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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 20, 2014, Pages 4854-4860

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors

(6) Drung, Binia a Scholz, Christoph a Barbosa, Valéria A b Nazari, Azadeh a Sarragiotto, Maria H b Schmidt, Boris a

a DARMSTADT UNIVERSITY OF TECHNOLOGY (Germany)

b STATE UNIVERSITY OF MARINGÁ (Brazil)

Author keywords

Docking; DYRK1A; Inhibitor; MAO A; Pharmacophore; SAR; Carboline

Indexed keywords

CARBOLINE DERIVATIVE; DYRK KINASE; LIGAND; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; DOSE RESPONSE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CARBOLINES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908699102 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.08.054 Document Type: Article

Times cited : (35)

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