15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma

Molecular and Cellular Proteomics

Volumn 7, Issue 10, 2008, Pages 1795-1809

  Celis, Julio E ^a,b   Gromov, Pavel ^a,b   Cabezón, Teresa ^a,b   Moreira, José M A ^a,b   Friis, Esbern ^b,c   Jirström, Karin ^d   Llombart Bosch, Antonio ^e   Timmermans Wielenga, Vera ^b,c   Rank, Fritz ^b,c   Gromova, Irina ^a,b  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b Institute of Cancer Biolog   (Denmark)

^c Mental Health Services CPH   (Denmark)

^d LUND UNIVERSITY   (Sweden)

^e UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; ACYL COENZYME A SYNTHETASE MEDIUM CHAIN FAMILY MEMBER1; PROTEIN ACSM1; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOCRINE CARCINOMA; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; TISSUE MICROARRAY; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ADULT; AGED; AGED, 80 AND OVER; APOCRINE GLANDS; BREAST NEOPLASMS; COENZYME A LIGASES; COHORT STUDIES; DISEASE PROGRESSION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; MIDDLE AGED; NEOPLASM INVASIVENESS; PARAFFIN EMBEDDING; PHENOTYPE; SILVER STAINING; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 55049118192     PISSN: 15359476     EISSN: None     Source Type: Journal    
DOI: 10.1074/mcp.R800011-MCP200     Document Type: Article

References (56)

1. Kamangar, F., Dores, G. M., and Anderson, W. F. (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol. 24, 2137-2150
2. Gondos, A., Bray, F., Brewster, D. H., Coebergh, J. W., Hakulinen, T., Janssen-Heijnen, M. L., Kurtinaitis, J., and Brenner, H.; The EUNICE Survival Working Group (2008) Recent trends in cancer survival across Europe between 2000 and 2004: a model-based period analysis from 12 cancer registries. Eur. J. Cancer 44, 1463-1475
3. Perry, N., Broeders, M., de Wolf, C., Törnberg, S., Holland, R., and von Karsa, L. (eds) (2006) in European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis, 4th Ed., pp. 221-311, European Commission, Brussels, Belgium
4. Perou, C. M., Sørlie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Rees, C. A., Pollack, J. R., Ross, D. T., Johnsen, H., Akslen, L. A., Fluge, O., Pergamenschikov, A., Williams, C., Zhu, S. X., Lonning, P. E., Børresen-Dale, A. L., Brown, P. O., and Botsteln, D. (2000) Molecular portraits of human breast tumours. Nature 406, 747-752
5. Sørlie, T., Perou C. M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Thorsen, T., Quist, H., Matese, J. C., Brown, P. O., Botstein, D., Eystein Lonning, P., and Børresen-Dale, A. L. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. U. S. A. 98, 10869-10874
6. Farmer, P., Bonnefoi, H., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., Macgrogan, G., Bergh, J., Cameron, D., Goldstein, D., Duss, S., Nicoulaz, A. L, Brisken, C., Fiche, M., Delorenzi, M., and Iggo, R. (2005) Identification of molecular apocrine breast tumours by microarray analysis. Oncogene 24, 4660-4671
7. Frable, W. J., and Kay, S. (1968) Carcinoma of the breast. Histologic and clinical features of apocrine tumors. Cancer 21, 756-763
8. Mossler, J. A., Barton, T. K., Brinkhous, A. D., McCarty, K. S., Moylan, J. A., and McCarty, K. S., Jr. (1980) Apocrine differentiation in human mammary carcinoma. Cancer 46, 2463-2471
9. Eusebi, V., Millis, R. R., Cattani, M. G., Bussolati, G., and Azzopardi, J. G. (1986) Apocrine carcinoma of the breast. A morphologic and immunocytochemical study. Am. J. Pathol. 123, 532-541
10. O'Malley, F. P., and Bane, A. (2008) An update on apocrine lesions of the breast. Histopathology 52, 3-10
11. Japaze, H., Emina, J., Diaz, C., Schwam, R. J., Gercovich, N., Demonty, G., Morgenfeld, E., Rivarola, E., Gil Deza, E., and Gercovich, F. G. (2005) 'Pure' invasive apocrine carcinoma of the breast: a new clinicopathological entity? Breast 14, 3-10
12. Page, D. L. (2005) Apocrine carcinomas of the breast. Breast 14, 1-2
13. Wells, C. A., and El-Ayat, G. A. (2007) Non-operative breast pathology: apocrine lesions. J. Clin. Pathol. 60, 1313-1320
14. Tanaka, K., Imoto, S., Wada, N., Sakemura, N., and Hasebe, K. (2008) Invasive apocrine carcinoma of the breast: clinicopathologic features of 57 patients. Breast J. 14, 164-168
15. Abati, A. D., Kimmel, M., and Rosen, P. P. (1990) Apocrine mammary carcinoma. A clinicopathologic study of 72 cases. Am. J. Clin. Pathol. 94, 371-377
16. Celis, J. E., Gromov, P., Moreira, J. M., Cabezón, T., Friis, E., Vejborg, I. M., Proess, G., Rank, F., and Gromova, I. (2006) Apocrine cysts of the breast: biomarkers, origin, enlargement, and relation with cancer phenotype. Mol. Cell. Proteomics 5, 462-483
17. Celis, J. E., Gromova, I., Gromov, P., Moreira, J. M., Cabezón, T., Friis, E., and Rank, F. (2006) Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia. FEBS Lett. 580, 2935-2944
18. Tavassoli, F. A., Purcell, C., and Man, Y. G. (1996) Down regulation of bcl2, ER, PR, associatied with AR expression is triggered by apocrine differentiation of mammary epithelium. Mod. Pathol.. 9, 25 A
19. Gatalica, Z. (1997) Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ. Pathol. Res. Pract. 193, 753-758
20. Salim, A. G., and Wells, C. A. (1999) Immunohistochemical localisation of androgen receptor in apocrine metaplasla and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors. J. Clin. Pathol. 52, 838-841
21. Sapp, M., Malik, A., and Hanna, W. (2003) Hormone receptor profile of apocrine lesions of the breast. Breast J. 9, 335-356
22. Selim, A. G., El-Ayat, G., and Wells, C. A. (2002) Expression of c-erbB2, p53, Bcl-2, Bax, c-myc and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. Virchows Arch. 441, 449-455
23. Moinfar, F., Okcu, M., Tsybrovskyy, O., Regitnig, P., Lax, S. F., Weybora, W., Ratschek, M., Tavassoli, F. A., and Dank, H. (2003) Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies. Cancer 98, 703-711
24. Mazoujian, G., Pinkus, G. S., Davis, S., and Haagensen, D. E., Jr. (1983) Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Am. J. Pathol. 110, 105-112
25. Miller, W. R., Shivas, A. A., Franchimont, P., and Haagensen, D. E. (1988) Breast gross cystic disease protein 15 in human breast cancer in culture. Eur. J. Cancer Clin. Oncol. 24, 223-228
26. Honma, N., Takubo, K., Akiyama, F., Sawabe, M., Arai, T., Younes, M., Kasumi, F., and Sakamoto, G. (2005) Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. Histopathology 47, 195-201
27. Moriya, T., Sakamoto, K., Sasano, H., Kawanaka, M., Sonoo, H., Manabe, T., and Ito, J. (2000) Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases. Mod. Pathol. 13, 13-18
28. Washington, C., Dalbègue, F., Abreo, F., Taubenberger, J. K., and Lichy, J. H. (2000) Loss of heterozygosity in fibrocystic change of the breast: genetic relationship between benign proliferative lesions and associated carcinomas. Am. J. Pathol. 157, 323-329
29. Maitra, A., Wistuba, I. I., Washington, C., Virmani, A. K., Ashfaq, R., Milchgrub, S., Gazdar, A. F., and Minna, J. D. (2001) High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss. Am. J. Pathol. 159, 119-130
30. Jones, C., Damiani, S., Wells, D., Chaggar, R., Lakhani, S. R., and Eusebi, V. (2001) Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast. Am. J. Pathol. 158, 207-214
31. Celis, J. E., Moreira, J. M. A., Irina Gromova, I., Teresa Cabezón, T., Gromov, P., Shen, T., Timmermans, V., and Rank, F. (2007) Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia. Mol. Oncol. 1, 97-119
32. Borgquist, S., Holm, C., Stendahl, M., Anagnostaki, L., Landberg, G., and Jirström, K. J. (2008) Oestrogen receptors α and β show different associations to clinicopathological parameters and their co-expression might predict a better response to endocrine treatment in breast cancer. Clin. Pathol. 61, 197-203
33. O'Farrell, P. H. (1975) High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250, 4007-4021
34. Celis, J. E., Trentemølle, S., and Gromov, P. (2005) Gel-based proteomics: high-resolution two-dimensional gel electrophoresis of proteins. Isoelectric focusing (IEF) and nonequilibrium pH gradient electrophoresis (NEPHGE), in Cell Biology. A Laboratory Handbook (Celis, J. E., Carter, N., Hunter, T., Shotton, D., Simons, K., and Small, J. V., eds) Vol. 4, pp. 165-177, Elsevier, San Diego, CA
35. Celis, J. E., Moreira, J. M., Cabezón, T., Gromov, P., Friis, E., Rank, F., and Gromova I. (2005) Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromall cell interactions. Mol. Cell. Proteomics 4, 492-522
36. Celis, J. E., Gromova, I., Cabezón, T., Gromov, P., Shen, T., Timmermans-Wielenga, V., Rank, F., and Moreira, J. M. A. (2007) Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/ amplified cells and premalignant lesions and invasive disease. Mol. Oncol. 1, 321-349
37. Moll, R. (1998) Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell. Biochem. 31, 205-262
38. Gromova, I., and Celis, J. E. (2006). Protein detection in gels by silver staining: a procedure compatible with mass-spectrometry, in Cell Biology. A Laboratory Handbook (Celis, J. E., Carter, N., Hunter, T., Shotton, D., Simons, K., and Small, J. V. eds.) Vol. 4, pp. 219-223, Academic Press, San Diego, CA
39. Celis, J. E., Moreira, J. M. A., and Gromov, P. (2006) Determination of antibody specificity by Western blotting in Cell Biology. A Laboratory Handbook (Celis, J. E., Carter, N., Hunter, T., Shotton, D., Simons, K., and Small, J. V. eds.) Vol. 4, pp. 527-532, Academic Press, San Diego, CA
40. Shevchenko, A., Wilm, M., Vorm, O., and Mann M. (1996) Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem. 68, 850-858
41. Celis, J. E., Gromov, P., Cabezón, T., Moreira, J. M., Ambartsumian, N., Sandelin, K., Rank, F., and Gromova, I. (2004) Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery. Mol. Cell. Proteomics 3, 327-344
42. Celis, J. E., Ostergaard, M., Besse, B., Celis, A., Lauridsen, J. B., Ratz, G. P., Andersen, I., Hein, B., Wolf, H., Orntoft, T. F., and Rasmussen, H. H. (1996) Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas. Cancer Res. 56, 4782-4790
43. Moreira, J. M., Ohlsson, G., Rank, F. E., and Celis, J. E. (2005) Down-regulation of the tumor suppressor protein 14-3-3 sigma is a sporadic event in cancer of the breast. Mol. Cell. Proteomics 4, 555-569
44. Hughes, L. E., and Bundred, N. J. (1989) Breast macrocysts. World J. Surg. 13, 711-714
45. Leal, C., Henrique, R., Monteiro, P., Lopes, C., Bento, M. J., De Sousa, C. P., Lopes, P., Olson, S., Silva, M. D., and Page, D. L. (2001) Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. Hum. Pathol. 32, 487-493
46. Kouros-Mehr, H., Slorach, E. M., Stemlicht, M. D., and Werb, Z. (2006) GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 127, 1041-1055
47. Asselin-Labat, M. L., Sutherland, K. D., Barker, H., Thomas, R., Shackleton, M., Forrest, N. C., Hartley, L., Robb, L., Grosveld, F. G., van der Wass, J., Lindeman, G. J., and Visvader, J. E. (2007) Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat. Cell Biol. 9, 201-209
48. Sorlie, T., Fibshirani, R., Parker, J., Hastie, T., Marron, J. S., Nobel, A., Deng, S., Johnsen, H., Pesich, R., Geisler, S., Demeter, J., Perou, C. M., Lonning, P. E., Brown, P. O., Borresen-Dale, A. L., and Botstein, D. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl. Acad. Sci. U. S. A. 100, 8418-8423
49. Lam, L., and Cao, Y. (2005) Statins and their roles in cancer. Drugs Today 41, 329-334
50. Wang, D., and Dubois, R. N. (2006) Prostaglandins and cancer. Gut 55, 115-122
51. Katz, M. S., Schapira, L., Harisinghani, M. G., and Hughes, K. S. (2005) Palpable right breast mass in a pregnant woman. Nat. Clin. Pract. Oncol. 2, 218-221
52. Hirsch, F. R., and Lippman, S. M. (2005) Advances in the biology of lung cancer chemoprevention. J. Clin. Oncol. 23, 3186-3197
53. Waters, D. D. (2001) What do the statin trials tell us? Clin. Cardiol. 24, 3-7
54. Wolf, I., O'Kelly, J., Rubinek, T., Tong, M., Nguyen, A., Lin, B. T., Tai, H. H., Karlan, B. Y., and Koeffler, H. P. (2006) 15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Res. 66, 7818-7823
55. Elston, C. W., and Ellis, I. O. (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 119, 403-410
56. Dowcett, M., Bartlett, J., Ellis, I. O., Salter, J., Hills, M., Mallon, E., Watters, A. D., Cooke, T., Paish, C., Wencyk, P. M., and Pinder, S. E. (2003) Correlation between immunohistochemistry (Hercep Test) and fluorescence in situ hybridization (FISH) for HER-2 in 426 breast carcinomas from 37 centres. J. Pathol. 199, 418-423