Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Kidney International

Volumn 90, Issue 4, 2016, Pages 797-808

  Baumann, Bethany ^a   Hayashida, Tomoko ^a,b   Liang, Xiaoyan ^a   Schnaper, H William ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

fibrosis; glomerulus; hypoxia; TGF

Indexed keywords

COLLAGEN TYPE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; COL1A2 PROTEIN, MOUSE; COLLAGEN TYPE 1; HIF1A PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOACCUMULATION; COL1A2 GENE; CONTROLLED STUDY; FIBROBLAST; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE INTERACTION; GENETIC TRANSCRIPTION; GLOMERULOSCLEROSIS; KIDNEY CELL; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHRONIC KIDNEY FAILURE; CYTOLOGY; DISEASE MODEL; GENETICS; GLOMERULUS; HUMAN; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SCLEROSIS;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; PODOCYTES; PROMOTER REGIONS, GENETIC; RENAL INSUFFICIENCY, CHRONIC; SCLEROSIS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84994253012     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.05.026     Document Type: Article

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