메뉴 건너뛰기




Volumn 287, Issue , 2015, Pages 9-14

Tormentic acid reduces inflammation in BV-2 microglia by activating the liver X receptor alpha

Author keywords

LPS; LXR ; Microglia; NF B; PGE2; Tormentic acid

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LIVER X RECEPTOR ALPHA; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; TORMENTIC ACID; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; TRITERPENE;

EID: 84920271722     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.12.005     Document Type: Article
Times cited : (15)

References (31)
  • 1
    • 79952735309 scopus 로고    scopus 로고
    • Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-alpha expression through inactivation of the nuclear factor-kappa b pathway in RAW 264.7 macrophages
    • An H.J., Kim I.T., Park H.J., Kim H.M., Choi J.H., Lee K.T. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-alpha expression through inactivation of the nuclear factor-kappa b pathway in RAW 264.7 macrophages. Int Immunopharmacol 2011, 11:504-510.
    • (2011) Int Immunopharmacol , vol.11 , pp. 504-510
    • An, H.J.1    Kim, I.T.2    Park, H.J.3    Kim, H.M.4    Choi, J.H.5    Lee, K.T.6
  • 2
    • 0037287331 scopus 로고    scopus 로고
    • Role of the immune system in the pathogenesis, prevention and treatment of Alzheimer's disease
    • Blasko I., Grubeck-Loebenstein B. Role of the immune system in the pathogenesis, prevention and treatment of Alzheimer's disease. Drugs Aging 2003, 20:101-113.
    • (2003) Drugs Aging , vol.20 , pp. 101-113
    • Blasko, I.1    Grubeck-Loebenstein, B.2
  • 3
    • 79952537526 scopus 로고    scopus 로고
    • Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo
    • Chang C.T., Huang S.S., Lin S.S., Amagaya S., Ho H.Y., Hou W.C., Shie P.H., Wu J.B., Huang G.J. Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo. Food Chem 2011, 127:1131-1137.
    • (2011) Food Chem , vol.127 , pp. 1131-1137
    • Chang, C.T.1    Huang, S.S.2    Lin, S.S.3    Amagaya, S.4    Ho, H.Y.5    Hou, W.C.6    Shie, P.H.7    Wu, J.B.8    Huang, G.J.9
  • 4
    • 84904106826 scopus 로고    scopus 로고
    • Evidence of inflammatory system involvement in Parkinson's disease
    • Chao Y., Wong S.C., Tan E.K. Evidence of inflammatory system involvement in Parkinson's disease. Biomed Res Int 2014, 2014:308654.
    • (2014) Biomed Res Int , vol.2014 , pp. 308654
    • Chao, Y.1    Wong, S.C.2    Tan, E.K.3
  • 5
    • 84893372286 scopus 로고    scopus 로고
    • LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes
    • Dib L., Bugge A., Collins S. LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes. J Lipid Res 2014, 55:247-257.
    • (2014) J Lipid Res , vol.55 , pp. 247-257
    • Dib, L.1    Bugge, A.2    Collins, S.3
  • 6
    • 84901301565 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of alpha-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells
    • Dilshara M.G., Lee K.T., Kim H.J., Lee H.J., Choi Y.H., Lee C.M., Kim L.K., Kim G.Y. Anti-inflammatory mechanism of alpha-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells. Cell Immunol 2014, 290:21-29.
    • (2014) Cell Immunol , vol.290 , pp. 21-29
    • Dilshara, M.G.1    Lee, K.T.2    Kim, H.J.3    Lee, H.J.4    Choi, Y.H.5    Lee, C.M.6    Kim, L.K.7    Kim, G.Y.8
  • 7
    • 84876789513 scopus 로고    scopus 로고
    • High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway
    • Dong B., Kan C.F., Singh A.B., Liu J. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. J Lipid Res 2013, 54:1241-1254.
    • (2013) J Lipid Res , vol.54 , pp. 1241-1254
    • Dong, B.1    Kan, C.F.2    Singh, A.B.3    Liu, J.4
  • 8
    • 84888884020 scopus 로고    scopus 로고
    • The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: structure-activity relationships of flavones
    • During A., Larondelle Y. The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: structure-activity relationships of flavones. Biochem Pharmacol 2013, 86:1739-1746.
    • (2013) Biochem Pharmacol , vol.86 , pp. 1739-1746
    • During, A.1    Larondelle, Y.2
  • 9
    • 67449146879 scopus 로고    scopus 로고
    • Tormentic acid reduces vascular smooth muscle cell proliferation and survival
    • Fogo A.S., Antonioli E., Calixto J.B., Campos A.H. Tormentic acid reduces vascular smooth muscle cell proliferation and survival. Eur J Pharmacol 2009, 615:50-54.
    • (2009) Eur J Pharmacol , vol.615 , pp. 50-54
    • Fogo, A.S.1    Antonioli, E.2    Calixto, J.B.3    Campos, A.H.4
  • 10
    • 84881085639 scopus 로고    scopus 로고
    • Ca(2+) spiking activity caused by the activation of store-operated Ca(2+) channels mediates TNF-alpha release from microglial cells under chronic purinergic stimulation
    • Ikeda M., Tsuno S., Sugiyama T., Hashimoto A., Yamoto K., Takeuchi K., Kishi H., Mizuguchi H., Kohsaka S., Yoshioka T. Ca(2+) spiking activity caused by the activation of store-operated Ca(2+) channels mediates TNF-alpha release from microglial cells under chronic purinergic stimulation. Biochim Biophys Acta 2013, 1833:2573-2585.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2573-2585
    • Ikeda, M.1    Tsuno, S.2    Sugiyama, T.3    Hashimoto, A.4    Yamoto, K.5    Takeuchi, K.6    Kishi, H.7    Mizuguchi, H.8    Kohsaka, S.9    Yoshioka, T.10
  • 12
    • 0023769396 scopus 로고
    • Hypoglycemic and insulin release effects of tormentic acid: a new hypoglycemic natural product
    • Ivorra M.D., Paya M., Villar A. Hypoglycemic and insulin release effects of tormentic acid: a new hypoglycemic natural product. Planta Med 1988, 54:282-285.
    • (1988) Planta Med , vol.54 , pp. 282-285
    • Ivorra, M.D.1    Paya, M.2    Villar, A.3
  • 13
    • 84894091562 scopus 로고    scopus 로고
    • Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia
    • Jeong J.W., Lee H.H., Han M.H., Kim G.Y., Kim W.J., Choi Y.H. Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia. Chem Biol Interact 2014, 212:30-39.
    • (2014) Chem Biol Interact , vol.212 , pp. 30-39
    • Jeong, J.W.1    Lee, H.H.2    Han, M.H.3    Kim, G.Y.4    Kim, W.J.5    Choi, Y.H.6
  • 14
    • 70349384629 scopus 로고    scopus 로고
    • Recent advances on the roles of NO in cancer and chronic inflammatory disorders
    • Kanwar J.R., Kanwar R.K., Burrow H., Baratchi S. Recent advances on the roles of NO in cancer and chronic inflammatory disorders. Curr Med Chem 2009, 16:2373-2394.
    • (2009) Curr Med Chem , vol.16 , pp. 2373-2394
    • Kanwar, J.R.1    Kanwar, R.K.2    Burrow, H.3    Baratchi, S.4
  • 15
    • 84891298600 scopus 로고    scopus 로고
    • 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation
    • Kim H.W., Kim J., Kim J., Lee S., Choi B.R., Han J.S., Lee K.W., Lee H.J. 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. Toxicol Sci 2014, 137:158-167.
    • (2014) Toxicol Sci , vol.137 , pp. 158-167
    • Kim, H.W.1    Kim, J.2    Kim, J.3    Lee, S.4    Choi, B.R.5    Han, J.S.6    Lee, K.W.7    Lee, H.J.8
  • 16
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 2003, 304:1-7.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 17
    • 43549084328 scopus 로고    scopus 로고
    • Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice
    • Liu Z., Fan Y., Wang Y., Han C., Pan Y., Huang H., Ye Y., Luo L., Yin Z. Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice. FEBS Lett 2008, 582:1643-1650.
    • (2008) FEBS Lett , vol.582 , pp. 1643-1650
    • Liu, Z.1    Fan, Y.2    Wang, Y.3    Han, C.4    Pan, Y.5    Huang, H.6    Ye, Y.7    Luo, L.8    Yin, Z.9
  • 18
    • 84880172562 scopus 로고    scopus 로고
    • Antiproliferative activities on renal, prostate and melanoma cancer cell lines of sarcopoterium spinosum aerial parts and its major constituent tormentic acid
    • Loizzo M.R., Bonesi M., Passalacqua N.G., Saab A., Menichini F., Tundis R. Antiproliferative activities on renal, prostate and melanoma cancer cell lines of sarcopoterium spinosum aerial parts and its major constituent tormentic acid. Anticancer Agent Med Chem 2013, 13:768-776.
    • (2013) Anticancer Agent Med Chem , vol.13 , pp. 768-776
    • Loizzo, M.R.1    Bonesi, M.2    Passalacqua, N.G.3    Saab, A.4    Menichini, F.5    Tundis, R.6
  • 21
    • 84884906968 scopus 로고    scopus 로고
    • Morphine mediates a proinflammatory phenotype via mu-opioid receptor-PKCvarepsilon-Akt-ERK1/2 signaling pathway in activated microglial cells
    • Merighi S., Gessi S., Varani K., Fazzi D., Stefanelli A., Borea P.A. Morphine mediates a proinflammatory phenotype via mu-opioid receptor-PKCvarepsilon-Akt-ERK1/2 signaling pathway in activated microglial cells. Biochem Pharmacol 2013, 86:487-496.
    • (2013) Biochem Pharmacol , vol.86 , pp. 487-496
    • Merighi, S.1    Gessi, S.2    Varani, K.3    Fazzi, D.4    Stefanelli, A.5    Borea, P.A.6
  • 22
    • 0028792386 scopus 로고
    • Mediation of inflammation by encephalitogenic cells: interferon gamma induction of nitric oxide synthase and cyclooxygenase 2
    • Misko T.P., Trotter J.L., Cross A.H. Mediation of inflammation by encephalitogenic cells: interferon gamma induction of nitric oxide synthase and cyclooxygenase 2. J Neuroimmunol 1995, 61:195-204.
    • (1995) J Neuroimmunol , vol.61 , pp. 195-204
    • Misko, T.P.1    Trotter, J.L.2    Cross, A.H.3
  • 23
    • 33847189252 scopus 로고    scopus 로고
    • Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia
    • Moon D.O., Choi Y.H., Kim N.D., Park Y.M., Kim G.Y. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. Int Immunopharmacol 2007, 7:506-514.
    • (2007) Int Immunopharmacol , vol.7 , pp. 506-514
    • Moon, D.O.1    Choi, Y.H.2    Kim, N.D.3    Park, Y.M.4    Kim, G.Y.5
  • 24
    • 84897954445 scopus 로고    scopus 로고
    • Microglial dysfunction in brain aging and Alzheimer's disease
    • Mosher K.I., Wyss-Coray T. Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol 2014, 88:594-604.
    • (2014) Biochem Pharmacol , vol.88 , pp. 594-604
    • Mosher, K.I.1    Wyss-Coray, T.2
  • 25
    • 84862265730 scopus 로고    scopus 로고
    • Inhibitory effects of diallyl disulfide on the production of inflammatory mediators and cytokines in lipopolysaccharide-activated BV2 microglia
    • Park H.Y., Kim N.D., Kim G.Y., Hwang H.J., Kim B.W., Kim W.J., Choi Y.H. Inhibitory effects of diallyl disulfide on the production of inflammatory mediators and cytokines in lipopolysaccharide-activated BV2 microglia. Toxicol Appl Pharmacol 2012, 262:177-184.
    • (2012) Toxicol Appl Pharmacol , vol.262 , pp. 177-184
    • Park, H.Y.1    Kim, N.D.2    Kim, G.Y.3    Hwang, H.J.4    Kim, B.W.5    Kim, W.J.6    Choi, Y.H.7
  • 27
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • Takeuchi H., Jin S., Wang J., Zhang G., Kawanokuchi J., Kuno R., Sonobe Y., Mizuno T., Suzumura A. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 2006, 281:21362-21368.
    • (2006) J Biol Chem , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 28
    • 34547435817 scopus 로고    scopus 로고
    • Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
    • Tilleux S., Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 2007, 85:2059-2070.
    • (2007) J Neurosci Res , vol.85 , pp. 2059-2070
    • Tilleux, S.1    Hermans, E.2
  • 29
    • 84914707849 scopus 로고    scopus 로고
    • Activation of Liver X receptor improves viability of adipose-derived mesenchymal stem cells (AD-MSCs) to attenuate myocardial ischemia injury through TLR4/NF-kappaB and Keap-1/Nrf2 signaling pathways
    • Wang Y., Li C., Cheng K., Zhang R., Narsinh K., Li S., Li X., Qin X., Zhang R., Li C., Su T., Chen J., Cao F. Activation of Liver X receptor improves viability of adipose-derived mesenchymal stem cells (AD-MSCs) to attenuate myocardial ischemia injury through TLR4/NF-kappaB and Keap-1/Nrf2 signaling pathways. Antioxid Redox Signal 2014, 21:2543-2557.
    • (2014) Antioxid Redox Signal , vol.21 , pp. 2543-2557
    • Wang, Y.1    Li, C.2    Cheng, K.3    Zhang, R.4    Narsinh, K.5    Li, S.6    Li, X.7    Qin, X.8    Zhang, R.9    Li, C.10    Su, T.11    Chen, J.12    Cao, F.13
  • 30
    • 84875229989 scopus 로고    scopus 로고
    • Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-kappaB and MAPKs activation via the phosphatidylinositol 3-kinase signaling
    • Yang P., Han Y., Gui L., Sun J., Chen Y.L., Song R., Guo J.Z., Xie Y.N., Lu D., Sun L. Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-kappaB and MAPKs activation via the phosphatidylinositol 3-kinase signaling. Biochem Pharmacol 2013, 85:1124-1133.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1124-1133
    • Yang, P.1    Han, Y.2    Gui, L.3    Sun, J.4    Chen, Y.L.5    Song, R.6    Guo, J.Z.7    Xie, Y.N.8    Lu, D.9    Sun, L.10
  • 31
    • 84899805162 scopus 로고    scopus 로고
    • Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia
    • Zhou M., Yang W.L., Ji Y., Qiang X., Wang P. Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia. Biochim Biophys Acta 2014, 1840:2253-2261.
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 2253-2261
    • Zhou, M.1    Yang, W.L.2    Ji, Y.3    Qiang, X.4    Wang, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.