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Volumn 74, Issue 3, 2014, Pages 808-817

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINE, TUMOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MUTATION; NEOPLASMS; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEOLYSIS; UBIQUITINATION;

EID: 84893876085     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-1655     Document Type: Article
Times cited : (108)

References (44)
  • 1
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012;489:519-25.
    • (2012) Nature , vol.489 , pp. 519-525
  • 2
    • 11144264663 scopus 로고    scopus 로고
    • BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
    • Furukawa M, Xiong Y. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 2005;25:162-71.
    • (2005) Mol Cell Biol , vol.25 , pp. 162-171
    • Furukawa, M.1    Xiong, Y.2
  • 3
    • 33344463325 scopus 로고    scopus 로고
    • Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
    • Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol 2006;26:2887-900.
    • (2006) Mol Cell Biol , vol.26 , pp. 2887-2900
    • Tong, K.I.1    Katoh, Y.2    Kusunoki, H.3    Itoh, K.4    Tanaka, T.5    Yamamoto, M.6
  • 4
    • 84876011848 scopus 로고    scopus 로고
    • Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination
    • Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, et al. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res 2013;73: 2199-210.
    • (2013) Cancer Res , vol.73 , pp. 2199-2210
    • Hast, B.E.1    Goldfarb, D.2    Mulvaney, K.M.3    Hast, M.A.4    Siesser, P.F.5    Yan, F.6
  • 6
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 2012;22:66-79.
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3    Shibata, T.4    Nukiwa, T.5    Aburatani, H.6
  • 7
    • 77954351631 scopus 로고    scopus 로고
    • High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    • Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, et al. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res 2010;70:5486-96.
    • (2010) Cancer Res , vol.70 , pp. 5486-5496
    • Jiang, T.1    Chen, N.2    Zhao, F.3    Wang, X.J.4    Kong, B.5    Zheng, W.6
  • 8
    • 67349089075 scopus 로고    scopus 로고
    • Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma
    • Mahaffey CM, Zhang H, Rinna A, Holland W, Mack PC, Forman HJ. Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma. Free Radic Biol Med 2009;46:1650-7.
    • (2009) Free Radic Biol Med , vol.46 , pp. 1650-1657
    • Mahaffey, C.M.1    Zhang, H.2    Rinna, A.3    Holland, W.4    Mack, P.C.5    Forman, H.J.6
  • 9
    • 84871519753 scopus 로고    scopus 로고
    • The high Nrf2 expression in human acute myeloid leukemia is driven by NF-kB and underlies its chemo-resistance
    • Rushworth SA, Zaitseva L, Murray MY, Shah NM, Bowles KM, MacEwan DJ. The high Nrf2 expression in human acute myeloid leukemia is driven by NF-kB and underlies its chemo-resistance. Blood 2012; 120:5188-98.
    • (2012) Blood , vol.120 , pp. 5188-5198
    • Rushworth, S.A.1    Zaitseva, L.2    Murray, M.Y.3    Shah, N.M.4    Bowles, K.M.5    Macewan, D.J.6
  • 11
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes JD, McMahon M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 2009;34:176-88.
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 13
    • 84857997256 scopus 로고    scopus 로고
    • Methylation of the KEAP1 gene promoter region in human colorectal cancer
    • Hanada N, Takahata T, Zhou Q, Ye X, Sun R, Itoh J, et al. Methylation of the KEAP1 gene promoter region in human colorectal cancer. BMC Cancer 2012;12:66.
    • (2012) BMC Cancer , vol.12 , pp. 66
    • Hanada, N.1    Takahata, T.2    Zhou, Q.3    Ye, X.4    Sun, R.5    Itoh, J.6
  • 15
    • 84876869343 scopus 로고    scopus 로고
    • Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients
    • Safaee M, Clark AJ, Oh MC, Ivan ME, Bloch O, Kaur G, et al. Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients. PLoS ONE 2013;8:e62765.
    • (2013) PLoS ONE , vol.8
    • Safaee, M.1    Clark, A.J.2    Oh, M.C.3    Ivan, M.E.4    Bloch, O.5    Kaur, G.6
  • 16
    • 84879466482 scopus 로고    scopus 로고
    • Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network
    • Hakimi AA, Ostrovnaya I, Reva BA, Schultz N, Chen YB, Gonen M, et al. Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clin Cancer Res 2013;19:3259-67.
    • (2013) Clin Cancer Res , vol.19 , pp. 3259-3267
    • Hakimi, A.A.1    Ostrovnaya, I.2    Reva, B.A.3    Schultz, N.4    Chen, Y.B.5    Gonen, M.6
  • 17
    • 84876092402 scopus 로고    scopus 로고
    • TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway
    • Meng X, Cai C, Wu J, Cai S, Ye C, Chen H, et al. TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. Cancer Lett 2013;333:96-102.
    • (2013) Cancer Lett , vol.333 , pp. 96-102
    • Meng, X.1    Cai, C.2    Wu, J.3    Cai, S.4    Ye, C.5    Chen, H.6
  • 19
    • 84857493148 scopus 로고    scopus 로고
    • Wilms tumor gene on the X chromosome (WTX) inhibits the degradation of NRF2 through competitive binding to KEAP1
    • Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, et al. Wilms tumor gene on the X chromosome (WTX) inhibits the degradation of NRF2 through competitive binding to KEAP1. J Biol Chem 2012;287:6539-50.
    • (2012) J Biol Chem , vol.287 , pp. 6539-6550
    • Camp, N.D.1    James, R.G.2    Dawson, D.W.3    Yan, F.4    Davison, J.M.5    Houck, S.A.6
  • 20
    • 33747606306 scopus 로고    scopus 로고
    • Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling
    • Lo SC, Li X, Henzl MT, Beamer LJ, Hannink M. Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J. 2006;25:3605-17.
    • (2006) EMBO J. , vol.25 , pp. 3605-3617
    • Lo, S.C.1    Li, X.2    Henzl, M.T.3    Beamer, L.J.4    Hannink, M.5
  • 21
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
    • Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 2004; 24:8477-86.
    • (2004) Mol Cell Biol , vol.24 , pp. 8477-8486
    • Cullinan, S.B.1    Gordan, J.D.2    Jin, J.3    Harper, J.W.4    Diehl, J.A.5
  • 22
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 2004;24:10941-53.
    • (2004) Mol Cell Biol , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 23
    • 41849146057 scopus 로고    scopus 로고
    • Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3
    • Rachakonda G, Xiong Y, Sekhar KR, Stamer SL, Liebler DC, Freeman ML. Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3. Chem Res Toxicol 2008; 21:705-10.
    • (2008) Chem Res Toxicol , vol.21 , pp. 705-710
    • Rachakonda, G.1    Xiong, Y.2    Sekhar, K.R.3    Stamer, S.L.4    Liebler, D.C.5    Freeman, M.L.6
  • 24
    • 77950887186 scopus 로고    scopus 로고
    • Activation of NRF2 by nitrosative agents andH2O2 involves KEAP1 disulfide formation
    • Fourquet S, Guerois R, Biard D, Toledano MB. Activation of NRF2 by nitrosative agents andH2O2 involves KEAP1 disulfide formation. J Biol Chem 2010;285:8463-71.
    • (2010) J Biol Chem , vol.285 , pp. 8463-8471
    • Fourquet, S.1    Guerois, R.2    Biard, D.3    Toledano, M.B.4
  • 25
    • 0027326586 scopus 로고
    • The tumor suppressor genes
    • Levine AJ. The tumor suppressor genes. Annu Rev Biochem 1993; 62:623-51.
    • (1993) Annu Rev Biochem , vol.62 , pp. 623-651
    • Levine, A.J.1
  • 27
    • 50949092996 scopus 로고    scopus 로고
    • Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells
    • Kato A, Kurita S, Hayashi A, Kaji N, Ohashi K, Mizuno K. Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells. Biochem J 2008;414:261-70.
    • (2008) Biochem J , vol.414 , pp. 261-270
    • Kato, A.1    Kurita, S.2    Hayashi, A.3    Kaji, N.4    Ohashi, K.5    Mizuno, K.6
  • 28
    • 0032575659 scopus 로고    scopus 로고
    • Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization
    • Takei Y, Tsujimoto G. Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization. J Biol Chem 1998;273:22177-80.
    • (1998) J Biol Chem , vol.273 , pp. 22177-22180
    • Takei, Y.1    Tsujimoto, G.2
  • 29
    • 0029000522 scopus 로고
    • Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
    • Kubota Y, Mimura S, Nishimoto S, Takisawa H, Nojima H. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 1995;81:601-9.
    • (1995) Cell , vol.81 , pp. 601-609
    • Kubota, Y.1    Mimura, S.2    Nishimoto, S.3    Takisawa, H.4    Nojima, H.5
  • 30
    • 0030930614 scopus 로고    scopus 로고
    • Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae
    • Young MR, Tye BK. Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae. Mol Biol Cell 1997;8: 1587-601.
    • (1997) Mol Biol Cell , vol.8 , pp. 1587-1601
    • Young, M.R.1    Tye, B.K.2
  • 32
    • 44849086561 scopus 로고    scopus 로고
    • FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration
    • Wagner S, Storbeck CJ, Roovers K, Chaar ZY, Kolodziej P, McKay M, et al. FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLoS ONE 2008;3:e1868.
    • (2008) PLoS ONE , vol.3
    • Wagner, S.1    Storbeck, C.J.2    Roovers, K.3    Chaar, Z.Y.4    Kolodziej, P.5    McKay, M.6
  • 33
    • 0033539894 scopus 로고    scopus 로고
    • Induction of apoptosis by SLK, a Ste20-related kinase
    • Sabourin LA, Rudnicki MA. Induction of apoptosis by SLK, a Ste20-related kinase. Oncogene 1999;18:7566-75.
    • (1999) Oncogene , vol.18 , pp. 7566-7575
    • Sabourin, L.A.1    Rudnicki, M.A.2
  • 34
    • 33645651908 scopus 로고    scopus 로고
    • Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38
    • Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky AV. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem 2006;281:3075-84.
    • (2006) J Biol Chem , vol.281 , pp. 3075-3084
    • Hao, W.1    Takano, T.2    Guillemette, J.3    Papillon, J.4    Ren, G.5    Cybulsky, A.V.6
  • 35
    • 84861312722 scopus 로고    scopus 로고
    • PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function
    • Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, et al. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol 2012;32:1506-17.
    • (2012) Mol Cell Biol , vol.32 , pp. 1506-1517
    • Ma, J.1    Cai, H.2    Wu, T.3    Sobhian, B.4    Huo, Y.5    Alcivar, A.6
  • 36
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nature Cell Biol 2010;12:213-23.
    • (2010) Nature Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5    Ichimura, Y.6
  • 37
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, et al. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 2009;34:663-73.
    • (2009) Mol Cell , vol.34 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3    Jiang, T.4    Huang, Z.5    Fang, D.6
  • 38
    • 84866875515 scopus 로고    scopus 로고
    • Superbinder SH2 domains act as antagonists of cell signaling
    • Kaneko T, Huang H, Cao X, Li X, Li C, Voss C, et al. Superbinder SH2 domains act as antagonists of cell signaling. Sci Signal 2012;5:ra68.
    • (2012) Sci Signal , vol.5
    • Kaneko, T.1    Huang, H.2    Cao, X.3    Li, X.4    Li, C.5    Voss, C.6
  • 39
    • 65649115267 scopus 로고    scopus 로고
    • Recognition and processing of ubiquitin-protein conjugates by the proteasome
    • Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem 2009;78:477-513.
    • (2009) Annu Rev Biochem , vol.78 , pp. 477-513
    • Finley, D.1
  • 40
    • 40449107193 scopus 로고    scopus 로고
    • Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    • Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 2008;68:1303-9.
    • (2008) Cancer Res , vol.68 , pp. 1303-1309
    • Ohta, T.1    Iijima, K.2    Miyamoto, M.3    Nakahara, I.4    Tanaka, H.5    Ohtsuji, M.6
  • 42
    • 84879666141 scopus 로고    scopus 로고
    • ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells
    • Cong ZX, Wang HD, Wang JW, Zhou Y, Pan H, Zhang DD, et al. ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells. Oncol Rep 2013;30:715-22.
    • (2013) Oncol Rep , vol.30 , pp. 715-722
    • Cong, Z.X.1    Wang, H.D.2    Wang, J.W.3    Zhou, Y.4    Pan, H.5    Zhang, D.D.6
  • 43
    • 77955653742 scopus 로고    scopus 로고
    • Suppression of NF-kB signaling by KEAP1 regulation of IKKb activity through autophagic degradation and inhibition of phosphorylation
    • Kim JE, You DJ, Lee C, Ahn C, Seong JY, Hwang JI. Suppression of NF-kB signaling by KEAP1 regulation of IKKb activity through autophagic degradation and inhibition of phosphorylation. Cell Signal 2010;22:1645-54.
    • (2010) Cell Signal , vol.22 , pp. 1645-1654
    • Kim, J.E.1    You, D.J.2    Lee, C.3    Ahn, C.4    Seong, J.Y.5    Hwang, J.I.6
  • 44
    • 78650509515 scopus 로고    scopus 로고
    • Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    • McMahon M, Lamont DJ, Beattie KA, Hayes JD. Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci U S A 2010;107: 18838-43.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18838-18843
    • McMahon, M.1    Lamont, D.J.2    Beattie, K.A.3    Hayes, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.