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Volumn 26, Issue 12, 2016, Pages 1129-1139

Intracellular and extracellular miRNome deregulation in cellular models of NAFLD or NASH: Clinical implications

Author keywords

FFAs; HepG2; microRNAs; NAFLD; NASH

Indexed keywords

BIOLOGICAL MARKER; CD36 ANTIGEN; CERAMIDE; DIACYLGLYCEROL; FATTY ACID; FATTY ACID TRANSPORTER; INSULIN RECEPTOR SUBSTRATE 1; MICRORNA; MICRORNA 1226; MICRORNA 1255B; MICRORNA 126; MICRORNA 1290; MICRORNA 1303; MICRORNA 148B; MICRORNA 150; MICRORNA 204; MICRORNA 214; MICRORNA 223; MICRORNA 27A; MICRORNA 31; MICRORNA 320B; MICRORNA 483 3P; MICRORNA 529; MICRORNA 744; MICRORNA 92A 1; MICRORNA 99B; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE B; UNCLASSIFIED DRUG; UNINDEXED DRUG; COENZYME A LIGASE; GENETIC MARKER; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; LONG-CHAIN-FATTY-ACID-COA LIGASE;

EID: 84994475836     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2016.08.004     Document Type: Article
Times cited : (36)

References (53)
  • 1
    • 79251524594 scopus 로고    scopus 로고
    • Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • [1] Dowman, J.K., Tomlinson, J.W., Newsome, P.N., Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 33 (2011), 525–540.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 525-540
    • Dowman, J.K.1    Tomlinson, J.W.2    Newsome, P.N.3
  • 2
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    • [2] Neuschwander-Tetri, B.A., Caldwell, S.H., Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37 (2003), 1202–1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 3
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    • [3] Wieckowska, A., McCullough, A.J., Feldstein, A.E., Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 46 (2007), 582–589.
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 6
    • 84925884839 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers for inflammatory diseases
    • [6] Mi, S., Zhang, J., Zhang, W., Huang, R.S., Circulating microRNAs as biomarkers for inflammatory diseases. Microrna 2 (2013), 63–71.
    • (2013) Microrna , vol.2 , pp. 63-71
    • Mi, S.1    Zhang, J.2    Zhang, W.3    Huang, R.S.4
  • 7
    • 79957845984 scopus 로고    scopus 로고
    • Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells
    • [7] Chu, J.H., Wang, H., Ye, Y., Chan, P.K., Pan, S.Y., Fong, W.F., et al. Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells. World J Gastroenterol 17 (2011), 2379–2388.
    • (2011) World J Gastroenterol , vol.17 , pp. 2379-2388
    • Chu, J.H.1    Wang, H.2    Ye, Y.3    Chan, P.K.4    Pan, S.Y.5    Fong, W.F.6
  • 8
    • 84891830448 scopus 로고    scopus 로고
    • Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells
    • [8] Kwan, H.Y., Fong, W.F., Yang, Z., Yu, Z.L., Hsiao, W.L., Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. Eur J Nutr 52 (2013), 1621–1630.
    • (2013) Eur J Nutr , vol.52 , pp. 1621-1630
    • Kwan, H.Y.1    Fong, W.F.2    Yang, Z.3    Yu, Z.L.4    Hsiao, W.L.5
  • 9
    • 65949090538 scopus 로고    scopus 로고
    • Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
    • [9] Ricchi, M., Odoardi, M.R., Carulli, L., Anzivino, C., Ballestri, S., Pinetti, A., et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 24 (2009), 830–840.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 830-840
    • Ricchi, M.1    Odoardi, M.R.2    Carulli, L.3    Anzivino, C.4    Ballestri, S.5    Pinetti, A.6
  • 11
    • 77949655879 scopus 로고    scopus 로고
    • Palmitoleate attenuates palmitate-induced Bim and PUMA upregulation and hepatocyte lipoapoptosis
    • [11] Akazawa, Y., Cazanave, S., Mott, J.L., Elmi, N., Bronk, S.F., Kohno, S., et al. Palmitoleate attenuates palmitate-induced Bim and PUMA upregulation and hepatocyte lipoapoptosis. J Hepatol 52 (2010), 586–593.
    • (2010) J Hepatol , vol.52 , pp. 586-593
    • Akazawa, Y.1    Cazanave, S.2    Mott, J.L.3    Elmi, N.4    Bronk, S.F.5    Kohno, S.6
  • 12
    • 84983537497 scopus 로고    scopus 로고
    • Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification
    • [12] Alaimo, S., Giugno, R., Acunzo, M., Veneziano, D., Ferro, A., Pulvirenti, A., Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification. Oncotarget, 2016.
    • (2016) Oncotarget
    • Alaimo, S.1    Giugno, R.2    Acunzo, M.3    Veneziano, D.4    Ferro, A.5    Pulvirenti, A.6
  • 13
    • 84907442435 scopus 로고    scopus 로고
    • Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications
    • [13] Ragusa, M., Statello, L., Maugeri, M., Barbagallo, C., Passanisi, R., Alhamdani, M.S., et al. Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications. Oncoscience 1 (2014), 132–157.
    • (2014) Oncoscience , vol.1 , pp. 132-157
    • Ragusa, M.1    Statello, L.2    Maugeri, M.3    Barbagallo, C.4    Passanisi, R.5    Alhamdani, M.S.6
  • 14
    • 0021923858 scopus 로고
    • Nile red: a selective fluorescent stain for intracellular lipid droplets
    • [14] Greenspan, P., Mayer, E.P., Fowler, S.D., Nile red: a selective fluorescent stain for intracellular lipid droplets. J Cell Biol 100 (1985), 965–973.
    • (1985) J Cell Biol , vol.100 , pp. 965-973
    • Greenspan, P.1    Mayer, E.P.2    Fowler, S.D.3
  • 15
    • 79957561550 scopus 로고    scopus 로고
    • Lipotoxicity in HepG2 cells triggered by free fatty acids
    • [15] Yao, H.R., Liu, J., Plumeri, D., Cao, Y.B., He, T., Lin, L., et al. Lipotoxicity in HepG2 cells triggered by free fatty acids. Am J Transl Res 3 (2011), 284–291.
    • (2011) Am J Transl Res , vol.3 , pp. 284-291
    • Yao, H.R.1    Liu, J.2    Plumeri, D.3    Cao, Y.B.4    He, T.5    Lin, L.6
  • 16
    • 84982889717 scopus 로고    scopus 로고
    • Altered expression of uncoupling protein 2 in GLP-1-producing cells after chronic high glucose exposure: implications for the pathogenesis of diabetes mellitus
    • [16] Urbano, F., Filippello, A., Di Pino, A., Barbagallo, D., Di Mauro, S., Pappalardo, A., et al. Altered expression of uncoupling protein 2 in GLP-1-producing cells after chronic high glucose exposure: implications for the pathogenesis of diabetes mellitus. Am J Physiol Cell Physiol 310 (2016), C558–C567.
    • (2016) Am J Physiol Cell Physiol , vol.310 , pp. C558-C567
    • Urbano, F.1    Filippello, A.2    Di Pino, A.3    Barbagallo, D.4    Di Mauro, S.5    Pappalardo, A.6
  • 17
    • 77956047687 scopus 로고    scopus 로고
    • Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    • [17] Piro, S., Maniscalchi, E.T., Monello, A., Pandini, G., Mascali, L.G., Rabuazzo, A.M., et al. Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line. Endocrinology 151 (2010), 4197–4206.
    • (2010) Endocrinology , vol.151 , pp. 4197-4206
    • Piro, S.1    Maniscalchi, E.T.2    Monello, A.3    Pandini, G.4    Mascali, L.G.5    Rabuazzo, A.M.6
  • 18
    • 84896497879 scopus 로고    scopus 로고
    • Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (alpha-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells
    • e90093
    • [18] Piro, S., Mascali, L.G., Urbano, F., Filippello, A., Malaguarnera, R., Calanna, S., et al. Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (alpha-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells. PLoS One, 9, 2014 e90093.
    • (2014) PLoS One , vol.9
    • Piro, S.1    Mascali, L.G.2    Urbano, F.3    Filippello, A.4    Malaguarnera, R.5    Calanna, S.6
  • 19
    • 84902309873 scopus 로고    scopus 로고
    • Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and multiple system atrophy
    • [19] Vallelunga, A., Ragusa, M., Di Mauro, S., Iannitti, T., Pilleri, M., Biundo, R., et al. Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and multiple system atrophy. Front Cell Neurosci, 8, 2014, 156.
    • (2014) Front Cell Neurosci , vol.8 , pp. 156
    • Vallelunga, A.1    Ragusa, M.2    Di Mauro, S.3    Iannitti, T.4    Pilleri, M.5    Biundo, R.6
  • 20
    • 84872910667 scopus 로고    scopus 로고
    • miR-296-3p, miR-298-5p and their downstream networks are causally involved in the higher resistance of mammalian pancreatic alpha cells to cytokine-induced apoptosis as compared to beta cells
    • [20] Barbagallo, D., Piro, S., Condorelli, A.G., Mascali, L.G., Urbano, F., Parrinello, N., et al. miR-296-3p, miR-298-5p and their downstream networks are causally involved in the higher resistance of mammalian pancreatic alpha cells to cytokine-induced apoptosis as compared to beta cells. BMC Genomics, 14, 2013, 62.
    • (2013) BMC Genomics , vol.14 , pp. 62
    • Barbagallo, D.1    Piro, S.2    Condorelli, A.G.3    Mascali, L.G.4    Urbano, F.5    Parrinello, N.6
  • 21
    • 84941806468 scopus 로고    scopus 로고
    • miRNA profiling in vitreous humor, vitreal exosomes and serum from uveal melanoma patients: pathological and diagnostic implications
    • [21] Ragusa, M., Barbagallo, C., Statello, L., Caltabiano, R., Russo, A., Puzzo, L., et al. miRNA profiling in vitreous humor, vitreal exosomes and serum from uveal melanoma patients: pathological and diagnostic implications. Cancer Biol Ther 16 (2015), 1387–1396.
    • (2015) Cancer Biol Ther , vol.16 , pp. 1387-1396
    • Ragusa, M.1    Barbagallo, C.2    Statello, L.3    Caltabiano, R.4    Russo, A.5    Puzzo, L.6
  • 22
    • 38649096259 scopus 로고    scopus 로고
    • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
    • [22] Zhou, J., Febbraio, M., Wada, T., Zhai, Y., Kuruba, R., He, J., et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology 134 (2008), 556–567.
    • (2008) Gastroenterology , vol.134 , pp. 556-567
    • Zhou, J.1    Febbraio, M.2    Wada, T.3    Zhai, Y.4    Kuruba, R.5    He, J.6
  • 23
    • 84860482342 scopus 로고    scopus 로고
    • A ceramide-centric view of insulin resistance
    • [23] Chavez, J.A., Summers, S.A., A ceramide-centric view of insulin resistance. Cell Metab 15 (2012), 585–594.
    • (2012) Cell Metab , vol.15 , pp. 585-594
    • Chavez, J.A.1    Summers, S.A.2
  • 24
    • 84956932380 scopus 로고    scopus 로고
    • Hepatocyte- specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice
    • [24] Wilson, C.G., Tran, J.L., Erion, D.M., Vera, N.B., Febbraio, M., Weiss, E.J., Hepatocyte- specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice. Endocrinology 157 (2016), 570–585.
    • (2016) Endocrinology , vol.157 , pp. 570-585
    • Wilson, C.G.1    Tran, J.L.2    Erion, D.M.3    Vera, N.B.4    Febbraio, M.5    Weiss, E.J.6
  • 25
    • 84902038794 scopus 로고    scopus 로고
    • Hepatic fatty acid trafficking: multiple forks in the road
    • [25] Mashek, D.G., Hepatic fatty acid trafficking: multiple forks in the road. Adv Nutr 4 (2013), 697–710.
    • (2013) Adv Nutr , vol.4 , pp. 697-710
    • Mashek, D.G.1
  • 26
    • 84909619421 scopus 로고    scopus 로고
    • Noninvasive biomarkers in non-alcoholic fatty liver disease: current status and a glimpse of the future
    • [26] Fitzpatrick, E., Dhawan, A., Noninvasive biomarkers in non-alcoholic fatty liver disease: current status and a glimpse of the future. World J Gastroenterol 20 (2014), 10851–10863.
    • (2014) World J Gastroenterol , vol.20 , pp. 10851-10863
    • Fitzpatrick, E.1    Dhawan, A.2
  • 27
    • 84941743657 scopus 로고    scopus 로고
    • Circulating microRNA-223 as a potential biomarker for obesity
    • [27] Wen, D., Qiao, P., Wang, L., Circulating microRNA-223 as a potential biomarker for obesity. Obes Res Clin Pract 9 (2015), 398–404.
    • (2015) Obes Res Clin Pract , vol.9 , pp. 398-404
    • Wen, D.1    Qiao, P.2    Wang, L.3
  • 29
    • 84865310423 scopus 로고    scopus 로고
    • Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol
    • [29] Sun, X., Zhang, M., Sanagawa, A., Mori, C., Ito, S., Iwaki, S., et al. Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol. Thromb J, 10, 2012, 16.
    • (2012) Thromb J , vol.10 , pp. 16
    • Sun, X.1    Zhang, M.2    Sanagawa, A.3    Mori, C.4    Ito, S.5    Iwaki, S.6
  • 30
    • 84934990059 scopus 로고    scopus 로고
    • Micro-RNAs Let7e and 126 in plasma as markers of metabolic dysfunction in 10 to 12 years old children
    • e0128140
    • [30] Krause, B.J., Carrasco-Wong, I., Dominguez, A., Arnaiz, P., Farias, M., Barja, S., et al. Micro-RNAs Let7e and 126 in plasma as markers of metabolic dysfunction in 10 to 12 years old children. PLoS One, 10, 2015 e0128140.
    • (2015) PLoS One , vol.10
    • Krause, B.J.1    Carrasco-Wong, I.2    Dominguez, A.3    Arnaiz, P.4    Farias, M.5    Barja, S.6
  • 31
    • 77957259803 scopus 로고    scopus 로고
    • Plasma VmicroRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes
    • [31] Zampetaki, A., Kiechl, S., Drozdov, I., Willeit, P., Mayr, U., Prokopi, M., et al. Plasma VmicroRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 107 (2010), 810–817.
    • (2010) Circ Res , vol.107 , pp. 810-817
    • Zampetaki, A.1    Kiechl, S.2    Drozdov, I.3    Willeit, P.4    Mayr, U.5    Prokopi, M.6
  • 33
    • 79953301730 scopus 로고    scopus 로고
    • MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • [33] Vickers, K.C., Palmisano, B.T., Shoucri, B.M., Shamburek, R.D., Remaley, A.T., MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 13 (2011), 423–433.
    • (2011) Nat Cell Biol , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3    Shamburek, R.D.4    Remaley, A.T.5
  • 34
    • 84892903367 scopus 로고    scopus 로고
    • MicroRNA control of high-density lipoprotein metabolism and function
    • [34] Rayner, K.J., Moore, K.J., MicroRNA control of high-density lipoprotein metabolism and function. Circ Res 114 (2014), 183–192.
    • (2014) Circ Res , vol.114 , pp. 183-192
    • Rayner, K.J.1    Moore, K.J.2
  • 35
    • 84879109514 scopus 로고    scopus 로고
    • Characterization of levels and cellular transfer of circulating lipoprotein-bound microRNAs
    • [35] Wagner, J., Riwanto, M., Besler, C., Knau, A., Fichtlscherer, S., Röxe, T., et al. Characterization of levels and cellular transfer of circulating lipoprotein-bound microRNAs. Arterioscler Thromb Vasc Biol 33 (2013), 1392–1400.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1392-1400
    • Wagner, J.1    Riwanto, M.2    Besler, C.3    Knau, A.4    Fichtlscherer, S.5    Röxe, T.6
  • 36
    • 84907853062 scopus 로고    scopus 로고
    • A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease
    • [36] Tan, Y., Ge, G., Pan, T., Wen, D., Gan, J., A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease. PLoS One, 9, 2014, e105192.
    • (2014) PLoS One , vol.9 , pp. e105192
    • Tan, Y.1    Ge, G.2    Pan, T.3    Wen, D.4    Gan, J.5
  • 38
    • 84895874726 scopus 로고    scopus 로고
    • Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma
    • e89446
    • [38] Hung, T.M., Ho, C.M., Liu, Y.C., Lee, J.L., Liao, Y.R., Wu, Y.M., et al. Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. PLoS One, 9, 2014 e89446.
    • (2014) PLoS One , vol.9
    • Hung, T.M.1    Ho, C.M.2    Liu, Y.C.3    Lee, J.L.4    Liao, Y.R.5    Wu, Y.M.6
  • 40
    • 84881614241 scopus 로고    scopus 로고
    • Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-alpha
    • [40] Meerson, A., Traurig, M., Ossowski, V., Fleming, J.M., Mullins, M., Baier, L.J., Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-alpha. Diabetologia 56 (2013), 1971–1979.
    • (2013) Diabetologia , vol.56 , pp. 1971-1979
    • Meerson, A.1    Traurig, M.2    Ossowski, V.3    Fleming, J.M.4    Mullins, M.5    Baier, L.J.6
  • 41
    • 78951474461 scopus 로고    scopus 로고
    • MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1
    • [41] Yang, Z., Bian, C., Zhou, H., Huang, S., Wang, S., Liao, L., et al. MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. Stem Cells Dev 20 (2011), 259–267.
    • (2011) Stem Cells Dev , vol.20 , pp. 259-267
    • Yang, Z.1    Bian, C.2    Zhou, H.3    Huang, S.4    Wang, S.5    Liao, L.6
  • 43
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic Micro-RNA expression
    • [43] Cheung, O., Puri, P., Eicken, C., Contos, M.J., Mirshahi, F., Maher, J.W., et al. Nonalcoholic steatohepatitis is associated with altered hepatic Micro-RNA expression. Hepatology 48 (2008), 1810–1820.
    • (2008) Hepatology , vol.48 , pp. 1810-1820
    • Cheung, O.1    Puri, P.2    Eicken, C.3    Contos, M.J.4    Mirshahi, F.5    Maher, J.W.6
  • 44
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • [44] Browning, J.D., Horton, J.D., Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114 (2004), 147–152.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 45
    • 84860326669 scopus 로고    scopus 로고
    • NASH is an inflammatory disorder: pathogenic, prognostic and therapeutic implications
    • [45] Farrell, G.C., van Rooyen, D., Gan, L., Chitturi, S., NASH is an inflammatory disorder: pathogenic, prognostic and therapeutic implications. Gut Liver 6 (2012), 149–171.
    • (2012) Gut Liver , vol.6 , pp. 149-171
    • Farrell, G.C.1    van Rooyen, D.2    Gan, L.3    Chitturi, S.4
  • 46
    • 84924772254 scopus 로고    scopus 로고
    • Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids
    • [46] Arendt, B.M., Comelli, E.M., Ma, D.W., Lou, W., Teterina, A., Kim, T., et al. Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids. Hepatology 61 (2015), 1565–1578.
    • (2015) Hepatology , vol.61 , pp. 1565-1578
    • Arendt, B.M.1    Comelli, E.M.2    Ma, D.W.3    Lou, W.4    Teterina, A.5    Kim, T.6
  • 47
    • 78649560195 scopus 로고    scopus 로고
    • Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice
    • [47] Gupte, A.A., Liu, J.Z., Ren, Y., Minze, L.J., Wiles, J.R., Collins, A.R., et al. Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology 52 (2010), 2001–2011.
    • (2010) Hepatology , vol.52 , pp. 2001-2011
    • Gupte, A.A.1    Liu, J.Z.2    Ren, Y.3    Minze, L.J.4    Wiles, J.R.5    Collins, A.R.6
  • 48
    • 35148881190 scopus 로고    scopus 로고
    • Reevaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    • [48] Kohjima, M., Enjoji, M., Higuchi, N., Kato, M., Kotoh, K., Yoshimoto, T., et al. Reevaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med 20 (2007), 351–358.
    • (2007) Int J Mol Med , vol.20 , pp. 351-358
    • Kohjima, M.1    Enjoji, M.2    Higuchi, N.3    Kato, M.4    Kotoh, K.5    Yoshimoto, T.6
  • 49
    • 80052211344 scopus 로고    scopus 로고
    • The role of hepatic liver X receptor alpha- and sterol regulatory element binding protein-1c-mediated lipid disorder in the pathogenesis of nonalcoholic steatohepatitis in rats
    • [49] Ai, Z.L., Zhu, C.H., Min, M., Wang, J., Lan, C.H., Fan, L.L., et al. The role of hepatic liver X receptor alpha- and sterol regulatory element binding protein-1c-mediated lipid disorder in the pathogenesis of nonalcoholic steatohepatitis in rats. J Int Med Res 39 (2011), 1219–1229.
    • (2011) J Int Med Res , vol.39 , pp. 1219-1229
    • Ai, Z.L.1    Zhu, C.H.2    Min, M.3    Wang, J.4    Lan, C.H.5    Fan, L.L.6
  • 52
    • 84923652533 scopus 로고    scopus 로고
    • Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy
    • [52] Nagaya, T., Tanaka, N., Kimura, T., Kitabatake, H., Fujimori, N., Komatsu, M., et al. Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. BBA Clin 3 (2015), 168–174.
    • (2015) BBA Clin , vol.3 , pp. 168-174
    • Nagaya, T.1    Tanaka, N.2    Kimura, T.3    Kitabatake, H.4    Fujimori, N.5    Komatsu, M.6
  • 53
    • 84975704385 scopus 로고    scopus 로고
    • Palmitate-induced regulation of PPARgamma via PGC1alpha: a mechanism for lipid accumulation in the liver in nonalcoholic fatty liver disease
    • [53] Maruyama, H., Kiyono, S., Kondo, T., Sekimoto, T., Yokosuka, O., Palmitate-induced regulation of PPARgamma via PGC1alpha: a mechanism for lipid accumulation in the liver in nonalcoholic fatty liver disease. Int J Med Sci 13 (2016), 169–178.
    • (2016) Int J Med Sci , vol.13 , pp. 169-178
    • Maruyama, H.1    Kiyono, S.2    Kondo, T.3    Sekimoto, T.4    Yokosuka, O.5


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