Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

BMJ (Online)

Volumn 349, Issue , 2014, Pages

  Holmes, Michael V ^a,b,c   Dale, Caroline E ^d   Zuccolo, Luisa ^e   Silverwood, Richard J ^d   Guo, Yiran ^f,g   Ye, Zheng ^h   Prieto Merino, David ^d   Dehghan, Abbas ⁱ   Trompet, Stella ^j   Wong, Andrew ^a   Cavadino, Alana ^k   Drogan, Dagmar ^l   Padmanabhan, Sandosh ^m   Li, Shanshan ⁿ   Yesupriya, Ajay ^o   Leusink, Maarten ^p   Sundstrom, Johan ^q   Hubacek, Jaroslav A ^r   Pikhart, Hynek ^a   Swerdlow, Daniel I ^a   Panayiotou, Andrie G ^s   Borinskaya, Svetlana A ^t   Finan, Chris ^a   Shah, Sonia ^a   Kuchenbaecker, Karoline B ^u   Shah, Tina ^a   Engmann, Jorgen ^a   Folkersen, Lasse ^v   Eriksson, Per ^v   Ricceri, Fulvio ^x   Melander, Olle ^w   Sacerdote, Carlotta ^x   Gamble, Dale M ^y   Rayaprolu, Sruti ^y   Ross, Owen A ^y   McLachlan, Stela ^z   Vikhireva, Olga ^a   Sluijs, Ivonne ^aa   Scott, Robert A ^h   Adamkova, Vera ^r   Flicker, Leon ^ab   Van Bockxmeer, Frank M ^ac   Power, Christine ^k   Marques Vidal, Pedro ^ad   Meade, Tom ^d   Marmot, Michael G ^a   Ferro, Jose M ^ae,af   Paulos Pinheiro, Sofia ^ag,ah   Humphries, Steve E ^a   Talmud, Philippa J ^a   Leach, Irene Mateo ^ai   Verweij, Niek ^ai   Linneberg, Allan ^aj   Skaaby, Tea ^aj   Doevendans, Pieter A ^aa   Cramer, Maarten J ^aa   Van Der Harst, Pim ^ai,ak   Klungel, Olaf H ^p   Dowling, Nicole F ^o   Dominiczak, Anna F ^m   Kumari, Meena ^a   Nicolaides, Andrew N ^al,am,an   Weikert, Cornelia ^l   Boeing, Heiner ^l   Ebrahim, Shah ^d   Gaunt, Tom R ^e   Price, Jackie F ^z   Lannfelt, Lars ^ao   Peasey, Anne ^a   Kubinova, Ruzena ^ap   Pajak, Andrzej ^aq   Malyutina, Sofia ^ar,as   Voevoda, Mikhail I ^ar,at   Tamosiunas, Abdonas ^au   Maitland van Der Zee, Anke H ^p   Norman, Paul E ^ac   Hankey, Graeme J ^av,aw   Bergmann, Manuela M ^l   Hofman, Albert ⁱ   Franco, Oscar H ⁱ   Cooper, Jackie ^a   Palmen, Jutta ^a   Spiering, Wilko ^aa   De Jong, Pim A ^aa   Kuh, Diana ^a   Hardy, Rebecca ^a   Uitterlinden, Andre G ⁱ   Ikram, M Arfan ⁱ   Ford, Ian ^ax   Hyppönen, Elina ^k,ay,az   Almeida, Osvaldo P ^ab,ac,ba   Wareham, Nicholas J ^h   Khaw, Kay Tee ^u   Hamsten, Anders ^v,bb   Husemoen, Lise Lotte N ^aj   Tjønneland, Anne ^bc   Tolstrup, Janne S ^bd   Rimm, Eric ^n,be   Beulens, Joline W J ^aa   Verschuren, W M Monique ^bf   Onland Moret, N Charlotte ^aa   Hofker, Marten H ^ai   Wannamethee, S Goya ^a   Whincup, Peter H ^bg   Morris, Richard ^a   Vicente, Astrid M ^ag,bh,bi   Watkins, Hugh ^bj,bk   Farrall, Martin ^bj,bk   Jukema, J Wouter ^j   Meschia, James ^y   Cupples, L Adrienne ^bl,bm   Sharp, Stephen J ^h   Fornage, Myriam ^bn   Kooperberg, Charles ^bo   LaCroix, Andrea Z ^bo   Dai, James Y ^bo   Lanktree, Matthew B ^bp   Siscovick, David S ^bq   Jorgenson, Eric ^br   Spring, Bonnie ^bs   Coresh, Josef ^bt   Li, Yun R ^f   Buxbaum, Sarah G ^bu   Schreiner, Pamela J ^bv   Ellison, R Curtis ^bw   Tsai, Michael Y ^bx   Patel, Sanjay R ^by,ce   Redline, Susan ^by   Johnson, Andrew D ^bm   Hoogeveen, Ron C ^bz   Hakonarson, Hakon ^f   Rotter, Jerome I ^ca   Boerwinkle, Eric ^cb   De Bakker, Paul I W ^aa   Kivimaki, Mika ^a   Asselbergs, Folkert W ^a,aa,ak   Sattar, Naveed ^cc   Lawlor, Debbie A ^e   Whittaker, John ^d,cd   Smith, George Davey ^e   Mukamal, Kenneth ^ce   Psaty, Bruce M ^ce,cf,cg   Wilson, James G ^ch   Lange, Leslie A ^ci   Hamidovic, Ajna ^cj   Nordestgaard, Børge G ^a,ck,cl,cm   Bobak, Martin ^a   Leon, David A ^d   Langenberg, Claudia ^h   Palmer, Tom M ^cn   Reiner, Alex P ^bo   Keating, Brendan J ^b,f   Dudbridge, Frank ^d   Casas, Juan P ^a,d   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^g BGI SHENZHEN   (China)

^h INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

ⁱ ERASMUS MEDICAL CENTER   (Netherlands)

^j LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^k UNIVERSITY COLLEGE LONDON   (United Kingdom)

^l GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^m UNIVERSITY OF GLASGOW   (United Kingdom)

ⁿ HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^o CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^p UTRECHT UNIVERSITY   (Netherlands)

^q UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^r INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^s CYPRUS UNIVERSITY OF TECHNOLOGY   (Cyprus)

^t VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

^u UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^v KAROLINSKA INSTITUTE   (Sweden)

^w LUND UNIVERSITY   (Sweden)

^x MOLINETTE HOSPITAL   (Italy)

^y MAYO CLINIC   (United States)

^z UNIVERSITY OF EDINBURGH   (United Kingdom)

^aa UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^ab UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ac UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ad LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^ae INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^af HOSPITAL DE SANTA MARIA   (Portugal)

^ag NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^ah UNIVERSITY OF LISBON   (Portugal)

^ai UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^aj GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^ak ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^al Vascular Screening and Diagnostic Centre Nicosia   (Cyprus)

^am IMPERIAL COLLEGE LONDON   (United Kingdom)

^an Cyprus Cardiovascular Disease Educational and Research Trust   (Cyprus)

^ao UPPSALA UNIVERSITY   (Sweden)

^ap NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^aq JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^ar INSTITUTE OF PHYSIOLOGY   (Russian Federation)

^as NOVOSIBIRSK STATE MEDICAL UNIVERSITY   (Russian Federation)

^at NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

^au LITHUANIAN UNIVERSITY OF HEALTH SCIENCES   (Lithuania)

^av SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^aw UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ax UNIVERSITY OF GLASGOW   (United Kingdom)

^ay UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^az SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^ba ROYAL PERTH HOSPITAL   (Australia)

^bb KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^bc DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^bd UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^be HARVARD MEDICAL SCHOOL   (United States)

^bf NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^bg ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^bh School of Medicine and Pharmacology University of Western Australia ^*  (Portugal)

^bi UNIVERSITY OF LISBON   (Portugal)

^bj UNIVERSITY OF OXFORD   (United Kingdom)

^bk UNIVERSITY OF OXFORD   (United Kingdom)

^bl BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^bm FRAMINGHAM HEART STUDY   (United States)

^bn UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^bo Fred Hutchinson Cancer Research Center   (United States)

^bp MCMASTER UNIVERSITY   (Canada)

^bq NEW YORK ACADEMY OF MEDICINE   (United States)

^br DIVISION OF RESEARCH   (United States)

^bs NORTHWESTERN UNIVERSITY   (United States)

^bt JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^bu JACKSON STATE UNIVERSITY   (United States)

^bv UNIVERSITY OF MINNESOTA   (United States)

^bw BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bx UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^by BRIGHAM AND WOMEN S HOSPITAL   (United States)

^bz BAYLOR COLLEGE OF MEDICINE   (United States)

^ca Los Angeles Biomedical Research Institute   (United States)

^cb UNIVERSITY OF TEXAS   (United States)

^cc UNIVERSITY OF GLASGOW   (United Kingdom)

^cd GLAXOSMITHKLINE   (United Kingdom)

^ce BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^cf UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^cg GROUP HEALTH RESEARCH INSTITUTE   (United States)

^ch UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^ci UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^cj UNIVERSITY OF NEW MEXICO   (United States)

^ck GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^cl UNIVERSITY OF COPENHAGEN   (Denmark)

^cm School of Health Sciences Jackson State University ^*  (Denmark)

^cn UNIVERSITY OF WARWICK   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; UNCLASSIFIED DRUG;

ADULT; AGED; ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOL DEHYDROGENASE 1B GENE; ARTICLE; BINGE DRINKING; BODY MASS; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; DRINKING BEHAVIOR; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; ISCHEMIC HEART DISEASE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MOLECULAR PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; RISK REDUCTION; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE;

ADULT; AGED; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; BIOLOGICAL MARKERS; CORONARY DISEASE; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; MODELS, STATISTICAL; POLYMORPHISM, SINGLE NUCLEOTIDE; STROKE;

EID: 84904064886     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.g4164     Document Type: Article

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