IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia

Brain Research Bulletin

Volumn 106, Issue , 2014, Pages 30-38

  Song, Xiu Yun ^a   Hu, Jin Feng ^a   Sun, Ming Na ^a   Li, Zhi Peng ^a   Zhu, Zhi Xiang ^a   Song, Lian Kun ^a   Yuan, Yu He ^a   Liu, Gang ^a   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Conditioned medium; IMM H004; Inflammatory mediators; MAPK; Neuroinflammation; NF B

Indexed keywords

7 HYDROXY 5 METHOXY 4 METHYL 3 (4 METHYLPIPERAZIN 1 YL) COUMARIN; ASCORBIC ACID; COUMARIN DERIVATIVE; CYCLOOXYGENASE 2; CYTOKINE; HYDROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; NITRIC OXIDE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SCAVENGER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; AUTACOID; IMM-H004;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DEGENERATIVE DISEASE; DISEASE COURSE; DRUG STRUCTURE; INFLAMMATION; MEDIATOR; MEDIATOR RELEASE; MICROGLIA; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PC12 CELL LINE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; COUMARINS; CYTOKINES; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICROGLIA; NEURONS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84902109009     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2014.05.002     Document Type: Article

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