Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of l -ascorbic or imino- l -ascorbic acid: Synthesis, antitumour and antiviral activity evaluations

European Journal of Medicinal Chemistry

Volumn 102, Issue , 2015, Pages 288-302

  Stipković Babić, Maja ^a   Makuc, Damjan ^b,c   Plavec, Janez ^b,c   Martinović, Tamara ^d   Kraljević Pavelić, Sandra ^d   Pavelić, Krešimir ^d   Snoeck, Robert ^e   Andrei, Graciela ^e   Schols, Dominique ^e   Wittine, Karlo ^a   Mintas, Mladen ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^c EN FIST CENTRE OF EXCELLENCE   (Slovenia)

^d University of Rijeka   (Croatia)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

3 Deazapurines; 7 Deazapurines; 9 Deazapurines; activity Antiviral activity; Cytostatic; Imino L ascorbic acid; L Ascorbic acid

Indexed keywords

1 [5 (3,4 DI O BENZYL 5 HYDROXY FURAN 2(5H) ONE)ETHYL] 7 [5 (3,4 DI O BENZYL 5 HYDROXY FURAN 2(5H) ONE)ETHYL] 3H PYRROLO[3,2 D]PYRIMIDINE 4(5H) ONE; 1,7 DI [5 (3,4 DI O BENZYL FURAN 2(5H) ONE)ETILIDEN] 3H PIROLO[3,2 D]PYRIMIDINE 4(5H) ONE; 3,4 BIS(BENZYLOXY) 5 [2 (4 CHLORO 1H IMIDAZO[4,5 C]PYRIDINE 1 YL)ETHYLIDENE]FURAN 2(5H) ONE; 3,4 DI O BENZYL 5 HYDROXY 5 [1 (3H PYRROLO[3,2 D]PYRIMIDINE 4(5H) ONE 1 YL)ETHYL] 1H PYRROLO 2(5H) ONE; 3,4 DI O BENZYL 5 HYDROXY 5 [7 (2,4 DIMETHOXY 5H PYRROLO [3,2 D]PYRIMIDINE 7 YL)ETHYL] 1H PYRROLO 2(5H) ONE; 3,4 DI O BENZYL 5 HYDROXY 5 [7 (6 CHLORO 3H IMIDAZO[4,5 C]PYRIDINE 7 YL)ETHYL] 1H PYRROLO 2(5H) ONE; 3,4 DI O BENZYL 5 [1 (3H PYRROLO[3,2 D]PYRIMIDINE 4(5H) ONE 1 YL)ETHYLIDENE]FURAN 2(5H) ONE; 3,4 DI O BENZYL 5 [2 (5 BROMO 3H PYRROLO[2,3 D]PYRIMIDINE)ETHYL]5 HYDROXY 1H PYRROLO 2(5H) ONE; 3,4 DI O BENZYL 5 [7 (2,4 DIMETHOXY 5H PYRROLO[3,2 D]PYRIMIDINE 7 YL)ETHYLIDENE]FURAN 2(5H) ONE; 3,4 DI O BENZYL 5 [7 (3 CHLORO 2,6 DI FLUORO 1H IMIDAZO[4,5 C]PYRIDINE 7 YL)ETHYLIDENE]FURAN 2(5H) ONE; 3,4 DI O BENZYL 5 [9 (3 BROMO 1H IMIDAZO[4,5 C]PYRIDINE 9 YL)ETHYLIDENE]FURAN 2(5H) ONE; 3,4 DI O BENZYL 5 [9 (3 BROMO 1H IMIDAZO[4,5 C]PYRIDINE 9 YL)ETHYL] 5 HYDROXY 1H PYRROLO 2(5H) ONE; 3,4 DI O BENZYL 5 [9 (3 CHLORO 2,6 DIFLUORO 1H IMIDAZO [4,5 C]PYRIDINE 9 YL)ETHYLIDENE]FURAN 2(5H) ONE; 3,4 DI O BENZYL 5 [9 (6 CHLORO 7 IODO 7H PYRROLO[2,3 D]PYRIMIDINE 9 YL) VINYL] 5 HYDROXY 1H PYRROLO 2(5H) ONE; 4,5 DIDEHYDRO 5,6 DIDEOXY ASCORBIC ACID 3,4 DI O BENZYL 5 [1 (7 BROMO 3H PYRROLO[2,3 D]PYRIMIDINE 1 YL)ETHYLIDENE]FURAN 2(5H) ONE; 4,5 DIDEHYDRO 5,6 DIDEOXY ASCORBIC ACID 3,4 DI O BENZYL 5 [9 (6 CHLORO 7 IODO 7H PYRROLO[2,3 D]PYRIMIDINE 9 YL)ETHYLIDENE]FURAN 2(5H) ONE; 5 [2 (7 CHLORO 4,6 DI FLUORO 3H IMIDAZO[4,5-C]PYRIDINE 3 YL)ETHYLIDENE]3,4 DIHYDROXYFURAN 2(5H) ONE; 5 [9 (6 AMINO 3 CHLORO 2 FLUORO 1H IMIDAZO[4,5 C]PYRIDINE 9 YL)ETHYL] 3,4 DI O BENZYL 5 HYDROXY 1H PYRROLO 2(5H) ONE; ANTIVIRUS AGENT; ASCORBIC ACID DERIVATIVE; CYTOSTATIC AGENT; GANCICLOVIR; PURINE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ASCORBIC ACID;

AMMONOLYSIS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; FIBROBLAST; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; MITSUNOBU REACTION; MOUSE; NONHUMAN; POLYMERIZATION; ANIMAL; CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOMEGALOVIRUS; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ASCORBIC ACID; CELL LINE; CELL PROLIFERATION; CYTOMEGALOVIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84939489234     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.08.008     Document Type: Article

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