An improved synthesis of a hydroxymethyl tricyclic ketone from cyclohexanone, the key processes for the synthesis of a highly potent anti-inflammatory and cytoprotective agent

Synthesis (Germany)

Volumn 45, Issue 23, 2013, Pages 3251-3254

  Saito, Akira ^a   Zheng, Suqing ^a   Takahashi, Motohiro ^a   Li, Wei ^a   Ojima, Iwao ^a   Honda, Tadashi ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

anti inflammatory agents; antitumor agents; oxidation; reduction; reductive methylation; regioselectivity

Indexed keywords

ANTI-INFLAMMATORIES; ANTI-INFLAMMATORY AGENTS; ANTI-TUMOR AGENTS; CYCLOHEXANONES; KEY PROCESS;

ALKYLATION; CHEMICAL COMPOUNDS; DRUG PRODUCTS; KETONES; OXIDATION; REDUCTION; REGIOSELECTIVITY;

METHANOL;

10A ETHINYL 4B,8,8 TRIMETHYL 3,7 DIOXO 3,4B,7,8,8A,9,10,10A OCTAHYDROPHENANTHRENE 2,6 DICARBONITRILE; 8A (HYDROXYMETHYL) 1,1,4A TRIMETHYL 3,4,4A,6,7,8,8A,9,10,10A DECAHYDROPHENANTHREN 2(1H)ONE; ANTIINFLAMMATORY AGENT; CYCLOHEXANONE; HYDROXYMETHYL TRICYCLIC KETONE; KETONE DERIVATIVE; PROTECTIVE AGENT; TBE 31; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CHEMICAL REACTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 84888134099     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0033-1339900     Document Type: Article

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