Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol

Alcohol Research and Health

Volumn 29, Issue 4, 2006, Pages 258-265

  Quertemont, Etienne ^a   Didone, Vincent ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Acetaldehyde; Alcohol dehydrogenase (ADH); Alcohol flush reaction; Alcohol metabolite; Aldehyde dehydrogenases (ALDHs); Brain; Catalase; Central nervous system; Ethanol metabolism; Ethanol to acetaldehyde metabolism; Protective factors

Indexed keywords

ACETALDEHYDE; ALCOHOL; CATALASE;

ADDICTION; BEHAVIOR; BRAIN; DRINKING BEHAVIOR; DRUG EFFECT; HUMAN; METABOLISM; PSYCHOLOGICAL ASPECT; REVIEW;

ACETALDEHYDE; ALCOHOL DRINKING; BEHAVIOR; BEHAVIOR, ADDICTIVE; BRAIN; CATALASE; ETHANOL; HUMANS;

EID: 34347266946     PISSN: 0090838X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. ARAGON, C.M.G., AND AMIT, Z. The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: Evidence for brain catalase involvement in the mechanism of action. Neuropharmacology 31:709-712, 1992.
2. ARAGON, C.M.G.; PESOLD, C.N.; AND AMIT, Z. Ethanol-induced motor activity in normal and acatalasemic mice. Alcohol 9:207-211, 1992.
3. ARIZZI-LAFRANCE, M.N.; CORREA, M.; ARAGON, C.M.G.; AND SALAMONE, J.D. Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: Importance of catalase-mediated metabolism and the role of acetaldehyde. Neuropsychopharmacology 31:997-1008, 2006.
4. BELLUZZI, J.D.; WANG, R.; AND LESLIE, F.M. Acetaldehyde enhances acquisition of nicotine self-administration in adolescent rats. Neuropsychopharmacology 30:705-712, 2005.
5. BROWN, Z.W.; AMIT, Z.; AND ROCKMAN, G.E. Intraventricular self-administration of acetaldehyde, but not ethanol, in naïe laboratory rats. Psychopharmacology 64:271-276, 1979.
6. CORREA, M.; PASCUAL, M.; SANCHIS-S EGURA, C.; ET AL. Lead-induced catalase activity differentially modulates behaviors induced by short-chain alcohols. Pharmacology Biochemistry and Behavior 82:443-452, 2005.
7. DEITRICH, R.A. Acetaldehyde: Deja vu du jour. Journal of Studies on Alcohol 65:557-572, 2004.
8. ERIKSSON, C.J.P. The role of acetaldehyde in the actions of alcohol (update 2000). Alcoholism: Clinical and Experimental Research 25(Suppl. 5): 15S-32S, 2001.
9. ESCARABAJAL, D.; MIQUEL, M.; AND ARAGON, C.M.G. A psychopharmacological study of the relationship between brain catalase activity and ethanol-induced locomotor activity in mice. Journal of Studies on Alcohol 61:493-498, 2000.
10. FODDAI, M.; DOSIA, G.; SPIGA, S.; AND DIANA, M. Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 29:530-536, 2004.
11. FREEMAN, T.L.; TUMA, D.J.; THIELE, G.M.; ET AL. Recent advances in alcohol-induced adduct formation. Alcoholism: Clinical and Experimental Research 29:1310-1316, 2005.
12. HE, X.X.; NEBERT, D.W.; VASILIOU, V.; ET AL. Genetic differences in alcohol drinking preference between inbred strains of mice. Pharmacogenetics 7:223-233, 1997.
13. ISSE, T.; OYAMA, T.; MATSUNO, K.; ET AL. Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality. Journal of Toxicological Sciences 30:315-328, 2005.
14. QUERTEMONT, E. Genetic polymorphism in ethanol metabolism: Acetaldehyde contribution to alcohol abuse and alcoholism. Molecular Psychiatry 9:570-581, 2004.
15. QUERTEMONT, E., AND TAMBOUR, S. Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol. Trends in Pharmacological Sciences 25:130-134, 2004.
16. QUERTEMONT, E.; TAMBOUR, S.; BERNAERTS, P.; ET AL. Behavioral characterization of acetaldehyde in C57BL/6J mice: Locomotor, hypnotic, anxiolytic and amnesic effects. Psychopharmacology 177:84-92, 2004.
17. QUERTEMONT, E.; TAMBOUR, S.; AND TIRELLI, E. The role of acetaldehyde in the neurobehavioral effects of ethanol: A comprehensive review of animal studies. Progress in Neurobiology 75:247-274, 2005.
18. RASKIN, N.H. Alcoholism or acetaldehydism? The New England Journal of Medicine 292:422-423, 1975.
19. RODD-HENRICKS, Z.A.; MELENDEZ, R.I.; ZAFFARONI, A.; ET AL. The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacology Biochemistry and Behavior 72:55-64, 2002.
20. SMITH, B.R.; ARAGON, C.M.G.; AND AMIT, Z. Catalase and the production of brain acetaldehyde: A possible mediator of the psychopharmacological effects of ethanol. Addiction Biology 2:277-289, 1997.
21. TAMBOUR, S.; DIDONE, V.; TIRELLI, E.; AND QUERTEMONT, E. Dissociation between the locomotor and anxiolytic effects of acetaldehyde in the elevated plus-maze: Evidence that acetaldehyde is not involved in the anxiolytic effects of ethanol in mice. European Neuropsychopharmacology 15:655-662, 2005.
22. ZIMATKIN, S.M., AND DEITRICH, R.A. Ethanol metabolism in the brain. Addiction Biology 2:387-399, 1997.
23. ZIMATKIN, S.M., AND LINDROS, K.O. Distribution of catalase in rat brain: Aminergic neurons as possible targets for ethanol effects. Alcohol and Alcoholism 31:167-174, 1996.
24. ZIMATKIN, S.M.; PRONKO, S.P.; VASILIOU, V.; ET AL. Enzymatic mechanisms of ethanol oxidation in the brain. Alcoholism: Clinical and Experimental Research 30:1500-1505, 2006.