Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 23, 2014, Pages 10072-10079

  Flanagan, Mark E ^a   Abramite, Joseph A ^a   Anderson, Dennis P ^a   Aulabaugh, Ann ^a   Dahal, Upendra P ^b   Gilbert, Adam M ^a   Li, Chao ^a   Montgomery, Justin ^a   Oppenheimer, Stacey R ^a   Ryder, Tim ^a   Schuff, Brandon P ^a   Uccello, Daniel P ^a   Walker, Gregory S ^a   Wu, Yan ^c   Brown, Matthew F ^a   Chen, Jinshan M ^a   Hayward, Matthew M ^a   Noe, Mark C ^a   Obach, R Scott ^a   Philippe, Laurence ^a   Shanmugasundaram, Veerabahu ^a   Shapiro, Michael J ^a   Starr, Jeremy ^a   Stroh, Justin ^a   Che, Ye ^a   more..

^a PFIZER INC   (United States)

^b CELGENE CORPORATION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE DERIVATIVE; BETA AMINOMETHYL SUBSTITUTED ACRYLAMIDE DERIVATIVE; ELECTROPHILE; ENZYME INHIBITOR; GLUTATHIONE; INDOPROFEN; IRREVERSIBLE INHIBITOR; NUCLEOPHILE; PHOSPHOTRANSFERASE INHIBITOR; SULFONAMIDE; THIOL REACTIVE COVALENT INHIBITOR; UNCLASSIFIED DRUG; DRUG;

ARTICLE; CALCULATION; CHEMICAL REACTION; CONTROLLED STUDY; COVALENT BOND; DRUG DESIGN; ELECTROPHILICITY; HUMAN; KINETICS; MATHEMATICAL ANALYSIS; NUCLEOPHILICITY; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE;

DRUG DESIGN; ENZYME INHIBITORS; GLUTATHIONE; HUMANS; KINETICS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHARMACEUTICAL PREPARATIONS;

EID: 84918547663     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501412a     Document Type: Article

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