-
1
-
-
0023024826
-
Occurrence of rheumatoid arthritis in a nationwide series of twins
-
Aho, K., Koskenvuo, M., Tuominen, J. & Kaprio, J. Occurrence of rheumatoid arthritis in a nationwide series of twins. J. Rheumatol. 13, 899-902 (1986).
-
(1986)
J. Rheumatol
, vol.13
, pp. 899-902
-
-
Aho, K.1
Koskenvuo, M.2
Tuominen, J.3
Kaprio, J.4
-
2
-
-
0027375302
-
Twin concordance rates for rheumatoid arthritis: Results from a nationwide study
-
Silman, A. J. et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br. J. Rheumatol. 32, 903-907 (1993).
-
(1993)
Br. J. Rheumatol
, vol.32
, pp. 903-907
-
-
Silman, A.J.1
-
3
-
-
0034121235
-
Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins
-
MacGregor, A. J. et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 43, 30-37 (2000).
-
(2000)
Arthritis Rheum
, vol.43
, pp. 30-37
-
-
Macgregor, A.J.1
-
4
-
-
65249103342
-
Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis
-
van der Woude, D. et al. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. Arthritis Rheum. 60, 916-923 (2009).
-
(2009)
Arthritis Rheum
, vol.60
, pp. 916-923
-
-
Van Der Woude, D.1
-
5
-
-
84958522995
-
A twin study of rheumatoid arthritis in the Japanese population
-
Terao, C. et al. A twin study of rheumatoid arthritis in the Japanese population. Mod. Rheumatol. 26, 685-689 (2016).
-
(2016)
Mod. Rheumatol
, vol.26
, pp. 685-689
-
-
Terao, C.1
-
6
-
-
84894288992
-
Genetics of rheumatoid arthritis contributes to biology and drug discovery
-
Okada, Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376-381 (2014).
-
(2014)
Nature
, vol.506
, pp. 376-381
-
-
Okada, Y.1
-
7
-
-
84940590102
-
Widespread non-Additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
-
Lenz, T. L. et al. Widespread non-Additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nat. Genet. 47, 1085-1090 (2015).
-
(2015)
Nat. Genet
, vol.47
, pp. 1085-1090
-
-
Lenz, T.L.1
-
8
-
-
84860333083
-
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
-
Stahl, E. A. et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat. Genet. 44, 483-489 (2012).
-
(2012)
Nat. Genet
, vol.44
, pp. 483-489
-
-
Stahl, E.A.1
-
9
-
-
9444295337
-
Gene map of the extended human MHC
-
Horton, R. et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5, 889-899 (2004).
-
(2004)
Nat. Rev. Genet
, vol.5
, pp. 889-899
-
-
Horton, R.1
-
10
-
-
0023500817
-
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
-
Gregersen, P. K., Silver, J. & Winchester, R. J. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205-1213 (1987).
-
(1987)
Arthritis Rheum
, vol.30
, pp. 1205-1213
-
-
Gregersen, P.K.1
Silver, J.2
Winchester, R.J.3
-
11
-
-
84879964739
-
Interaction of HLA-DRB109:01 and 04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope
-
Bang, S. Y., Lee, H. S., Lee, K. W. & Bae, S. C. Interaction of HLA-DRB109:01 and 04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope. J. Rheumatol. 40, 1054-1062 (2013).
-
(2013)
J. Rheumatol
, vol.40
, pp. 1054-1062
-
-
Bang, S.Y.1
Lee, H.S.2
Lee, K.W.3
Bae, S.C.4
-
12
-
-
84879835766
-
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: Effects of09:01 allele on disease phenotypes
-
Shimane, K. et al. An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of09:01 allele on disease phenotypes. Rheumatology (Oxford) 52, 1172-1182 (2013).
-
(2013)
Rheumatology (Oxford)
, vol.52
, pp. 1172-1182
-
-
Shimane, K.1
-
13
-
-
84912020278
-
HLA-DRB1-Associated rheumatoid arthritis risk at multiple levels in African Americans: Hierarchical classification systems, amino acid positions, and residues
-
Reynolds, R. J. et al. HLA-DRB1-Associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues. Arthritis Rheumatol. 66, 3274-3282 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 3274-3282
-
-
Reynolds, R.J.1
-
14
-
-
8444224296
-
Increased susceptibility to rheumatoid arthritis in Koreans heterozygous for HLA-DRB10405 and 0901
-
Lee, H. S. et al. Increased susceptibility to rheumatoid arthritis in Koreans heterozygous for HLA-DRB10405 and 0901. Arthritis Rheum. 50, 3468-3475 (2004).
-
(2004)
Arthritis Rheum
, vol.50
, pp. 3468-3475
-
-
Lee, H.S.1
-
15
-
-
84878802935
-
Imputing amino acid polymorphisms in human leukocyte antigens
-
Jia, X. et al. Imputing amino acid polymorphisms in human leukocyte antigens. PLoS ONE 8, e64683 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e64683
-
-
Jia, X.1
-
16
-
-
84862776511
-
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
-
Raychaudhuri, S. et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44, 291-296 (2012).
-
(2012)
Nat. Genet
, vol.44
, pp. 291-296
-
-
Raychaudhuri, S.1
-
17
-
-
84960465745
-
Imputing variants in HLA-DR beta genes reveals that HLA-DRB1 is solely associated with rheumatoid arthritis and systemic lupus erythematosus
-
Kim, K. et al. Imputing variants in HLA-DR beta genes reveals that HLA-DRB1 is solely associated with rheumatoid arthritis and systemic lupus erythematosus. PLoS ONE 11, e0150283 (2016).
-
(2016)
PLoS ONE
, vol.11
, pp. e0150283
-
-
Kim, K.1
-
18
-
-
84911495256
-
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations
-
Okada, Y. et al. Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum. Mol. Genet. 23, 6916-6926 (2014).
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 6916-6926
-
-
Okada, Y.1
-
19
-
-
84897992288
-
Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity
-
Han, B. et al. Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. Am. J. Hum. Genet. 94, 522-532 (2014).
-
(2014)
Am. J. Hum. Genet
, vol.94
, pp. 522-532
-
-
Han, B.1
-
20
-
-
84976541994
-
A molecular analysis of the shared epitope hypothesis binding of arthritogenic peptides to DRB104 alleles
-
Anderson, K. M. et al. A molecular analysis of the shared epitope hypothesis binding of arthritogenic peptides to DRB104 alleles. Arthritis Rheumatol. 68, 1627-1636 (2016).
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 1627-1636
-
-
Anderson, K.M.1
-
21
-
-
84938256620
-
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
-
Hu, X. et al. Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nat. Genet. 47, 898-905 (2015).
-
(2015)
Nat. Genet
, vol.47
, pp. 898-905
-
-
Hu, X.1
-
22
-
-
85018199056
-
Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis
-
Kim, K. et al. Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis. Arthritis Rheumatol. 67, 2611-2623 (2015).
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 2611-2623
-
-
Kim, K.1
-
23
-
-
78650860672
-
Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records
-
Kurreeman, F. et al. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am. J. Hum. Genet. 88, 57-69 (2011).
-
(2011)
Am. J. Hum. Genet
, vol.88
, pp. 57-69
-
-
Kurreeman, F.1
-
24
-
-
82755160838
-
A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects
-
Terao, C. et al. A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects. Ann. Rheum. Dis. 70, 2134-2139 (2011).
-
(2011)
Ann. Rheum. Dis
, vol.70
, pp. 2134-2139
-
-
Terao, C.1
-
25
-
-
84868502721
-
Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
-
Viatte, S. et al. Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. Ann. Rheum. Dis. 71, 1984-1990 (2012).
-
(2012)
Ann. Rheum. Dis
, vol.71
, pp. 1984-1990
-
-
Viatte, S.1
-
26
-
-
85027928051
-
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides
-
Bossini-Castillo, L. et al. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Ann. Rheum. Dis. 74, e15 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.74
, pp. e15
-
-
Bossini-Castillo, L.1
-
27
-
-
84922347461
-
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: Association with cigarette smoking and HLA-DRB1 shared epitope alleles
-
Wagner, C. A. et al. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: Association with cigarette smoking and HLA-DRB1 shared epitope alleles. Ann. Rheum. Dis. 74, 579-586 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.74
, pp. 579-586
-
-
Wagner, C.A.1
-
28
-
-
84928106416
-
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
-
Kim, K. et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann. Rheum. Dis. 74, e13 (2015).
-
(2015)
Ann. Rheum. Dis
, vol.74
, pp. e13
-
-
Kim, K.1
-
29
-
-
84879258952
-
Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in Europeans
-
Cobb, J. E. et al. Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in Europeans. PLoS ONE 8, e66456 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e66456
-
-
Cobb, J.E.1
-
30
-
-
84888988248
-
Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-Analysis of genome-wide data
-
McAllister, K. et al. Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-Analysis of genome-wide data. Arthritis Rheum. 65, 3058-3062 (2013).
-
(2013)
Arthritis Rheum
, vol.65
, pp. 3058-3062
-
-
McAllister, K.1
-
31
-
-
84897018997
-
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study
-
Orozco, G. et al. Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. Arthritis Rheumatol. 66, 24-30 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 24-30
-
-
Orozco, G.1
-
32
-
-
84959477574
-
Significant impact of miRNA-Target gene networks on genetics of human complex traits
-
Okada, Y. et al. Significant impact of miRNA-Target gene networks on genetics of human complex traits. Sci. Rep. 6, 22223 (2016).
-
(2016)
Sci. Rep
, vol.6
, pp. 22223
-
-
Okada, Y.1
-
33
-
-
84974603621
-
Association-heterogeneity mapping identifies and Asian-spcific association of the GTF2I locus with rheumatoid arthritis
-
Kim, K. et al. Association-heterogeneity mapping identifies and Asian-spcific association of the GTF2I locus with rheumatoid arthritis. Sci. Rep. 6, 27563 (2016).
-
(2016)
Sci. Rep
, vol.6
, pp. 27563
-
-
Kim, K.1
-
34
-
-
84933277343
-
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
-
Fortune, M. D. et al. Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Nat. Genet. 47, 839-846 (2015).
-
(2015)
Nat. Genet
, vol.47
, pp. 839-846
-
-
Fortune, M.D.1
-
35
-
-
84892746185
-
Quantifying missing heritability at known GWAS loci
-
Gusev, A. et al. Quantifying missing heritability at known GWAS loci. PLoS Genet. 9, e1003993 (2013).
-
(2013)
PLoS Genet
, vol.9
, pp. e1003993
-
-
Gusev, A.1
-
36
-
-
84862809846
-
Meta-Analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
-
Okada, Y. et al. Meta-Analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat. Genet. 44, 511-516 (2012).
-
(2012)
Nat. Genet
, vol.44
, pp. 511-516
-
-
Okada, Y.1
-
37
-
-
84862790007
-
Use of a multiethnic approach to identify rheumatoid-Arthritis-susceptibility loci, 1p36 and 17q12
-
Kurreeman, F. A. et al. Use of a multiethnic approach to identify rheumatoid-Arthritis-susceptibility loci, 1p36 and 17q12. Am. J. Hum. Genet. 90, 524-532 (2012).
-
(2012)
Am. J. Hum. Genet
, vol.90
, pp. 524-532
-
-
Kurreeman, F.A.1
-
38
-
-
84923326765
-
Genetic and epigenetic fine mapping of causal autoimmune disease variants
-
Farh, K. K. et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518, 337-343 (2015).
-
(2015)
Nature
, vol.518
, pp. 337-343
-
-
Farh, K.K.1
-
39
-
-
84938982145
-
Leveraging functional-Annotation data in trans-ethnic fine-mapping studies
-
Kichaev, G. & Pasaniuc, B. Leveraging functional-Annotation data in trans-ethnic fine-mapping studies. Am. J. Hum. Genet. 97, 260-271 (2015).
-
(2015)
Am. J. Hum. Genet
, vol.97
, pp. 260-271
-
-
Kichaev, G.1
Pasaniuc, B.2
-
40
-
-
84873086126
-
Chromatin marks identify critical cell types for fine mapping complex trait variants
-
Trynka, G. et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat. Genet. 45, 124-130 (2013).
-
(2013)
Nat. Genet
, vol.45
, pp. 124-130
-
-
Trynka, G.1
-
41
-
-
33847334699
-
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
-
Heintzman, N. D. et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 39, 311-318 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 311-318
-
-
Heintzman, N.D.1
-
42
-
-
84937424402
-
Disentangling the effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex-Trait loci
-
Trynka, G. et al. Disentangling the effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex-Trait loci. Am. J. Hum. Genet. 97, 139-152 (2015).
-
(2015)
Am. J. Hum. Genet
, vol.97
, pp. 139-152
-
-
Trynka, G.1
-
43
-
-
84897459814
-
An atlas of active enhancers across human cell types and tissues
-
Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455-461 (2014).
-
(2014)
Nature
, vol.507
, pp. 455-461
-
-
Andersson, R.1
-
44
-
-
84935880348
-
Enrichment of genetic variants for rheumatoid arthritis within T-cell and NK-cell enhancer regions
-
Freudenberg, J., Gregersen, P. & Li, W. Enrichment of genetic variants for rheumatoid arthritis within T-cell and NK-cell enhancer regions. Mol. Med. 21, 180-184 (2015).
-
(2015)
Mol. Med
, vol.21
, pp. 180-184
-
-
Freudenberg, J.1
Gregersen, P.2
Li, W.3
-
45
-
-
84928560965
-
Super-enhancers delineate disease-Associated regulatory nodes in T cells
-
Vahedi, G. et al. Super-enhancers delineate disease-Associated regulatory nodes in T cells. Nature 520, 558-562 (2015).
-
(2015)
Nature
, vol.520
, pp. 558-562
-
-
Vahedi, G.1
-
46
-
-
84923545705
-
Expression profiles of long non-coding RNAs located in autoimmune disease-Associated regions reveal immune cell-Type specificity
-
Hrdlickova, B. et al. Expression profiles of long non-coding RNAs located in autoimmune disease-Associated regions reveal immune cell-Type specificity. Genome Med. 6, 88 (2014).
-
(2014)
Genome Med
, vol.6
, pp. 88
-
-
Hrdlickova, B.1
-
47
-
-
84865727393
-
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
-
Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775-1789 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 1775-1789
-
-
Derrien, T.1
-
48
-
-
84881478367
-
A long noncoding RNA mediates both activation and repression of immune response genes
-
Carpenter, S. et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science 341, 789-792 (2013).
-
(2013)
Science
, vol.341
, pp. 789-792
-
-
Carpenter, S.1
-
49
-
-
33745193973
-
Gene expression microarrays: Glimpses of the immunological genome
-
Hyatt, G. et al. Gene expression microarrays: glimpses of the immunological genome. Nat. Immunol. 7, 686-691 (2006).
-
(2006)
Nat. Immunol
, vol.7
, pp. 686-691
-
-
Hyatt, G.1
-
50
-
-
80053896562
-
Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets
-
Hu, X. et al. Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets. Am. J. Hum. Genet. 89, 496-506 (2011).
-
(2011)
Am. J. Hum. Genet
, vol.89
, pp. 496-506
-
-
Hu, X.1
-
51
-
-
0033554726
-
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
-
Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
-
(1999)
Nature
, vol.401
, pp. 708-712
-
-
Sallusto, F.1
Lenig, D.2
Forster, R.3
Lipp, M.4
Lanzavecchia, A.5
-
52
-
-
84900338300
-
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
-
Raj, T. et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 344, 519-523 (2014).
-
(2014)
Science
, vol.344
, pp. 519-523
-
-
Raj, T.1
-
53
-
-
84903457544
-
Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells
-
Hu, X. et al. Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells. PLoS Genet. 10, e1004404 (2014).
-
(2014)
PLoS Genet
, vol.10
, pp. e1004404
-
-
Hu, X.1
-
54
-
-
84897855294
-
Obesity-Associated variants within FTO form long-range functional connections with IRX3
-
Smemo, S. et al. Obesity-Associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-375 (2014).
-
(2014)
Nature
, vol.507
, pp. 371-375
-
-
Smemo, S.1
-
55
-
-
78649464259
-
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-Associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling
-
Stratigopoulos, G., LeDuc, C. A., Cremona, M. L., Chung, W. K. & Leibel, R. L. Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-Associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J. Biol. Chem. 286, 2155-2170 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 2155-2170
-
-
Stratigopoulos, G.1
Leduc, C.A.2
Cremona, M.L.3
Chung, W.K.4
Leibel, R.L.5
-
56
-
-
84899900892
-
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice
-
Stratigopoulos, G. et al. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab. 19, 767-779 (2014).
-
(2014)
Cell Metab
, vol.19
, pp. 767-779
-
-
Stratigopoulos, G.1
-
57
-
-
84948686586
-
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
-
Martin, P. et al. Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Nat. Commun. 6, 10069 (2015).
-
(2015)
Nat. Commun
, vol.6
, pp. 10069
-
-
Martin, P.1
-
58
-
-
77957342306
-
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits
-
Segre, A. V. et al. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet. 6, e1001058 (2010).
-
(2010)
PLoS Genet
, vol.6
, pp. e1001058
-
-
Segre, A.V.1
-
59
-
-
84859727275
-
The Mouse Genome Database (MGD): Comprehensive resource for genetics and genomics of the laboratory mouse
-
Eppig, J. T. et al. The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res. 40, D881-D886 (2012).
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D881-D886
-
-
Eppig, J.T.1
-
60
-
-
84875920469
-
Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis
-
de Rooy, D. P. et al. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Ann. Rheum. Dis. 72, 769-775 (2013).
-
(2013)
Ann. Rheum. Dis
, vol.72
, pp. 769-775
-
-
De Rooy, D.P.1
-
61
-
-
84880922498
-
Enrichment of Vitamin D response elements in RA-Associated loci supports a role for Vitamin D in the pathogenesis of RA
-
Yarwood, A. et al. Enrichment of vitamin D response elements in RA-Associated loci supports a role for vitamin D in the pathogenesis of RA. Genes Immun. 14, 325-329 (2013).
-
(2013)
Genes Immun
, vol.14
, pp. 325-329
-
-
Yarwood, A.1
-
62
-
-
84885820463
-
Measles contributes to rheumatoid arthritis: Evidence from pathway and network analyses of genome-wide association studies
-
Liu, G. et al. Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies. PLoS ONE 8, e75951 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e75951
-
-
Liu, G.1
-
63
-
-
84929459112
-
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms
-
Andreassen, O. A. et al. Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PLoS ONE 10, e0123057 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0123057
-
-
Andreassen, O.A.1
-
64
-
-
84886388469
-
Integrative pathway-based approach for genome-wide association studies: Identification of new pathways for rheumatoid arthritis and type 1 diabetes
-
Buchel, F. et al. Integrative pathway-based approach for genome-wide association studies: identification of new pathways for rheumatoid arthritis and type 1 diabetes. PLoS ONE 8, e78577 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e78577
-
-
Buchel, F.1
-
65
-
-
84905495063
-
The intersection of immune deficiency and autoimmunity
-
Maggadottir, S. M. & Sullivan, K. E. The intersection of immune deficiency and autoimmunity. Curr. Opin. Rheumatol. 26, 570-578 (2014).
-
(2014)
Curr. Opin. Rheumatol
, vol.26
, pp. 570-578
-
-
Maggadottir, S.M.1
Sullivan, K.E.2
-
66
-
-
84940999709
-
Multiple sources of bias confound functional enrichment analysis of global-omics data
-
Timmons, J. A., Szkop, K. J. & Gallagher, I. J. Multiple sources of bias confound functional enrichment analysis of global-omics data. Genome Biol. 16, 186 (2015).
-
(2015)
Genome Biol
, vol.16
, pp. 186
-
-
Timmons, J.A.1
Szkop, K.J.2
Gallagher, I.J.3
-
67
-
-
84875278357
-
Different effects of biological drugs in rheumatoid arthritis
-
Atzeni, F. et al. Different effects of biological drugs in rheumatoid arthritis. Autoimmun. Rev. 12, 575-579 (2013).
-
(2013)
Autoimmun. Rev
, vol.12
, pp. 575-579
-
-
Atzeni, F.1
-
68
-
-
84900449627
-
Identification of novel therapeutics for complex diseases from genome-wide association data
-
Grover, M. P. et al. Identification of novel therapeutics for complex diseases from genome-wide association data. BMC Med. Genomics 7 (Suppl. 1), S8 (2014).
-
(2014)
BMC Med. Genomics
, vol.7
, pp. S8
-
-
Grover, M.P.1
-
69
-
-
1842368507
-
IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkins lymphoma
-
Maloney, D. G. et al. IDEC-C2B8 (rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkins lymphoma. Blood 90, 2188-2195 (1997).
-
(1997)
Blood
, vol.90
, pp. 2188-2195
-
-
Maloney, D.G.1
-
70
-
-
2942537697
-
Efficacy of B-cell-Targeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards, J. C. et al. Efficacy of B-cell-Targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350, 2572-2581 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2572-2581
-
-
Edwards, J.C.1
-
71
-
-
84881315517
-
Validating therapeutic targets through human genetics
-
Plenge, R. M., Scolnick, E. M. & Altshuler, D. Validating therapeutic targets through human genetics. Nat. Rev. Drug Discov. 12, 581-594 (2013).
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 581-594
-
-
Plenge, R.M.1
Scolnick, E.M.2
Altshuler, D.3
-
72
-
-
84878492072
-
Human genetics in rheumatoid arthritis guides a high-Throughput drug screen of the CD40 signaling pathway
-
Li, G. et al. Human genetics in rheumatoid arthritis guides a high-Throughput drug screen of the CD40 signaling pathway. PLoS Genet. 9, e1003487 (2013).
-
(2013)
PLoS Genet
, vol.9
, pp. e1003487
-
-
Li, G.1
-
73
-
-
84928637582
-
The rheumatoid arthritis risk gene LBH regulates growth in fibroblast-like synoviocytes
-
Ekwall, A. K. et al. The rheumatoid arthritis risk gene LBH regulates growth in fibroblast-like synoviocytes. Arthritis Rheumatol. 67, 1193-1202 (2015).
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 1193-1202
-
-
Ekwall, A.K.1
-
74
-
-
84925858486
-
Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis
-
Giles, J. L., Choy, E., van den Berg, C., Morgan, B. P. & Harris, C. L. Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis. J. Immunol. 194, 3029-3034 (2015).
-
(2015)
J. Immunol
, vol.194
, pp. 3029-3034
-
-
Giles, J.L.1
Choy, E.2
Van Den Berg, C.3
Morgan, B.P.4
Harris, C.L.5
-
75
-
-
84929712572
-
The autoimmunity-Associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection
-
Schuster, C. et al. The autoimmunity-Associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection. Immunity 42, 942-952 (2015).
-
(2015)
Immunity
, vol.42
, pp. 942-952
-
-
Schuster, C.1
-
76
-
-
84940121364
-
The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis
-
Chang, H. H., Dwivedi, N., Nicholas, A. P. & Ho, I. C. The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis. Arthritis Rheumatol. 67, 2323-2334 (2015).
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 2323-2334
-
-
Chang, H.H.1
Dwivedi, N.2
Nicholas, A.P.3
Ho, I.C.4
-
77
-
-
84937717591
-
Cutting edge: Chronic NF-κB activation in CD4+ T Cells in rheumatoid arthritis is genetically determined by HLA risk alleles
-
Spurlock, C. F. III, Tossberg, J. T., Olsen, N. J. & Aune, T. M. Cutting edge: chronic NF-κB activation in CD4+ T Cells in rheumatoid arthritis is genetically determined by HLA risk alleles. J. Immunol. 195, 791-795 (2015).
-
(2015)
J. Immunol
, vol.195
, pp. 791-795
-
-
Spurlock, C.F.1
Tossberg, J.T.2
Olsen, N.J.3
Aune, T.M.4
-
78
-
-
84941671291
-
C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis
-
Muthana, M. et al. C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Proc. Natl Acad. Sci. USA 112, 11618-11623 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 11618-11623
-
-
Muthana, M.1
-
79
-
-
84959559197
-
A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels
-
Messemaker, T. C. et al. A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels. Genes Immun. 17, 85-92 (2015).
-
(2015)
Genes Immun
, vol.17
, pp. 85-92
-
-
Messemaker, T.C.1
-
80
-
-
84872832172
-
The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling
-
de la Puerta, M. L. et al. The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling. PLoS ONE 8, e54569 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e54569
-
-
De La Puerta, M.L.1
-
81
-
-
84874407375
-
Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis
-
Han, T. U. et al. Association of an activity-enhancing variant of IRAK1 and an MECP2-IRAK1 haplotype with increased susceptibility to rheumatoid arthritis. Arthritis Rheum. 65, 590-598 (2013).
-
(2013)
Arthritis Rheum
, vol.65
, pp. 590-598
-
-
Han, T.U.1
-
82
-
-
84876828211
-
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
-
Ferreira, R. C. et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet. 9, e1003444 (2013).
-
(2013)
PLoS Genet
, vol.9
, pp. e1003444
-
-
Ferreira, R.C.1
-
83
-
-
84925144681
-
UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases
-
Lewis, M. J. et al. UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. Am. J. Hum. Genet. 96, 221-234 (2015).
-
(2015)
Am. J. Hum. Genet
, vol.96
, pp. 221-234
-
-
Lewis, M.J.1
-
84
-
-
84953344680
-
From genetics to functional insights into rheumatoid arthritis
-
Suzuki, A. & Yamamoto, K. From genetics to functional insights into rheumatoid arthritis. Clin. Exp. Rheumatol. 33 (4 Suppl. 92), S40-S43 (2015).
-
(2015)
Clin. Exp. Rheumatol
, vol.33
, Issue.4
, pp. S40-S43
-
-
Suzuki, A.1
Yamamoto, K.2
-
85
-
-
84928731411
-
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response
-
Viatte, S. et al. Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response. JAMA 313, 1645-1656 (2015).
-
(2015)
JAMA
, vol.313
, pp. 1645-1656
-
-
Viatte, S.1
-
86
-
-
40849097776
-
Heritability in the genomics era-concepts and misconceptions
-
Visscher, P. M., Hill, W. G. & Wray, N. R. Heritability in the genomics era-concepts and misconceptions. Nat. Rev. Genet. 9, 255-266 (2008).
-
(2008)
Nat. Rev. Genet
, vol.9
, pp. 255-266
-
-
Visscher, P.M.1
Hill, W.G.2
Wray, N.R.3
-
87
-
-
84874521997
-
On the origin of rheumatoid arthritis: The impact of environment and genes-A population based twin study
-
Svendsen, A. J. et al. On the origin of rheumatoid arthritis: The impact of environment and genes-A population based twin study. PLoS ONE 8, e57304 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e57304
-
-
Svendsen, A.J.1
-
88
-
-
84872323563
-
Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis
-
Diogo, D. et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. Am. J. Hum. Genet. 92, 15-27 (2013).
-
(2013)
Am. J. Hum. Genet
, vol.92
, pp. 15-27
-
-
Diogo, D.1
-
89
-
-
84928920020
-
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-Autoimmune complex traits
-
Diogo, D. et al. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-Autoimmune complex traits. PLoS ONE 10, e0122271 (2015).
-
(2015)
PLoS ONE
, vol.10
, pp. e0122271
-
-
Diogo, D.1
-
90
-
-
84988891166
-
Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis
-
Bang, S. Y. et al. Targeted exon sequencing fails to identify rare coding variants with large effect in rheumatoid arthritis. Arthritis Res. Ther. 16, 447 (2014).
-
(2014)
Arthritis Res. Ther
, vol.16
, pp. 447
-
-
Bang, S.Y.1
-
91
-
-
84895770158
-
Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene
-
Okada, Y. et al. Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS ONE 9, e87645 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e87645
-
-
Okada, Y.1
-
92
-
-
84891908638
-
A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3
-
Veal, C. D. et al. A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3. Hum. Mutat. 35, 248-256 (2014).
-
(2014)
Hum. Mutat
, vol.35
, pp. 248-256
-
-
Veal, C.D.1
-
93
-
-
84898669483
-
Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis
-
Du, Y. et al. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol. 66, 822-830 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 822-830
-
-
Du, Y.1
-
94
-
-
84939450760
-
Association of FCGR3A and FCGR3B copy number variations with systemic lupus erythematosus and rheumatoid arthritis in Taiwanese patients
-
Chen, J. Y. et al. Association of FCGR3A and FCGR3B copy number variations with systemic lupus erythematosus and rheumatoid arthritis in Taiwanese patients. Arthritis Rheumatol. 66, 3113-3121 (2014).
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 3113-3121
-
-
Chen, J.Y.1
-
95
-
-
84954394547
-
Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes
-
Franke, L. et al. Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes. Eur. J. Hum. Genet. 24, 263-270 (2016).
-
(2016)
Eur. J. Hum. Genet
, vol.24
, pp. 263-270
-
-
Franke, L.1
-
96
-
-
84874545024
-
Whole-genome detection of disease-Associated deletions or excess homozygosity in a case-control study of rheumatoid arthritis
-
Wu, C. C. et al. Whole-genome detection of disease-Associated deletions or excess homozygosity in a case-control study of rheumatoid arthritis. Hum. Mol. Genet. 22, 1249-1261 (2013).
-
(2013)
Hum. Mol. Genet
, vol.22
, pp. 1249-1261
-
-
Wu, C.C.1
-
97
-
-
77955505564
-
Biological, clinical and population relevance of 95 loci for blood lipids
-
Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
|