Synthesis, cytotoxicity and antiviral evaluation of new series of imidazo[4,5-g[quinoline and pyrido[2,3-g[quinoxalinone derivatives

European Journal of Medicinal Chemistry

Volumn 105, Issue , 2015, Pages 63-79

  Briguglio, Irene ^a   Loddo, Roberta ^b   Laurini, Erik ^c   Fermeglia, Maurizio ^c   Piras, Sandra ^a   Corona, Paola ^a   Giunchedi, Paolo ^a   Gavini, Elisabetta ^a   Sanna, Giuseppina ^b   Giliberti, Gabriele ^b   Ibba, Cristina ^b   Farci, Pamela ^b   La Colla, Paolo ^b   Pricl, Sabrina ^c   Carta, Antonio ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Antiviral activity; DNA viruses; Imidazo 4,5 g quinolines; Pyrido 2,3 g quinoxalines; RNA viruses

Indexed keywords

2 BENZYL 3 (CYCLOHEXYLMETHYL) 3H IMIDAZO[4,5 G]QUINOLINE; 2 BENZYL 5 CHLORO 4 CYCLOHEXYLPYRIDO[2,3 G]QUINOXALIN 3(4H) ONE; 2 PHENYL 3 PROPYL 3H IMIDAZO[4,5 G]QUINOLINE; 2' C ETHYNYL CYTIDINE; 2' C METHYL CYTIDINE; 2' C METHYL GUANOSINE; 2,3 SUBSTITUTED 3H IMIDAZO[4,5 G]QUINOLINE DERIVATIVE; 3 CYCLOHEXYL 2 (THIOPHEN 2 YL) 3H IMIDAZO[4,5 G]QUINOLINE; 3 CYCLOHEXYL 2 PHENYL 3H IMIDAZO[4,5 G]QUINOLINE; 5 CHLORO 1 METHYL 3 (THIOPHEN 2 YL)PYRIDO[2,3 G]QUINOXALIN 2(1H) ONE; 5 CHLORO 1 METHYL 3 PHENYLPYRIDO[2,3 G]QUINOXALIN 2(1H) ONE; 5 CHLORO 2 METHOXY 3 (THIOPHEN 2 YL)PYRIDO[2,3 G]QUINOXALINE; 5 CHLORO 2 PHENYL 4 PROPYLPYRIDO[2,3 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 2,4 SUBSTITUTED PYRIDO[2,3 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 2,4 SUBSTITUTED PYRIDO[2,3 G]QUINOXALIN 3(4H) ONE DERIVATIVE; 5 CHLORO 3 (THIOPHEN 2 YL)PYRIDO[2,3 G]QUINOXALIN 2(1H) ONE; 5 CHLORO 4 (CYCLOHEXYLMETHYL) 2 PHENYLPYRIDO[2,3 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 4 CYCLOHEXYL 2 (THIOPHEN 2 YL)PYRIDO[2,3 G]QUINOXALIN 3(4H) ONE; 5 CHLORO 4 CYCLOHEXYL 2 PHENYLPYRIDO[2,3 G]QUINOXALIN 3(4H) ONE; ACICLOVIR; ANTIVIRUS AGENT; AZAURIDINE; CIDOFOVIR; CYTIDINE DERIVATIVE; EFAVIRENZ; GUANOSINE DERIVATIVE; IMIDAZOQUINOLINE DERIVATIVE; PYRIDO[2,3 G ]QUINOXALINONE DERIVATIVE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; DNA VIRUS; IMIDAZO(4,5-G)QUINOLINE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIDO(2,3-G)QUINOXALINONE; QUINOLINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; ASSAY; ATOM; CONTROLLED STUDY; CYTOTOXICITY; DNA VIRUS; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; GENOME; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN RESPIRATORY SYNCYTIAL VIRUS; PESTIVIRUS; REOVIRIDAE; RNA VIRUS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIVIRAL AGENTS; DNA VIRUSES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIDINES; QUINOLINES; QUINOXALINES; RNA VIRUSES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84944732256     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.10.002     Document Type: Article

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