Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol

Journal of Applied Biomedicine

Volumn 12, Issue 4, 2014, Pages 193-202

  Iriti, Marcello ^a   Varoni, Elena M ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Coronary heart disease; De alcoholized wine; Melatonin; Phytosterols; Polyphenols; Spirits

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; POLYPHENOL;

ALCOHOL CONSUMPTION; ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CELL ACTIVATION; CHRONOBIOLOGY; DIASTOLIC BLOOD PRESSURE; DRUG STRUCTURE; ENDOTHELIUM CELL; ENVIRONMENTAL HEALTH; FOOD INTAKE; GENETIC VARIABILITY; HEALTH PROMOTION; HEART ATRIUM FIBRILLATION; HEART PROTECTION; HUMAN; HYPERTENSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RED WINE; REVIEW; RISK REDUCTION; THROMBOCYTE VOLUME; WHITE WINE;

VITACEAE;

EID: 84994607803     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.1016/j.jab.2014.09.003     Document Type: Review

References (56)

1. Arriola, L., Martinez-Camblor, P., Larrañaga, N., Basterretxea, M., Amiano, P., Moreno-Iribas, C., Dorronsoro, M., 2010. Alcohol intake and the risk of coronary heart disease in the Spanish EPIC cohort study. Heart 96, 124-130.
2. Barbero-Becerra, V.J., López-Velázquez, J.A., Sánchez-Valle, V., Uribe, M., Měndez-Sánchez, N., 2011. Alcohol effects on liver diseases: good or bad buddy? Ann. Hepatol. 11, 944-948.
3. Berger, J., 2011. The age of biomedicine: current trends in traditional subjects. J. Appl. Biomed. 9, 57-61.
4. Brien, S.E., Ronksley, P.E., Turner, B.J., Mukamal, K.J., Ghali, W.A., 2011. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ 342, d636.
5. Cesena, F.H.Y., Coimbra, S.R., Andrade, A.C.M., da Luz, P.L., 2011. The relationship between body mass index and the variation in plasma levels of triglycerides after short-term red wine consumption. J. Clin. Lipidol. 5, 4-8.
6. Chiva-Blanch, G., Urpi-Sarda, M., Llorach, R., Rotches-Ribalta, M., Guillěn, M., Casas, R., Arranz, S., Valderas-Martinez, P., Portoles, O., Corella, D., Tinahones, F., Lamuela-Raventos, R. M., Andres-Lacueva, C., Estruch, R., 2012a. Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. Am. J. Clin. Nutr. 95, 326-334.
7. Chiva-Blanch, G., Urpi-Sarda, M., Ros, E., Arranz, S., Valderas-Martínez, P., Casas, R., Sacanella, E., Llorach, R., Lamuela-Raventos, R.M., Andres-Lacueva, C., Estruch, R., 2012b. Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide short communication. Circ. Res. 111, 1065-1068.
8. Chiva-Blanch, G., Urpi-Sarda, M., Ros, E., Valderas-Martinez, P., Casas, R., Arranz, S., Guillěn, M., Lamuela-Raventos, R.M., Llorach, R., Andres-Lacueva, C., Estruch, R., 2013a. Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial. Clin. Nutr. 32, 200-206.
9. Chiva-Blanch, G., Arranz, S., Lamuela-Raventos, R.M., Estruch, R., 2013b. Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: evidences from human studies. Alcohol Alcohol. 48, 270-277.
10. Cicero, A., Borghi, C., 2013. Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals. Curr. Hypertens. Rep. 15, 260-267.
11. Costanzo, S., Di Castelnuovo, A., Donati, M.B., Iacoviello, L., de Gaetano, G., 2010. Alcohol consumption and mortality in patents with cardiovascular disease. J. Am. Coll. Cardiol. 55, 1339-1347.
12. Costanzo, S., Di Castelnuovo, A., Donati, M.B., Iacoviello, L., de Gaetano, G., 2011. Wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events: meta-analysis. Eur. J. Epidemiol. 11, 833-850.
13. Covas, M.I., Gambert, P., Fitó, M., de la Torre, R., 2010. Wine and oxidative stress: up-to-date evidence of the effects of moderate wine consumption on oxidative damage in humans. Atherosclerosis 208, 297-304.
14. Dhankhar, J., 2013. Cardioprotective effects of phytosterols. Int. J. Pharm. Sci. Res. 4, 590-596.
15. Di Castelnuovo, A., Rotondo, S., Iacoviello, L., Donati, M.B., de Gaetano, G., 2002. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation 105, 2836-2844.
16. Di Castelnuovo, A., Costanzo, S., Bagnardi, V., Donati, M.B., Iacoviello, L., de Gaetano, G., 2006. Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch. Intern. Med. 166, 2437-2445.
17. Djoussě, L., Lee, I.M., Buring, J.E., Gaziano, J.M., 2009. Alcohol consumption and risk of cardiovascular disease and death in women-potential mediating mechanisms. Circulation 120, 237-244.
18. Drogan, D., Sheldrick, A.J., Schutze, M., Knuppel, S., Andersohn, F., di Giuseppe, R., Herrmann, B., Willich, S.N., Garbe, E., Bergmann, M.M., Boering, H., Weikert, C., 2012. Alcohol consumption, genetic variants in alcohol deydrogenases, and risk of cardiovascular diseases: a prospective study and meta-analysis. PLoS ONE 7, e32176.
19. Edenberg, H.J., 2007. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health 30, 5-13.
20. Estruch, R., Sacanella, E., Badia, E., Antúnez, E., Nicolás, J.M., Fernández-Solá, J., Rotilio, D., de Gaetano, G., Rubin, E., Urbano-Marquez, A., 2004. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial: effects of wine on inflammatory markers. Atherosclerosis 175, 117-123.
21. Estruch, R., Sacanella, E., Mota, F., Chiva-Blanch, G., Antúnez, E., Casals, E., Deulofeu, R., Rotilio, D., Andres-Lacueva, C., Lamuela-Raventos, R.M., de Gaetano, G., Urbano-Marquez, A., 2011. Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial. Nutr. Metab. Cardiovasc. Dis. 21, 46-53.
22. Favero, G., Rodella, L., Reiter, R., Rezzani, R., 2013. Melatonin and its atheroprotective effects: a review. Mol. Cell. Endocrinol. 382, 926-937.
23. Grossman, E., Laudon, M., Zisapel, N., 2011. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc. Health Risk Manage. 7, 577-584.
24. Hansel, B., Thomas, F., Pannier, B., Bean, K., Kontush, A., Chapman, M.J., Guize, L., Bruckert, E., 2010. Relationship between alcohol intake, health and social status and cardiovascular risk factors in the urban Paris-Ile-De-France Cohort: is the cardioprotective action of alcohol a myth? Eur. J. Clin. Nutr. 64, 561-568.
25. Hansel, B., Kontush, A., Bruckert, E., 2012. Is a cardioprotective action of alcohol a myth? Curr. Opin. Cardiol. 27, 550-555.
26. Holmes, M., Zuccolo, L., Silverwood, R., Guo, Y., Ye, Z., Prieto-Merino, D., et al., 2014. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ 349, g4164.
27. Howie, E.K., Sui, X., Lee, D.C., Hooker, S.P., Hěbert, J.R., Blair, S.N., 2011. Alcohol consumption and risk of all-cause and cardiovascular disease mortality in men. J. Aging Res. ID: 805062.
28. Iriti, M., Faoro, F., 2009. Bioactivity of grape chemicals for human health. Nat. Prod. Commun. 4, 1-24.
29. Iriti, M., Vitalini, S., 2012. Health-promoting effects of traditional Mediterranean diets. Pol. J. Food Nutr. Sci. 62, 71-76.
30. Kato, N., Takeuchi, F., Tabara, Y., Kelly, T.N., Go, M.J., Sim, X., et al., 2011. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in East Asians. Nat. Genet. 43, 531-538.
31. Lawlor, D.A., Nordestgaard, B.G., Benn, M., Zuccolo, L., Tybjaerg-Hansen, A., Davey Smith, G., 2013. Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study. Eur. Heart J. 34, 2519-2528.
32. Leger, A.S., Cochrane, A.L., Moore, F., 1979. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 313, 1017-1020.
33. Li, H., Förstermann, U., 2012. Red wine and cardiovascular health. Circ. Res. 111, 959-961.
34. Marangoni, F., Poli, A., 2010. Phytosterols mad cardiovascular health. Pharmacol. Res. 61, 193-199.
35. Natella, F., Ghiselli, A., Guidi, A., Ursini, F., Scaccini, C., 2001. Red wine mitigates the postprandial increase of LDL susceptibility to oxidation. Free Radic. Biol. Med. 30, 1036-1044.
36. Noguer, M.A., Cerezo, A.B., Navarro, E.D., Garcia-Parrilla, M., 2012. Intake of alcohol-free red wine modulates antioxidant enzyme activities in a human intervention study. Pharmacol. Res. 65, 609-614.
37. Okubo, Y., Suwazono, Y., Kobayashi, E., Nogava, K., 2001. Alcohol consumption and blood pressure change: 5-year follow-up study of the association in normotensive workers. J. Hum. Hypertens. 15, 367-372.
38. Onat, A., Hergenç, G., Kucukdurmaz, Z., Ugur, M., Kaya, Z., Can, G., 2009. Moderate and heavy alcohol consumption among Turks: long-term impact on mortality and cardiometabolic risk. Turk. Kardiyol. Dern. Ars. 37, 83-90.
39. Perissinotto, E., Buja, A., Maggi, S., Enzi, G., Manzato, E., Scafato, E., Mastrangelo, G., Frigo, A.C., Coin, A., Crepaldi, G., Sergi, G., 2010. Alcohol consumption and cardiovascular risk factors in older lifelong wine drinkers: the Italian Longitudinal Study on Aging. Nutr. Metab. Cardiovasc. Dis. 20, 647-655.
40. Queipo-Ortuño, M.I., Boto-Ordóñez, M., Murri, M., Gomez-Zumaquero, J.M., Clemente-Postigo, M., Estruch, R., Cardona Diaz, F., Anděs-Lacueva, C., Tinahones, F.J., 2012. Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. Am. J. Clin. Nutr. 95, 1323-1334.
41. Quertemont, E., Didone, V., 2006. Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol. Alcohol Res. Health 29, 258-265.
42. Retterstol, L., Berger, K.E., Braaten, Ø., Eikvar, L., Pedersen, T.R., Sandvik, L., 2005. A daily glass of red wine: does it affect markers of inflammation? Alcohol Alcohol. 40, 102-105.
43. Rifler, J.P., Lorcerie, F., Durand, P., Delmas, D., Ragot, K., Limagne, E., Mazuě, F., Riedinger, J.-M., d'Athis, P., Hudelot, B., Prost, M., Lizard, G., Latruffe, N., 2012. A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients. Mol. Nutr. Food Res. 56, 345-351.
44. Rodella, L.F., Favero, G., Foglio, E., Rossini, C., Castrezzati, S., Lonati, C., Rezzani, R., 2013. Vascular endothelial cells and dysfunctions: role of melatonin. Front. Biosci. 5, 119-129.
45. Ronksley, P.E., Brien, S.E., Turner, B.J., Mukamal, K.J., Ghali, W.A., 2011. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ 342, d671.
46. Ruggiero, A., Vitalini, S., Burlini, N., Bernasconi, S., Iriti, M., 2013. Phytosterols in grapes and wine, and effects of agrochemicals on their levels. Food Chem. 141, 3473-3479.
47. Sacanella, E., Vázquez-Agell, M., Mena, M.P., Antúnez, E., Fernández-Solá, J., Nicolás, J.M., Lamuela-Raventos, R.M., Ros, E., Estruch, R., 2007. Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial. Am. J. Clin. Nutr. 86, 1463-1469.
48. Stockley, C.S., 2012. Is it merely a myth that alcoholic beverages such as red wine can be cardioprotective? J. Sci. Food Agric. 92, 1815-1821.
49. Stranges, S., Wu, T., Dorn, J.M., Freudenheim, J.L., Muti, P., Farinaro, E., Russell, M., Nochajski, T.H., Trevisan, M., 2004. Relationship of alcohol drinking pattern to risk of hypertension: a population-based study. Hypertension 44, 813-819.
50. Taylor, B., Irving, H.M., Baliunas, D., Roerecke, M., Patra, J., Mohapatra, S., Rehm, J., 2009. Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis. Addiction 104, 1981-1990.
51. Tozzi Ciancarelli, M.G., Di Massimo, C., De Amicis, D., Ciancarelli, I., Carolei, A., 2011. Moderate consumption of red wine and human platelet responsiveness. Thromb. Res. 128, 124-129.
52. Trichopoulou, A., Bamia, C., Trichopoulos, D., 2009. Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. BMJ 338, b2337.
53. Urquiaga, I., Strobel, P., Perez, D., Martinez, C., Cuevas, A., Castillo, O., Marshall, G., Rozowski, J., Leighton, F., 2010. Mediterranean diet and red wine protect against oxidative damage in young volunteers. Atherosclerosis 211, 694-699.
54. Varoni, E.M., Vitalini, S., Contino, D., Lodi, G., Simonetti, P., Carrassi, A., Sardella, A., Iriti, M., 2013. Effects of red wine intake on human salivary antiradical capacity and total polyphenol content. Food Chem. Toxicol. 58, 289-294.
55. Vitalini, S., Gardana, C., Simonetti, P., Fico, G., Iriti, M., 2013. Melatonin, melatonin isomers and stilbenes in Italian traditional grape products and their antiradical capacity. J. Pineal Res. 54, 322-333.
56. Yokoyama, A., Yokoyama, T., Mizukami, T., Matsui, T., Kimura, M., Matsushita, S., Higuchi, S., Maruyama, K., 2014. Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes. Alcohol Alcohol. 49, 31-37.