Elucidation of the regulatory role of the fructose operon reveals a novel target for enhancing the NADPH supply in Corynebacterium glutamicum

Metabolic Engineering

Volumn 38, Issue , 2016, Pages 344-357

  Wang, Zhihao ^a   Chan, Siu Hung Joshua ^a   Sudarsan, Suresh ^b   Blank, Lars M ^b   Jensen, Peter Ruhdal ^a   Solem, Christian ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Convergent evolution; Corynebacterium glutamicum; Fructose operon; Hexose phosphates; NADPH; Transcriptomics

Indexed keywords

AMINO ACIDS; BIOLOGY; GENE ENCODING; GENE EXPRESSION; GENES; METABOLISM; PHOSPHATES; PHYSIOLOGY; SUGAR (SUCROSE); SUGARS;

COMPARATIVE GENOMIC; CONVERGENT EVOLUTION; CORYNEBACTERIUM GLUTAMICUM; NADPH; REGULATORY MECHANISM; TRANSCRIPTIONAL REGULATION; TRANSCRIPTOME DATUM; TRANSCRIPTOMICS;

FRUCTOSE;

1 PHOSPHOFRUCTOKINASE; FRUCTOSE; FRUCTOSE 1 PHOSPHATE; LYSINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCROSE; SUGAR PHOSPHATE; TRANSCRIPTOME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIUM MUTANT; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; CULTURE MEDIUM; ENZYMATIC ASSAY; ENZYME ASSAY; GENE EXPRESSION; GENE INACTIVATION; GENOME ANALYSIS; METABOLIC REGULATION; NONHUMAN; OPERON; OXIDATION REDUCTION REACTION; PFKB GENE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; WILD TYPE; BIOAVAILABILITY; BIOLOGICAL MODEL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETIC ENHANCEMENT; GENETICS; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLISM; PHYSIOLOGY; PROCEDURES;

BIOLOGICAL AVAILABILITY; BIOSYNTHETIC PATHWAYS; CORYNEBACTERIUM GLUTAMICUM; FRUCTOSE; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; GENE TARGETING; GENETIC ENHANCEMENT; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; MODELS, GENETIC; NADP; OPERON;

EID: 84994177759     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.08.004     Document Type: Article

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