Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways

Phytomedicine

Volumn 23, Issue 13, 2016, Pages 1629-1637

  Guo, Chao ^a   Yang, Lei ^a   Wan, Chuan Xing ^a   Xia, Yuan Zheng ^a   Zhang, Chao ^a   Chen, Meng Han ^a   Wang, Zhen Dong ^a   Li, Zhong Rui ^a   Li, Xue Mei ^a   Geng, Ya Di ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

BV2; LPS; Neuroinflammation; Sophoraflavanone G

Indexed keywords

ANTIINFLAMMATORY AGENT; CENTRAL NERVOUS SYSTEM AGENTS; CYCLOOXYGENASE 2; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROSTAGLANDIN E2; SOPHORA ALOPECUROIDES EXTRACT; SOPHORAFLAVANONE G; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; FLAVANONE DERIVATIVE; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; STAT PROTEIN; VEXIBINOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CHINESE HERB; DRUG MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOPHORA ALOPECUROIDES; UPREGULATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; GENETICS; INFLAMMATION; METABOLISM; MOUSE; SOPHORA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; DINOPROSTONE; FLAVANONES; HEME OXYGENASE-1; INFLAMMATION; JANUS KINASES; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; SOPHORA; STAT TRANSCRIPTION FACTORS;

EID: 84993929605     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2016.10.007     Document Type: Article

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