Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study

Biochemical Pharmacology

Volumn 82, Issue 5, 2011, Pages 535-547

  Turpaev, Kyril ^a,b,c,d   Ermolenko, Mikhail ^a   Cresteil, Thierry ^a   Drapier, Jean Claude ^a  

^a INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^b VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

^c CENTER FOR THEORETICAL PROBLEMS OF PHYSICOCHEMICAL PHARMACOLOGY   (Russian Federation)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Benzylidenemalononitriles; c Jun; Heme oxygenase; Nrf2; Oxidative stress

Indexed keywords

(4 METHOXYBENZYLIDENE)MALONONITRILE; 3 HYDROXY 4 NITROBENZYLIDENEMALONONITRILE; 4 HYDROXYBENZYLIDENEMALONONITRILE; 5 (2,2 DICYANOVINYL) 2 NITROPHENOL; AG 10; AG 9; BENZYLIDENEMALONONITRILE; CYANIDE; EMK 041; EMK 081; EMK 1071; EMK 121; EMK 131; EMK 151; EMK 201; EMK 281; EMK 721; EMK 731; EMK 841; GLUTATHIONE; HALOGEN; HEME OXYGENASE 1; MALONONITRILE; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE P38; MORPHOLINE DERIVATIVE; NITROGEN DIOXIDE; PROTEIN C JUN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; DRUG STRUCTURE; ELECTRON; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCYTE; MULTIPLE SIGNALING PATHWAY; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; UPREGULATION;

BENZYLIDENE COMPOUNDS; CHROMATOGRAPHY, LIQUID; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; NITRILES; OXIDATIVE STRESS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TYRPHOSTINS; U937 CELLS;

EID: 79960909224     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.05.028     Document Type: Article

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