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Volumn 18, Issue 12, 2016, Pages 1269-1280

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors

Author keywords

[No Author keywords available]

Indexed keywords

FIZZY RELATED PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EMX2; TRANSCRIPTION FACTOR FOXC1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR LHX1; TRANSCRIPTION FACTOR PAX8; TRANSCRIPTION FACTOR TFAP2B; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84994609134     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3437     Document Type: Article
Times cited : (117)

References (58)
  • 2
    • 84947241512 scopus 로고    scopus 로고
    • Nephron organoids derived from human pluripotent stem cells model kidney development and injury
    • Morizane R, et al. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat. Biotechnol. 33, 1193-1200 (2015).
    • (2015) Nat. Biotechnol , vol.33 , pp. 1193-1200
    • Morizane, R.1
  • 3
    • 84891737192 scopus 로고    scopus 로고
    • Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells
    • Taguchi A, et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53-67 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 53-67
    • Taguchi, A.1
  • 4
    • 84891298711 scopus 로고    scopus 로고
    • Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
    • Takasato M, et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat. Cell Biol. 16, 118-126 (2014).
    • (2014) Nat. Cell Biol , vol.16 , pp. 118-126
    • Takasato, M.1
  • 5
    • 84945283561 scopus 로고    scopus 로고
    • Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
    • Takasato M, et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564-568 (2015).
    • (2015) Nature , vol.526 , pp. 564-568
    • Takasato, M.1
  • 6
    • 84891281146 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells
    • Xia Y, et al. Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells. Nat. Cell Biol. 15, 1507-1515 (2013).
    • (2013) Nat. Cell Biol , vol.15 , pp. 1507-1515
    • Xia, Y.1
  • 7
    • 84933671669 scopus 로고    scopus 로고
    • Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts
    • Papadimou E, et al. Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts. Stem Cell Rep. 4, 685-698 (2015).
    • (2015) Stem Cell Rep , vol.4 , pp. 685-698
    • Papadimou, E.1
  • 8
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine
    • Knoepfler P. S. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 27, 1050-1056 (2009).
    • (2009) Stem Cells , vol.27 , pp. 1050-1056
    • Knoepfler, P.S.1
  • 9
    • 84924264526 scopus 로고    scopus 로고
    • Direct lineage reprogramming: Strategies, mechanisms, and applications
    • Xu J, Du Y, & Deng H. Direct lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell 16, 119-134 (2015).
    • (2015) Cell Stem Cell , vol.16 , pp. 119-134
    • Xu, J.1    Du, Y.2    Deng, H.3
  • 10
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen T, et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041 (2010).
    • (2010) Nature , vol.463 , pp. 1035-1041
    • Vierbuchen, T.1
  • 11
    • 84877337520 scopus 로고    scopus 로고
    • Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells
    • Najm F. J, et al. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat. Biotechnol. 31, 426-433 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 426-433
    • Najm, F.J.1
  • 12
    • 84877329018 scopus 로고    scopus 로고
    • Generation of oligodendroglial cells by direct lineage conversion
    • Yang N, et al. Generation of oligodendroglial cells by direct lineage conversion. Nat. Biotechnol. 31, 434-439 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 434-439
    • Yang, N.1
  • 13
    • 77955321344 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
    • Ieda M, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375-386 (2010).
    • (2010) Cell , vol.142 , pp. 375-386
    • Ieda, M.1
  • 14
    • 84896132644 scopus 로고    scopus 로고
    • Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming
    • Du Y, et al. Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell 14, 394-403 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 394-403
    • Du, Y.1
  • 15
    • 79960637387 scopus 로고    scopus 로고
    • Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors
    • Huang P, et al. Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 475, 386-389 (2011).
    • (2011) Nature , vol.475 , pp. 386-389
    • Huang, P.1
  • 16
    • 79960649307 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
    • Sekiya S, & Suzuki A. Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390-393 (2011).
    • (2011) Nature , vol.475 , pp. 390-393
    • Sekiya, S.1    Suzuki, A.2
  • 17
    • 84866085864 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors
    • Buganim Y, et al. Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors. Cell Stem Cell 11, 373-386 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 373-386
    • Buganim, Y.1
  • 18
    • 84884299771 scopus 로고    scopus 로고
    • Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors
    • Hendry C. E, et al. Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. J. Am. Soc. Nephrol. 24, 1424-1434 (2013).
    • (2013) J. Am. Soc. Nephrol , vol.24 , pp. 1424-1434
    • Hendry, C.E.1
  • 19
    • 84880839435 scopus 로고    scopus 로고
    • Gene-pair expression signatures reveal lineage control
    • Heinaniemi M, et al. Gene-pair expression signatures reveal lineage control. Nat. Methods 10, 577-583 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 577-583
    • Heinaniemi, M.1
  • 20
    • 84865351152 scopus 로고    scopus 로고
    • Reprogramming cell fates: Insights from combinatorial approaches
    • Pereira C. F, Lemischka I. R, & Moore K. Reprogramming cell fates: insights from combinatorial approaches. Ann. NY Acad. Sci. 1266, 7-17 (2012).
    • (2012) Ann. NY Acad. Sci , vol.1266 , pp. 7-17
    • Pereira, C.F.1    Lemischka, I.R.2    Moore, K.3
  • 21
    • 84959344588 scopus 로고    scopus 로고
    • A predictive computational framework for direct reprogramming between human cell types
    • Rackham O. J, et al. A predictive computational framework for direct reprogramming between human cell types. Nat. Genet. 48, 331-335 (2016).
    • (2016) Nat Genet , vol.48 , pp. 331-335
    • Rackham, O.J.1
  • 22
    • 84927955044 scopus 로고    scopus 로고
    • Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming genes
    • Lang A. H, Li H, Collins J. J, & Mehta P. Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming genes. PLoS Comput. Biol. 10, e1003734 (2014).
    • (2014) PLoS Comput. Biol , vol.10 , pp. e1003734
    • Lang, A.H.1    Li, H.2    Collins, J.J.3    Mehta, P.4
  • 23
    • 77649299348 scopus 로고    scopus 로고
    • An atlas of combinatorial transcriptional regulation in mouse and man
    • Ravasi T, et al. An atlas of combinatorial transcriptional regulation in mouse and man. Cell 140, 744-752 (2010).
    • (2010) Cell , vol.140 , pp. 744-752
    • Ravasi, T.1
  • 24
    • 79958171563 scopus 로고    scopus 로고
    • The gudmap database-An online resource for genitourinary research
    • Harding S. D, et al. The GUDMAP database-An online resource for genitourinary research. Development 138, 2845-2853 (2011).
    • (2011) Development , vol.138 , pp. 2845-2853
    • Harding, S.D.1
  • 25
    • 44349104804 scopus 로고    scopus 로고
    • Gudmap: The genitourinary developmental molecular anatomy project
    • McMahon A. P, et al. GUDMAP: the genitourinary developmental molecular anatomy project. J. Am. Soc. Nephrol. 19, 667-671 (2008).
    • (2008) J. Am. Soc. Nephrol , vol.19 , pp. 667-671
    • McMahon, A.P.1
  • 26
    • 84859817028 scopus 로고    scopus 로고
    • Identification of molecular compartments and genetic circuitry in the developing mammalian kidney
    • Yu J, et al. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 139, 1863-1873 (2012).
    • (2012) Development , vol.139 , pp. 1863-1873
    • Yu, J.1
  • 27
    • 0036291255 scopus 로고    scopus 로고
    • Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract
    • Shao X, Somlo S, & Igarashi P. Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J. Am. Soc. Nephrol. 13, 1837-1846 (2002).
    • (2002) J. Am. Soc. Nephrol , vol.13 , pp. 1837-1846
    • Shao, X.1    Somlo, S.2    Igarashi, P.3
  • 28
    • 84880849098 scopus 로고    scopus 로고
    • Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons
    • Liu M. L, et al. Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat. Commun. 4, 2183 (2013).
    • (2013) Nat. Commun , vol.4 , pp. 2183
    • Liu, M.L.1
  • 29
    • 84908574127 scopus 로고    scopus 로고
    • Small molecules facilitate rapid and synchronous iPSC generation
    • Bar-Nur O, et al. Small molecules facilitate rapid and synchronous iPSC generation. Nat. Methods 11, 1170-1176 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 1170-1176
    • Bar-Nur, O.1
  • 30
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • Huangfu D, et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26, 795-797 (2008).
    • (2008) Nat. Biotechnol , vol.26 , pp. 795-797
    • Huangfu, D.1
  • 31
    • 84896142695 scopus 로고    scopus 로고
    • Direct reprogramming of human fibroblasts to functional and expandable hepatocytes
    • Huang P, et al. Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. Cell Stem Cell 14, 370-384 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 370-384
    • Huang, P.1
  • 32
    • 0018288981 scopus 로고
    • Hemicyst formation stimulated by cyclic AMP in dog kidney cell line MDCK
    • Valentich J. D, Tchao R, & Leighton J. Hemicyst formation stimulated by cyclic AMP in dog kidney cell line MDCK. J. Cell. Physiol. 100, 291-304 (1979).
    • (1979) J. Cell. Physiol , vol.100 , pp. 291-304
    • Valentich, J.D.1    Tchao, R.2    Leighton, J.3
  • 33
    • 84908446782 scopus 로고    scopus 로고
    • CellNet: Network biology applied to stem cell engineering
    • Cahan P, et al. CellNet: network biology applied to stem cell engineering. Cell 158, 903-915 (2014).
    • (2014) Cell , vol.158 , pp. 903-915
    • Cahan, P.1
  • 34
    • 80052978224 scopus 로고    scopus 로고
    • Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
    • Cabili M. N, et al. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 25, 1915-1927 (2011).
    • (2011) Genes Dev , vol.25 , pp. 1915-1927
    • Cabili, M.N.1
  • 35
    • 84864462544 scopus 로고    scopus 로고
    • A map of the cis-regulatory sequences in the mouse genome
    • Shen Y, et al. A map of the cis-regulatory sequences in the mouse genome. Nature 488 116-120 (2012).
    • (2012) Nature , vol.488 , pp. 116-120
    • Shen, Y.1
  • 36
    • 84866361701 scopus 로고    scopus 로고
    • Circuitry and dynamics of human transcription factor regulatory networks
    • Neph S, et al. Circuitry and dynamics of human transcription factor regulatory networks. Cell 150, 1274-1286 (2012).
    • (2012) Cell , vol.150 , pp. 1274-1286
    • Neph, S.1
  • 37
    • 73549112180 scopus 로고    scopus 로고
    • Salt, nac, kc-Atpase and hypertension
    • Jaitovich A, & Bertorello A. M. Salt, NaC, KC-ATPase and hypertension. Life Sci. 86, 73-78 (2010).
    • (2010) Life Sci , vol.86 , pp. 73-78
    • Jaitovich, A.1    Bertorello, A.M.2
  • 38
    • 84942794172 scopus 로고    scopus 로고
    • Deep sequencing in microdissected renal tubules identifies nephron segment-specific transcriptomes
    • Lee J. W, Chou C. L, & Knepper M. A. Deep sequencing in microdissected renal tubules identifies nephron segment-specific transcriptomes. J. Am. Soc. Nephrol. 26, 2669-2677 (2015).
    • (2015) J. Am. Soc. Nephrol , vol.26 , pp. 2669-2677
    • Lee, J.W.1    Chou, C.L.2    Knepper, M.A.3
  • 39
    • 0029908225 scopus 로고    scopus 로고
    • Megalin/gp330 mediates uptake of albumin in renal proximal tubule
    • Cui S, Verroust P. J, Moestrup S. K, & Christensen E. I. Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am. J. Physiol. 271, F900-F907 (1996).
    • (1996) Am. J. Physiol , vol.271 , pp. F900-F907
    • Cui, S.1    Verroust, P.J.2    Moestrup, S.K.3    Christensen, E.I.4
  • 40
    • 77952160766 scopus 로고    scopus 로고
    • Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    • Vaidya V. S, et al. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat. Biotechnol. 28, 478-485 (2010).
    • (2010) Nat. Biotechnol , vol.28 , pp. 478-485
    • Vaidya, V.S.1
  • 41
    • 28244486151 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2
    • Ciarimboli G, et al. Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am. J. Pathol. 167, 1477-1484 (2005).
    • (2005) Am. J. Pathol , vol.167 , pp. 1477-1484
    • Ciarimboli, G.1
  • 42
    • 27744602975 scopus 로고    scopus 로고
    • Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat
    • Yonezawa A, et al. Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat. Biochem. Pharmacol. 70, 1823-1831 (2005).
    • (2005) Biochem. Pharmacol , vol.70 , pp. 1823-1831
    • Yonezawa, A.1
  • 43
    • 76749153829 scopus 로고    scopus 로고
    • Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues
    • Unbekandt M, & Davies J. A. Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues. Kidney Int. 77, 407-416 (2010).
    • (2010) Kidney Int , vol.77 , pp. 407-416
    • Unbekandt, M.1    Davies, J.A.2
  • 44
    • 84877624830 scopus 로고    scopus 로고
    • Regeneration and experimental orthotopic transplantation of a bioengineered kidney
    • Song J. J, et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat. Med. 19, 646-651 (2013).
    • (2013) Nat. Med , vol.19 , pp. 646-651
    • Song, J.J.1
  • 45
    • 84928116338 scopus 로고    scopus 로고
    • Ex vivo analysis of renal proximal tubular cells
    • Legouis D, et al. Ex vivo analysis of renal proximal tubular cells. BMC Cell Biol. 16, 12 (2015).
    • (2015) BMC Cell Biol , vol.16 , pp. 12
    • Legouis, D.1
  • 46
    • 84908431264 scopus 로고    scopus 로고
    • Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors
    • Nam Y. J, et al. Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors. Development 141, 4267-4278 (2014).
    • (2014) Development , vol.141 , pp. 4267-4278
    • Nam, Y.J.1
  • 47
    • 49449096588 scopus 로고    scopus 로고
    • A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
    • Wernig M, et al. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol. 26, 916-924 (2008).
    • (2008) Nat Biotechnol , vol.26 , pp. 916-924
    • Wernig, M.1
  • 48
    • 78650558594 scopus 로고    scopus 로고
    • Inversin relays Frizzled-8 signals to promote proximal pronephros development
    • Lienkamp S, et al. Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proc. Natl Acad. Sci. USA 107, 20388-20393 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20388-20393
    • Lienkamp, S.1
  • 50
    • 84941639441 scopus 로고    scopus 로고
    • 3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders
    • Giles R. H, Ajzenberg H, & Jackson P. K. 3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders. Nat. Protoc. 9, 2725-2731 (2014).
    • (2014) Nat. Protoc , vol.9 , pp. 2725-2731
    • Giles, R.H.1    Ajzenberg, H.2    Jackson, P.K.3
  • 52
    • 84973094812 scopus 로고    scopus 로고
    • The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update
    • Afgan E, et al. The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update. Nucleic Acids Res. 44, W3-W10 (2016).
    • (2016) Nucleic Acids Res , vol.44 , pp. W3-W10
    • Afgan, E.1
  • 53
    • 64749107970 scopus 로고    scopus 로고
    • Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors
    • Kutner R. H, Zhang X. Y, & Reiser J. Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors. Nat. Protoc. 4, 495-505 (2009).
    • (2009) Nat. Protoc , vol.4 , pp. 495-505
    • Kutner, R.H.1    Zhang, X.Y.2    Reiser, J.3
  • 54
    • 84999547971 scopus 로고    scopus 로고
    • Direct reprogramming of mouse embryonic fibroblasts into renal tubular epithelial cells (iRECs
    • Kaminski M. M, et al. Direct reprogramming of mouse embryonic fibroblasts into renal tubular epithelial cells (iRECs). Nat. Protoc. Exch. http://dx.doi.org/10.1038/protex.2016.70 (2016).
    • (2016) Nat. Protoc. Exch
    • Kaminski, M.M.1
  • 55
    • 84908209313 scopus 로고    scopus 로고
    • The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells
    • Xia Y, et al. The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. Nat. Protoc. 9, 2693-2704 (2014).
    • (2014) Nat. Protoc , vol.9 , pp. 2693-2704
    • Xia, Y.1
  • 56
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: A software environment for integrated models of biomolecular interaction networks
    • Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498-2504 (2003).
    • (2003) Genome Res , vol.13 , pp. 2498-2504
    • Shannon, P.1
  • 57
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang D. W, Sherman B. T, & Lempicki R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57 (2009).
    • (2009) Nat. Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 58
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-Time PCR data by the comparative C(T) method
    • Schmittgen T. D, & Livak K. J. Analyzing real-Time PCR data by the comparative C(T) method. Nat. Protoc. 3, 1101-1108 (2008).
    • (2008) Nat. Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2


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