Synthesis and evaluation of novel hybrids β-carboline-4-thiazolidinones as potential antitumor and antiviral agents

European Journal of Medicinal Chemistry

Volumn 124, Issue , 2016, Pages 1093-1104

  Barbosa, Valéria Aquilino ^a   Baréa, Paula ^a   Mazia, Renata Sespede ^a   Ueda Nakamura, Tania ^a   Costa, Willian Ferreira da ^a   Foglio, Mary Ann ^b   Goes Ruiz, Ana Lucia T ^b   Carvalho, João Ernesto de ^b   Vendramini–Costa, Débora Barbosa ^b   Nakamura, Celso Vataru ^a   Sarragiotto, Maria Helena ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

4 Thiazolidinone; Antitumor; Antiviral; Carboline

Indexed keywords

1 (2 CHLOROPHENYL) N' (4 OXOTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 (2 FLUOROPHENYL) N' (4 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 (2 FLUOROPHENYL) N' (4 OXOTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 (3 NITROPHENYL) N' (4 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 (3 NITROPHENYL) N' (4 OXOTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 (4 DIMETHYLAMINOPHENYL) N' (4 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 (4 METHOXYPHENYL) N' (4 OXOTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 1 [4 (DIMETHYLAMINO)PHENYL] N' (4 OXOTHIAZOLIDIN 2 YLIDENE) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; 4 THIAZOLIDINONE DERIVATIVE; ACICLOVIR; ANTIVIRUS AGENT; BETA CARBOLINE DERIVATIVE; COLCHICINE; CYTOTOXIC AGENT; DOXORUBICIN; N (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL) 1 (2 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL) 1 (3 NITROPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL) 1 (4 DIMETHYLAMINOPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL) 1 PHENYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N (4 OXO 2 THIENYLTHIAZOLIDIN 3 YL) 1 PHENYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N [4 OXO 2 (2 CHLOROPHENYL)THIAZOLIDIN 3 YL] 1 PHENYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOXAMIDE; N' (3 ETHYL 4 OXOTHIAZOLIDIN 2 YLIDENE) 1 (2 CHLOROPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' (3 ETHYL 4 OXOTHIAZOLIDIN 2 YLIDENE) 1 (2 FLUOROPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' (3 ETHYL 4 OXOTHIAZOLIDIN 2 YLIDENE) 1 (3 NITROPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' (3 ETHYL 4 OXOTHIAZOLIDIN 2 YLIDENE) 1 (4 DIMETHYLAMINOPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' (3 ETHYL 4 OXOTHIAZOLIDIN 2 YLIDENE) 1 (4 METHOXYPHENYL) 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' (3 ETHYL 4 OXOTHIAZOLIDIN 2 YLIDENE) 1 PHENYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' (4 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE) 1 PHENYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; N' [4 OXOTHIAZOLIDIN 2 YLIDENE] 1 PHENYL 9H PYRIDO[3,4 B]INDOLE 3 CARBOHYDRAZIDE; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CARBOLINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; EC50; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GLIOMA CELL LINE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LC50; MALE; NONHUMAN; OVARIAN CANCER CELL LINE; RENAL CANCER CELL LINE; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CARBOLINES; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HERPESVIRUS 1, HUMAN; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84993965476     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.10.018     Document Type: Article

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