-
1
-
-
84857918033
-
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
-
Agyeman AS, Chaerkady R, Shaw PG, Davidson NE, Visvanathan K, Pandey A, Kensler TW (2012) Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Res Treat 132: 175-187.
-
(2012)
Breast Cancer Res Treat
, vol.132
, pp. 175-187
-
-
Agyeman, A.S.1
Chaerkady, R.2
Shaw, P.G.3
Davidson, N.E.4
Visvanathan, K.5
Pandey, A.6
Kensler, T.W.7
-
3
-
-
84941956168
-
NRF2 pathway activation and adjuvant chemotherapy benefit in lung squamous cell carcinoma
-
Cescon DW, She D, Sakashita S, Zhu CQ, Pintilie M, Shepherd FA, Tsao MS (2015) NRF2 pathway activation and adjuvant chemotherapy benefit in lung squamous cell carcinoma. Clin Cancer Res 21: 2499-2505.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 2499-2505
-
-
Cescon, D.W.1
She, D.2
Sakashita, S.3
Zhu, C.Q.4
Pintilie, M.5
Shepherd, F.A.6
Tsao, M.S.7
-
4
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
CGARN
-
CGARN (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489: 519-525.
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
5
-
-
70349991888
-
Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells
-
Chien CW, Ho IC, Lee TC (2009) Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cells. Carcinogenesis 30: 1813-1820.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1813-1820
-
-
Chien, C.W.1
Ho, I.C.2
Lee, T.C.3
-
6
-
-
4644249735
-
Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase
-
Deng HB, Adikari M, Parekh HK, Simpkins H (2004) Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase. Cancer Chemother Pharmacol 54: 301-307.
-
(2004)
Cancer Chemother Pharmacol
, vol.54
, pp. 301-307
-
-
Deng, H.B.1
Adikari, M.2
Parekh, H.K.3
Simpkins, H.4
-
7
-
-
79960060305
-
Oncogeneinduced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
Denicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA (2011) Oncogeneinduced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475: 106-109.
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
Denicola, G.M.1
Karreth, F.A.2
Humpton, T.J.3
Gopinathan, A.4
Wei, C.5
Frese, K.6
Mangal, D.7
Yu, K.H.8
Yeo, C.J.9
Calhoun, E.S.10
Scrimieri, F.11
Winter, J.M.12
Hruban, R.H.13
Iacobuzio-Donahue, C.14
Kern, S.E.15
Blair, I.A.16
Tuveson, D.A.17
-
8
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99: 11908-11913.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
9
-
-
67349089549
-
Kinetic studies of AKR1B10, human aldose reductase-like protein: Endogenous substrates and inhibition by steroids
-
Endo S, Matsunaga T, Mamiya H, Ohta C, Soda M, Kitade Y, Tajima K, Zhao HT, El-Kabbani O, Hara A (2009) Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids. Arch Biochem Biophys 487: 1-9.
-
(2009)
Arch Biochem Biophys
, vol.487
, pp. 1-9
-
-
Endo, S.1
Matsunaga, T.2
Mamiya, H.3
Ohta, C.4
Soda, M.5
Kitade, Y.6
Tajima, K.7
Zhao, H.T.8
El-Kabbani, O.9
Hara, A.10
-
10
-
-
20144387888
-
Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' nonsmall cell lung carcinomas
-
Fukumoto S, Yamauchi N, Moriguchi H, Hippo Y, Watanabe A, Shibahara J, Taniguchi H, Ishikawa S, Ito H, Yamamoto S, Iwanari H, Hironaka M, Ishikawa Y, Niki T, Sohara Y, Kodama T, Nishimura M, Fukayama M, Dosaka-Akita H, Aburatani H (2005) Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' nonsmall cell lung carcinomas. Clin Cancer Res 11: 1776-1785.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1776-1785
-
-
Fukumoto, S.1
Yamauchi, N.2
Moriguchi, H.3
Hippo, Y.4
Watanabe, A.5
Shibahara, J.6
Taniguchi, H.7
Ishikawa, S.8
Ito, H.9
Yamamoto, S.10
Iwanari, H.11
Hironaka, M.12
Ishikawa, Y.13
Niki, T.14
Sohara, Y.15
Kodama, T.16
Nishimura, M.17
Fukayama, M.18
Dosaka-Akita, H.19
Aburatani, H.20
more..
-
11
-
-
84893876085
-
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination
-
Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB (2014) Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res 74: 808-817.
-
(2014)
Cancer Res
, vol.74
, pp. 808-817
-
-
Hast, B.E.1
Cloer, E.W.2
Goldfarb, D.3
Li, H.4
Siesser, P.F.5
Yan, F.6
Walter, V.7
Zheng, N.8
Hayes, D.N.9
Major, M.B.10
-
12
-
-
63549121490
-
NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
-
Hayes JD, McMahon M (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34: 176-188.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
14
-
-
34247270839
-
Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: Highly potent anti-inflammatory and cytoprotective agents
-
Honda T, Sundararajan C, Yoshizawa H, Su X, Honda Y, Liby KT, Sporn MB, Gribble GW (2007) Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents. J Med Chem 50: 1731-1734.
-
(2007)
J Med Chem
, vol.50
, pp. 1731-1734
-
-
Honda, T.1
Sundararajan, C.2
Yoshizawa, H.3
Su, X.4
Honda, Y.5
Liby, K.T.6
Sporn, M.B.7
Gribble, G.W.8
-
15
-
-
27644465419
-
Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization
-
Inamura K, Fujiwara T, Hoshida Y, Isagawa T, Jones MH, Virtanen C, Shimane M, Satoh Y, Okumura S, Nakagawa K, Tsuchiya E, Ishikawa S, Aburatani H, Nomura H, Ishikawa Y (2005) Two subclasses of lung squamous cell carcinoma with different gene expression profiles and prognosis identified by hierarchical clustering and non-negative matrix factorization. Oncogene 24: 7105-7113.
-
(2005)
Oncogene
, vol.24
, pp. 7105-7113
-
-
Inamura, K.1
Fujiwara, T.2
Hoshida, Y.3
Isagawa, T.4
Jones, M.H.5
Virtanen, C.6
Shimane, M.7
Satoh, Y.8
Okumura, S.9
Nakagawa, K.10
Tsuchiya, E.11
Ishikawa, S.12
Aburatani, H.13
Nomura, H.14
Ishikawa, Y.15
-
16
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236: 313-322.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
17
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
18
-
-
33847021147
-
Aldo-keto reductases and bioactivation/ detoxication
-
Jin Y, Penning TM (2007) Aldo-keto reductases and bioactivation/ detoxication. Annu Rev Pharmacol Toxicol 47: 263-292.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 263-292
-
-
Jin, Y.1
Penning, T.M.2
-
19
-
-
84873443918
-
Identification of aldo-keto reductases as NRF2-target marker genes in human cells
-
Jung KA, Choi BH, Nam CW, Song M, Kim ST, Lee JY, Kwak MK (2013) Identification of aldo-keto reductases as NRF2-target marker genes in human cells. Toxicol Lett 218: 39-49.
-
(2013)
Toxicol Lett
, vol.218
, pp. 39-49
-
-
Jung, K.A.1
Choi, B.H.2
Nam, C.W.3
Song, M.4
Kim, S.T.5
Lee, J.Y.6
Kwak, M.K.7
-
20
-
-
76749106638
-
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
-
KimYR, Oh JE, KimMS, Kang MR, Park SW, Han JY, EomHS, YooNJ, Lee SH (2010) Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 220: 446-451.
-
(2010)
J Pathol
, vol.220
, pp. 446-451
-
-
Kim, Y.R.1
Oh, J.E.2
Kim, M.S.3
Kang, M.R.4
Park, S.W.5
Han, J.Y.6
Eom, H.S.7
Yoo, N.J.8
Lee, S.H.9
-
21
-
-
58149343905
-
Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expression
-
Lee ES, Son DS, Kim SH, Lee J, Jo J, Han J, Kim H, Lee HJ, Choi HY, Jung Y, Park M, Lim YS, Kim K, Shim Y, Kim BC, Lee K, Huh N, Ko C, Park K, Lee JW, Choi YS, Kim J (2008) Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expression. Clin Cancer Res 14: 7397-7404.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7397-7404
-
-
Lee, E.S.1
Son, D.S.2
Kim, S.H.3
Lee, J.4
Jo, J.5
Han, J.6
Kim, H.7
Lee, H.J.8
Choi, H.Y.9
Jung, Y.10
Park, M.11
Lim, Y.S.12
Kim, K.13
Shim, Y.14
Kim, B.C.15
Lee, K.16
Huh, N.17
Ko, C.18
Park, K.19
Lee, J.W.20
Choi, Y.S.21
Kim, J.22
more..
-
22
-
-
84933506443
-
Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2
-
Li D, Ma S, Ellis EM (2015) Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2. Chem Biol Interact 234: 366-371.
-
(2015)
Chem Biol Interact
, vol.234
, pp. 366-371
-
-
Li, D.1
Ma, S.2
Ellis, E.M.3
-
23
-
-
84886726161
-
Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10)
-
Li H, Yang AL, Chung YT, Zhang W, Liao J, Yang GY (2013) Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10). Carcinogenesis 34: 2090-2098.
-
(2013)
Carcinogenesis
, vol.34
, pp. 2090-2098
-
-
Li, H.1
Yang, A.L.2
Chung, Y.T.3
Zhang, W.4
Liao, J.5
Yang, G.Y.6
-
24
-
-
53049090607
-
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
-
Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB (2008) A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer Res 68: 6727-6733.
-
(2008)
Cancer Res
, vol.68
, pp. 6727-6733
-
-
Liby, K.1
Yore, M.M.2
Roebuck, B.D.3
Baumgartner, K.J.4
Honda, T.5
Sundararajan, C.6
Yoshizawa, H.7
Gribble, G.W.8
Williams, C.R.9
Risingsong, R.10
Royce, D.B.11
Dinkova-Kostova, A.T.12
Stephenson, K.K.13
Egner, P.A.14
Yates, M.S.15
Groopman, J.D.16
Kensler, T.W.17
Sporn, M.B.18
-
25
-
-
33645893202
-
Induction of AKR1C2 by phase II inducers: Identification of a distal consensus antioxidant response element regulated by NRF2
-
Lou H, Du S, Ji Q, Stolz A (2006) Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2. Mol Pharmacol 69: 1662-1672.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1662-1672
-
-
Lou, H.1
Du, S.2
Ji, Q.3
Stolz, A.4
-
26
-
-
70249138697
-
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: Demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
-
MacLeod AK, McMahon M, Plummer SM, Higgins LG, Penning TM, Igarashi K, Hayes JD (2009) Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis 30: 1571-1580.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1571-1580
-
-
MacLeod, A.K.1
McMahon, M.2
Plummer, S.M.3
Higgins, L.G.4
Penning, T.M.5
Igarashi, K.6
Hayes, J.D.7
-
27
-
-
77957237159
-
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
-
Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, WassermanWW, Biswal S (2010) Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res 38: 5718-5734.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5718-5734
-
-
Malhotra, D.1
Portales-Casamar, E.2
Singh, A.3
Srivastava, S.4
Arenillas, D.5
Happel, C.6
Shyr, C.7
Wakabayashi, N.8
Kensler, T.W.9
Wasserman, W.W.10
Biswal, S.11
-
28
-
-
84885524071
-
Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer
-
Martinez VD, Vucic EA, Pikor LA, Thu KL, Hubaux R, Lam WL (2013) Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Mol Cancer 12: 124.
-
(2013)
Mol Cancer
, vol.12
, pp. 124
-
-
Martinez, V.D.1
Vucic, E.A.2
Pikor, L.A.3
Thu, K.L.4
Hubaux, R.5
Lam, W.L.6
-
29
-
-
84913580308
-
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents
-
McMahon M, Campbell KH, MacLeod AK, McLaughlin LA, Henderson CJ, Wolf CR (2014) HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents. PLoS One 9: e114055.
-
(2014)
PLoS One
, vol.9
, pp. e114055
-
-
McMahon, M.1
Campbell, K.H.2
MacLeod, A.K.3
McLaughlin, L.A.4
Henderson, C.J.5
Wolf, C.R.6
-
30
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon M, Itoh K, Yamamoto M, Hayes JD (2003) Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278: 21592-21600.
-
(2003)
J Biol Chem
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
31
-
-
79957558400
-
Regulation of aldo-keto reductase AKR1B10 gene expression: Involvement of transcription factor Nrf2
-
Nishinaka T, Miura T, Okumura M, Nakao F, Nakamura H, Terada T (2011) Regulation of aldo-keto reductase AKR1B10 gene expression: Involvement of transcription factor Nrf2. Chem Biol Interact 191: 185-191.
-
(2011)
Chem Biol Interact
, vol.191
, pp. 185-191
-
-
Nishinaka, T.1
Miura, T.2
Okumura, M.3
Nakao, F.4
Nakamura, H.5
Terada, T.6
-
32
-
-
80054772589
-
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
-
Ooi A, Wong JC, Petillo D, Roossien D, Perrier-Trudova V, Whitten D, Min BW, Tan MH, Zhang Z, Yang XJ, Zhou M, Gardie B, Molinie V, Richard S, Tan PH, Teh BT, Furge KA (2011) An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 20: 511-523.
-
(2011)
Cancer Cell
, vol.20
, pp. 511-523
-
-
Ooi, A.1
Wong, J.C.2
Petillo, D.3
Roossien, D.4
Perrier-Trudova, V.5
Whitten, D.6
Min, B.W.7
Tan, M.H.8
Zhang, Z.9
Yang, X.J.10
Zhou, M.11
Gardie, B.12
Molinie, V.13
Richard, S.14
Tan, P.H.15
Teh, B.T.16
Furge, K.A.17
-
33
-
-
0037025386
-
Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells
-
Palackal NT, Lee SH, Harvey RG, Blair IA, Penning TM (2002) Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells. J Biol Chem 277: 24799-24808.
-
(2002)
J Biol Chem
, vol.277
, pp. 24799-24808
-
-
Palackal, N.T.1
Lee, S.H.2
Harvey, R.G.3
Blair, I.A.4
Penning, T.M.5
-
34
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler TW (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98: 3410-3415.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
35
-
-
84888134099
-
An improved synthesis of a hydroxymethyl tricyclic ketone from cyclohexanone, the key processes for the synthesis of a highly potent anti-inflammatory and cytoprotective agent
-
Saito A, Zheng S, Takahashi M, Li W, Ojima I, Honda T (2013) An improved synthesis of a hydroxymethyl tricyclic ketone from cyclohexanone, the key processes for the synthesis of a highly potent anti-inflammatory and cytoprotective agent. Synthesis (Mass) 45: 3251-3254.
-
(2013)
Synthesis (Mass)
, vol.45
, pp. 3251-3254
-
-
Saito, A.1
Zheng, S.2
Takahashi, M.3
Li, W.4
Ojima, I.5
Honda, T.6
-
36
-
-
84880048347
-
Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis
-
Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M (2013) Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis. Cancer Res 73: 4158-4168.
-
(2013)
Cancer Res
, vol.73
, pp. 4158-4168
-
-
Satoh, H.1
Moriguchi, T.2
Takai, J.3
Ebina, M.4
Yamamoto, M.5
-
37
-
-
53049105119
-
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
-
(e14)
-
Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S (2008) Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 135: 1358-1368, (e1-4).
-
(2008)
Gastroenterology
, vol.135
, pp. 1358-1368
-
-
Shibata, T.1
Kokubu, A.2
Gotoh, M.3
Ojima, H.4
Ohta, T.5
Yamamoto, M.6
Hirohashi, S.7
-
38
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S (2008) Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci USA 105: 13568-13573.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
Kokubu, A.4
Odogawa, R.5
Tsuta, K.6
Asamura, H.7
Yamamoto, M.8
Hirohashi, S.9
-
39
-
-
54249087596
-
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
-
Singh A, Boldin-Adamsky S, Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, Biswal S (2008) RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res 68: 7975-7984.
-
(2008)
Cancer Res
, vol.68
, pp. 7975-7984
-
-
Singh, A.1
Boldin-Adamsky, S.2
Thimmulappa, R.K.3
Rath, S.K.4
Ashush, H.5
Coulter, J.6
Blackford, A.7
Goodman, S.N.8
Bunz, F.9
Watson, W.H.10
Gabrielson, E.11
Feinstein, E.12
Biswal, S.13
-
40
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S (2006) Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 3: e420.
-
(2006)
PLoS Med
, vol.3
, pp. e420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
Herman, J.G.7
Baylin, S.B.8
Sidransky, D.9
Gabrielson, E.10
Brock, M.V.11
Biswal, S.12
-
41
-
-
78649668597
-
Retinoids, retinoic acid receptors, and cancer
-
Tang XH, Gudas LJ (2011) Retinoids, retinoic acid receptors, and cancer. Annu Rev Pathol 6: 345-364.
-
(2011)
Annu Rev Pathol
, vol.6
, pp. 345-364
-
-
Tang, X.H.1
Gudas, L.J.2
-
42
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62: 5196-5203.
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
43
-
-
84883743438
-
MIR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells
-
van Jaarsveld MT, Helleman J, Boersma AW, van Kuijk PF, van Ijcken WF, Despierre E, Vergote I, Mathijssen RH, Berns EM, Verweij J, Pothof J, Wiemer EA (2013) miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. Oncogene 32: 4284-4293.
-
(2013)
Oncogene
, vol.32
, pp. 4284-4293
-
-
Van Jaarsveld, M.T.1
Helleman, J.2
Boersma, A.W.3
Van Kuijk, P.F.4
Van Ijcken, W.F.5
Despierre, E.6
Vergote, I.7
Mathijssen, R.H.8
Berns, E.M.9
Verweij, J.10
Pothof, J.11
Wiemer, E.A.12
-
44
-
-
33749055937
-
Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers
-
Woenckhaus M, Klein-Hitpass L, Grepmeier U, Merk J, Pfeifer M, Wild P, Bettstetter M, Wuensch P, Blaszyk H, Hartmann A, Hofstaedter F, Dietmaier W (2006) Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers. J Pathol 210: 192-204.
-
(2006)
J Pathol
, vol.210
, pp. 192-204
-
-
Woenckhaus, M.1
Klein-Hitpass, L.2
Grepmeier, U.3
Merk, J.4
Pfeifer, M.5
Wild, P.6
Bettstetter, M.7
Wuensch, P.8
Blaszyk, H.9
Hartmann, A.10
Hofstaedter, F.11
Dietmaier, W.12
-
45
-
-
84862786878
-
Somatic mutations of the KEAP1 gene in common solid cancers
-
Yoo NJ, Kim HR, Kim YR, An CH, Lee SH (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60: 943-952.
-
(2012)
Histopathology
, vol.60
, pp. 943-952
-
-
Yoo, N.J.1
Kim, H.R.2
Kim, Y.R.3
An, C.H.4
Lee, S.H.5
-
46
-
-
59049088289
-
Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers
-
Zhang L, Lee JJ, Tang H, Fan YH, Xiao L, Ren H, Kurie J, Morice RC, Hong WK, Mao L (2008) Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers. Cancer Prev Res (Phila) 1: 112-118.
-
(2008)
Cancer Prev Res (Phila)
, vol.1
, pp. 112-118
-
-
Zhang, L.1
Lee, J.J.2
Tang, H.3
Fan, Y.H.4
Xiao, L.5
Ren, H.6
Kurie, J.7
Morice, R.C.8
Hong, W.K.9
Mao, L.10
-
47
-
-
76649089973
-
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
-
Zhang P, Singh A, Yegnasubramanian S, Esopi D, Kombairaju P, Bodas M, Wu H, Bova SG, Biswal S (2010) Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol Cancer Ther 9: 336-346.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 336-346
-
-
Zhang, P.1
Singh, A.2
Yegnasubramanian, S.3
Esopi, D.4
Kombairaju, P.5
Bodas, M.6
Wu, H.7
Bova, S.G.8
Biswal, S.9
-
48
-
-
78649680251
-
Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer
-
Zhu CQ, Ding K, Strumpf D, Weir BA, Meyerson M, Pennell N, Thomas RK, Naoki K, Ladd-Acosta C, Liu N, Pintilie M, Der S, Seymour L, Jurisica I, Shepherd FA, Tsao MS (2010) Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer. J Clin Oncol 28: 4417-4424.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4417-4424
-
-
Zhu, C.Q.1
Ding, K.2
Strumpf, D.3
Weir, B.A.4
Meyerson, M.5
Pennell, N.6
Thomas, R.K.7
Naoki, K.8
Ladd-Acosta, C.9
Liu, N.10
Pintilie, M.11
Der, S.12
Seymour, L.13
Jurisica, I.14
Shepherd, F.A.15
Tsao, M.S.16
-
49
-
-
84901761987
-
TCGA-assembler: Open-source software for retrieving and processing TCGA data
-
Zhu Y, Qiu P, Ji Y (2014) TCGA-assembler: open-source software for retrieving and processing TCGA data. Nat Methods 11: 599-600.
-
(2014)
Nat Methods
, vol.11
, pp. 599-600
-
-
Zhu, Y.1
Qiu, P.2
Ji, Y.3
|