Expression of the gapA gene encoding glyceraldehyde-3-phosphate dehydrogenase of Corynebacterium glutamicum is regulated by the global regulator SugR

Applied Microbiology and Biotechnology

Volumn 81, Issue 2, 2008, Pages 291-301

  Toyoda, Koichi ^a   Teramoto, Haruhiko ^a   Inui, Masayuki ^a   Yukawa, Hideaki ^a  

^a RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH   (Japan)

Author keywords

Corynebacterium glutamicum; Gene expression; Glyceraldehyde 3 phosphate dehydrogenase; Glycolysis

Indexed keywords

BINDING ENERGY; BINDING SITES; ELECTROPHORETIC MOBILITY; ENCODING (SYMBOLS); ENZYMES; FRUCTOSE; GENE EXPRESSION; GENES; NUCLEIC ACIDS; ORGANIC ACIDS; PATHOLOGY; SUGAR (SUCROSE); SUGARS;

BISPHOSPHATE; CONSENSUS SEQUENCES; CORYNEBACTERIUM GLUTAMICUM; DELETION MUTANTS; DNA AFFINITIES; ELECTROPHORETIC MOBILITY SHIFT ASSAYS; FRUCTOSE-1; FUSION EXPRESSIONS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GLYCOLYSIS; PROMOTER REGIONS; SUGAR TRANSPORTS; TRANSCRIPTIONAL REGULATORS;

GENE ENCODING;

BETA GALACTOSIDASE; BINDING PROTEIN; FRUCTOSE; FRUCTOSE 1 PHOSPHATE; FRUCTOSE 1,6 BISPHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PROTEIN SUGR; SUCROSE; UNCLASSIFIED DRUG;

ALDEHYDE; BACTERIUM; BIOASSAY; ENZYME ACTIVITY; GENE EXPRESSION; SUGAR;

ARTICLE; BACTERIAL GENE; BINDING SITE; CARBON SOURCE; CATABOLISM; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; ENZYME ACTIVITY; GAPA GENE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN ISOLATION; SUGAR TRANSPORT; TRANSCRIPTION REGULATION; UPREGULATION;

ARTIFICIAL GENE FUSION; BACTERIAL PROTEINS; BETA-GALACTOSIDASE; BINDING SITES; CORYNEBACTERIUM GLUTAMICUM; DNA, BACTERIAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FRUCTOSE; GENE DELETION; GENES, BACTERIAL; GENES, REGULATOR; GENES, REPORTER; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; SUCROSE;

CORYNEBACTERIUM GLUTAMICUM;

EID: 55649090788     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-008-1682-0     Document Type: Article

References (41)

1. M Bott 2007 Offering surprises: TCA cycle regulation in Corynebacterium glutamicum Trends Microbiol 15 417 425
2. 32 J Bacteriol 176 830 839
3. Glc protein is involved in glucose-mediated activation of Escherichia coli gapA and gapB-pgk transcription J Bacteriol 180 6476 6483
4. A Cramer BJ Eikmanns 2007 RamA, the transcriptional regulator of acetate metabolism in Corynebacterium glutamicum, is subject to negative autoregulation J Mol Microbiol Biotechnol 12 51 59
5. A Cramer R Gerstmeir S Schaffer M Bott BJ Eikmanns 2006 Identification of RamA, a novel LuxR-type transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum J Bacteriol 188 2554 2567
6. A Cramer M Auchter J Frunzke M Bott BJ Eikmanns 2007 RamB, the transcriptional regulator of acetate metabolism in Corynebacterium glutamicum, is subject to regulation by RamA and RamB J Bacteriol 189 1145 1149
7. T Doan S Aymerich 2003 Regulation of the central glycolytic genes in Bacillus subtilis: binding of the repressor CggR to its single DNA target sequence is modulated by fructose-1,6-bisphosphate Mol Microbiol 47 1709 1721
8. H Dominguez ND Lindley 1996 Complete sucrose metabolism requires fructose phosphotransferase activity in Corynebacterium glutamicum to ensure phosphorylation of liberated fructose Appl Environ Microbiol 62 3878 3880
9. V Engels VF Wendisch 2007 The DeoR-Type regulator SugR represses expression of ptsG in Corynebacterium glutamicum J Bacteriol 189 2955 2966
10. S Fillinger S Boschi-Muller S Azza E Dervyn G Branlant S Aymerich 2000 Two glyceraldehyde-3-phosphate dehydrogenases with opposite physiological roles in a nonphotosynthetic bacterium J Biol Chem 275 14031 14037
11. L Gaigalat JP Schlüeter M Hartmann S Mormann A Tauch A Püehler J Kalinowski 2007 The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum BMC Mol Biol 8 104
12. SO Han M Inui H Yukawa 2007 Expression of Corynebacterium glutamicum glycolytic genes varies with carbon source and growth phase Microbiology 153 2190 2202
13. M Hayashi H Mizoguchi N Shiraishi M Obayashi S Nakagawa J Imai S Watanabe T Ota M Ikeda 2002 Transcriptome analysis of acetate metabolism in Corynebacterium glutamicum using a newly developed metabolic array Biosci Biotechnol Biochem 66 1337 1344
14. T Hermann 2003 Industrial production of amino acids by coryneform bacteria J Biotechnol 104 155 172
15. M Inui S Murakami S Okino H Kawaguchi AA Vertès H Yukawa 2004 Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions J Mol Microbiol Biotechnol 7 182 196
16. M Inui H Kawaguchi S Murakami AA Vertès H Yukawa 2004 Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions J Mol Microbiol Biotechnol 8 243 254
17. M Inui M Suda S Okino H Nonaka LG Puskás AA Vertès H Yukawa 2007 Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions Microbiology 153 2491 2504
18. HJ Kim TH Kim Y Kim HS Lee 2004 Identification and characterization of glxR, a gene involved in regulation of glyoxylate bypass in Corynebacterium glutamicum J Bacteriol 186 3453 3460
19. S Kinoshita S Udaka M Shimono 1957 Studies on the amino acid fermentation. Part 1. Production of l-glutamic acid by various microorganisms J Gen Appl Microbiol 3 193 205
20. O Koksharova M Schubert S Shestakov R Cerff 1998 Genetic and biochemical evidence for distinct key functions of two highly divergent GAPDH genes in catabolic and anabolic carbon flow of the cyanobacterium Synechocystis sp. PCC 6803 Plant Mol Biol 36 183 194
21. J Kormanec A Lempelová M Farkašovský D Homerová 1995 Cloning, sequencing and expression in Escherichia coli of a Streptomyces aureofaciens gene encoding glyceraldehyde-3-phosphate dehydrogenase Gene 165 77 80
22. A Krug VF Wendisch M Bott 2005 Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum J Biol Chem 280 585 595
23. UK Laemmli 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 680 685
24. H Ludwig G Homuth M Schmalisch FM Dyka M Hecker J Stülke 2001 Transcription of glycolytic genes and operons in Bacillus subtilis: evidence for the presence of multiple levels of control of the gapA operon Mol Microbiol 41 409 422
25. H Ludwig N Rebhan H-M Blencke M Merzbacher J Stülke 2002 Control of the glycolytic gapA operon by the catabolite control protein A in Bacillus subtilis: a novel mechanism of CcpA-mediated regulation Mol Microbiol 45 543 553
26. C Martin R Cerff 1986 Prokaryotic features of a nucleus-encoded enzyme. cDNA sequences for chloroplast and cytosolic glyceraldehyde-3-phosphate dehydrogenases from mustard (Sinapis alba) Eur J Biochem 159 323 331
27. W Martin H Brinkmann C Savonna R Cerff 1993 Evidence for a chimeric nature of nuclear genomes: eubacterial origin of eukaryotic glyceraldehyde-3- phosphate dehydrogenase genes PNAS 90 8692 8696
28. Miller JH (1972) Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
29. MW Moon 2005 Analyses of enzyme II gene mutants for sugar transport and heterologous expression of fructokinase gene in Corynebacterium glutamicum ATCC 13032 FEMS Microbiol Lett 244 259 266
30. A Muffler S Bettermann M Haushalter A Horlein U Neveling M Schramm O Sorgenfrei 2002 Genome-wide transcription profiling of Corynebacterium glutamicum after heat shock and during growth on acetate and glucose J Biotechnol 98 255 268
31. S Okino M Inui H Yukawa 2005 Production of organic acids by Corynebacterium glutamicum under oxygen deprivation Appl Microbiol Biotechnol 68 475 480
32. CA Omumasaba N Okai M Inui H Yukawa 2004 Corynebacterium glutamicum glyceraldehyde-3-phosphate dehydrogenase isoforms with opposite, ATP-dependent regulation J Mol Microbiol Biotechnol 8 91 103
33. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning, a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
34. P Servant D Le Coq S Aymerich 2005 CcpN (YqzB), a novel regulator for CcpA-independent catabolite repression of Bacillus subtilis gluconeogenic genes Mol Microbiol 55 1435 1451
35. T Shimada N Fujita M Maeda A Ishihama 2005 Systematic search for the Cra-binding promoters using genomic SELEX system Genes Cells 10 907 918
36. O Sprušanský B Řežuchová D Homerová J Kormanec 2001 Expression of the gap gene encoding glyceraldehyde-3-phosphate dehydrogenase of Streptomyces aureofaciens requires GapR, a member of the AraC/XylS family of transcriptional activators Microbiology 147 1291 1301
37. FW Studier BA Moffatt 1986 Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes J Mol Biol 189 113 130
38. Y Tanaka H Teramoto M Inui H Yukawa 2008 Regulation of expression of general components of the phosphoenolpyruvate: carbohydrate phosphotransferase system (PTS) by the global regulator SugR in Corynebacterium glutamicum Appl Microbiol Biotechnol 78 309 318
39. AA Vertès M Inui M Kobayashi Y Kurusu H Yukawa 1993 Presence of mrr- and mcr-like restriction systems in coryneform bacteria Res Microbiol 144 181 185
40. J Wennerhold A Krug M Bott 2005 The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR J Biol Chem 280 40500 40508
41. H Yukawa CA Omumasaba H Nonaka P Kós N Okai N Suzuki M Suda Y Tsuge J Watanabe Y Ikeda AA Vertès M Inui 2007 Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R Microbiology 153 1042 1058