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Volumn 76, Issue 1, 2015, Pages e91-e97

Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; CARBAMAZEPINE; LAMOTRIGINE; LITHIUM CARBONATE; LITHIUM SALT; MEMANTINE; MOOD STABILIZER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; VALPROIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT;

EID: 84925372786     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.13m08956     Document Type: Article
Times cited : (19)

References (47)
  • 2
    • 79952488779 scopus 로고    scopus 로고
    • Number needed to treat analyses of drugs used for maintenance treatment of bipolar disorder
    • Popovic D, Reinares M, Amann B, et al. Number needed to treat analyses of drugs used for maintenance treatment of bipolar disorder. Psychopharmacology (Berl). 2011;213(4):657-667.
    • (2011) Psychopharmacology (Berl) , vol.213 , Issue.4 , pp. 657-667
    • Popovic, D.1    Reinares, M.2    Amann, B.3
  • 3
    • 80052979456 scopus 로고    scopus 로고
    • Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: A meta-analysis of randomized controlled trials
    • Vieta E, Günther O, Locklear J, et al. Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol. 2011;14(8):1029-1049.
    • (2011) Int J Neuropsychopharmacol , vol.14 , Issue.8 , pp. 1029-1049
    • Vieta, E.1    Günther, O.2    Locklear, J.3
  • 4
    • 84898597835 scopus 로고    scopus 로고
    • Treatments for acute bipolar depression: Meta-analyses of placebo-controlled, monotherapy trials of anticonvulsants, lithium and antipsychotics
    • Selle V, Schalkwijk S, Vázquez GH, et al. Treatments for acute bipolar depression: meta-analyses of placebo-controlled, monotherapy trials of anticonvulsants, lithium and antipsychotics. Pharmacopsychiatry. 2014;47(2):43-52.
    • (2014) Pharmacopsychiatry , vol.47 , Issue.2 , pp. 43-52
    • Selle, V.1    Schalkwijk, S.2    Vázquez, G.H.3
  • 5
    • 84887436090 scopus 로고    scopus 로고
    • The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders
    • Pacchiarotti I, Bond DJ, Baldessarini RJ, et al. The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry. 2013;170(11):1249-1262.
    • (2013) Am J Psychiatry , vol.170 , Issue.11 , pp. 1249-1262
    • Pacchiarotti, I.1    Bond, D.J.2    Baldessarini, R.J.3
  • 6
    • 84880537570 scopus 로고    scopus 로고
    • Overview of antidepressant treatment of bipolar depression
    • Vázquez GH, Tondo L, Undurraga J, et al. Overview of antidepressant treatment of bipolar depression. Int J Neuropsychopharmacol. 2013;16(7):1673-1685.
    • (2013) Int J Neuropsychopharmacol , vol.16 , Issue.7 , pp. 1673-1685
    • Vázquez, G.H.1    Tondo, L.2    Undurraga, J.3
  • 7
    • 77951029427 scopus 로고    scopus 로고
    • Morbidity in 303 first-episode bipolar I disorder patients
    • Baldessarini RJ, Salvatore P, Khalsa HM, et al. Morbidity in 303 first-episode bipolar I disorder patients. Bipolar Disord. 2010;12(3):264-270.
    • (2010) Bipolar Disord , vol.12 , Issue.3 , pp. 264-270
    • Baldessarini, R.J.1    Salvatore, P.2    Khalsa, H.M.3
  • 8
    • 0034777232 scopus 로고    scopus 로고
    • Excess mortality in bipolar and unipolar disorder in Sweden
    • Ösby U, Brandt L, Correia N, et al. Excess mortality in bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry. 2001;58(9):844-850.
    • (2001) Arch Gen Psychiatry , vol.58 , Issue.9 , pp. 844-850
    • Ösby, U.1    Brandt, L.2    Correia, N.3
  • 10
    • 84865198732 scopus 로고    scopus 로고
    • Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study
    • Ferrari AJ, Saha S, McGrath JJ, et al. Health states for schizophrenia and bipolar disorder within the Global Burden of Disease 2010 Study. Popul Health Metr. 2012;10(1):16-23.
    • (2012) Popul Health Metr , vol.10 , Issue.1 , pp. 16-23
    • Ferrari, A.J.1    Saha, S.2    McGrath, J.J.3
  • 11
    • 84877058712 scopus 로고    scopus 로고
    • Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease
    • Noetzli M, Eap CB. Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease. Clin Pharmacokinet. 2013;52(4):225-241.
    • (2013) Clin Pharmacokinet , vol.52 , Issue.4 , pp. 225-241
    • Noetzli, M.1    Eap, C.B.2
  • 12
    • 84863536950 scopus 로고    scopus 로고
    • N-methyl-d-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease
    • Olivares D, Deshpande VK, Shi Y, et al. N-methyl-d-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Curr Alzheimer Res. 2012;9(6):746-758.
    • (2012) Curr Alzheimer Res , vol.9 , Issue.6 , pp. 746-758
    • Olivares, D.1    Deshpande, V.K.2    Shi, Y.3
  • 13
    • 0037223439 scopus 로고    scopus 로고
    • Reversal of antidepressant-induced dopaminergic behavioural supersensitivity after long-term chronic imipramine withdrawal
    • D'Aquila PS, Peana AT, Panin F, et al. Reversal of antidepressant-induced dopaminergic behavioural supersensitivity after long-term chronic imipramine withdrawal. Eur J Pharmacol. 2003;458(1-2):129-134.
    • (2003) Eur J Pharmacol , vol.458 , Issue.1-2 , pp. 129-134
    • D'Aquila, P.S.1    Peana, A.T.2    Panin, F.3
  • 14
    • 33645415220 scopus 로고    scopus 로고
    • Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole
    • D'Aquila PS, Panin F, Serra G. Chronic valproate fails to prevent imipramine-induced behavioural sensitization to the dopamine D2-like receptor agonist quinpirole. Eur J Pharmacol. 2006;535(1-3):208-211.
    • (2006) Eur J Pharmacol , vol.535 , Issue.1-3 , pp. 208-211
    • D'Aquila, P.S.1    Panin, F.2    Serra, G.3
  • 15
    • 84931842001 scopus 로고    scopus 로고
    • Memantine prevents the "bipolar-like behavior" induced by chronic imipramine in rats
    • abstract, Poster presented at the, May 21-23, Nice, France
    • Demontis F, Cubeddu A, Serra G. Memantine prevents the "bipolar-like behavior" induced by chronic imipramine in rats [abstract]. Poster presented at the 12th International Review of Bipolar Disorders; May 21-23, 2012; Nice, France.
    • (2012) 12th International Review of Bipolar Disorders
    • Demontis, F.1    Cubeddu, A.2    Serra, G.3
  • 16
    • 0037417238 scopus 로고    scopus 로고
    • Memantine in moderate-to-severe Alzheimer's disease
    • Reisberg B, Doody R, Stöffler A, et al Memantine Study Group. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003;348(14):1333-1341.
    • (2003) N Engl J Med , vol.348 , Issue.14 , pp. 1333-1341
    • Reisberg, B.1    Doody, R.2    Stöffler, A.3
  • 17
    • 79959389773 scopus 로고    scopus 로고
    • Lack of evidence for the efficacy of memantine in mild Alzheimer disease
    • Schneider LS, Dagerman KS, Higgins JP, et al. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol. 2011;68(8):991-998.
    • (2011) Arch Neurol , vol.68 , Issue.8 , pp. 991-998
    • Schneider, L.S.1    Dagerman, K.S.2    Higgins, J.P.3
  • 18
    • 67649394221 scopus 로고    scopus 로고
    • Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: A double-blind, placebo-controlled, multicentre trial
    • Aarsland D, Ballard C, Walker Z, et al. Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2009;8(7):613-618.
    • (2009) Lancet Neurol , vol.8 , Issue.7 , pp. 613-618
    • Aarsland, D.1    Ballard, C.2    Walker, Z.3
  • 19
    • 77955288247 scopus 로고    scopus 로고
    • Memantine-related psychotic symptoms in a patient with bipolar disorder
    • Canan F, Ataoglu A. Memantine-related psychotic symptoms in a patient with bipolar disorder. J Clin Psychiatry. 2010;71(7):957.
    • (2010) J Clin Psychiatry , vol.71 , Issue.7 , pp. 957
    • Canan, F.1    Ataoglu, A.2
  • 20
    • 47749150634 scopus 로고    scopus 로고
    • A systematic review of off-label uses of memantine for psychiatric disorders
    • Zdanys K, Tampi RR. A systematic review of off-label uses of memantine for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1362-1374.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , Issue.6 , pp. 1362-1374
    • Zdanys, K.1    Tampi, R.R.2
  • 21
    • 84863685351 scopus 로고    scopus 로고
    • The role of memantine in the treatment of psychiatric disorders other than the dementias: A review of current preclinical and clinical evidence
    • Sani G, Serra G, Kotzalidis GD, et al. The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence. CNS Drugs. 2012;26(8):663-690.
    • (2012) CNS Drugs , vol.26 , Issue.8 , pp. 663-690
    • Sani, G.1    Serra, G.2    Kotzalidis, G.D.3
  • 22
    • 52249112068 scopus 로고    scopus 로고
    • Evaluation of the impact of memantine treatment initiation on psychotropics use: A study from the French national health care database
    • Vidal JS, Lacombe JM, Dartigues JF, et al. Evaluation of the impact of memantine treatment initiation on psychotropics use: a study from the French national health care database. Neuroepidemiology. 2008;31(3):193-200.
    • (2008) Neuroepidemiology , vol.31 , Issue.3 , pp. 193-200
    • Vidal, J.S.1    Lacombe, J.M.2    Dartigues, J.F.3
  • 23
    • 42249111378 scopus 로고    scopus 로고
    • Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: A pooled analysis of 3 studies
    • Wilcock GK, Ballard CG, Cooper JA, et al. Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. J Clin Psychiatry. 2008;69(3):341-348.
    • (2008) J Clin Psychiatry , vol.69 , Issue.3 , pp. 341-348
    • Wilcock, G.K.1    Ballard, C.G.2    Cooper, J.A.3
  • 24
    • 68949192813 scopus 로고    scopus 로고
    • Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: A pilot evaluation
    • Keck PE Jr, Hsu HA, Papadakis K, et al. Memantine efficacy and safety in patients with acute mania associated with bipolar I disorder: a pilot evaluation. Clin Neuropharmacol. 2009;32(4):199-204.
    • (2009) Clin Neuropharmacol , vol.32 , Issue.4 , pp. 199-204
    • Keck, P.E.1    Hsu, H.A.2    Papadakis, K.3
  • 25
    • 84857048940 scopus 로고    scopus 로고
    • The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: Findings from a 12-month naturalistic trial
    • Koukopoulos A, Serra G, Koukopoulos AE, et al. The sustained mood-stabilizing effect of memantine in the management of treatment resistant bipolar disorders: findings from a 12-month naturalistic trial. J Affect Disord. 2012;136(1-2):163-166.
    • (2012) J Affect Disord , vol.136 , Issue.1-2 , pp. 163-166
    • Koukopoulos, A.1    Serra, G.2    Koukopoulos, A.E.3
  • 26
    • 84883783192 scopus 로고    scopus 로고
    • Antimanic and long-lasting mood stabilizing effect of memantine in bipolar I mood disorder: Two case reports
    • Serra G, De Chiara L, Koukopoulos A, et al. Antimanic and long-lasting mood stabilizing effect of memantine in bipolar I mood disorder: two case reports. J Clin Psychopharmacol. 2013;33(5):715-717.
    • (2013) J Clin Psychopharmacol , vol.33 , Issue.5 , pp. 715-717
    • Serra, G.1    De Chiara, L.2    Koukopoulos, A.3
  • 27
    • 84998133492 scopus 로고    scopus 로고
    • Memantine in the management of affective recurrences of bipolar disorders after the discontinuation of long-term lithium treatment: Three case histories
    • Serra G, De Chiara L, Manfredi G, et al. Memantine in the management of affective recurrences of bipolar disorders after the discontinuation of long-term lithium treatment: three case histories. Ther Adv Psychopharmacol. 2014;4(1):53-55.
    • (2014) Ther Adv Psychopharmacol , vol.4 , Issue.1 , pp. 53-55
    • Serra, G.1    De Chiara, L.2    Manfredi, G.3
  • 28
    • 84856875518 scopus 로고    scopus 로고
    • Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: A double-blind, randomized, placebo-controlled trial
    • Anand A, Gunn AD, Barkay G, et al. Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar Disord. 2012;14(1):64-70.
    • (2012) Bipolar Disord , vol.14 , Issue.1 , pp. 64-70
    • Anand, A.1    Gunn, A.D.2    Barkay, G.3
  • 29
    • 84881541644 scopus 로고    scopus 로고
    • Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder
    • Lee SY, Chen SL, Chang YH, et al. Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder. J Psychiatr Res. 2013;47(10):1343-1348.
    • (2013) J Psychiatr Res , vol.47 , Issue.10 , pp. 1343-1348
    • Lee, S.Y.1    Chen, S.L.2    Chang, Y.H.3
  • 30
    • 0031555277 scopus 로고    scopus 로고
    • Modification of the Clinical Global Impressions (CGI) scale for use in bipolar illness (BP): The CGI-BP
    • Spearing MK, Post RM, Leverich GS, et al. Modification of the Clinical Global Impressions (CGI) scale for use in bipolar illness (BP): the CGI-BP. Psychiatry Res. 1997;73(3):159-171.
    • (1997) Psychiatry Res , vol.73 , Issue.3 , pp. 159-171
    • Spearing, M.K.1    Post, R.M.2    Leverich, G.S.3
  • 31
    • 84888637883 scopus 로고    scopus 로고
    • Course sequences in bipolar disorder: Depressions preceding or following manias or hypomanias
    • Koukopoulos A, Reginaldi D, Tondo L, et al. Course sequences in bipolar disorder: depressions preceding or following manias or hypomanias. J Affect Disord. 2013;151(1):105-110.
    • (2013) J Affect Disord , vol.151 , Issue.1 , pp. 105-110
    • Koukopoulos, A.1    Reginaldi, D.2    Tondo, L.3
  • 32
    • 0038281515 scopus 로고    scopus 로고
    • Suicidal behaviour in bipolar disorder: Risk and prevention
    • Tondo L, Isacsson G, Baldessarini RJ. Suicidal behaviour in bipolar disorder: risk and prevention. CNS Drugs. 2003;17(7):491-511.
    • (2003) CNS Drugs , vol.17 , Issue.7 , pp. 491-511
    • Tondo, L.1    Isacsson, G.2    Baldessarini, R.J.3
  • 33
    • 84876475748 scopus 로고    scopus 로고
    • Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders
    • Tondo L, Baldessarini RJ, Vázquez GH, et al. Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders. Acta Psychiatr Scand. 2013;127(5):355-364.
    • (2013) Acta Psychiatr Scand , vol.127 , Issue.5 , pp. 355-364
    • Tondo, L.1    Baldessarini, R.J.2    Vázquez, G.H.3
  • 34
    • 84865225624 scopus 로고    scopus 로고
    • Open-label pilot study of memantine in the treatment of compulsive buying
    • Grant JE, Odlaug BL, Mooney M, et al. Open-label pilot study of memantine in the treatment of compulsive buying. Ann Clin Psychiatry. 2012;24(2):119-126.
    • (2012) Ann Clin Psychiatry , vol.24 , Issue.2 , pp. 119-126
    • Grant, J.E.1    Odlaug, B.L.2    Mooney, M.3
  • 35
    • 84875698756 scopus 로고    scopus 로고
    • Memantine as adjunctive treatment to risperidone in children with autistic disorder: A randomized, double-blind, placebo-controlled trial
    • Ghaleiha A, Asadabadi M, Mohammadi MR, et al. Memantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial. Int J Neuropsychopharmacol. 2013;16(4):783-789.
    • (2013) Int J Neuropsychopharmacol , vol.16 , Issue.4 , pp. 783-789
    • Ghaleiha, A.1    Asadabadi, M.2    Mohammadi, M.R.3
  • 36
    • 30044450251 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of memantine in the treatment of major depression
    • Zarate CA Jr, Singh JB, Quiroz JA, et al. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry. 2006;163(1):153-155.
    • (2006) Am J Psychiatry , vol.163 , Issue.1 , pp. 153-155
    • Zarate, C.A.1    Singh, J.B.2    Quiroz, J.A.3
  • 37
    • 84887043337 scopus 로고    scopus 로고
    • Antidepressant augmentation using the N-methyl-d-aspartate antagonist memantine: Randomized, double-blind, placebo-controlled trial
    • Smith EG, Deligiannidis KM, Ulbricht CM, et al. Antidepressant augmentation using the N-methyl-d-aspartate antagonist memantine: randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2013;74(10):966-973.
    • (2013) J Clin Psychiatry. , vol.74 , Issue.10 , pp. 966-973
    • Smith, E.G.1    Deligiannidis, K.M.2    Ulbricht, C.M.3
  • 38
    • 84896728934 scopus 로고    scopus 로고
    • Neural correlates of rapid antidepressant response to ketamine in bipolar disorder
    • Nugent AC, Diazgranados N, Carlson PJ, et al. Neural correlates of rapid antidepressant response to ketamine in bipolar disorder. Bipolar Disord. 2014;16(2):119-128.
    • (2014) Bipolar Disord , vol.16 , Issue.2 , pp. 119-128
    • Nugent, A.C.1    Diazgranados, N.2    Carlson, P.J.3
  • 39
    • 0015787765 scopus 로고
    • Does lithium prevent depressions by suppressing manias?
    • Kukopulos A, Reginaldi D. Does lithium prevent depressions by suppressing manias? Int Pharmacopsychiatry. 1973;8(3):152-158.
    • (1973) Int Pharmacopsychiatry , vol.8 , Issue.3 , pp. 152-158
    • Kukopulos, A.1    Reginaldi, D.2
  • 40
    • 60949099494 scopus 로고    scopus 로고
    • The primacy of mania: A reconsideration of mood disorders
    • Koukopoulos A, Ghaemi SN. The primacy of mania: a reconsideration of mood disorders. Eur Psychiatry. 2009;24(2):125-134.
    • (2009) Eur Psychiatry , vol.24 , Issue.2 , pp. 125-134
    • Koukopoulos, A.1    Ghaemi, S.N.2
  • 41
    • 38449099231 scopus 로고    scopus 로고
    • Dopamine dysregulation syndrome: Implications for a dopamine hypothesis of bipolar disorder
    • Berk M, Dodd S. Kauer-Sant'Anna M, et al. Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatr Scand. 2007;116(suppl 434):41-49.
    • (2007) Acta Psychiatr Scand , vol.116 , pp. 41-49
    • Berk, M.1    Dodd, S.2    Kauer-SanT'Anna, M.3
  • 42
    • 71049173312 scopus 로고    scopus 로고
    • The role of dopamine in bipolar disorder
    • Cousins DA, Butts K, Young AH. The role of dopamine in bipolar disorder. Bipolar Disord. 2009;11(8):787-806.
    • (2009) Bipolar Disord , vol.11 , Issue.8 , pp. 787-806
    • Cousins, D.A.1    Butts, K.2    Young, A.H.3
  • 43
    • 1642307557 scopus 로고    scopus 로고
    • Role of neurotrophic factors in the etiology and treatment of mood disorders
    • Duman RS. Role of neurotrophic factors in the etiology and treatment of mood disorders. Neuromolecular Med. 2004;5(1):11-25.
    • (2004) Neuromolecular Med , vol.5 , Issue.1 , pp. 11-25
    • Duman, R.S.1
  • 44
    • 71549155031 scopus 로고    scopus 로고
    • Memantine strikes the perfect balance
    • La Spada AR. Memantine strikes the perfect balance. Nat Med. 2009;15(12):1355-1356.
    • (2009) Nat Med , vol.15 , Issue.12 , pp. 1355-1356
    • La Spada, A.R.1
  • 45
    • 52949123611 scopus 로고    scopus 로고
    • Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    • Ongür D, Jensen JE, Prescot AP, et al. Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol Psychiatry. 2008;64(8):718-726.
    • (2008) Biol Psychiatry , vol.64 , Issue.8 , pp. 718-726
    • Ongür, D.1    Jensen, J.E.2    Prescot, A.P.3
  • 46
    • 79960699890 scopus 로고    scopus 로고
    • Memantine reduces mania-like symptoms in animal models
    • Gao Y, Payne RS, Schurr A, et al. Memantine reduces mania-like symptoms in animal models. Psychiatry Res. 2011;188(3):366-371.
    • (2011) Psychiatry Res , vol.188 , Issue.3 , pp. 366-371
    • Gao, Y.1    Payne, R.S.2    Schurr, A.3
  • 47
    • 84873322483 scopus 로고    scopus 로고
    • Altered neurochemical ingredient of hippocampus in patients with bipolar depression
    • Atmaca M, Yildirim H. Altered neurochemical ingredient of hippocampus in patients with bipolar depression. Depress Res Treat. 2012;2012:485249.
    • (2012) Depress Res Treat , vol.2012 , pp. 485249
    • Atmaca, M.1    Yildirim, H.2


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