Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway

Journal of Neuroinflammation

Volumn 11, Issue 1, 2014, Pages

  Dong, Hongquan ^a   Zhang, Xiang ^a   Dai, Xiaonan ^b   Lu, Shunmei ^a   Gui, Bo ^a   Jin, Wenjie ^a   Zhang, Susu ^a   Zhang, Shu ^a   Qian, Yanning ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

FoxO1; lithium; microglia; PI3K Akt; TLR4

Indexed keywords

INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LITHIUM CHLORIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA; CD11B ANTIGEN; ENZYME INHIBITOR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, RAT; NERVE PROTEIN; TRANQUILIZER;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CELL VIABILITY; CELLULAR STRESS RESPONSE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; MICROGLIA; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIMARY CELL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BRAIN; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; NEWBORN; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIMANIC AGENTS; BRAIN; CELLS, CULTURED; ENZYME INHIBITORS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LITHIUM CHLORIDE; MACROPHAGE-1 ANTIGEN; MICROGLIA; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84910104889     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-014-0140-4     Document Type: Article

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