Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 12, 2014, Pages 3311-3319

  Velagapudi, Ravikanth ^a   Aderogba, Mutallib ^b   Olajide, Olumayokun A ^a  

^a UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

^b OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

Antioxidant; Neuroinflammation; NF B p38; Tiliroside; TRAF 6

Indexed keywords

CYCLOOXYGENASE 2; FLAVONOID; GAMMA INTERFERON; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRITE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; TILIROSIDE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEUROINFLAMMATORY ACTION; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; REPORTER GENE; WESTERN BLOTTING;

EID: 84907096973     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.08.008     Document Type: Article

References (52)

1. S.T. Dheen, C. Kaur, and E.A. Ling Microglial activation and its implications in the brain diseases Curr. Med. Chem. 14 2007 1189 1197
2. I.V. Lima, L.F. Bastos, M. Limborco-Filho, B.L. Fiebich, and A.C. de Oliveira Role of prostaglandins in neuroinflammatory and neurodegenerative diseases Mediat. Inflamm. 2012 2012 946813
3. C. Consilvio, A.M. Vincent, and E.L. Feldman Neuroinflammation, COX-2, and ALS-a dual role? Exp. Neurol. 187 2004 1 10
4. G.H. Doherty Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories Neurosci. Bull. 27 2011 366 382
5. D.L. Krause, and N. Muller Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease Int. J. Alzheimers Dis. 2010 2010
6. B. Kaminska, A. Gozdz, M. Zawadzka, A. Ellert-Miklaszewska, and M. Lipko MAPK signal transduction underlying brain inflammation and gliosis as therapeutic target Anat. Rec. 292 2009 1902 1913
7. S. Duraisamy, M. Bajpai, U. Bughani, S.G. Dastidar, A. Ray, and P. Chopra MK2: a novel molecular target for anti-inflammatory therapy Expert Opin. Ther. Targets 12 2008 921 936
8. A.A. Culbert, S.D. Skaper, D.R. Howlett, N.A. Evans, L. Facci, P.E. Soden, Z.M. Seymour, F. Guillot, M. Gaestel, and J.C. Richardson MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease J. Biol. Chem. 281 2006 23658 23667
9. J.F. Schindler, J.B. Monahan, and W.G. Smith p38 pathway kinases as anti-inflammatory drug targets J. Dent. Res. 86 2007 800 811
10. H.L. Hsieh, and C.M. Yang Role of redox signaling in neuroinflammation and neurodegenerative diseases Biomed. Res. Int. 2013 2013 484613
11. I.T. Lee, and C.M. Yang Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases Biochem. Pharmacol. 84 2012 581 590
12. R. von Bernhardi, and J. Eugenín Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms Antioxid. Redox Signal. 16 2012 974 1031
13. M. Sandberg, J. Patil, B. D'Angelo, S.G. Weber, and C. Mallard NRF2-regulation in brain health and disease: implication of cerebral inflammation Neuropharmacology 79 2014 298 306
14. S. Nair, S.T. Doh, J.Y. Chan, A.N. Kong, and L. Cai Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis Br. J. Cancer 99 2008 2070 2082
15. H. Matsuda, K. Ninomiya, H. Shimoda, and M. Yoshikawa Hepatoprotective principles from the flowers of Tilia argentea (linden): structure requirements of tiliroside and mechanisms of action Bioorg. Med. Chem. 10 2002 707 712
16. S. Tsukamoto, K. Tomise, M. Aburatani, H. Onuki, H. Hirorta, E. Ishiharajima, and T. Ohta Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa J. Nat. Prod. 67 2004 1839 1841
17. Y. Gong, B. Xue, J. Jiao, L. Jing, and X. Wang Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia J. Neurochem. 107 2008 779 788
18. S. Ghosh, and M.S. Hayden Celebrating 25 years of NF-κB research Immunol. Rev. 246 2012 5 13
19. G. Sabio, and R.J. Davis TNF and MAP kinase signalling pathways Semin. Immunol. 2014 10.1016/j.smim.2014.02.009
20. B. Kaminska MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits Biochim. Biophys. Acta 1754 2005 253 262
21. B.L. Fiebich, K. Lieb, S. Engels, and M. Heinrich Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells J. Neuroimmunol. 132 2002 18 24
22. Y.B. Lee, J.W. Schrader, and S.U. Kim p38 MAP kinase regulates TNF-α production in human astrocytes and microglia by multiple mechanisms Cytokine 12 2000 874 880
23. B. Xing, T. Xin, R. Hunter, and G. Bing Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt J. Neuroinflammation 5 2008 4
24. L. Munoz, and A.J. Ammit Targeting p38 MAPK pathway for the treatment of Alzheimer's disease Neuropharmacology 58 2010 561 568
25. A.B. Carter, K.L. Knudtson, M.M. Monick, and G.W. Hunninghake The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression, the role of TATA-binding protein (TBP) J. Biol. Chem. 274 1999 30858 30863
26. M. Avila, and C. Gonzalez-Espinosa Signaling through Tolllike receptor 4 and mast celldependent innate immunity responses IUBMB Life 63 2011 873 880
27. P.J. Syapin Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders Br. J. Pharmacol. 155 2008 623 640
28. L.F. Lue, L. Brachova, W.H. Civin, and J. Rogers Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration J. Neuropathol. Exp. Neurol. 55 1996 1083 1088
29. J.M. Rubio-Perez, and J.M. Morillas-Ruiz A review: inflammatory process in Alzheimer's disease, role of cytokines Sci. World J. 2012 2012 756357
30. A. Sala, M.C. Recio, G.R. Schinella, S. Máñez, R.M. Giner, M. Cerdá-Nicolás, and J.L. Rosí Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside Eur. J. Pharmacol. 461 2003 53 61
31. C.C. Chao, S. Hu, T.W. Molitor, E.G. Shaskan, and P.K. Peterson Activated microglia mediate neuronal cell injury via a nitric oxide mechanism J. Immunol. 149 1992 2736 2741
32. S.V. More, H. Kumar, I.S. Kim, S.Y. Song, and D.K. Choi Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease Mediators Inflamm. 2013 2013
33. J.P. Spencer, K. Vafeiadou, R.J. Williams, and D. Vauzour Neuroinflammation: modulation by flavonoids and mechanisms of action Mol. Aspects Med. 33 2012 83 97
34. J.C. Chen, F.M. Ho, C. Pei-Dawn Lee, C.P. Chen, K.C. Jeng, H.B. Hsu, S.T. Lee, W. Wen Tung, and W.W. Lin Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of I kappa B kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia Eur. J. Pharmacol. 521 2005 9 20
35. G. Bureau, F. Longpre, and M.G. Martinoli Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation J. Neurosci. Res. 86 2008 403 410
36. T.K. Kao, Y.C. Ou, S.L. Raung, C.Y. Lai, S.L. Liao, and C.J. Chen Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia Life Sci. 86 2010 315 321
37. T. Koda, Y. Kuroda, and H. Imai Rutin supplementation in the diet has protective effects against toxicant-induced hippocampal injury by suppression of microglial activation and pro-inflammatory cytokines: protective effect of rutin against toxicant-induced hippocampal injury Cell. Mol. Neurobiol. 29 2009 523 531
38. K. Vafeiadou, D. Vauzour, H.Y. Lee, A. Rodriguez-Mateos, R.J. Williams, and J.P.E. Spencer The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury Arch. Biochem. Biophys. 484 2009 100 109
39. C.L. Chao, C.S. Weng, N.C. Chang, J.S. Lin, S.T. Kao, and F.M. Ho Naringenin more effectively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in macrophages than in microglia Nutr. Res. 30 2010 858 864
40. R. Li, Y.G. Huang, D. Fang, and W.D. Le (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury J. Neurosci. Res. 78 2004 723 731
41. K. Yamamoto, T. Arakawa, N. Ueda, and S. Yamamoto Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells J. Biol. Chem. 270 1995 31315 31320
42. Y.S. Kim, and T.H. Joh Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease Exp. Mol. Med. 38 2006 333 347
43. Z. Guan, S.Y. Buckman, A.P. Pentland, D.J. Templeton, and A.R. Morrison Induction of cyclooxygenase-2 by the activated MEKK1 - > SEK1/MKK4 - > p38 mitogen-activated protein kinase pathway J. Biol. Chem. 273 1998 12901 12908
44. I.O. Han, K.W. Kim, J.H. Ryu, and W.K. Kim p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells Neurosci. Lett. 325 2002 9 12
45. M.P. Butler, J.A. Hanly, and P.N. Moynagh Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner J. Biol. Chem. 280 2005 27759 27768
46. I.A. Rojo, G. McBean, M. Cindric, J. Egea, M.G. Lopez, P. Rada, N. Zarkovic, and A. Cuadrado Redox control of microglial function: molecular mechanisms and functional significance Antioxid. Redox Signal. 2014 10.1089/ars.2013.5745
47. H. Kim, Y.S. Kim, S.Y. Kim, and K. Suk The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production Neurosci. Lett. 309 2001 67 71
48. H. Lee, Y.O. Kim, H. Kim, S.Y. Kim, H.S. Noh, S.S. Kang, G.J. Cho, W.S. Choi, and K. Suk Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia FASEB J. 17 2003 1943 1944
49. W. Chun, H.J. Lee, P.J. Kong, G.H. Lee, I.Y. Cheong, H. Park, and S.S. Kim Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity Arch. Pharm. Res. 28 2005 216 219
50. K. Suk, H. Lee, S.S. Kang, G.J. Cho, and W.S. Choi Flavonoid baicalein attenuates activation-induced cell death of brain microglia J. Pharmacol. Exp. Ther. 305 2003 638 645
51. C.J. Chen, S.L. Raung, S.L. Liao, and S.Y. Chen Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokine-stimulated microglia Biochem. Pharmacol. 67 2004 957 965
52. F.Q. Li, T. Wang, Z. Pei, B. Liu, and J.S. Hong Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons J. Neural Transm. 112 2005 331 347