Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat

Biochemical Pharmacology

Volumn 70, Issue 12, 2005, Pages 1823-1831

  Yonezawa, Atsushi ^a   Masuda, Satohiro ^a   Nishihara, Kumiko ^a   Yano, Ikuko ^a   Katsura, Toshiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cisplatin; Cytotoxicity; Nephrotoxicity; Organic cation transporter 2; Pharmacokinetics; Renal tubular epithelial cells

Indexed keywords

CIMETIDINE; CISPLATIN; CORTICOSTERONE; LACTATE DEHYDROGENASE; N ACETYL BETA GLUCOSAMINIDASE; ORGANIC CATION TRANSPORTER; PLATINUM; PROTEIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; CASTRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG CLEARANCE; DRUG TRANSPORT; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME RELEASE; EPITHELIUM CELL; FEMALE; GENETIC TRANSFECTION; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; KIDNEY TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EPITHELIUM; LIVER FUNCTION; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; URINE VOLUME;

ANIMALS; CATECHOLAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; CISPLATIN; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, WISTAR; SEX FACTORS; TETRAETHYLAMMONIUM COMPOUNDS;

EID: 27744602975     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.09.020     Document Type: Article

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