop, and C.B. Nemeroff The role of dopamine in the pathophysiology of depression Archives of General Psychiatry 64 2007 327 337 (Pubitemid 46376789)
11. J. Endicott, and R.L. Spitzer A diagnostic interview: the schedule for affective disorders and schizophrenia Archives of General Psychiatry 35 1978 837 844 (Pubitemid 9076798)
12. F. Faul, E. Erdfelder, A. Buchner, and A.G. Lang Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses Behavior Research Methods 41 2009 1149 1160
13. M.A. Frye, J.R. Calabrese, M.L. Reed, K.D. Wagner, L. Lewis, J. McNulty, and R.M. Hirschfeld Use of health care services among persons who screen positive for bipolar disorder Psychiatric Services 56 2005 1529 1533 (Pubitemid 41790112)
14. R.A. Furlong, T.A. Coleman, L. Ho, J.S. Rubinsztein, C. Walsh, E.S. Paykel, and D.C. Rubinsztein No association of a functional polymorphism in the dopamine D2 receptor promoter region with bipolar or unipolar affective disorders American Journal of Medical Genetics 81 1998 385 387 (Pubitemid 28413466)
15. P.L. Gendreau, J.M. Petitto, J.L. Gariepy, and M.H. Lewis D2-like dopamine receptor mediation of social-emotional reactivity in a mouse model of anxiety: strain and experience effects Neuropsychopharmacology 18 1998 210 221 (Pubitemid 28062584)
16. R.H. Gerner, R.M. Post, and W.E. Bunney Jr. A dopaminergic mechanism in mania The American Journal of Psychiatry 133 1976 1177 1180
17. A.A. Gershon, T. Vishne, and L. Grunhaus Dopamine D2-like receptors and the antidepressant response Biological Psychiatry 61 2007 145 153 (Pubitemid 46072787)
18. J.F. Goldberg, J.L. Garno, A.C. Leon, J.H. Kocsis, and L. Portera Association of recurrent suicidal ideation with nonremission from acute mixed mania The American Journal of Psychiatry 155 1998 1753 1755 (Pubitemid 28547502)
19. J.F. Goldberg, R.H. Perlis, C.L. Bowden, M.E. Thase, D.J. Miklowitz, L.B. Marangell, J.R. Calabrese, A.A. Nierenberg, and G.S. Sachs Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD The American Journal of Psychiatry 166 2009 173 181
20. D.K. Grandy, Y. Zhang, and O. Civelli PCR detection of the TaqA RFLP at the DRD2 locus Human Molecular Genetics 2 1993 2197 (Pubitemid 24003431)
21. Q. Greba, A. Gifkins, and L. Kokkinidis Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle Brain Research 899 2001 218 226 (Pubitemid 32324163)
22. M. Hamilton Development of a rating scale for primary depressive illness The British Journal of Social and Clinical Psychology 6 1967 278 296
23. F. Holsboer How can we realize the promise of personalized antidepressant medicines? Nature Reviews Neuroscience 9 2008 638 646
24. S. Horstmann, and E.B. Binder Pharmacogenomics of antidepressant drugs Pharmacology and Therapeutics 124 2009 57 73
25. S.Y. Huang, W.W. Lin, H.C. Ko, J.F. Lee, T.J. Wang, Y.H. Chou, S.J. Yin, and R.B. Lu Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence Alcoholism, Clinical and Experimental Research 28 2004 374 384
26. E.G. Jonsson, M.M. Nothen, F. Grunhage, L. Farde, Y. Nakashima, P. Propping, and G.C. Sedvall Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers Molecular Psychiatry 4 1999 290 296 (Pubitemid 29292183)
27. M. Kato, and A. Serretti Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder Molecular Psychiatry 15 2010 473 500
28. P.E. Keck Jr.; S.L. McElroy, and L.M. Arnold Bipolar disorder The Medical Clinics of North America 85 2001 645 661 ix. (Pubitemid 32397220)
29. S.K. Kidd, and J.S. Schneider Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Neuroscience 194 2011 189 194
30. G. Kirov, I. Jones, F. McCandless, N. Craddock, and M.J. Owen Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5 Molecular Psychiatry 4 1999 558 565
31. R.A. Kowatch, M. Fristad, B. Birmaher, K.D. Wagner, R.L. Findling, and M. Hellander Treatment guidelines for children and adolescents with bipolar disorder Journal of the American Academy of Child and Adolescent Psychiatry 44 2005 213 235 (Pubitemid 40299835)
32. H.Y. Lane, C.C. Lee, Y.C. Chang, C.T. Lu, C.H. Huang, and W.H. Chang Effects of dopamine D2 receptor Ser311Cys polymorphism and clinical factors on risperidone efficacy for positive and negative symptoms and social function The International Journal of Neuropsychopharmacology 7 2004 461 470
33. A. Leszczyńska-Rodziewicz, J. Hauser, M. Dmitrzak-Weglarz, M. Skibińka, P. Czerski, A. Zakrzewska, M. Kosmowska, and J. Rybakowski Lack of association between polymorphisms of dopamine receptors, type D2, and bipolar affective illness in a Polish population Medical Science Monitor 11 2005 CR289 295
34. T. Li, X. Liu, P. Sham, K. Aitchison, G. Cai, M. Arranz, H. Deng, J. Liu, G. Kirov, R. Murray, and D. Collier Association analysis between dopamine receptor genes and bipolar affective disorder Psychiatry Research 86 1999 193 201 (Pubitemid 29393041)
35. B. Liu, and J.S. Hong Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures Methods in Molecular Medicine 79 2003 387 395
36. G.M. MacQueen, L.T. Young, and R.T. Joffe A review of psychosocial outcome in patients with bipolar disorder Acta Psychiatrica Scandinavica 103 2001 163 170 (Pubitemid 32154347)
37. A.K. Malhotra, G.M. Murphy Jr.; and J.L. Kennedy Pharmacogenetics of psychotropic drug response The American Journal of Psychiatry 161 2004 780 796 (Pubitemid 38625331)
38. P.B. Mitchell, G.S. Malhi, and J.R. Ball Major advances in bipolar disorder The Medical Journal of Australia 181 2004 207 210 (Pubitemid 39172939)
39. E.P. Noble, K. Blum, T. Ritchie, A. Montgomery, and P.J. Sheridan Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism Archives of General Psychiatry 48 1991 648 654
40. U. Osby, L. Brandt, N. Correia, A. Ekbom, and P. Sparen Excess mortality in bipolar and unipolar disorder in Sweden Archives of General Psychiatry 58 2001 844 850 (Pubitemid 32979302)
41. G.S. Peng, G. Li, N.S. Tzeng, P.S. Chen, D.M. Chuang, Y.D. Hsu, S. Yang, and J.S. Hong Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia Brain Research. Molecular Brain Research 134 2005 162 169 (Pubitemid 40403648)
42. M.A. Pezze, and J. Feldon Mesolimbic dopaminergic pathways in fear conditioning Progress in Neurobiology 74 2004 301 320 (Pubitemid 39586721)
43. T. Pohjalainen, J.O. Rinne, K. Nagren, P. Lehikoinen, K. Anttila, E.K. Syvalahti, and J. Hietala The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers Molecular Psychiatry 3 1998 256 260 (Pubitemid 28266335)
44. T. Ritchie, and E.P. Noble Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics Neurochemical Research 28 2003 73 82 (Pubitemid 36173228)
45. J.A. Saint-Cyr, A.E. Taylor, and A.E. Lang Neuropsychological and psychiatric side effects in the treatment of Parkinson's disease Neurology 43 1993 S47 S52
46. E.J. Shin, J.H. Bach, S.Y. Lee, J.M. Kim, J. Lee, J.S. Hong, T. Nabeshima, and H.C. Kim Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs Journal of Pharmacological Sciences 116 2011 137 148
47. T. Silverstone, and S. Romans-Clarkson Bipolar affective disorder: causes and prevention of relapse The British Journal of Psychiatry 154 1989 321 335 (Pubitemid 19091808)
48. D. Souery, O. Lipp, B. Mahieu, K. Mendelbaum, V. De Martelaer, C. Van Broeckhoven, and J. Mendlewicz Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes American Journal of Medical Genetics 67 1996 551 555
49. G. Stober, S. Jatzke, A. Heils, G. Jungkunz, M. Knapp, R. Mossner, P. Riederer, and K.P. Lesch Insertion/deletion variant (- 141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder. Short communication Journal of Neural Transmission 105 1998 101 109 (Pubitemid 28132599)
50. A.L. Stoll, P.F. Renshaw, D.A. Yurgelun-Todd, and B.M. Cohen Neuroimaging in bipolar disorder: what have we learned? Biological Psychiatry 48 2000 505 517
51. T. Suppes, E.B. Dennehy, R.M. Hirschfeld, L.L. Altshuler, C.L. Bowden, J.R. Calabrese, M.L. Crismon, T.A. Ketter, G.S. Sachs, and A.C. Swann The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder The Journal of Clinical Psychiatry 66 2005 870 886 (Pubitemid 41032829)
52. A.E. Taylor, and J.A. Saint-Cyr Depression in Parkinson's disease: reconciling physiological and psychological perspectives The Journal of Neuropsychiatry and Clinical Neurosciences 2 1990 92 98 (Pubitemid 20125851)
53. H.R. Thomasson, H.J. Edenberg, D.W. Crabb, X.L. Mai, R.E. Jerome, T.K. Li, S.P. Wang, Y.T. Lin, R.B. Lu, and S.J. Yin Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men American Journal of Human Genetics 48 1991 677 681 (Pubitemid 21891610)
54. S.Y. Tsai, J.C. Lee, and C.C. Chen Characteristics and psychosocial problems of patients with bipolar disorder at high risk for suicide attempt Journal of Affective Disorders 52 1999 145 152
55. S.C. Wang, D.T. Chou, and M.C. Wallenstein Studies on the potency of various antitussive agents Agents and Actions 7 1977 337 340 (Pubitemid 8183972)
56. X. Wu, P.S. Chen, S. Dallas, B. Wilson, M.L. Block, C.C. Wang, H. Kinyamu, N. Lu, X. Gao, Y. Leng, D.M. Chuang, W. Zhang, R.B. Lu, and J.S. Hong Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons The International Journal of Neuropsychopharmacology 11 2008 1123 1134
57. L.N. Yatham, J.M. Goldstein, E. Vieta, C.L. Bowden, H. Grunze, R.M. Post, T. Suppes, and J.R. Calabrese Atypical antipsychotics in bipolar depression: potential mechanisms of action The Journal of Clinical Psychiatry 66 Suppl 5 2005 40 48 (Pubitemid 40934073)
58. R.C. Young, J.T. Biggs, V.E. Ziegler, and D.A. Meyer A rating scale for mania: reliability, validity and sensitivity The British Journal of Psychiatry 133 1978 429 435 (Pubitemid 9006756)
59. S.L. Zeger, K.Y. Liang, and P.S. Albert Models for longitudinal data: a generalized estimating equation approach Biometrics 44 1988 1049 1060 (Pubitemid 19026037)
60. W. Zhang, T. Wang, L. Qin, H.-M. Gao, B. Wilson, S.F. Ali, W. Zhang, J.-S. Hong, and B. Liu Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase The FASEB Journal 18 2004 589 591
61. W. Zhang, L. Qin, T. Wang, S.-J. Wei, H.-m. Gao, J. Liu, B. Wilson, B. Liu, W. Zhang, H.-C. Kim, and J.-S. Hong 3-Hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity The FASEB Journal 19 2005 395 397 (Pubitemid 40316528)
62. Y.F. Zou, F. Wang, X.L. Feng, W.F. Li, Y.H. Tian, J.H. Tao, F.M. Pan, and F. Huang Association of DRD2 gene polymorphisms with mood disorders: a meta-analysis Journal of Affective Disorders 2010 doi: 10.1016/j.jad.2010.11.012