Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

Nature Genetics

Volumn 47, Issue 8, 2015, Pages 898-905

  Hu, Xinli ^a,b,c,d,e   Deutsch, Aaron J ^a,b,c,d,e   Lenz, Tobias L ^b,f   Onengut Gumuscu, Suna ^g   Han, Buhm ^b,d,h   Chen, Wei Min ^g   Howson, Joanna M M ⁱ   Todd, John A ^j   De Bakker, Paul I W ^k,l   Rich, Stephen S ^g   Raychaudhuri, Soumya ^a,b,c,d,m  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c LABORATORY FOR MOLECULAR MEDICINE   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^f MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

^g UNIVERSITY OF VIRGINIA   (United States)

^h University of Ulsan College of Medicine   (South Korea)

ⁱ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^k UTRECHT UNIVERSITY   (Netherlands)

^l UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^m UNIVERSITY OF MANCHESTER   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; HETERODIMER; HISTIDINE; HLA DPB1 ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; LYSINE; SERINE; HLA DQ ANTIGEN; HLA-DQA1 ANTIGEN; HLA-DQB1 ANTIGEN;

ALLELE; AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; CONTROL; CONTROLLED STUDY; FOLLICULAR LYMPHOMA; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; HAPLOTYPE; HLA TYPING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; ALGORITHM; BIOLOGICAL MODEL; CASE CONTROL STUDY; EPISTASIS; FEMALE; GENETICS; GENOTYPE; MALE; PATHOLOGY; PHENOTYPE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

ALGORITHMS; AMINO ACIDS; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; EPISTASIS, GENETIC; FEMALE; GENOTYPE; HAPLOTYPES; HLA-DQ ALPHA-CHAINS; HLA-DQ BETA-CHAINS; HLA-DRB1 CHAINS; HUMANS; LOGISTIC MODELS; MALE; MODELS, GENETIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84938256620     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3353     Document Type: Article

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