Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

Journal of Clinical Investigation

Volumn 126, Issue 11, 2016, Pages 4076-4087

  Wei, Liang ^a   Leibowitz, Brian J ^a   Xinwei, Wang ^a   Epperly, Michael ^a   Greenberger, Joel ^a   Lin, Zhang ^a   Jian, Yu ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PALBOCICLIB; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; APOPTOSIS REGULATORY PROTEIN; CDK4 PROTEIN, MOUSE; CDK6 PROTEIN, MOUSE; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, MOUSE; PIPERAZINE DERIVATIVE; PUMA PROTEIN, MOUSE; PYRIDINE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA END JOINING REPAIR; DNA REPLICATION; INTESTINAL STEM CELL; INTESTINE CRYPT; INTESTINE INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION INJURY; RADIATION PROTECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INTESTINAL DISEASES; KNOCKOUT MOUSE; PATHOLOGY; RADIATION INJURIES, EXPERIMENTAL; STEM CELL;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; INTESTINAL DISEASES; MICE; MICE, KNOCKOUT; PIPERAZINES; PYRIDINES; RADIATION INJURIES, EXPERIMENTAL; RECEPTORS, G-PROTEIN-COUPLED; STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84994589401     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI88410     Document Type: Article

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