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Volumn 9, Issue 2, 2014, Pages

Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (a-TC1): Evidence of a direct effect of GLP-1 on pancreatic alpha cells

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROPROTEIN CONVERTASE 1; TRANSCRIPTION FACTOR PAX6;

EID: 84896497879     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090093     Document Type: Article
Times cited : (28)

References (65)
  • 1
    • 84858383401 scopus 로고    scopus 로고
    • Diabetes mellitus and the beta cell: The last ten years
    • Ashcroft FM, Rorsman P (2012) Diabetes mellitus and the beta cell: the last ten years. Cell 148: 1160-1171.
    • (2012) Cell , vol.148 , pp. 1160-1171
    • Ashcroft, F.M.1    Rorsman, P.2
  • 2
    • 0016423677 scopus 로고
    • The essential role of glucagon in the pathogenesis of diabetes mellitus
    • Unger RH, Orci L (1975) The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1: 14-16.
    • (1975) Lancet , vol.1 , pp. 14-16
    • Unger, R.H.1    Orci, L.2
  • 3
    • 75149128665 scopus 로고    scopus 로고
    • Incretin-based therapies for the treatment of type 2 diabetes: Evaluation of the risks and benefits
    • Drucker DJ, Sherman SI, Gorelick FS, Bergenstal RM, Sherwin RS, et al. (2010) Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits. Diabetes Care 33: 428-433.
    • (2010) Diabetes Care , vol.33 , pp. 428-433
    • Drucker, D.J.1    Sherman, S.I.2    Gorelick, F.S.3    Bergenstal, R.M.4    Sherwin, R.S.5
  • 4
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132: 2131-2157. (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 5
    • 36749042536 scopus 로고    scopus 로고
    • GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors
    • DOI 10.1007/s11892-007-0056-9
    • Ahren B (2007) GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors. Curr Diab Rep 7: 340-347. (Pubitemid 350200016)
    • (2007) Current Diabetes Reports , vol.7 , Issue.5 , pp. 340-347
    • Ahren, B.1
  • 6
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • DOI 10.1007/s00125-001-0719-z
    • Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M (2002) The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 45: 195-202. (Pubitemid 34208381)
    • (2002) Diabetologia , vol.45 , Issue.2 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 7
    • 70849096647 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide
    • Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M (2009) Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol 68: 898-905.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 898-905
    • Jacobsen, L.V.1    Hindsberger, C.2    Robson, R.3    Zdravkovic, M.4
  • 8
    • 78049365082 scopus 로고    scopus 로고
    • Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase
    • Malm-Erjefalt M, Bjornsdottir I, Vanggaard J, Helleberg H, Larsen U, et al. (2010) Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos 38: 1944-1953.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1944-1953
    • Malm-Erjefalt, M.1    Bjornsdottir, I.2    Vanggaard, J.3    Helleberg, H.4    Larsen, U.5
  • 9
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: Influence of glucagon-like peptide-1
    • DOI 10.1007/s00125-005-1878-0
    • Dunning BE, Foley JE, Ahren B (2005) Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 48: 1700-1713. (Pubitemid 41317822)
    • (2005) Diabetologia , vol.48 , Issue.9 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahren, B.3
  • 10
    • 69249208511 scopus 로고    scopus 로고
    • Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia
    • Kedees MH, Grigoryan M, Guz Y, Teitelman G (2009) Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia. Mol Cell Endocrinol 311: 69-76.
    • (2009) Mol Cell Endocrinol , vol.311 , pp. 69-76
    • Kedees, M.H.1    Grigoryan, M.2    Guz, Y.3    Teitelman, G.4
  • 11
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, et al. (1993) Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36: 741-744. (Pubitemid 23218642)
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 12
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • de Heer J, Rasmussen C, Coy DH, Holst JJ (2008) Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 51: 2263-2270.
    • (2008) Diabetologia , vol.51 , pp. 2263-2270
    • De Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 13
    • 0030943464 scopus 로고    scopus 로고
    • 2+-induced secretion in rat α-cells by a protein kinase A- mediated mechanism
    • Ding WG, Renstrom E, Rorsman P, Buschard K, Gromada J (1997) Glucagonlike peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism. Diabetes 46: 792-800. (Pubitemid 27188256)
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 792-800
    • Ding, W.-G.1    Renstrom, E.2    Rorsman, P.3    Buschard, K.4    Gromada, J.5
  • 14
    • 77956399106 scopus 로고    scopus 로고
    • GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis
    • De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, et al. (2010) GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metab 11: 543-553.
    • (2010) Cell Metab , vol.11 , pp. 543-553
    • De Marinis, Y.Z.1    Salehi, A.2    Ward, C.E.3    Zhang, Q.4    Abdulkader, F.5
  • 15
  • 16
    • 3843149483 scopus 로고    scopus 로고
    • Altered proglucagon processing in an α-cell line derived from prohormone convertase 2 null mouse islets
    • DOI 10.1074/jbc.M404110200
    • Webb GC, Dey A, Wang J, Stein J, Milewski M, et al. (2004) Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets. J Biol Chem 279: 31068-31075. (Pubitemid 39037767)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.30 , pp. 31068-31075
    • Webb, G.C.1    Dey, A.2    Wang, J.3    Stein, J.4    Milewski, M.5    Steiner, D.F.6
  • 17
    • 0242441605 scopus 로고    scopus 로고
    • Cellular Interaction between Mouse Pancreatic α-Cell and β-Cell Lines: Possible Contact-Dependent Inhibition of Insulin Secretion
    • Hamaguchi K, Utsunomiya N, Takaki R, Yoshimatsu H, Sakata T (2003) Cellular interaction between mouse pancreatic alpha-cell and beta-cell lines: possible contact-dependent inhibition of insulin secretion. Exp Biol Med (Maywood) 228: 1227-1233. (Pubitemid 37413684)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.10 , pp. 1227-1233
    • Hamaguchi, K.1    Utsunomiya, N.2    Takaki, R.3    Yoshimatsu, H.4    Sakata, T.5
  • 18
    • 0034751632 scopus 로고    scopus 로고
    • The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: Studies using high density oligonucleotide microarray
    • DOI 10.1210/en.142.11.4777
    • Xiao J, Gregersen S, Kruhoffer M, Pedersen SB, Orntoft TF, et al. (2001) The effect of chronic exposure to fatty acids on gene expression in clonal insulinproducing cells: studies using high density oligonucleotide microarray. Endocrinology 142: 4777-4784. (Pubitemid 33022353)
    • (2001) Endocrinology , vol.142 , Issue.11 , pp. 4777-4784
    • Xiao, J.1    Gregersen, S.2    Kruhoffer, M.3    Pedersen, S.B.4    Orntoft, T.F.5    Hermansen, K.6
  • 19
    • 77956047687 scopus 로고    scopus 로고
    • Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line
    • Piro S, Maniscalchi ET, Monello A, Pandini G, Mascali LG, et al. (2010) Palmitate affects insulin receptor phosphorylation and intracellular insulin signal in a pancreatic alpha-cell line. Endocrinology 151: 4197-4206.
    • (2010) Endocrinology , vol.151 , pp. 4197-4206
    • Piro, S.1    Maniscalchi, E.T.2    Monello, A.3    Pandini, G.4    Mascali, L.G.5
  • 20
    • 20444444322 scopus 로고    scopus 로고
    • PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP
    • DOI 10.1111/j.1742-4658.2005.04694.x
    • Chen L, Wang P, Andrade CF, Zhao IY, Dube PE, et al. (2005) PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP. FEBS J 272: 2746-2759. (Pubitemid 40825422)
    • (2005) FEBS Journal , vol.272 , Issue.11 , pp. 2746-2759
    • Chen, L.1    Wang, P.2    Andrade, C.F.3    Zhao, I.Y.4    Dube, P.E.5    Brubaker, P.L.6    Liu, M.7    Jin, T.8
  • 21
    • 0028846161 scopus 로고
    • Interaction of glucagon-like peptide-I (GLP-I) and galanin in insulin (beta TC-1)- and somatostatin (RIN T3)-secreting cells and evidence that both peptides have no receptors on glucagon (INR1G9)-secreting cells
    • Fehmann HC, Janssen M, Goke B (1995) Interaction of glucagon-like peptide-I (GLP-I) and galanin in insulin (beta TC-1)- and somatostatin (RIN T3)-secreting cells and evidence that both peptides have no receptors on glucagon (INR1G9)-secreting cells. Acta Diabetol 32: 176-181.
    • (1995) Acta Diabetol , vol.32 , pp. 176-181
    • Fehmann, H.C.1    Janssen, M.2    Goke, B.3
  • 22
    • 0026034765 scopus 로고
    • Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line
    • Fehmann HC, Habener JF (1991) Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line. FEBS Lett 279: 335-340.
    • (1991) FEBS Lett , vol.279 , pp. 335-340
    • Fehmann, H.C.1    Habener, J.F.2
  • 23
    • 0026093003 scopus 로고
    • The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells
    • Drucker DJ, Campos R, Reynolds R, Stobie K, Brubaker PL (1991) The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells. Endocrinology 128: 394-400.
    • (1991) Endocrinology , vol.128 , pp. 394-400
    • Drucker, D.J.1    Campos, R.2    Reynolds, R.3    Stobie, K.4    Brubaker, P.L.5
  • 24
    • 0021854805 scopus 로고
    • A new in vitro model for the study of pancreatic A and B cells
    • Pipeleers DG, in't Veld PA, Van de Winkel M, Maes E, Schuit FC, et al. (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117: 806-816. (Pubitemid 15019997)
    • (1985) Endocrinology , vol.117 , Issue.3 , pp. 806-816
    • Pipeleers, D.G.1    In't Veld, P.A.2    Van De Winkel, M.3
  • 27
    • 84855685549 scopus 로고    scopus 로고
    • Pancreatic betacell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels
    • Kim SJ, Widenmaier SB, Choi WS, Nian C, Ao Z, et al. (2012) Pancreatic betacell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels. Cell Death Differ 19: 333-344.
    • (2012) Cell Death Differ , vol.19 , pp. 333-344
    • Kim, S.J.1    Widenmaier, S.B.2    Choi, W.S.3    Nian, C.4    Ao, Z.5
  • 28
    • 79958000440 scopus 로고    scopus 로고
    • Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes
    • Wang L, Guo F, Wei S, Zhao R (2011) Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes. Peptides 32: 1313-1319.
    • (2011) Peptides , vol.32 , pp. 1313-1319
    • Wang, L.1    Guo, F.2    Wei, S.3    Zhao, R.4
  • 29
    • 79959390543 scopus 로고    scopus 로고
    • Glucose- and hormone-induced cAMP oscillations in alpha- and beta-cells within intact pancreatic islets
    • Tian G, Sandler S, Gylfe E, Tengholm A (2011) Glucose- and hormone-induced cAMP oscillations in alpha- and beta-cells within intact pancreatic islets. Diabetes 60: 1535-1543.
    • (2011) Diabetes , vol.60 , pp. 1535-1543
    • Tian, G.1    Sandler, S.2    Gylfe, E.3    Tengholm, A.4
  • 30
    • 0021329604 scopus 로고
    • Distinct mechanisms of forskolin-stimulated cyclic AMP accumulation and forskolin-potentiated hormone responses in C6-2B cells
    • Barovsky K, Pedone C, Brooker G (1984) Distinct mechanisms of forskolinstimulated cyclic AMP accumulation and forskolin-potentiated hormone responses in C6-2B cells. Mol Pharmacol 25: 256-260. (Pubitemid 14173332)
    • (1984) Molecular Pharmacology , vol.25 , Issue.2 , pp. 256-260
    • Barovsky, K.1    Pedone, C.2    Brooker, G.3
  • 31
    • 84862065072 scopus 로고    scopus 로고
    • Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in metabolic syndrome
    • Calanna S, Urbano F, Piro S, Zagami RM, Di Pino A, et al. (2012) Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in metabolic syndrome. Eur J Endocrinol 166: 917-922.
    • (2012) Eur J Endocrinol , vol.166 , pp. 917-922
    • Calanna, S.1    Urbano, F.2    Piro, S.3    Zagami, R.M.4    Di Pino, A.5
  • 32
    • 84876236726 scopus 로고    scopus 로고
    • Beta and alpha cell function in metabolically healthy but obese subjects: Relationship with entero-insular axis
    • Calanna S, Piro S, Di Pino A, Maria Zagami R, Urbano F, et al. (2013) Beta and alpha cell function in metabolically healthy but obese subjects: relationship with entero-insular axis. Obesity (Silver Spring) 21: 320-325.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 320-325
    • Calanna, S.1    Piro, S.2    Di Pino, A.3    Maria Zagami, R.4    Urbano, F.5
  • 33
    • 0021230368 scopus 로고
    • Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria
    • Umezawa H, Aoyagi T, Ogawa K, Naganawa H, Hamada M, et al. (1984) Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. J Antibiot (Tokyo) 37: 422-425. (Pubitemid 14129498)
    • (1984) Journal of Antibiotics , vol.37 , Issue.4 , pp. 422-425
    • Umezawa, H.1    Aoyagi, T.2    Ogawa, K.3
  • 34
    • 0036724256 scopus 로고    scopus 로고
    • Glucose-sensing in glucagon-like peptide-1-secreting cells
    • Reimann F, Gribble FM (2002) Glucose-sensing in glucagon-like peptide-1-secreting cells. Diabetes 51: 2757-2763. (Pubitemid 34970929)
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2757-2763
    • Reimann, F.1    Gribble, F.M.2
  • 37
    • 0030912680 scopus 로고    scopus 로고
    • Hexokinase shift to mitochondria is associated with an increased sensitivity to glucose in rat pancreatic islets
    • Rabuazzo AM, Patane G, Anello M, Piro S, Vigneri R, et al. (1997) Hexokinase shift to mitochondria is associated with an increased sensitivity to glucose in rat pancreatic islets. Diabetes 46: 1148-1152. (Pubitemid 27271075)
    • (1997) Diabetes , vol.46 , Issue.7 , pp. 1148-1152
    • Rabuazzo, A.M.1    Patane, G.2    Anello, M.3    Piro, S.4    Vigneri, R.5    Purrello, F.6
  • 40
    • 0033591344 scopus 로고    scopus 로고
    • Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase
    • Mikkola I, Bruun JA, Bjorkoy G, Holm T, Johansen T (1999) Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. J Biol Chem 274: 15115-15126.
    • (1999) J Biol Chem , vol.274 , pp. 15115-15126
    • Mikkola, I.1    Bruun, J.A.2    Bjorkoy, G.3    Holm, T.4    Johansen, T.5
  • 42
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
    • DOI 10.1038/387406a0
    • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P (1997) Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387: 406-409. (Pubitemid 27227205)
    • (1997) Nature , vol.387 , Issue.6631 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 44
    • 0031455165 scopus 로고    scopus 로고
    • Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1
    • DOI 10.1074/jbc.272.52.32810
    • Rouille Y, Kantengwa S, Irminger JC, Halban PA (1997) Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. J Biol Chem 272: 32810-32816. (Pubitemid 28023615)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.52 , pp. 32810-32816
    • Rouille, Y.1    Kantengwa, S.2    Irminger, J.-C.3    Halban, P.A.4
  • 46
    • 84871675071 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor-or not?
    • Pyke C, Knudsen LB (2013) The Glucagon-Like Peptide-1 Receptor-or Not? Endocrinology 154: 4-8.
    • (2013) Endocrinology , vol.154 , pp. 4-8
    • Pyke, C.1    Knudsen, L.B.2
  • 47
    • 84871686739 scopus 로고    scopus 로고
    • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice
    • Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, et al. (2013) GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology 154: 127-139.
    • (2013) Endocrinology , vol.154 , pp. 127-139
    • Panjwani, N.1    Mulvihill, E.E.2    Longuet, C.3    Yusta, B.4    Campbell, J.E.5
  • 48
    • 84878185729 scopus 로고    scopus 로고
    • A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Are the GLP-1 therapies safe?
    • Butler PC, Elashoff M, Elashoff R, Gale EA (2013) A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Are the GLP-1 therapies safe? Diabetes Care.
    • (2013) Diabetes Care
    • Butler, P.C.1    Elashoff, M.2    Elashoff, R.3    Gale, E.A.4
  • 49
    • 33749347851 scopus 로고    scopus 로고
    • Paradoxical stimulation of glucagon secretion by high glucose concentrations
    • DOI 10.2337/db06-0080
    • Salehi A, Vieira E, Gylfe E (2006) Paradoxical stimulation of glucagon secretion by high glucose concentrations. Diabetes 55: 2318-2323. (Pubitemid 44743630)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2318-2323
    • Salehi, A.1    Vieira, E.2    Gylfe, E.3
  • 50
    • 33846856711 scopus 로고    scopus 로고
    • α-cells of the endocrine pancreas: 35 years of research but the enigma remains
    • DOI 10.1210/er.2006-0007
    • Gromada J, Franklin I, Wollheim CB (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 28: 84-116. (Pubitemid 46220851)
    • (2007) Endocrine Reviews , vol.28 , Issue.1 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 51
    • 84859140033 scopus 로고    scopus 로고
    • Pax6 is crucial for beta-cell function, insulin biosynthesis, and glucose-induced insulin secretion
    • Gosmain Y, Katz LS, Masson MH, Cheyssac C, Poisson C, et al. (2012) Pax6 is crucial for beta-cell function, insulin biosynthesis, and glucose-induced insulin secretion. Mol Endocrinol 26: 696-709.
    • (2012) Mol Endocrinol , vol.26 , pp. 696-709
    • Gosmain, Y.1    Katz, L.S.2    Masson, M.H.3    Cheyssac, C.4    Poisson, C.5
  • 52
    • 0025343831 scopus 로고
    • Both amidated and nonamidated forms of glucagon-like peptide i are synthesized in the rat intestine and the pancreas
    • Mojsov S, Kopczynski MG, Habener JF (1990) Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem 265: 8001-8008.
    • (1990) J Biol Chem , vol.265 , pp. 8001-8008
    • Mojsov, S.1    Kopczynski, M.G.2    Habener, J.F.3
  • 53
    • 0029189516 scopus 로고
    • Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide
    • Heller RS, Aponte GW (1995) Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide. Am J Physiol 269: G852-860.
    • (1995) Am J Physiol , vol.269
    • Heller, R.S.1    Aponte, G.W.2
  • 54
    • 0025994409 scopus 로고
    • Developmental patterns of glucagon-like peptide-1-(7-36) amide and peptide-YY in rat pancreas and gut
    • Kreymann B, Ghatei MA, Domin J, Kanse S, Bloom SR (1991) Developmental patterns of glucagon-like peptide-1-(7-36) amide and peptide-YY in rat pancreas and gut. Endocrinology 129: 1001-1005.
    • (1991) Endocrinology , vol.129 , pp. 1001-1005
    • Kreymann, B.1    Ghatei, M.A.2    Domin, J.3    Kanse, S.4    Bloom, S.R.5
  • 55
    • 17844404229 scopus 로고    scopus 로고
    • Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining β-cell function
    • DOI 10.1210/me.2004-0350
    • Masur K, Tibaduiza EC, Chen C, Ligon B, Beinborn M (2005) Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining beta-cell function. Mol Endocrinol 19: 1373-1382. (Pubitemid 40594131)
    • (2005) Molecular Endocrinology , vol.19 , Issue.5 , pp. 1373-1382
    • Masur, K.1    Tibaduiza, E.C.2    Chen, C.3    Ligon, B.4    Beinborn, M.5
  • 56
    • 33645868980 scopus 로고    scopus 로고
    • Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin
    • Thyssen S, Arany E, Hill DJ (2006) Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology 147: 2346-2356.
    • (2006) Endocrinology , vol.147 , pp. 2346-2356
    • Thyssen, S.1    Arany, E.2    Hill, D.J.3
  • 57
    • 80555157690 scopus 로고    scopus 로고
    • Processing of proglucagon to GLP-1 in pancreatic alpha-cells: Is this a paracrine mechanism enabling GLP-1 to act on beta-cells?
    • Whalley NM, Pritchard LE, Smith DM, White A (2011) Processing of proglucagon to GLP-1 in pancreatic alpha-cells: is this a paracrine mechanism enabling GLP-1 to act on beta-cells? J Endocrinol 211: 99-106.
    • (2011) J Endocrinol , vol.211 , pp. 99-106
    • Whalley, N.M.1    Pritchard, L.E.2    Smith, D.M.3    White, A.4
  • 58
    • 81255157471 scopus 로고    scopus 로고
    • Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    • Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, et al. (2011) Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med 17: 1481-1489.
    • (2011) Nat Med , vol.17 , pp. 1481-1489
    • Ellingsgaard, H.1    Hauselmann, I.2    Schuler, B.3    Habib, A.M.4    Baggio, L.L.5
  • 59
    • 80052523733 scopus 로고    scopus 로고
    • Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus-an adaptive response to hyperglycaemia?
    • Hansen AM, Bodvarsdottir TB, Nordestgaard DN, Heller RS, Gotfredsen CF, et al. (2011) Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus-an adaptive response to hyperglycaemia? Diabetologia 54: 1379-1387.
    • (2011) Diabetologia , vol.54 , pp. 1379-1387
    • Hansen, A.M.1    Bodvarsdottir, T.B.2    Nordestgaard, D.N.3    Heller, R.S.4    Gotfredsen, C.F.5
  • 60
    • 67749096276 scopus 로고    scopus 로고
    • Induced in vitro differentiation of pancreatic-like cells from human amnion-derived fibroblast-like cells
    • Tamagawa T, Ishiwata I, Sato K, Nakamura Y (2009) Induced in vitro differentiation of pancreatic-like cells from human amnion-derived fibroblast-like cells. Hum Cell 22: 55-63.
    • (2009) Hum Cell , vol.22 , pp. 55-63
    • Tamagawa, T.1    Ishiwata, I.2    Sato, K.3    Nakamura, Y.4
  • 61
    • 0032415359 scopus 로고    scopus 로고
    • Pax 4 and 6 regulate gastrointestinal endocrine cell development
    • DOI 10.1016/S0925-4773(98)00182-8, PII S0925477398001828
    • Larsson LI, St-Onge L, Hougaard DM, Sosa-Pineda B, Gruss P (1998) Pax 4 and 6 regulate gastrointestinal endocrine cell development. Mech Dev 79: 153-159. (Pubitemid 29038030)
    • (1998) Mechanisms of Development , vol.79 , Issue.1-2 , pp. 153-159
    • Larsson, L.-I.1    St-Onge, L.2    Hougaard, D.M.3    Sosa-Pineda, B.4    Gruss, P.5
  • 63
    • 35748962950 scopus 로고    scopus 로고
    • A switch from Prohormone Convertase (PC)-2 to PC1/3 expression in transplanted α-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
    • DOI 10.2337/db07-0563
    • Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ (2007) A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alphacells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes 56: 2744-2752. (Pubitemid 350044917)
    • (2007) Diabetes , vol.56 , Issue.11 , pp. 2744-2752
    • Wideman, R.D.1    Covey, S.D.2    Webb, G.C.3    Drucker, D.J.4    Kieffer, T.J.5
  • 64
    • 58149215525 scopus 로고    scopus 로고
    • Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice
    • Wideman RD, Gray SL, Covey SD, Webb GC, Kieffer TJ (2009) Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Mol Ther 17: 191-198.
    • (2009) Mol Ther , vol.17 , pp. 191-198
    • Wideman, R.D.1    Gray, S.L.2    Covey, S.D.3    Webb, G.C.4    Kieffer, T.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.