Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 10-22

  Shi, Buxi ^a   Cao, Rihui ^a   Fan, Wenxi ^b   Guo, Liang ^b   Ma, Qin ^b   Chen, Xuemei ^b   Zhang, Guoxian ^a   Qiu, Liqin ^a   Song, Huacan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Xinjiang Huashidan Pharmaceutical Co Ltd   (China)

Author keywords

Antitumor; Bivalent carbolines; Structure activity relationships; Synthesis

Indexed keywords

1 METHYL 9 [10 (1 METHYL BETA CARBOLINE 9 YL)DECYL]BETA CARBOLINE; 1 METHYL 9 [3 (1 METHYL BETA CARBOLINE 9 YL)PROPYL]BETA CARBOLINE; 1 METHYL 9 [4 (1 METHYL BETA CARBOLINE 9 YL)BUTYL]BETA CARBOLINE; 1 METHYL 9 [5 (1 METHYL BETA CARBOLINE 9 YL)PENTYL]BETA CARBOLINE; 1 METHYL 9 [6 (1 METHYL BETA CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 1 METHYL 9 [7 (1 METHYL BETA CARBOLINE 9 YL)HEPTYL]BETA CARBOLINE; 1 METHYL 9 [8 (1 METHYL CARBOLINE 9 YL)OCTYL]BETA CARBOLINE; 1 METHYL 9 [9 (1 METHYL BETA CARBOLINE 9 YL)NONYL]BETA CARBOLINE; 3 ETHOXYCARBONYL 1 METHYL 9 [6 (3 ETHOXYCARBONYL 1 METHYL CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 6 BROMO 1 METHYL 9 [5 (6 BROMO 1 METHYL BETA CARBOLINE 9 YL)PENTYL]BETA CARBOLINE; 6 BROMO 1 METHYL 9 [6 (6 BROMO 1 METHYL BETA CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 6 BROMO 9 [4 (6 BROMO BETA CARBOLINE 9 YL)BUTYL]BETA CARBOLINE; 7 BUTOXY 1 METHYL 9 [4 (7 BUTOXY 1 METHYL BETA CARBOLINE 9 YL)BUTYL]BETA CARBOLINE; 7 ISOPROXY 1 METHYL 9 [6 (7 ISOPROXY 1 METHYL BETA CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 7 ISOPROXY 1 METHYL 9 [9 (7 ISOPROXY 1 METHYL BETA CARBOLINE 9 YL)NONYL]BETA CARBOLINE; 7 METHOXY 1 METHYL 9 [4 (7 METHOXY 1 METHYL BETA CARBOLINE 9 YL)BUTYL]BETA CARBOLINE; 7 METHOXY 1 METHYL 9 [5 (7 METHOXY 1 METHYL BETA CARBOLINE 9 YL)PENTYL]BETA CARBOLINE; 7 METHOXY 1 METHYL 9 [6 (7 METHOXY 1 METHYL BETA CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 7 METHOXY 1 METHYL 9 [7 (7 METHOXY 1 METHYL BETA CARBOLINE 9 YL)HEPTYL]BETA CARBOLINE; 7 METHOXY 1 METHYL 9 [8 (7 METHOXY 1 METHYL BETA CARBOLINE 9 YL)HEPTYL]BETA CARBOLINE; 8 BROMO 9 [6 (8 BROMO BETA CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 9 [4 (BETA CARBOLINE 9 YL)BUTYL]BETA CARBOLINE; 9 [5 (BETA CARBOLINE 9 YL)PENTYL]BETA CARBOLINE; 9 [6 (BETA CARBOLINE 9 YL)HEXYL]BETA CARBOLINE; 9 [7 (BETA CARBOLINE 9 YL)HEPTYL]BETA CARBOLINE; 9 [8 (BETA CARBOLINE 9 YL)OCTYL]BETA CARBOLINE; ANTINEOPLASTIC AGENT; BETA CARBOLINE DERIVATIVE; CISPLATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871544584     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.033     Document Type: Article

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