메뉴 건너뛰기




Volumn 10, Issue 9, 2016, Pages 1415-1429

Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells

Author keywords

15 PGDH; Colon cancer; JNK; WNT 5A; Catenin

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; BETA CATENIN; MESSENGER RNA; MUCIN 2; STRESS ACTIVATED PROTEIN KINASE; WNT5A PROTEIN; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE; FOXY-5 PEPTIDE; OLIGOPEPTIDE; WNT5A PROTEIN, HUMAN;

EID: 84994336855     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2016.07.011     Document Type: Article
Times cited : (45)

References (48)
  • 1
    • 13544268334 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
    • Backlund, M.G., Mann, J.R., Holla, V.R., et al. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J. Biol. Chem. 280 (2005), 3217–3223.
    • (2005) J. Biol. Chem. , vol.280 , pp. 3217-3223
    • Backlund, M.G.1    Mann, J.R.2    Holla, V.R.3
  • 2
    • 14644427141 scopus 로고    scopus 로고
    • Low expression of Wnt-5a gene is associated with high-risk neuroblastoma
    • Blanc, E., Roux, G.L., Benard, J., et al. Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene 24 (2005), 1277–1283.
    • (2005) Oncogene , vol.24 , pp. 1277-1283
    • Blanc, E.1    Roux, G.L.2    Benard, J.3
  • 3
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: a molecular target for colorectal cancer prevention
    • Brown, J.R., DuBois, R.N., COX-2: a molecular target for colorectal cancer prevention. J. Clin. Oncol. 23 (2005), 2840–2855.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 4
    • 55049118192 scopus 로고    scopus 로고
    • 15-Prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma
    • Celis, J.E., Gromov, P., Cabezon, T., et al. 15-Prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma. Mol. Cell. Prot. MCP 7 (2008), 1795–1809.
    • (2008) Mol. Cell. Prot. MCP , vol.7 , pp. 1795-1809
    • Celis, J.E.1    Gromov, P.2    Cabezon, T.3
  • 5
    • 84898025518 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma
    • Chen, E.Y., DeRan, M.T., Ignatius, M.S., et al. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 5349–5354.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 5349-5354
    • Chen, E.Y.1    DeRan, M.T.2    Ignatius, M.S.3
  • 6
    • 84903622908 scopus 로고    scopus 로고
    • Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition
    • Cheng, R., Sun, B., Liu, Z., et al. Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition. J. Cell. Physiol. 229:12 (2014), 1908–1917.
    • (2014) J. Cell. Physiol. , vol.229 , Issue.12 , pp. 1908-1917
    • Cheng, R.1    Sun, B.2    Liu, Z.3
  • 7
    • 84902179818 scopus 로고    scopus 로고
    • Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis
    • Choi, S.H., Kim, B.G., Robinson, J., et al. Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J. Clin. Invest. 124 (2014), 2472–2482.
    • (2014) J. Clin. Invest. , vol.124 , pp. 2472-2482
    • Choi, S.H.1    Kim, B.G.2    Robinson, J.3
  • 8
    • 27144450534 scopus 로고    scopus 로고
    • Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis
    • Dejmek, J., Dejmek, A., Safholm, A., et al. Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res. 65 (2005), 9142–9146.
    • (2005) Cancer Res. , vol.65 , pp. 9142-9146
    • Dejmek, J.1    Dejmek, A.2    Safholm, A.3
  • 9
    • 18244387242 scopus 로고    scopus 로고
    • Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival
    • Dejmek, J., Leandersson, K., Manjer, J., et al. Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival. Clin. Cancer Res. 11 (2005), 520–528.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 520-528
    • Dejmek, J.1    Leandersson, K.2    Manjer, J.3
  • 10
    • 0028889575 scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase
    • Ensor, C.M., Tai, H.H., 15-Hydroxyprostaglandin dehydrogenase. J. Lipid Med. Cell Signal. 12 (1995), 313–319.
    • (1995) J. Lipid Med. Cell Signal. , vol.12 , pp. 313-319
    • Ensor, C.M.1    Tai, H.H.2
  • 12
    • 0034465665 scopus 로고    scopus 로고
    • The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone
    • Greenland, K.J., Jantke, I., Jenatschke, S., et al. The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone. Endocrinology 141 (2000), 581–597.
    • (2000) Endocrinology , vol.141 , pp. 581-597
    • Greenland, K.J.1    Jantke, I.2    Jenatschke, S.3
  • 13
    • 66149133290 scopus 로고    scopus 로고
    • The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence
    • Huxley, R.R., Ansary-Moghaddam, A., Clifton, P., et al. The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int. J. Cancer 125 (2009), 171–180.
    • (2009) Int. J. Cancer , vol.125 , pp. 171-180
    • Huxley, R.R.1    Ansary-Moghaddam, A.2    Clifton, P.3
  • 14
    • 0034960540 scopus 로고    scopus 로고
    • Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells
    • Jonsson, M., Andersson, T., Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J. Cell Sci. 114 (2001), 2043–2053.
    • (2001) J. Cell Sci. , vol.114 , pp. 2043-2053
    • Jonsson, M.1    Andersson, T.2
  • 15
    • 0037081290 scopus 로고    scopus 로고
    • Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
    • Jonsson, M., Dejmek, J., Bendahl, P.O., et al. Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res. 62 (2002), 409–416.
    • (2002) Cancer Res. , vol.62 , pp. 409-416
    • Jonsson, M.1    Dejmek, J.2    Bendahl, P.O.3
  • 16
    • 83155181734 scopus 로고    scopus 로고
    • Wnt5a: its signalling, functions and implication in diseases
    • Kikuchi, A., Yamamoto, H., Sato, A., et al. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol. 204 (2012), 17–33.
    • (2012) Acta Physiol. , vol.204 , pp. 17-33
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3
  • 17
    • 16444372007 scopus 로고    scopus 로고
    • Wnt-5a has tumor suppressor activity in thyroid carcinoma
    • Kremenevskaja, N., von Wasielewski, R., Rao, A.S., et al. Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 24 (2005), 2144–2154.
    • (2005) Oncogene , vol.24 , pp. 2144-2154
    • Kremenevskaja, N.1    von Wasielewski, R.2    Rao, A.S.3
  • 18
    • 84856746129 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells
    • Lehtinen, L., Vainio, P., Wikman, H., et al. 15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells. J. Pathol. 226 (2012), 674–686.
    • (2012) J. Pathol. , vol.226 , pp. 674-686
    • Lehtinen, L.1    Vainio, P.2    Wikman, H.3
  • 19
    • 57049176565 scopus 로고    scopus 로고
    • Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene
    • Li, M., Xie, J., Cheng, L., et al. Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene. Cancer Invest. 26 (2008), 905–912.
    • (2008) Cancer Invest. , vol.26 , pp. 905-912
    • Li, M.1    Xie, J.2    Cheng, L.3
  • 20
    • 0345356929 scopus 로고    scopus 로고
    • Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue
    • Liang, H., Chen, Q., Coles, A.H., et al. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell. 4:5 (2003), 349–360.
    • (2003) Cancer Cell. , vol.4 , Issue.5 , pp. 349-360
    • Liang, H.1    Chen, Q.2    Coles, A.H.3
  • 21
    • 76049111365 scopus 로고    scopus 로고
    • Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer
    • Magnusson, C., Mezhybovska, M., Lörinc, E., et al. Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer. Eur. J. Cancer 46 (2010), 826–835.
    • (2010) Eur. J. Cancer , vol.46 , pp. 826-835
    • Magnusson, C.1    Mezhybovska, M.2    Lörinc, E.3
  • 22
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: molecular basis of colorectal cancer
    • Markowitz, S.D., Bertagnolli, M.M., Molecular origins of cancer: molecular basis of colorectal cancer. N. Engl. J. Med. 361 (2009), 2449–2460.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 23
    • 33747081906 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
    • Myung, S.J., Rerko, R.M., Yan, M., et al. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 12098–12102.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 12098-12102
    • Myung, S.J.1    Rerko, R.M.2    Yan, M.3
  • 24
    • 54249099723 scopus 로고    scopus 로고
    • Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
    • Nomachi, A., Nishita, M., Inaba, D., et al. Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J. Biol. Chem. 283 (2008), 27973–27981.
    • (2008) J. Biol. Chem. , vol.283 , pp. 27973-27981
    • Nomachi, A.1    Nishita, M.2    Inaba, D.3
  • 25
    • 77950237476 scopus 로고    scopus 로고
    • Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors
    • Pham, H., Chen, M., Li, A., et al. Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. Pancreas 39 (2010), 332–339.
    • (2010) Pancreas , vol.39 , pp. 332-339
    • Pham, H.1    Chen, M.2    Li, A.3
  • 26
    • 84884280193 scopus 로고    scopus 로고
    • WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells
    • Prasad, C.P., Chaurasiya, S.K., Axelsson, L., et al. WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells. Mol. Oncol. 7 (2013), 870–883.
    • (2013) Mol. Oncol. , vol.7 , pp. 870-883
    • Prasad, C.P.1    Chaurasiya, S.K.2    Axelsson, L.3
  • 27
    • 33645789040 scopus 로고    scopus 로고
    • A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells
    • Säfholm, A., Leandersson, K., Dejmek, J., et al. A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J. Biol. Chem. 281 (2006), 2740–2749.
    • (2006) J. Biol. Chem. , vol.281 , pp. 2740-2749
    • Säfholm, A.1    Leandersson, K.2    Dejmek, J.3
  • 28
    • 58149190789 scopus 로고    scopus 로고
    • The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility
    • Säfholm, A., Tuomela, J., Rosenkvist, J., et al. The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin. Cancer Res. 14 (2008), 6556–6563.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6556-6563
    • Säfholm, A.1    Tuomela, J.2    Rosenkvist, J.3
  • 29
    • 84878851884 scopus 로고    scopus 로고
    • Nuclear expression of glycogen synthase kinase-3beta and lack of membranous beta-catenin is correlated with poor survival in colon cancer
    • Salim, T., Sjölander, A., Sand-Dejmek, J., Nuclear expression of glycogen synthase kinase-3beta and lack of membranous beta-catenin is correlated with poor survival in colon cancer. Int. J. Cancer 133 (2013), 807–815.
    • (2013) Int. J. Cancer , vol.133 , pp. 807-815
    • Salim, T.1    Sjölander, A.2    Sand-Dejmek, J.3
  • 30
    • 84882748802 scopus 로고    scopus 로고
    • The prognostic significance of Wnt-5a expression in primary breast cancer is extended to premenopausal women
    • Sand-Dejmek, J., Ehrnström, R., Berglund, P., et al. The prognostic significance of Wnt-5a expression in primary breast cancer is extended to premenopausal women. PLoS One, 8, 2013, e70890.
    • (2013) PLoS One , vol.8 , pp. e70890
    • Sand-Dejmek, J.1    Ehrnström, R.2    Berglund, P.3
  • 32
    • 1242314857 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in colorectal cancer
    • Sinicrope, F.A., Gill, S., Role of cyclooxygenase-2 in colorectal cancer. Cancer Met. Rev. 23 (2004), 63–75.
    • (2004) Cancer Met. Rev. , vol.23 , pp. 63-75
    • Sinicrope, F.A.1    Gill, S.2
  • 33
    • 84867895532 scopus 로고    scopus 로고
    • beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
    • Smartt, H.J., Greenhough, A., Ordonez-Moran, P., et al. beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?. Br. J. Cancer 107 (2012), 1514–1517.
    • (2012) Br. J. Cancer , vol.107 , pp. 1514-1517
    • Smartt, H.J.1    Greenhough, A.2    Ordonez-Moran, P.3
  • 34
    • 84864987488 scopus 로고    scopus 로고
    • Beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells
    • Smartt, H.J., Greenhough, A., Ordonez-Moran, P., et al. Beta-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61 (2012), 1306–1314.
    • (2012) Gut , vol.61 , pp. 1306-1314
    • Smartt, H.J.1    Greenhough, A.2    Ordonez-Moran, P.3
  • 35
    • 79953802545 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase is downregulated and exhibits tumor suppressor activity in gastric cancer
    • Song, H.J., Myung, S.J., Kim, I.W., et al. 15-Hydroxyprostaglandin dehydrogenase is downregulated and exhibits tumor suppressor activity in gastric cancer. Cancer Invest. 29 (2011), 257–265.
    • (2011) Cancer Invest. , vol.29 , pp. 257-265
    • Song, H.J.1    Myung, S.J.2    Kim, I.W.3
  • 36
    • 80055047246 scopus 로고    scopus 로고
    • Elevated level of Wnt5a protein in localized prostate cancer tissue is associated with better outcome
    • Syed Khaja, A.S., Helczynski, L., Edsjo, A., et al. Elevated level of Wnt5a protein in localized prostate cancer tissue is associated with better outcome. PLoS One, 6, 2011, e26539.
    • (2011) PLoS One , vol.6 , pp. e26539
    • Syed Khaja, A.S.1    Helczynski, L.2    Edsjo, A.3
  • 37
    • 34247519066 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer
    • Tai, H.H., Tong, M., Ding, Y., 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer. Prost. Lipid Med. 83 (2007), 203–208.
    • (2007) Prost. Lipid Med. , vol.83 , pp. 203-208
    • Tai, H.H.1    Tong, M.2    Ding, Y.3
  • 38
    • 0032960673 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation
    • Taupin, D., Podolsky, D.K., Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. Gastroenterology 116 (1999), 1072–1080.
    • (1999) Gastroenterology , vol.116 , pp. 1072-1080
    • Taupin, D.1    Podolsky, D.K.2
  • 39
    • 67349245787 scopus 로고    scopus 로고
    • New insights into the aetiology of colorectal cancer from genome-wide association studies
    • Tenesa, A., Dunlop, M.G., New insights into the aetiology of colorectal cancer from genome-wide association studies. Nat. Rev. Genet. 10 (2009), 353–358.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 353-358
    • Tenesa, A.1    Dunlop, M.G.2
  • 40
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    • Topol, L., Jiang, X., Choi, H., et al. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 (2003), 899–908.
    • (2003) J. Cell Biol. , vol.162 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3
  • 41
    • 69249161777 scopus 로고    scopus 로고
    • Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies
    • Triantafillidis, J.K., Nasioulas, G., Kosmidis, P.A., Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res. Int. J. Cancer Res. Treat. 29 (2009), 2727–2737.
    • (2009) Anticancer Res. Int. J. Cancer Res. Treat. , vol.29 , pp. 2727-2737
    • Triantafillidis, J.K.1    Nasioulas, G.2    Kosmidis, P.A.3
  • 42
    • 77749245858 scopus 로고    scopus 로고
    • Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression
    • Tseng-Rogenski, S., Gee, J., Ignatoski, K.W., et al. Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression. Am. J. Pathol. 176 (2010), 1462–1468.
    • (2010) Am. J. Pathol. , vol.176 , pp. 1462-1468
    • Tseng-Rogenski, S.1    Gee, J.2    Ignatoski, K.W.3
  • 43
    • 0036177671 scopus 로고    scopus 로고
    • Cyclooxygenase-2: a therapeutic target
    • Turini, M.E., DuBois, R.N., Cyclooxygenase-2: a therapeutic target. Annu. Rev. Med. 53 (2002), 35–57.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 35-57
    • Turini, M.E.1    DuBois, R.N.2
  • 44
    • 84879739288 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase (JNK) mediates Wnt5a-induced cell motility dependent or independent of RhoA pathway in human dental papilla cells
    • Wang, C., Zhao, Y., Su, Y., et al. C-Jun N-terminal kinase (JNK) mediates Wnt5a-induced cell motility dependent or independent of RhoA pathway in human dental papilla cells. PLoS One, 8, 2013, e69440.
    • (2013) PLoS One , vol.8 , pp. e69440
    • Wang, C.1    Zhao, Y.2    Su, Y.3
  • 45
    • 84952975799 scopus 로고    scopus 로고
    • Prostaglandin E promotes colorectal cancer stem cell expansion and metastasis in mice
    • Wang, D., Fu, L., Sun, H., et al. Prostaglandin E promotes colorectal cancer stem cell expansion and metastasis in mice. Gastroenterology 149:7 (2015), 1884–1895.
    • (2015) Gastroenterology , vol.149 , Issue.7 , pp. 1884-1895
    • Wang, D.1    Fu, L.2    Sun, H.3
  • 46
    • 84856191525 scopus 로고    scopus 로고
    • Dysregulation of Wnt/beta-catenin signaling in gastrointestinal cancers
    • White, B.D., Chien, A.J., Dawson, D.W., Dysregulation of Wnt/beta-catenin signaling in gastrointestinal cancers. Gastroenterology 142 (2012), 219–232.
    • (2012) Gastroenterology , vol.142 , pp. 219-232
    • White, B.D.1    Chien, A.J.2    Dawson, D.W.3
  • 47
    • 10644274362 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers
    • Yan, M., Rerko, R.M., Platzer, P., et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 17468–17473.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 17468-17473
    • Yan, M.1    Rerko, R.M.2    Platzer, P.3
  • 48
    • 40749119357 scopus 로고    scopus 로고
    • WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer
    • Ying, J., Li, H., Yu, J., et al. WNT5A exhibits tumor-suppressive activity through antagonizing the Wnt/beta-catenin signaling, and is frequently methylated in colorectal cancer. Clin. Cancer Res. 14 (2008), 55–61.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 55-61
    • Ying, J.1    Li, H.2    Yu, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.