Premature aging in vitamin D receptor mutant mice

Journal of Steroid Biochemistry and Molecular Biology

Volumn 115, Issue 3-5, 2009, Pages 91-97

  Keisala, Tiina ^a   Minasyan, Anna ^a   Lou, Yan Ru ^a   Zou, Jing ^a   Kalueff, Allan V ^b,c   Pyykkö, Ilmari ^a   Tuohimaa, Pentti ^a,d  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Aging; Aging related genes; Fgf 23; Klotho; Vitamin D; Vitamin D receptor

Indexed keywords

FIBRINOGEN; FIBROBLAST GROWTH FACTOR 23; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN RECEPTOR; KLOTHO PROTEIN; PROTEIN P53; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; VITAMIN D RECEPTOR;

AGED; ALOPECIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DIET; EPIDERMOID CYST; FEMALE; GROWTH; HOMEOSTASIS; KIDNEY; KNOCKOUT MOUSE; LIVER; MALE; MORPHOLOGY; MOTOR PERFORMANCE; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PREMATURE AGING; PROSTATE; REGULATORY MECHANISM; SEBACEOUS GLAND; SKIN; SURVIVAL;

AGING, PREMATURE; ANIMALS; BODY WEIGHT; CEREBELLUM; CHOLECALCIFEROL; FEMALE; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MICE, KNOCKOUT; NF-KAPPA B; PHENOTYPE; RECEPTOR, IGF TYPE 1; RECEPTORS, CALCITRIOL; SKIN; SURVIVAL RATE; SWIMMING; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 67349140353     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.03.007     Document Type: Article

References (83)

1. Carmeliet G., Van Cromphaut S., Daci E., Maes C., and Bouillon R. Disorders of calcium homeostasis. Best Pract. Res. Clin. Endocrinol. Metab. 17 4 (2003) 529-546
2. Dusso A.S., Brown A.J., and Slatopolsky E. Vitamin D. Am. J. Physiol. Renal Physiol. 289 1 (2005) F8-28
3. Bouillon R., Carmeliet G., Verlinden L., van Etten E., Verstuyf A., Luderer H.F., Lieben L., Mathieu C., and Demay M. Vitamin d and human health: lessons from vitamin d receptor null mice. Endocr. Rev. 29 6 (2008) 726-776
4. Brown J., Bianco J.I., McGrath J.J., and Eyles D.W. 1, 25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci. Lett. 343 2 (2003) 139-143
5. Garcion E., Wion-Barbot N., Montero-Menei C.N., Berger F., and Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 13 3 (2002) 100-105
6. Kamei Y., Kawada T., Fukuwatari T., Ono T., Kato S., and Sugimoto E. Cloning and sequencing of the gene encoding the mouse vitamin D receptor. Gene 152 2 (1995) 281-282
7. Kato S., Takeyama K., Kitanaka S., Murayama A., Sekine K., and Yoshizawa T. In vivo function of VDR in gene expression-VDR knock-out mice. J. Steroid Biochem. Mol. Biol. 69 1-6 (1999) 247-251
8. Malloy P.J., Pike J.W., and Feldman D. The vitamin D receptor and the syndrome of hereditary 1, 25-dihydroxyvitamin D-resistant rickets. Endocr. Rev. 20 2 (1999) 156-188
9. Walbert T., Jirikowski G.F., and Prufer K. Distribution of 1, 25-dihydroxyvitamin D3 receptor immunoreactivity in the limbic system of the rat. Horm. Metab. Res. 33 9 (2001) 525-531
10. Prufer K., Veenstra T.D., Jirikowski G.F., and Kumar R. Distribution of 1, 25-dihydroxyvitamin D3 receptor immunoreactivity in the rat brain and spinal cord. J. Chem. Neuroanat. 16 2 (1999) 135-145
11. Langub M.C., Herman J.P., Malluche H.H., and Koszewski N.J. Evidence of functional vitamin D receptors in rat hippocampus. Neuroscience 104 1 (2001) 49-56
12. Eyles D.W., Smith S., Kinobe R., Hewison M., and McGrath J.J. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J. Chem. Neuroanat. 29 1 (2005) 21-30
13. Altemus K.L., Finger S., Wolf C., and Birge S.J. Behavioral correlates of vitamin D deficiency. Physiol. Behav. 39 4 (1987) 435-440
14. Becker A., Eyles D.W., McGrath J.J., and Grecksch G. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav. Brain Res. 161 2 (2005) 306-312
15. Burne T.H., Becker A., Brown J., Eyles D.W., Mackay-Sim A., and McGrath J.J. Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats. Behav. Brain Res. 154 2 (2004) 549-555
16. Carswell S. Vitamin D and the nervous system: action and therapeutic potential. In: Feldman D., Glorieux F.H., and Pike J.W. (Eds). Vitamin D (1997), Academic Press, San Diego 1197-2111
17. Kalueff A.V., Lou Y.R., Laaksi I., and Tuohimaa P. Increased grooming behavior in mice lacking vitamin D receptors. Physiol. Behav. 82 2-3 (2004) 405-409
18. Kalueff A.V., Lou Y.R., Laaksi I., and Tuohimaa P. Impaired motor performance in mice lacking neurosteroid vitamin D receptors. Brain Res. Bull. 64 1 (2004) 25-29
19. Kalueff A.V., Lou Y.R., Laaksi I., and Tuohimaa P. Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport 15 8 (2004) 1271-1274
20. Johnson F.B., Sinclair D.A., and Guarente L. Molecular biology of aging. Cell 96 2 (1999) 291-302
21. Takahashi Y., Kuro O.M., and Ishikawa F. Aging mechanisms. Proc. Natl. Acad. Sci. U.S.A. 97 23 (2000) 12407-12408
22. Russell S.J., and Kahn C.R. Endocrine regulation of ageing. Nat. Rev. Mol. Cell Biol. 8 9 (2007) 681-691
23. Lanske B., and Razzaque M.S. Vitamin D and aging: old concepts and new insights. J. Nutr. Biochem. 18 12 (2007) 771-777
24. Tuohimaa P., and Vitamin D. aging, and cancer. Nutr. Rev. 66 10 Suppl 2 (2008) S147-S152
25. Shiozaki M., Yoshimura K., Shibata M., Koike M., Matsuura N., Uchiyama Y., and Gotow T. Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience 152 4 (2008) 924-941
26. Razzaque M.S., Sitara D., Taguchi T., St-Arnaud R., and Lanske B. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. Faseb J. 20 6 (2006) 720-722
27. Montero-Odasso M., Duque G., and Vitamin. D in the aging musculoskeletal system: an authentic strength preserving hormone. Mol. Aspects Med. 26 3 (2005) 203-219
28. Cranney A., Weiler H.A., O'Donnell S., and Puil L. Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health. Am. J. Clin. Nutr. 88 2 (2008) 513S-S519
29. Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 16 2 (2005) 83-95
30. Giovannucci E., Liu Y., Rimm E.B., Hollis B.W., Fuchs C.S., Stampfer M.J., and Willett W.C. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J. Natl. Cancer Inst. 98 7 (2006) 451-459
31. Holick M.F., and Chen T.C. Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr. 87 4 (2008) 1080S-S1086
32. Hypponen E., Laara E., Reunanen A., Jarvelin M.R., and Virtanen S.M. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358 9292 (2001) 1500-1503
33. Zittermann A., and Koerfer R. Vitamin D in the prevention and treatment of coronary heart disease. Curr. Opin. Clin. Nutr. Metab. Care 11 6 (2008) 752-757
34. Kuningas M., Mooijaart S.P., Jolles J., Slagboom P.E., Westendorp R.G., and van Heemst D. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol. Aging. (2007)
35. Brookes G.B. Vitamin D deficiency and otosclerosis. Otolaryngol. Head Neck Surg. 93 3 (1985) 313-321
36. Brookes G.B. Vitamin D deficiency and deafness: 1984 update. Am. J. Otol. 6 1 (1985) 102-107
37. Cohen H.N., Fogelman I., Boyle I.T., and Doig J.A. Deafness due to hypervitaminosis D. Lancet 1 8123 (1979) 985
38. Ikeda K., Kobayashi T., Itoh Z., Kusakari J., and Takasaka T. Evaluation of vitamin D metabolism in patients with bilateral sensorineural hearing loss. Am. J. Otol. 10 1 (1989) 11-13
39. Ikeda K., Kobayashi T., Kusakari J., Takasaka T., Yumita S., and Furukawa Y. Sensorineural hearing loss associated with hypoparathyroidism. Laryngoscope 97 9 (1987) 1075-1079
40. Ishida S., Isotani H., Kameoka K., and Kishi T. Familial idiopathic hypoparathyroidism, sensorineural deafness and renal dysplasia. Intern. Med. 40 2 (2001) 110-113
41. Li Y.C., Amling M., Pirro A.E., Priemel M., Meuse J., Baron R., Delling G., and Demay M.B. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139 10 (1998) 4391-4396
42. Bikle D.D., Elalieh H., Chang S., Xie Z., and Sundberg J.P. Development and progression of alopecia in the vitamin D receptor null mouse. J. Cell Physiol. 207 2 (2006) 340-353
43. Kalueff A., Loseva E., Haapasalo H., Rantala I., Keranen J., Lou Y.R., Minasyan A., Keisala T., Miettinen S., Kuuslahti M., and Tuchimaa P. Thalamic calcification in vitamin D receptor knockout mice. Neuroreport 17 7 (2006) 717-721
44. Yoshizawa T., Handa Y., Uematsu Y., Takeda S., Sekine K., Yoshihara Y., Kawakami T., Arioka K., Sato H., Uchiyama Y., Masushige S., Fukamizu A., Matsumoto T., and Kato S. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat. Genet. 16 4 (1997) 391-396
45. Amling M., Priemel M., Holzmann T., Chapin K., Rueger J.M., Baron R., and Demay M.B. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140 11 (1999) 4982-4987
46. Masuyama R., Nakaya Y., Katsumata S., Kajita Y., Uehara M., Tanaka S., Sakai A., Kato S., Nakamura T., and Suzuki K. Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption. J. Bone Miner. Res. 18 7 (2003) 1217-1226
47. Zou J., Minasyan A., Keisala T., Zhang Y., Wang J.H., Lou Y.R., Kalueff A., Pyykko I., and Tuohimaa P. Progressive hearing loss in mice with a mutated vitamin D receptor gene. Audiol. Neurootol. 13 4 (2008) 219-230
48. Berryman D.E., Christiansen J.S., Johannsson G., Thorner M.O., and Kopchick J.J. Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm. IGF Res. 18 6 (2008) 455-471
49. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., and Nabeshima Y.I. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 6655 (1997) 45-51
50. Kurosu H., Yamamoto M., Clark J.D., Pastor J.V., Nandi A., Gurnani P., McGuinness O.P., Chikuda H., Yamaguchi M., Kawaguchi H., Shimomura I., Takayama Y., Herz J., Kahn C.R., Rosenblatt K.P., and Kuro-o M. Suppression of aging in mice by the hormone Klotho. Science 309 5742 (2005) 1829-1833
51. Minasyan A., Keisala T., Zou J., Zhang Y., Toppila E., Syvälä H., Lou Y.R., Kalueff A.V., Pyykkö I., and Tuohimaa P. Balance deficits in vitamin D receptor mutant mice. J. Steroid Biochem. Mol Biol. (2009)
52. Endo I., Inoue D., Mitsui T., Umaki Y., Akaike M., Yoshizawa T., Kato S., and Matsumoto T. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144 12 (2003) 5138-5144
53. Kato S., Yoshizazawa T., Kitanaka S., Murayama A., and Takeyama K. Molecular genetics of vitamin D-dependent hereditary rickets. Horm. Res. 57 3-4 (2002) 73-78
54. Ellison T.I., Smith M.K., Gilliam A.C., and MacDonald P.N. Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis. J. Invest. Dermatol. 128 10 (2008) 2508-2517
55. Boonen S., Aerssens J., Broos P., Pelemans W., and Dequeker J. Age-related bone loss and senile osteoporosis: evidence for both secondary hyperparathyroidism and skeletal growth factor deficiency in the elderly. Aging (Milano) 7 6 (1995) 414-422
56. Adamo M.L., and Farrar R.P. Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process. Ageing Res. Rev. 5 3 (2006) 310-331
57. Kuro-o M. Disease model: human aging. Trends Mol. Med. 7 4 (2001) 179-181
58. Sonntag W.E., Ramsey M., and Carter C.S. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res. Rev. 4 2 (2005) 195-212
59. Narvaez C.J., Matthews D., Broun E., Chan M., and Welsh J. Lean phenotype and resistance to diet-induced obesity in VDR knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology (2008)
60. Makrantonaki E., and Zouboulis C.C. Molecular mechanisms of skin aging: state of the art. Ann. N.Y. Acad. Sci. 1119 (2007) 40-50
61. Brewer L.D., Porter N.M., Kerr D.S., Landfield P.W., and Thibault O. Chronic 1alpha, 25-(OH)(2)vitamin D(3) treatment reduces Ca(2+)-mediated hippocampal biomarkers of aging. Cell Calcium 40 3 (2006) 277-286
62. Burke S.N., and Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 7 1 (2006) 30-40
63. Foster T.C., and Kumar A. Calcium dysregulation in the aging brain. Neuroscientist 8 4 (2002) 297-301
64. 2+ regulation and gene expression in normal brain aging. Trends Neurosci. 27 10 (2004) 614-620
65. Bokov A., Chaudhuri A., and Richardson A. The role of oxidative damage and stress in aging. Mech. Ageing Dev. 125 10-11 (2004) 811-826
66. Floyd R.A., and Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23 5 (2002) 795-807
67. Kokoszka J.E., Coskun P., Esposito L.A., and Wallace D.C. Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. U.S.A. 98 5 (2001) 2278-2283
68. Freeman S.H., Kandel R., Cruz L., Rozkalne A., Newell K., Frosch M.P., Hedley-Whyte E.T., Locascio J.J., Lipsitz L.A., and Hyman B.T. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. J. Neuropathol. Exp. Neurol. 67 12 (2008) 1205-1212
69. Feron F., Burne T.H., Brown J., Smith E., McGrath J.J., Mackay-Sim A., and Eyles D.W. Developmental Vitamin D3 deficiency alters the adult rat brain. Brain Res. Bull. 65 2 (2005) 141-148
70. Movement and its central control. In: Purves D., Augustine G.J., Fitzpatrick D., Katz L.C., LaMantia A.-S., McNamara J.O., and Williams S.M. (Eds). Neuroscience (2001), Sinauer Associates, Inc., Sunderland, MA 346-426
71. Burne T.H., Johnston A.N., McGrath J.J., and Mackay-Sim A. Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice. Brain Res. Bull. 69 1 (2006) 74-78
72. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev. 18 18 (2004) 2195-2224
73. Adler A.S., Sinha S., Kawahara T.L., Zhang J.Y., Segal E., and Chang H.Y. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 21 24 (2007) 3244-3257
74. Cohen-Lahav M., Shany S., Tobvin D., Chaimovitz C., and Douvdevani A. Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels. Nephrol. Dial. Transplant 21 4 (2006) 889-897
75. Kuro-o M. Endocrine FGFs and Klothos: emerging concepts. Trends Endocrinol. Metab. 19 7 (2008) 239-245
76. Matheu A., Maraver A., and Serrano M. The Arf/p53 pathway in cancer and aging. Cancer Res. 68 15 (2008) 6031-6034
77. Beausejour C.M., Krtolica A., Galimi F., Narita M., Lowe S.W., Yaswen P., and Campisi J. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22 16 (2003) 4212-4222
78. Kommagani R., Payal V., and Kadakia M.P. Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J. Biol. Chem. 282 41 (2007) 29847-29854
79. Audo I., Darjatmoko S.R., Schlamp C.L., Lokken J.M., Lindstrom M.J., Albert D.M., and Nickells R.W. Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma. Invest. Ophthalmol. Vis. Sci. 44 10 (2003) 4192-4199
80. Masuda H., Chikuda H., Suga T., Kawaguchi H., and Kuro-o M. Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech. Ageing Dev. 126 12 (2005) 1274-1283
81. Laron Z. The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency. Hormones (Athens) 7 1 (2008) 24-27
82. Gomez J.M. The role of insulin-like growth factor I components in the regulation of vitamin D. Curr. Pharm. Biotechnol. 7 2 (2006) 125-132
83. Matilainen M., Malinen M., Saavalainen K., and Carlberg C. Regulation of multiple insulin-like growth factor binding protein genes by 1alpha, 25-dihydroxyvitamin D3. Nucleic Acids Res. 33 17 (2005) 5521-5532