Measles Contributes to Rheumatoid Arthritis: Evidence from Pathway and Network Analyses of Genome-Wide Association Studies

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Liu, Guiyou ^a,b   Jiang, Yongshuai ^c   Chen, Xiaoguang ^d   Zhang, Ruijie ^c   Ma, Guoda ^a   Feng, Rennan ^c   Zhang, Liangcai ^e   Liao, Mingzhi ^c   Miao, Yingbo ^c   Chen, Zugen ^f   Zeng, Rong ^a   Li, Keshen ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b Tianjin Airport Economic Area   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d INSTITUTE OF PLANT PROTECTION   (China)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; JANUS KINASE; JANUS KINASE 3; MAJOR HISTOCOMPATIBILITY ANTIGEN; STAT PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME INHIBITION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOMICS; HUMAN; MAJOR CLINICAL STUDY; MEASLES; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MEASLES; PROTEIN INTERACTION MAPS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 84885820463     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075951     Document Type: Article

References (65)

1. Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, et al. (2009) Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet 41: 1313-1318.
2. Cerhan JR, Saag KG, Merlino LA, Mikuls TR, Criswell LA, (2003) Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol 157: 345-354.
3. Ballard DH, Aporntewan C, Lee JY, Lee JS, Wu Z, et al. (2009) A pathway analysis applied to Genetic Analysis Workshop 16 genome-wide rheumatoid arthritis data. BMC Proc 3 Suppl 7: S91.
4. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, et al. (2007) TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study. N Engl J Med 357: 1199-1209.
5. The Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
6. Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, et al. (2009) REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 41: 820-823.
7. Freudenberg J, Lee HS, Han BG, Shin HD, Kang YM, et al. (2011) Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. Arthritis Rheum 63: 884-893.
8. Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, et al. (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 42: 508-514.
9. Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, et al. (2012) Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 44: 511-516.
10. de Vries R, (2011) Genetics of rheumatoid arthritis: time for a change!. Curr Opin Rheumatol 23: 227-232.
11. Kalliomaki JL, Halonen P, Salmi A, (1975) Virus antibodies in serum and synovial fluid of patients with rheumatoid arthritis and other connective tissue diseases. Ann Rheum Dis 34: 43-48.
12. Rosenau BJ, Schur PH, (2009) Association of measles virus with rheumatoid arthritis. J Rheumatol 36: 893-897.
13. Heijstek MW, van Gageldonk PG, Berbers GA, Wulffraat NM, (2012) Differences in persistence of measles, mumps, rubella, diphtheria and tetanus antibodies between children with rheumatic disease and healthy controls: a retrospective cross-sectional study. Ann Rheum Dis 71: 948-954.
14. Beyene J, Hu P, Hamid JS, Parkhomenko E, Paterson AD, et al. (2009) Pathway-based analysis of a genome-wide case-control association study of rheumatoid arthritis. BMC Proc 3 Suppl 7: S128.
15. Eleftherohorinou H, Wright V, Hoggart C, Hartikainen AL, Jarvelin MR, et al. (2009) Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One 4: e8068.
16. Luo L, Peng G, Zhu Y, Dong H, Amos CI, et al. (2010) Genome-wide gene and pathway analysis. Eur J Hum Genet 18: 1045-1053.
17. Martin JE, Alizadeh BZ, Gonzalez-Gay MA, Balsa A, Pascual-Salcedo D, et al. (2010) Identification of the oxidative stress-related gene MSRA as a rheumatoid arthritis susceptibility locus by genome-wide pathway analysis. Arthritis Rheum 62: 3183-3190.
18. Eleftherohorinou H, Hoggart CJ, Wright VJ, Levin M, Coin LJ, (2011) Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways. Hum Mol Genet 20: 3494-3506.
19. Bakir-Gungor B, Sezerman OU, (2011) A new methodology to associate SNPs with human diseases according to their pathway related context. PLoS One 6: e26277.
20. Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, et al. (2009) Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet 18: 2078-2090.
21. Eyre S, Flynn E, Martin P, Hinks A, Wilson AG, et al. (2010) No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort. Annals of the Rheumatic Diseases 69: 1407-1408.
22. Julia A, Ballina J, Canete JD, Balsa A, Tornero-Molina J, et al. (2008) Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis and Rheumatism 58: 2275-2286.
23. Lee YC, Raychaudhuri S, Cui J, De Vivo I, Ding B, et al. (2009) The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility. Arthritis and Rheumatism 60: 1250-1254.
24. Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, et al. (2008) Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nature Genetics 40: 1216-1223.
25. Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, et al. (2009) Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nature Genetics 41: 1313-1318.
26. Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, et al. (2005) A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genetics 37: 478-485.
27. Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, et al. (2003) Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genetics 34: 395-402.
28. Suzuki A, Yamada R, Kochi Y, Sawada T, Okada Y, et al. (2008) Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population. Nature Genetics 40: 1224-1229.
29. Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, et al. (2010) A versatile gene-based test for genome-wide association studies. Am J Hum Genet 87: 139-145.
30. Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, et al. (2011) Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 7: e1002033.
31. Nogales-Cadenas R, Carmona-Saez P, Vazquez M, Vicente C, Yang X, et al. (2009) GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucleic Acids Res 37: W317-322.
32. Tabas-Madrid D, Nogales-Cadenas R, Pascual-Montano A, (2012) GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics. Nucleic Acids Res 40: W478-483.
33. Gui H, Li M, Sham PC, Cherny SS, (2011) Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset. BMC Res Notes 4: 386.
34. Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, et al. (2009) Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. American Journal of Human Genetics 84: 399-405.
35. Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, et al. (2011) Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med 3: 3.
36. Trynka G, Wijmenga C, van Heel DA, (2010) A genetic perspective on coeliac disease. Trends Mol Med 16: 537-550.
37. Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, et al. (2011) The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 39: D561-568.
38. Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, et al. (2013) STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 41: D808-815.
39. Heijstek MW, Kamphuis S, Armbrust W, Swart J, Gorter S, et al. (2013) Effects of the live attenuated measles-mumps-rubella booster vaccination on disease activity in patients with juvenile idiopathic arthritis: a randomized trial. JAMA 309: 2449-2456.
40. Brennan FM, McInnes IB, (2008) Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118: 3537-3545.
41. Gaestel M, Kotlyarov A, Kracht M, (2009) Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov 8: 480-499.
42. Seidel HM, Lamb P, Rosen J, (2000) Pharmaceutical intervention in the JAK/STAT signaling pathway. Oncogene 19: 2645-2656.
43. Lin TH, Hegen M, Quadros E, Nickerson-Nutter CL, Appell KC, et al. (2010) Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice. Arthritis Rheum 62: 2283-2293.
44. O'Shea JJ, Plenge R, (2012) JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 36: 542-550.
45. Maeshima K, Yamaoka K, Kubo S, Nakano K, Iwata S, et al. (2012) The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-gamma and interleukin-17 production by human CD4+ T cells. Arthritis Rheum 64: 1790-1798.
46. LaBranche TP, Jesson MI, Radi ZA, Storer CE, Guzova JA, et al. (2012) JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum.
47. Sakaguchi S, Benham H, Cope AP, Thomas R, (2012) T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. Immunol Cell Biol 90: 277-287.
48. Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, et al. (2011) Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet 7: e1002004.
49. Abreu JR, Krausz S, Dontje W, Grabiec AM, de Launay D, et al. (2010) Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis. Arthritis Rheum 62: 3289-3299.
50. Olasz K, Boldizsar F, Kis-Toth K, Tarjanyi O, Hegyi A, et al. (2012) T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice. Clin Exp Immunol 167: 346-355.
51. Malemud CJ, (2011) Myeloid-related protein activity in rheumatoid arthritis. Int J Inflam 2011: 580295.
52. Smith MD, Slavotinek J, Au V, Weedon H, Parker A, et al. (2001) Successful treatment of rheumatoid arthritis is associated with a reduction in synovial membrane cytokines and cell adhesion molecule expression. Rheumatology (Oxford) 40: 965-977.
53. Klimiuk PA, Fiedorczyk M, Sierakowski S, Chwiecko J, (2007) Soluble cell adhesion molecules (sICAM-1, sVCAM-1, and sE-selectin) in patients with early rheumatoid arthritis. Scand J Rheumatol 36: 345-350.
54. Hunt KA, Mistry V, Bockett NA, Ahmad T, Ban M, et al. (2013) Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature.
55. Elbers CC, van Eijk KR, Franke L, Mulder F, van der Schouw YT, et al. (2009) Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genetic Epidemiology 33: 419-431.
56. Jia P, Wang L, Meltzer HY, Zhao Z, (2011) Pathway-based analysis of GWAS datasets: effective but caution required. Int J Neuropsychopharmacol 14: 567-572.
57. Maxwell JR, Gowers IR, Kuet KP, Barton A, Worthington J, et al. (2012) Expression of the autoimmunity associated TNFAIP3 is increased in rheumatoid arthritis but does not differ according to genotype at 6q23. Rheumatology 51: 1514-1515.
58. Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, et al. (2011) A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nature Genetics 43: 908-912.
59. Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, et al. (2009) Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. Arthritis and Rheumatism 60: 1255-1260.
60. Hollis-Moffatt JE, Chen-Xu M, Topless R, Dalbeth N, Gow PJ, et al. (2010) Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. Arthritis Res Ther 12: R116.
61. Knevel R, de Rooy DP, Zhernakova A, Grondal G, Krabben A, et al. (2013) Association of Variants in IL2RA With Progression of Joint Destruction in Rheumatoid Arthritis. Arthritis and Rheumatism 65: 1684-1693.
62. Bryl E, Vallejo AN, Matteson EL, Witkowski JM, Weyand CM, et al. (2005) Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Arthritis and Rheumatism 52: 2996-3003.
63. Kasperkovitz PV, Verbeet NL, Smeets TJ, van Rietschoten JG, Kraan MC, et al. (2004) Activation of the STAT1 pathway in rheumatoid arthritis. Annals of the Rheumatic Diseases 63: 233-239.
64. Ishizaki M, Muromoto R, Akimoto T, Ohshiro Y, Takahashi M, et al. (2011) Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. International Immunology 23: 575-582.
65. Corr M, Boyle DL, Ronacher L, Flores N, Firestein GS, (2009) Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta. Annals of the Rheumatic Diseases 68: 257-263.