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Volumn 10, Issue 1, 2007, Pages 12-19

Neurosteroid hormone vitamin D and its utility in clinical nutrition

Author keywords

Neurosteroid hormone; Supplementation and therapy; Vitamin D

Indexed keywords

ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; IMMUNOMODULATING AGENT; NEUROPROTECTIVE AGENT; NEUROSTEROID; NEUROTROPIC AGENT; PSYCHOTROPIC AGENT; VITAMIN D; VITAMIN D RECEPTOR;

EID: 33845438695     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328010ca18     Document Type: Review
Times cited : (229)

References (105)
  • 2
    • 16244418604 scopus 로고    scopus 로고
    • Overview of general physiologic features and functions of vitamin D1-4
    • DeLuca HF. Overview of general physiologic features and functions of vitamin D1-4. Am J Clin Nutr 2004; 80 (6 Suppl):1689-1896.
    • (2004) Am J Clin Nutr , vol.80 , Issue.6 SUPPL. , pp. 1689-1896
    • DeLuca, H.F.1
  • 3
    • 33746741731 scopus 로고    scopus 로고
    • Resurrection of vitamin D deficiency and rickets
    • Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest 2006; 116:2062-2072. An excellent review on the growing incidence of vitamin D deficiency, summarizing the role of vitamin D in the prevention of rickets, and its importance in the overall health and welfare of infants and children.
    • (2006) J Clin Invest , vol.116 , pp. 2062-2072
    • Holick, M.F.1
  • 4
    • 11144337730 scopus 로고    scopus 로고
    • Why we should offer routine vitamin D supplementation in pregnancy and childhood to prevent multiple sclerosis
    • Chaudhuri A. Why we should offer routine vitamin D supplementation in pregnancy and childhood to prevent multiple sclerosis. Med Hypotheses 2005; 64:608-615. A comprehensive review discussing pathogenetic mechanisms of MS and the preventive role of vitamin D-related supplementation in pregnancy and childhood.
    • (2005) Med Hypotheses , vol.64 , pp. 608-615
    • Chaudhuri, A.1
  • 6
    • 33745115907 scopus 로고    scopus 로고
    • The vitamin D neuroendocrine system as a target for novel neurotropic drugs
    • Kalueff AV, Minasyan A, Keisala T, et al. The vitamin D neuroendocrine system as a target for novel neurotropic drugs. CNS Neurol Disords Drug Targets 2006; 5:363-371.
    • (2006) CNS Neurol Disords Drug Targets , vol.5 , pp. 363-371
    • Kalueff, A.V.1    Minasyan, A.2    Keisala, T.3
  • 8
    • 33646501518 scopus 로고    scopus 로고
    • The dose makes the medicine
    • Stumpf WE. The dose makes the medicine. Drug Discov Today 2006; 11:550-555.
    • (2006) Drug Discov Today , vol.11 , pp. 550-555
    • Stumpf, W.E.1
  • 13
    • 0037986472 scopus 로고    scopus 로고
    • 3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
    • 3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett 2003; 343:139-143.
    • (2003) Neurosci Lett , vol.343 , pp. 139-143
    • Brown, J.1    Bianco, J.I.2    McGrath, J.J.3    Eyles, D.W.4
  • 15
    • 10044272155 scopus 로고    scopus 로고
    • Distribution of the vitamin D receptor and 1α-hydroxylase in human brain
    • Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1α-hydroxylase in human brain. J Chem Neuroanat 2005; 29:21-30. The first report on the distribution and colocalization in human brain of vitamin D nuclear receptors and 1a-hydroxylase (the enzyme of vitamin D bioactivation). These findings support the role of the vitamin D system in human brain and imply that effective therapy of neuropsychiatric disorders can be based on targeting this system.
    • (2005) J Chem Neuroanat , vol.29 , pp. 21-30
    • Eyles, D.W.1    Smith, S.2    Kinobe, R.3
  • 16
  • 18
    • 0024517592 scopus 로고
    • 3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes
    • 3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes. Psychopharmacology 1989; 97:285-294.
    • (1989) Psychopharmacology , vol.97 , pp. 285-294
    • Stumpf, W.E.1    Privette, T.H.2
  • 19
    • 33645219855 scopus 로고    scopus 로고
    • Vitamin D as a neuroactive substance: Review
    • Kiraly SJ, Kiraly MA, Hawe RD, Makhani N. Vitamin D as a neuroactive substance: review. Sci World J 2006; 6:125-139. A comprehensive review focusing on different aspects of vitamin D action in the brain.
    • (2006) Sci World J , vol.6 , pp. 125-139
    • Kiraly, S.J.1    Kiraly, M.A.2    Hawe, R.D.3    Makhani, N.4
  • 20
    • 33845421189 scopus 로고    scopus 로고
    • Cross-talk of vitamin D and glucocorticoids in hippocampal cells
    • Obradovic D, Gronemeyer H, Lutz B, Rein T. Cross-talk of vitamin D and glucocorticoids in hippocampal cells. J Neurochem 2005; 10:1-10. An important study showing in vitro that vitamin D interplays with other hormones, such as glucocorticoids, in the hippocampal cells. Vitamin D protects against glucocorticoid-induced cell death, likely to represent an additional mechanism of vitamin D/VDR-mediated neuroprotection.
    • (2005) J Neurochem , vol.10 , pp. 1-10
    • Obradovic, D.1    Gronemeyer, H.2    Lutz, B.3    Rein, T.4
  • 21
    • 33748694457 scopus 로고    scopus 로고
    • Prenatal vitamin D deficiency and brain development
    • Stolzt VD, editor. New York: Nova Science
    • Burne THJ, McGrath JJ, Mackay-Sim A, Eyles DW. Prenatal vitamin D deficiency and brain development. In: Stolzt VD, editor. Vitamin D: new research. New York: Nova Science; 2006. pp. 113-123. An excellent review on prenatal role of vitamin D in brain development.
    • (2006) Vitamin D: New Research , pp. 113-123
    • Burne, T.H.J.1    McGrath, J.J.2    Mackay-Sim, A.3    Eyles, D.W.4
  • 23
    • 33746583990 scopus 로고    scopus 로고
    • Developmental vitamin D (DVD) deficiency in the rat alters adult behaviours independently of HPA function
    • Eyles DW, Rogers F, Buller K, et al. Developmental vitamin D (DVD) deficiency in the rat alters adult behaviours independently of HPA function. Psychoneuroendocrinology 2006; 31:958-964. An interesting report showing that hypothalamic-pituitary axis functions are normal in the maternally deficient animals, despite their pronounced behavioral alterations (hyperlocomotion). This is a clear demonstration that developmental factors strongly contribute to behavioral anomalies induced by vitamin D deficiency, suggesting that vitamin D pre/neonatal supplementation may help prevent certain developmental behavioral disorders in adults.
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 958-964
    • Eyles, D.W.1    Rogers, F.2    Buller, K.3
  • 25
    • 4644263432 scopus 로고    scopus 로고
    • 3 deprivation and the regulation of apoptosis and cell cycle during rat brain development
    • 3 deprivation and the regulation of apoptosis and cell cycle during rat brain development. Dev Brain Res 2004; 153:61-68.
    • (2004) Dev Brain Res , vol.153 , pp. 61-68
    • Ko, P.1    Burkert, R.2    McGrath, J.3    Eyles, D.4
  • 26
    • 2342558595 scopus 로고    scopus 로고
    • Schizophrenia, vitamin D, and brain development
    • Mackay-Sim A, Feron F, Eyles D, et al. Schizophrenia, vitamin D, and brain development. Int Rev Neurobiol 2004; 59:351-380.
    • (2004) Int Rev Neurobiol , vol.59 , pp. 351-380
    • Mackay-Sim, A.1    Feron, F.2    Eyles, D.3
  • 28
    • 23044460496 scopus 로고    scopus 로고
    • 3 metabolism in human glioblastoma multiforme: Functionality of CYP27B1 splice variants, metabolism of calcidiol, and effects of calcitriol
    • 3 metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effects of calcitriol. Clin Cancer Res 2005; 11:5370-5380. This study, examining vitamin D metabolism in human glioblastoma cells, shows the complexity of modes of action, including both pro- and antiproliferative dose-dependent mechanisms of vitamin D and its metabolites.
    • (2005) Clin Cancer Res , vol.11 , pp. 5370-5380
    • Diesel, B.1    Radermacher, J.2    Bureik, M.3
  • 29
    • 0642275412 scopus 로고    scopus 로고
    • Induction of apoptosis by vitamin D metabolites and analogs in a glioma cell line
    • Elias J, Marian B, Edling C, et al. Induction of apoptosis by vitamin D metabolites and analogs in a glioma cell line. Recent Results Cancer Res 2003; 164:319-321.
    • (2003) Recent Results Cancer Res , vol.164 , pp. 319-321
    • Elias, J.1    Marian, B.2    Edling, C.3
  • 30
    • 0034333364 scopus 로고    scopus 로고
    • Correlation of a unique 220-kDa protein with vitamin D sensitivity in glioma cells
    • Zou J, Landy H, Feun L, et al. Correlation of a unique 220-kDa protein with vitamin D sensitivity in glioma cells. Biochem Pharmacol 2000; 60:1361-1365.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1361-1365
    • Zou, J.1    Landy, H.2    Feun, L.3
  • 31
    • 33745460700 scopus 로고    scopus 로고
    • Hypocalcemia
    • Rose BD, editor. Welleslay: UpToDate
    • Agus ZS. Hypocalcemia. In: Rose BD, editor. UpToDate. Welleslay: UpToDate; 2004. pp. 1-24.
    • (2004) UpToDate , pp. 1-24
    • Agus, Z.S.1
  • 33
    • 2442517759 scopus 로고    scopus 로고
    • Tonic-clonic seizures in a patient with primary hypoparathyroidism: A case report
    • Armelisasso C, Vaccario ML, Pontecorvi A, Mazza A. Tonic-clonic seizures in a patient with primary hypoparathyroidism: a case report. Clin EEG Neurosci 2004; 35:97-99.
    • (2004) Clin EEG Neurosci , vol.35 , pp. 97-99
    • Armelisasso, C.1    Vaccario, M.L.2    Pontecorvi, A.3    Mazza, A.4
  • 34
    • 0016136415 scopus 로고
    • Anticonvulsant action' of vitamin D in epileptic patients? A controlled pilot study
    • Christiansen C, Rodbro P, Sjo O. 'Anticonvulsant action' of vitamin D in epileptic patients? A controlled pilot study. Br Med J 1974; 2:258-259.
    • (1974) Br Med J , vol.2 , pp. 258-259
    • Christiansen, C.1    Rodbro, P.2    Sjo, O.3
  • 35
    • 0018425373 scopus 로고
    • Antiepileptic drugs and vitamin D supplementation
    • Offermann G, Pinto V, Kruse R. Antiepileptic drugs and vitamin D supplementation. Epilepsia 1979; 20:3-15.
    • (1979) Epilepsia , vol.20 , pp. 3-15
    • Offermann, G.1    Pinto, V.2    Kruse, R.3
  • 36
    • 24044468728 scopus 로고    scopus 로고
    • Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice
    • Kalueff AV, Minasyan A, Tuohimaa P. Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice. Brain Res Bull 2005; 67:156-160.
    • (2005) Brain Res Bull , vol.67 , pp. 156-160
    • Kalueff, A.V.1    Minasyan, A.2    Tuohimaa, P.3
  • 38
    • 29744432821 scopus 로고    scopus 로고
    • Antioxidative effect of vitamin D on zinc-induced oxidative stress in CNS
    • Lin AM, Chen KB, Chao PL. Antioxidative effect of vitamin D on zinc-induced oxidative stress in CNS. Ann N Y Acad Sci 2005; 1053:319-329.
    • (2005) Ann N Y Acad Sci , vol.1053 , pp. 319-329
    • Lin, A.M.1    Chen, K.B.2    Chao, P.L.3
  • 39
    • 33744735681 scopus 로고    scopus 로고
    • Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders
    • McCarty MF. Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Med Hypotheses 2006; 67:251-269.
    • (2006) Med Hypotheses , vol.67 , pp. 251-269
    • McCarty, M.F.1
  • 40
    • 8644279704 scopus 로고    scopus 로고
    • 3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex
    • 3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex. J Chem Neuroanat 2004; 28:225-238.
    • (2004) J Chem Neuroanat , vol.28 , pp. 225-238
    • Oermann, E.1    Bidmon, H.J.2    Witte, O.W.3    Zilles, K.4
  • 41
    • 33644531284 scopus 로고    scopus 로고
    • 3 treatment does not alter neuronal cyclooxygenase-2 expression in the cerebral cortex after stroke
    • 3 treatment does not alter neuronal cyclooxygenase-2 expression in the cerebral cortex after stroke. Anat Embryol 2006; 211:129-137. This is an interesting study further confirming neuroprotective role of vitamin D and exploring in detail underlying mechanisms for such actions.
    • (2006) Anat Embryol , vol.211 , pp. 129-137
    • Oermann, E.1    Bidmon, H.J.2    Witte, O.W.3    Zilles, K.4
  • 42
    • 0026597610 scopus 로고
    • Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: Correlation with calbindin-28k mRNA levels
    • Sutherland MK, Somerville MJ, Yoong LK, et al. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. Mol Brain Res 1992; 13:239-250.
    • (1992) Mol Brain Res , vol.13 , pp. 239-250
    • Sutherland, M.K.1    Somerville, M.J.2    Yoong, L.K.3
  • 43
    • 33646373924 scopus 로고    scopus 로고
    • 3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons
    • 3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res 2006; 83:1179-1189. This study reports protective effects of chronic vitamin D treatment against glutamate neurotoxicity in cultured rat cortical neurons (accompanied by upregulation of VDRs), suggesting that long-term vitamin D supplementation may protect against glutamate toxicity in the CNS.
    • (2006) J Neurosci Res , vol.83 , pp. 1179-1189
    • Taniura, H.1    Ito, M.2    Sanada, N.3
  • 44
    • 20144376336 scopus 로고    scopus 로고
    • 3 on the seizure-induced changes in brain gene expression and immune activity in the rat
    • 3 on the seizure-induced changes in brain gene expression and immune activity in the rat. Brain Res 2005; 1039:1-13. An interesting study giving an example of biological activity of low-calcemic vitamin D analogs and outlining their potential utility in neuroprotection and immunomodulation.
    • (2005) Brain Res , vol.1039 , pp. 1-13
    • Tetich, M.1    Dziedzicka-Wasylewska, M.2    Kusmider, M.3
  • 45
    • 0036919768 scopus 로고    scopus 로고
    • 3 to suppress experimental autoimmune encephalomyelitis in mice
    • 3 to suppress experimental autoimmune encephalomyelitis in mice. Arch Biochem Biophys 2002; 408:200-204.
    • (2002) Arch Biochem Biophys , vol.408 , pp. 200-204
    • Meehan, T.F.1    DeLuca, H.F.2
  • 46
    • 23844452075 scopus 로고    scopus 로고
    • 3 reverses age-related inflammatory changes in the rat hippocampus
    • 3 acts as an anti-inflammatory agent in the hippocampus, reversing age-related activation of microglia and the accompanying increase in interleukin-1β.
    • (2005) Biochem Soc Trans , vol.33 , pp. 573-577
    • Moore, M.E.1    Piazza, A.2    McCartney, Y.3    Lynch, M.A.4
  • 47
    • 0024441381 scopus 로고
    • Symmetrical thalamic degeneration with calcifications of infancy
    • DiMario FJ, Clancy R. Symmetrical thalamic degeneration with calcifications of infancy. Am J Dis Child 1989; 143:1056-1060.
    • (1989) Am J Dis Child , vol.143 , pp. 1056-1060
    • DiMario, F.J.1    Clancy, R.2
  • 48
    • 2942522590 scopus 로고    scopus 로고
    • Idiopathic hypoparathyroidism and adhesive capsulitis of the shoulder in two first-degree relatives
    • Harzy T, Benbouazza K, Amine B, et al. Idiopathic hypoparathyroidism and adhesive capsulitis of the shoulder in two first-degree relatives. Joint Bone Spine 2004; 71:234-236.
    • (2004) Joint Bone Spine , vol.71 , pp. 234-236
    • Harzy, T.1    Benbouazza, K.2    Amine, B.3
  • 49
    • 0035297147 scopus 로고    scopus 로고
    • Bilateral striopallidodentate calcinosis: Clinical characteristics of patients seen in a registry
    • Manyam BV, Walters AS, Narla KR. Bilateral striopallidodentate calcinosis: clinical characteristics of patients seen in a registry. Mov Disord 2001; 16:258-264.
    • (2001) Mov Disord , vol.16 , pp. 258-264
    • Manyam, B.V.1    Walters, A.S.2    Narla, K.R.3
  • 50
    • 0027162716 scopus 로고
    • Familial idiopathic strio-pallido-dentate calcifications with late onset extrapyramidal syndrome
    • Martinelli P, Giuliani S, Ippoliti M, et al. Familial idiopathic strio-pallido-dentate calcifications with late onset extrapyramidal syndrome. Mov Disord 1993; 8:220-222.
    • (1993) Mov Disord , vol.8 , pp. 220-222
    • Martinelli, P.1    Giuliani, S.2    Ippoliti, M.3
  • 51
    • 0021864536 scopus 로고
    • Intracranial bilateral symmetrical calcification on CT-scanning. a case report and a review of the literature
    • Vakaet A, Rubens R, De Reuck J, Vander Eecken H. Intracranial bilateral symmetrical calcification on CT-scanning. A case report and a review of the literature. Clin Neurol Neurosurg 1985; 87:103-111.
    • (1985) Clin Neurol Neurosurg , vol.87 , pp. 103-111
    • Vakaet, A.1    Rubens, R.2    De Reuck, J.3    Vander Eecken, H.4
  • 52
    • 33745464027 scopus 로고    scopus 로고
    • Thalamic calcification in vitamin D receptor knockout mice
    • Kalueff A, Loseva E, Haapasalo H, et al. Thalamic calcification in vitamin D receptor knockout mice. Neuroreport 2006; 17:717-721. This study links VDR genetic ablation to brain calcification in mice. Insensitivity to vitamin D action due to receptor knockout may be relevant to mimicking similar brain disorders in vitamin D deficiency.
    • (2006) Neuroreport , vol.17 , pp. 717-721
    • Kalueff, A.1    Loseva, E.2    Haapasalo, H.3
  • 53
    • 33847612458 scopus 로고    scopus 로고
    • Vitamin D deficiency is associated with anxiety and depression in fibromyalgia
    • DOI: 10.1007/s10067-006-0348-5
    • Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 2006; DOI: 10.1007/s10067-006-0348-5. A particularly important recent study showing that fibromyalgia patients with vitamin D deficiency (below 25 nmol/l) have higher anxiety and depression than patients with insufficient or normal levels of vitamin D. These data strongly, although indirectly, confirm the link between vitamin D status and emotional/affective disorders.
    • (2006) Clin Rheumatol
    • Armstrong, D.J.1    Meenagh, G.K.2    Bickle, I.3
  • 54
    • 0033290687 scopus 로고    scopus 로고
    • Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder
    • Gloth FM, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging 2001; 3:5-7.
    • (2001) J Nutr Health Aging , vol.3 , pp. 5-7
    • Gloth, F.M.1    Alam, W.2    Hollis, B.3
  • 55
    • 2942592332 scopus 로고    scopus 로고
    • Increased anxiety in mice lacking vitamin D receptor gene
    • Kalueff AV, Lou YR, Laaksi I, Tuohimaa P. Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport 2004; 15:1271-1274.
    • (2004) Neuroreport , vol.15 , pp. 1271-1274
    • Kalueff, A.V.1    Lou, Y.R.2    Laaksi, I.3    Tuohimaa, P.4
  • 57
    • 33845435444 scopus 로고    scopus 로고
    • 3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients
    • 3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Am J Clin Nutr 2004; 80:1752S-1758S.
    • (2004) Am J Clin Nutr , vol.80
    • Vieth, R.1    Kimball, S.2    Hu, A.3    Walfish, P.G.4
  • 59
    • 33845423016 scopus 로고    scopus 로고
    • Atascadero: The Vitamin D Council
    • The Vitamin D Council. Understanding vitamin D: cholecalciferol [online]. Atascadero: The Vitamin D Council; 2006; http://www.vitamindcouncil.com. A useful web-resource on vitamin D, run by a group of concerned scientists who believe many humans are needlessly suffering and dying from Vitamin D deficiency. Their goal is to educate the public and professionals about vitamin D and the numerous diseases associated with its deficiency.
    • (2006) Understanding Vitamin D: Cholecalciferol [Online]
  • 60
    • 20944432796 scopus 로고    scopus 로고
    • Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases
    • Yan J, Feng J, Craddock N, et al. Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases. Neurosci Lett 2005; 380:37-41. This study examined VDR gene polymorphisms in psychiatric patients, describing novel structural variants of the receptor in some of these patients.
    • (2005) Neurosci Lett , vol.380 , pp. 37-41
    • Yan, J.1    Feng, J.2    Craddock, N.3
  • 61
    • 1642441361 scopus 로고    scopus 로고
    • Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin D-dependent rickets type IIA
    • Ozer S, Ulusahin A, Ulusoy S, et al. Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin D-dependent rickets type IIA. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28:255-266.
    • (2004) Prog Neuropsychopharmacol Biol Psychiatry , vol.28 , pp. 255-266
    • Ozer, S.1    Ulusahin, A.2    Ulusoy, S.3
  • 63
    • 20444418717 scopus 로고    scopus 로고
    • Molecules acting on receptor level at weaning, durably influence liver glucocorticoid receptors
    • Csaba G, Inczefi-Gonda A. Molecules acting on receptor level at weaning, durably influence liver glucocorticoid receptors. Acta Physiol Hung 2005; 92:33-38.
    • (2005) Acta Physiol Hung , vol.92 , pp. 33-38
    • Csaba, G.1    Inczefi-Gonda, A.2
  • 64
    • 0027303025 scopus 로고
    • 3 on metabolism and D-glucose transport in rat cerebral cortex
    • 3 on metabolism and D-glucose transport in rat cerebral cortex. J Neurochem Res 1993; 35:559-566.
    • (1993) J Neurochem Res , vol.35 , pp. 559-566
    • Stio, M.1    Lunghi, B.2    Iantomasi, T.3
  • 65
    • 33745676807 scopus 로고    scopus 로고
    • Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels: The Tromso study
    • Jorde R, Waterloo K, Saleh F, et al. Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels: the Tromso study. J Neurol 2006; 253:464-470.
    • (2006) J Neurol , vol.253 , pp. 464-470
    • Jorde, R.1    Waterloo, K.2    Saleh, F.3
  • 66
    • 0036181966 scopus 로고    scopus 로고
    • Well being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
    • Arlt W, Fremerey C, Callies F, Reincke M, et al. Well being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol 2002; 146:215-222.
    • (2002) Eur J Endocrinol , vol.146 , pp. 215-222
    • Arlt, W.1    Fremerey, C.2    Callies, F.3    Reincke, M.4
  • 67
    • 0025861194 scopus 로고
    • The steroid hormone of sunlight soltriol (vitamin D) as a seasonal regulator of biological activities and photoperiodic rhythms
    • Stumpf WE, Privette TH. The steroid hormone of sunlight soltriol (vitamin D) as a seasonal regulator of biological activities and photoperiodic rhythms. J Steroid Biochem Mol Biol 1991; 39:283-289.
    • (1991) J Steroid Biochem Mol Biol , vol.39 , pp. 283-289
    • Stumpf, W.E.1    Privette, T.H.2
  • 68
    • 21344465869 scopus 로고    scopus 로고
    • Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans
    • Kim JS, Kim YI, Song C, et al. Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans. J Korean Med Sci 2005; 20:495-498. An important study reporting an association between VDR genetic polymorphisms and Parkinsonism.
    • (2005) J Korean Med Sci , vol.20 , pp. 495-498
    • Kim, J.S.1    Kim, Y.I.2    Song, C.3
  • 69
    • 25144500069 scopus 로고    scopus 로고
    • Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population
    • Tajouri L, Ovcaric M, Curtain R, et al. Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. J Neurogenet 2005; 19:25-38. This study examined VDR gene polymorphisms in an Australian population and links genetic variation in this gene to increased risks of developing MS, particularly its progressive clinical subtypes.
    • (2005) J Neurogenet , vol.19 , pp. 25-38
    • Tajouri, L.1    Ovcaric, M.2    Curtain, R.3
  • 70
    • 0033563742 scopus 로고    scopus 로고
    • Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese
    • Fukazawa T, Yabe I, Kikuhi K, et al. Association of vitamin D receptor gene polymorphism with multiple sclerosis in Japanese. J Neurol Sci 1999; 166:47-52.
    • (1999) J Neurol Sci , vol.166 , pp. 47-52
    • Fukazawa, T.1    Yabe, I.2    Kikuhi, K.3
  • 71
    • 0034532265 scopus 로고    scopus 로고
    • Vitamin D: A natural inhibitor of multiple sclerosis
    • Hayes CE. Vitamin D: a natural inhibitor of multiple sclerosis. Proc Nutr Soc 2000; 59:531-535.
    • (2000) Proc Nutr Soc , vol.59 , pp. 531-535
    • Hayes, C.E.1
  • 72
    • 0345830740 scopus 로고    scopus 로고
    • Vitamin D intake and incidence of multiple sclerosis
    • Munger KL, Zhang SM, O'Reilly, et al. Vitamin D intake and incidence of multiple sclerosis. Neurol 2004; 62:60-65.
    • (2004) Neurol , vol.62 , pp. 60-65
    • Munger, K.L.1    Zhang, S.M.2    O'Reilly3
  • 74
    • 23944470825 scopus 로고    scopus 로고
    • 3) for relapsing-remitting multiple sclerosis
    • 3) for relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2005; 76:1294-1296. An interesting report showing that vitamin D dietary supplementation may be effective in relapsing-remitting MS.
    • (2005) J Neurol Neurosurg Psychiatry , vol.76 , pp. 1294-1296
    • Wingerchuk, D.M.1    Lesaux, L.2    Rice, G.P.A.3
  • 75
    • 33745941367 scopus 로고    scopus 로고
    • Toward prevention of Alzheimers disease - Potential nutraceutical strategies for suppressing the production of amyloid beta peptides
    • McCarty MF. Toward prevention of Alzheimers disease - potential nutraceutical strategies for suppressing the production of amyloid beta peptides. Med Hypotheses 2006; 67:682-697. An interesting review discussing various dietary factors to treat Alzheimer's disease, also noting potential importance of vitamin D status and supplementation.
    • (2006) Med Hypotheses , vol.67 , pp. 682-697
    • McCarty, M.F.1
  • 76
    • 33746253814 scopus 로고    scopus 로고
    • Experimental evidence for early nutritional programming of later health in animals
    • Symonds ME, Gardner DS. Experimental evidence for early nutritional programming of later health in animals. Curr Opin Clin Nutr Metab Care 2006; 9:278-283. A good review of animal models in clinical nutrition, particularly focusing on perinatal effects.
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , pp. 278-283
    • Symonds, M.E.1    Gardner, D.S.2
  • 77
    • 33748741283 scopus 로고    scopus 로고
    • Developmental vitamin D deficiency alters MK-801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia
    • DOI: 10.1016/j.biopsych.2006.02.033
    • Kesby JP, Burne THJ, McGrath JJ, Eyles DW. Developmental vitamin D deficiency alters MK-801-induced hyperlocomotion in the adult rat: an animal model of schizophrenia. Biol Psychiatry 2006; DOI: 10.1016/j.biopsych.2006.02. 033. An interesting study linking prenatal vitamin D deficit to spontaneous and drug-induced hyperactivity in rats. In general, these findings may be related to a wide range of behavioral disorders, in which vitamin D deficits, especially during early development, may play a causative role.
    • (2006) Biol Psychiatry
    • Kesby, J.P.1    Burne, T.H.J.2    McGrath, J.J.3    Eyles, D.W.4
  • 78
    • 2642536628 scopus 로고    scopus 로고
    • Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle
    • Burne TH, Feron F, Brown J, et al. Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startle. Physiol Behav 2004; 81:651-655.
    • (2004) Physiol Behav , vol.81 , pp. 651-655
    • Burne, T.H.1    Feron, F.2    Brown, J.3
  • 79
    • 4143074589 scopus 로고    scopus 로고
    • Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats
    • Burne TH, Becker A, Brown J, et al. Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats. Behav Brain Res 2004; 154:549-555.
    • (2004) Behav Brain Res , vol.154 , pp. 549-555
    • Burne, T.H.1    Becker, A.2    Brown, J.3
  • 80
    • 19544391458 scopus 로고    scopus 로고
    • Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats
    • Becker A, Eyles DW, McGrath JJ, Grecksch G. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav Brain Res 2005; 161:306-312. This study assessed learning and memory in adult rats exposed to transient prenatal vitamin D deficiency, showing that prenatally deplete animals had a significant impairment of latent inhibition, while deplete animals showed impaired hole-board habituation, but a better learning of brightness discrimination in a Y-chamber.
    • (2005) Behav Brain Res , vol.161 , pp. 306-312
    • Becker, A.1    Eyles, D.W.2    McGrath, J.J.3    Grecksch, G.4
  • 81
    • 27944492363 scopus 로고    scopus 로고
    • Pharmacological treatment to augment hole board habituation in prenatal vitamin D-deficient rats
    • Becker A, Grecksch G. Pharmacological treatment to augment hole board habituation in prenatal vitamin D-deficient rats. Behav Brain Res 2006; 166:177-183. An interesting study examining neurocognitive impairments in rats due to developmental vitamin D deficiency, also showing the utility of this model for detecting the effect of antipsychotic drugs and differentiating between typical and atypical antipsychotics.
    • (2006) Behav Brain Res , vol.166 , pp. 177-183
    • Becker, A.1    Grecksch, G.2
  • 83
    • 11444253492 scopus 로고    scopus 로고
    • Behavioural characterization of vitamin D receptor knockout mice
    • Burne TH, McGrath JJ, Eyles DW, Mackay-Sim A. Behavioural characterization of vitamin D receptor knockout mice. Behav Brain Res 2005; 157:299-308.
    • (2005) Behav Brain Res , vol.157 , pp. 299-308
    • Burne, T.H.1    McGrath, J.J.2    Eyles, D.W.3    Mackay-Sim, A.4
  • 84
    • 33644848969 scopus 로고    scopus 로고
    • Behavioural anomalies in mice evoked by 'Tokyo' disruption of the Vitamin D receptor gene
    • Kalueff AV, Keisala T, Minasyan A, et al. Behavioural anomalies in mice evoked by 'Tokyo' disruption of the Vitamin D receptor gene. Neurosci Res 2006; 54:254-260. Updated summary of behavioral anomalies observed in VDR knockout mice.
    • (2006) Neurosci Res , vol.54 , pp. 254-260
    • Kalueff, A.V.1    Keisala, T.2    Minasyan, A.3
  • 85
    • 31844436532 scopus 로고    scopus 로고
    • Swimming behavior and postswimming activity in vitamin D receptor knockout mice
    • Burne TH, Johnston AN, McGrath JJ, Mackay-Sim A. Swimming behavior and postswimming activity in vitamin D receptor knockout mice. Brain Res Bull 2006; 69:74-78. A detailed examination of motor functions in VDR mutant mice.
    • (2006) Brain Res Bull , vol.69 , pp. 74-78
    • Burne, T.H.1    Johnston, A.N.2    McGrath, J.J.3    Mackay-Sim, A.4
  • 87
    • 33745942786 scopus 로고    scopus 로고
    • Nutrition and aging - Practical advice for healthy eating
    • Johnson MA. Nutrition and aging - practical advice for healthy eating. J Am Med Womens Assoc 2004; 59:262-269.
    • (2004) J Am Med Womens Assoc , vol.59 , pp. 262-269
    • Johnson, M.A.1
  • 88
    • 33746234739 scopus 로고    scopus 로고
    • 2+-mediated hippocampal biomarkers of ageing
    • 2+-mediated hippocampal biomarkers of ageing. Cell Calcium 2006; 40:277-286. This study shows that 1,25-D regulates calcium-dependent processes in neurons, reducing age-related changes associated with calcium disregulation. These findings suggest that vitamin D-related compounds may have therapeutic implications in the brain during ageing.
    • (2006) Cell Calcium , vol.40 , pp. 277-286
    • Brewer, L.D.1    Porter, N.M.2    Kerr, D.S.3
  • 89
    • 33646238028 scopus 로고    scopus 로고
    • Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
    • Razzaque MS, Sitara D, Taguchi T, et al. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J 2006; 20:720-722.
    • (2006) FASEB J , vol.20 , pp. 720-722
    • Razzaque, M.S.1    Sitara, D.2    Taguchi, T.3
  • 90
    • 33746341155 scopus 로고    scopus 로고
    • Hypervitaminosis D and premature aging: Lessons learned from Fgf23 and Klotho mutant mice
    • Razzaque MS, Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med 2006; 12:298-305.
    • (2006) Trends Mol Med , vol.12 , pp. 298-305
    • Razzaque, M.S.1    Lanske, B.2
  • 91
    • 33744550350 scopus 로고    scopus 로고
    • Toward a better understanding of Klotho
    • Nabeshima Y. Toward a better understanding of Klotho. Sci Aging Knowledge Environ 2006; 8:11.
    • (2006) Sci Aging Knowledge Environ , vol.8 , pp. 11
    • Nabeshima, Y.1
  • 92
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    • Tsujikawa H, Kurotaki Y, Fujimori T, et al. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003; 17:2393-2403.
    • (2003) Mol Endocrinol , vol.17 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3
  • 93
    • 0036150953 scopus 로고    scopus 로고
    • Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene
    • Yoshida T, Fujimori T, Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 2002; 143:683-689.
    • (2002) Endocrinology , vol.143 , pp. 683-689
    • Yoshida, T.1    Fujimori, T.2    Nabeshima, Y.3
  • 94
    • 13844318061 scopus 로고    scopus 로고
    • Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
    • Li SA, Watanabe M, Yamada H, et al. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 2004; 29:91-99.
    • (2004) Cell Struct Funct , vol.29 , pp. 91-99
    • Li, S.A.1    Watanabe, M.2    Yamada, H.3
  • 95
    • 33845465132 scopus 로고    scopus 로고
    • Memphis: St Jude Children's Research Hospital
    • Brain Gene Expression Map. Mouse brain gene expression map [online]. Memphis: St Jude Children's Research Hospital; 2006. http://www.stjudebgem.org.
    • (2006) Mouse Brain Gene Expression Map [Online]
  • 96
    • 21344432144 scopus 로고    scopus 로고
    • Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells
    • Anamizu Y, Kawaguchi H, Seichi A, et al. Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells. Acta Neuropathol 2005; 109:457-466.
    • (2005) Acta Neuropathol , vol.109 , pp. 457-466
    • Anamizu, Y.1    Kawaguchi, H.2    Seichi, A.3
  • 97
    • 0037268531 scopus 로고    scopus 로고
    • Cognition impairment in the genetic model of aging klotho gene mutant mice: A role of oxidative stress
    • Nagai T, Yamada K, Kim HC, et al. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J 2003; 17:50-52.
    • (2003) FASEB J , vol.17 , pp. 50-52
    • Nagai, T.1    Yamada, K.2    Kim, H.C.3
  • 98
    • 14844313709 scopus 로고    scopus 로고
    • KLOTHO genotype and cognitive ability in childhood and old age in the same individuals
    • Deary IJ, Harris SE, Fox HC, et al. KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. Neurosci Lett 2005; 378:22-27.
    • (2005) Neurosci Lett , vol.378 , pp. 22-27
    • Deary, I.J.1    Harris, S.E.2    Fox, H.C.3
  • 101
    • 27644561555 scopus 로고
    • 3 (soltriol) levels influence serotonin levels in the hypothalamus of the rat
    • 3 (soltriol) levels influence serotonin levels in the hypothalamus of the rat. Abstr Soc Neurosci 1991; 17:498.
    • (1991) Abstr Soc Neurosci , vol.17 , pp. 498
    • Stumpf, W.E.1    Mueler, R.A.2    Hollis, B.W.3
  • 102
    • 30144432666 scopus 로고    scopus 로고
    • Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene
    • Kalueff AV, Minasyan A, Keisala T, et al. Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene. Neurosci Lett 2006; 394:69-73.
    • (2006) Neurosci Lett , vol.394 , pp. 69-73
    • Kalueff, A.V.1    Minasyan, A.2    Keisala, T.3
  • 103
    • 31544442474 scopus 로고    scopus 로고
    • The vitamin D epidemic and its health consequences
    • Holick MF. The vitamin D epidemic and its health consequences. J Nutr 2005; 135:2739S-2748S.
    • (2005) J Nutr , vol.135
    • Holick, M.F.1
  • 104
    • 0020960942 scopus 로고
    • The relationship of adequate and excessive intake of vitamin D to health and disease
    • Holmes RP, Kummerow FA. The relationship of adequate and excessive intake of vitamin D to health and disease. J Am Coll Nutr 1983; 2:173-199.
    • (1983) J Am Coll Nutr , vol.2 , pp. 173-199
    • Holmes, R.P.1    Kummerow, F.A.2
  • 105
    • 0038059244 scopus 로고    scopus 로고
    • Vitamin D in preventive medicine: Are we ignoring the evidence?
    • Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003; 89:552-555.
    • (2003) Br J Nutr , vol.89 , pp. 552-555
    • Zittermann, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.