Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

Nature Biotechnology

Volumn 28, Issue 5, 2010, Pages 478-485

  Vaidya, Vishal S ^a   Ozer, Josef S ^b,f   Dieterle, Frank ^c   Collings, Fitz B ^a   Ramirez, Victoria ^a   Troth, Sean ^b   Muniappa, Nagaraja ^b   Thudium, Douglas ^b   Gerhold, David ^b   Holder, Daniel J ^b   Bobadilla, Norma A ^d   Marrer, Estelle ^c   Perentes, Elias ^c   Cordier, André ^c   Vonderscher, Jacky ^c   Maurer, Gérard ^c   Goering, Peter L ^e   Sistare, Frank D ^b   Bonventre, Joseph V ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^e CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURATE PREDICTION; ANIMAL SYSTEMS; BLOOD UREA; DIAGNOSTIC PERFORMANCE; DRUG CANDIDATES; GOLD STANDARDS; KIDNEY DYSFUNCTION; NEPHROTOXICITY; PATIENT MORBIDITY; RAT MODEL; RENAL INJURY; SENSITIVITY AND SPECIFICITY; TRANSMEMBRANES;

BIOMARKERS; UREA;

TOXICITY;

KIDNEY INJURY MOLECULE 1; N ACETYL BETA GLUCOSAMINIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE EXPRESSION; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; KIDNEY INJURY; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UREA NITROGEN BLOOD LEVEL;

ACETYLGLUCOSAMINIDASE; ANIMALS; BIOMARKERS, PHARMACOLOGICAL; BLOOD UREA NITROGEN; CELL ADHESION MOLECULES; CISPLATIN; CREATININE; CYCLOSPORINE; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; GENTAMICINS; HISTOCYTOCHEMISTRY; KIDNEY; KIDNEY FUNCTION TESTS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; REPERFUSION INJURY; ROC CURVE; THIOACETAMIDE;

ANIMALIA; RATTUS;

EID: 77952160766     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1623     Document Type: Article

References (30)

1. Chertow, G.M., Burdick, E., Honour, M., Bonventre, J.V. & Bates, D.W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 16, 3365-3370 (2005). (Pubitemid 46179340)
2. Choudhury, D. & Ziauddin, A. Drug-associated renal dysfunction and injury. Nat. Clin. Pract. Nephrol. 2, 80-91 (2006). (Pubitemid 43355216)
3. Vaidya, V.S., Ramirez, V., Ichimura, T., Bobadilla, N.A. & Bonventre, J.V. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am. J. Physiol. Renal Physiol. 290, F517-F529 (2006). (Pubitemid 43725006)
4. Liangos, O. et al. Urinary N-acetyl-beta-(d)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J. Am. Soc. Nephrol. 18, 904-912 (2007). (Pubitemid 46434507)
5. Vaidya, V.S. et al. Urinary biomarkers for sensitive and specifc detection of acute kidney injury in humans. Clin. Transl. Sci. 1, 200-208 (2008). (Pubitemid 352831522)
6. Emeigh Hart, S.G. Assessment of renal injury in vivo. J. Pharmacol. Toxicol. Methods 52, 30-45 (2005).
7. Price, R.G. The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity. Clin. Nephrol. 38 Suppl 1, S14-S19 (1992).
8. Bonventre, J.V., Vaidya, V.S., Schmouder, R., Feig, P. & Dieterle, F. Next-generation biomarkers for detecting kidney toxicity. Nat. Biotechnol. 28, 436-440 (2010).
9. Ichimura, T. et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 273, 4135-4142 (1998). (Pubitemid 28103282)
10. Ichimura, T. et al. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J. Clin. Invest. 118, 1657-1668 (2008). (Pubitemid 351632370)
11. Amin, R.P. et al. Identifcation of putative gene based markers of renal toxicity. Environ. Health Perspect. 112, 465-479 (2004).
12. Bailly, V. et al. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J. Biol. Chem. 277, 39739-39748 (2002). (Pubitemid 35190957)
13. Prozialeck, W.C. et al. Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int. 72, 985-993 (2007).
14. Zhou, Y. et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol. Sci. 101, 159-170 (2008). (Pubitemid 350239020)
15. Han, W.K., Bailly, V., Abichandani, R., Thadhani, R. & Bonventre, J.V. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 62, 237-244 (2002). (Pubitemid 34754067)
16. van Timmeren, M.M. et al. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation 84, 1625-1630 (2007).
17. Perez-Rojas, J. et al. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am. J. Physiol. Renal Physiol. 292, F131-F139 (2007). (Pubitemid 46105252)
18. Ichimura, T., Hung, C.C., Yang, S.A., Stevens, J.L. & Bonventre, J.V. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am. J. Physiol. Renal Physiol. 286, F552-F563 (2004). (Pubitemid 38233650)
19. van Timmeren, M.M. et al. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am. J. Physiol. Renal Physiol. 291, F456-F464 (2006). (Pubitemid 44148135)
20. Carson, R.T. & Vignali, D.A. Simultaneous quantitation of 15 cytokines using a multiplexed fow cytometric assay. J. Immunol. Methods 227, 41-52 (1999).
21. Mattes, W.B. & Walker, E.G. Translational toxicology and the work of the predictive safety testing consortium. Clin. Pharmacol. Ther. 85, 327-330 (2009).
22. Sistare, F.D. et al. Towards consensus practices to qualify safety biomarkers for use in early drug development. Nat. Biotechnol. 28, 446-454 (2010).
23. Barker, E.A. & Smuckler, E.A. Nonhepatic thioacetamide injury. II. The morphologic features of proximal renal tubular injury. Am. J. Pathol. 74, 575-590 (1974).
24. Harrell, F.E. Regression Modeling Strategies, edn. 1. (Springer, New York; 2001).
25. Nagelkerke, N.J. A note on a general defnition of the coeffcient of determination. Biometrika 78, 691-692 (1991).
26. Pencina, M.J., D'Agostino, R.B. Sr., D'Agostino, R.B. Jr. & Vasan, R.S. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassifcation and beyond. Stat. Med. 27, 157-172 (2008).
27. Zhang, P.L. et al. Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int. 73, 608-614 (2008).
28. Vaidya, V.S. et al. A rapid urine test for early detection of kidney injury. Kidney Int. 76, 108-114 (2009).
29. Sing, T., Sander, O., Beerenwinkel, N. & Lengauer, T. ROCR: visualizing classifer performance in R. Bioinformatics 21, 3940-3941 (2005).
30. Hanley, J.A. & McNeil, B.J. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 148, 839-843 (1983).