Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1

Cell Reports

Volumn 17, Issue 5, 2016, Pages 1227-1237

  Mark, Karla A ^a   Dumas, Kathleen J ^a   Bhaumik, Dipa ^a   Schilling, Birgit ^a   Davis, Sonnet ^a   Oron, Tal Ronnen ^a   Sorensen, Dylan J ^a   Lucanic, Mark ^a   Brem, Rachel B ^a   Melov, Simon ^a   Ramanathan, Arvind ^a   Gibson, Bradford W ^a   Lithgow, Gordon J ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Alzheimer's disease; Ceanorhabditis elegans; insoluble protein; IRE 1; lifespan. aging; protein aggregation; proteostasis; SKN 1; vitamin D; XBP 1

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 12; TRANSCRIPTION FACTOR DAF 16; UNCLASSIFIED DRUG; VITAMIN D; X BOX BINDING PROTEIN 1; CAENORHABDITIS ELEGANS PROTEIN; CALCITRIOL; CARRIER PROTEIN; COLECALCIFEROL; DNA BINDING PROTEIN; IRE-1 PROTEIN, C ELEGANS; PROTEIN AGGREGATE; PROTEIN SERINE THREONINE KINASE; SKN-1 PROTEIN, C ELEGANS; XBP-1 PROTEIN, C ELEGANS;

ADULT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAENORHABDITIS ELEGANS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; IRE 1 GENE; LIFE EXTENSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; RNA INTERFERENCE; RNA SPLICING; SKN 1 GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; XBP 1 GENE; ANIMAL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; HOMEOSTASIS; LONGEVITY; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SOLUBILITY;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALCITRIOL; CARRIER PROTEINS; CHOLECALCIFEROL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; HOMEOSTASIS; LONGEVITY; PROTEIN AGGREGATES; PROTEIN-SERINE-THREONINE KINASES; SOLUBILITY; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE; VITAMIN D;

EID: 84994742910     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.09.086     Document Type: Article

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