Understanding the alphaviruses: Recent research on important emerging pathogens and progress towards their control

Antiviral Research

Volumn 87, Issue 2, 2010, Pages 111-124

  Gould, E A ^a,d   Coutard, B ^a   Malet, H ^a   Morin, B ^a   Jamal, S ^a   Weaver, S ^b   Gorbalenya, A ^c   Moureau, G ^a   Baronti, C ^a   Delogu, I ^a   Forrester, N ^b   Khasnatinov, M ^f   Gritsun, T ^e   de Lamballerie, X ^a   Canard, B ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b University of Texas Medical Branch School of Medicine   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

^e UNIVERSITY OF READING   (United Kingdom)

^f Institute of Epidemiology and Microbiology   (Russian Federation)

Author keywords

Alphavirus; Antivirals; Biogeography; Classification; Evolution; Genomics; Replicative enzymes; Structure function studies; VIZIER

Indexed keywords

ALPHA INTERFERON; CARBODINE; CHLOROQUINE; GENOMIC RNA; GLYCOPROTEIN; LIVE VACCINE; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; PEGINTERFERON ALPHA; QUININE; RIBAVIRIN; VIRUS VACCINE; ENZYME; VIRUS PROTEIN;

ALPHA VIRUS; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; BARMAH FOREST VIRUS; BIOGEOGRAPHY; CHIKUNGUNYA ALPHAVIRUS; CRYSTAL STRUCTURE; DISEASE CONTROL; DRUG EFFICACY; EASTERN EQUINE ENCEPHALOMYELITIS VIRUS; EVOLUTION; GEOGRAPHIC DISTRIBUTION; HUMAN; IMMUNE RESPONSE; MOLECULAR PHYLOGENY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RESEARCH; REVIEW; RNA VIRUS; SEMLIKI FOREST ALPHAVIRUS; SINDBIS VIRUS; VIRION; VIRUS ENTRY; VIRUS REPLICATION; WESTERN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; ALPHAVIRUS INFECTIONS; ANIMAL; CHEMISTRY; CLASSIFICATION; COMMUNICABLE DISEASES, EMERGING; DRUG EFFECTS; ENZYMOLOGY; EUROPEAN UNION; GENETICS; MEDICAL RESEARCH; METABOLISM; ORGANIZATION AND MANAGEMENT; PATHOGENICITY; TRENDS; VIROLOGY;

ALPHAVIRUS; ALPHAVIRUS INFECTIONS; ANIMALS; BIOMEDICAL RESEARCH; CHIKUNGUNYA VIRUS; COMMUNICABLE DISEASES, EMERGING; ENZYMES; EUROPEAN UNION; HUMANS; VIRAL PROTEINS;

ALPHAVIRUS; ANIMALIA; ARBOVIRUS; CHIKUNGUNYA VIRUS; HEXAPODA; RNA VIRUSES;

EID: 77954952122     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.07.007     Document Type: Review

References (164)

1. Ahola T., Kääriäinen L. Reaction in alphavirus mRNA capping: formation of a covalent complex of nonstructural protein nsP1 with 7-methyl-GMP. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:507-511.
2. Ahola T., Kujala P., Tuittila M., Blom T., Laakkonen P., Hinkkanen A., Auvinen P. Effects of palmitoylation of replicase protein nsP1 on alphavirus infection. J. Virol. 2000, 74:6725-6733.
3. Ahola T., Lampio A., Auvinen P., Kääriäinen L. Semliki Forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activity. EMBO J. 1999, 18:3164-3172.
4. Alevizatos A.C., McKinney R.W., Feigin R.D. Live, attenuated Venezuelan equine encephalomyelitis virus vaccine. I. Clinical effects in man. Am. J. Trop. Med. 1967, 16:762-768.
5. Andrei G., De Clercq E. Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro. Antiviral Res. 1990, 14:287-299.
6. Balistreri G., Caldentey J., Kääriäinen L., Ahola T. Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants. J. Virol. 2007, 81:2849-2860.
7. Benedict M., Levine R., Hawley W., Lounibos L. Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus. Vector Borne Zoonotic Dis. 2007, 7:76-85.
8. Berge T.O., Banks I.S., Tigertt W.D. Attenuation of Venezuelan equine encephalomyelitis virus by in vitro cultivation in guinea pig heart cells. Am. J. Hygiene 1961, 73:209-218.
9. Bloom K.J. The Mississippi Valley's great yellow fever epidemic of 1878 1993, Louisiana State University Press, Baton Rouge, Louisiana.
10. Boguszewska-Chachulska A.M., Krawczyk M., Stankiewicz A., Gozdek A., Haenni A.-L., Strokovskaya L. Direct fluorometric measurement of hepatitis C virus helicase activity. FEBS Lett. 2004, 567:253-258.
11. Bondarenko E.I., Protopopova E.V., Surovtsev I.V., Shvalov A.N., Loktev V.B. Replication by polyclonal antibodies to laminin-binding protein. Voprosi Virusologii 2004, 49:32-37.
12. Borowski P., Schalinski S., Schmitz H. Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy. Antiviral Res. 2002, 55:397-412.
13. Brault A.C., Powers A.M., Ortiz D., Estrada-Franco J.G., Navarro-Lopez R., Weaver S.C. Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:11344-11349.
14. Brighton S.W. Chloroquine phosphate treatment of chronic chikungunya arthritis. S. Afr. Med. J. 1984, 66:217-218.
15. Briolant S., Garin D., Scaramozzino N., Jouan A., Crance J.M. In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-α and ribavirin combination. Antiviral Res. 2004, 61:111-117.
16. Bryant J.E., Holmes E.C., Barrett A.D.T. Out of Africa: a molecular perspective on the introduction of yellow fever virus into the Americas. PLoS Pathog. 2007, 3:e75.
17. Burke D.S., Ramsburg H.H., Edelman R.J. Persistence in humans of antibody to subtypes of Venezuelan equine encephalomyelitis (VEE) virus after immunization with attenuated (TC-83) VEE virus vaccine. J. Infect. Dis. 1977, 136:354-359.
18. Calder L., Laird M. Mosquito travelers, arbovirus vectors and the used tire trade. Trav. Med. Int. 1994, 12:3-12.
19. Cassell S., Edwards J., Brown D.T. Effects of lysosomotropic weak bases on infection of BHK-21 cells by Sindbis virus. J. Virol. 1984, 52:857-864.
20. Chanas A.C., Johnson B.K., Simpson D.I.H. Antigenic relationships of alphaviruses by a simple micro-culture cross-neutralization method. J. Gen. Virol. 1976, 32:295-300.
21. Charrel R.N., de Lamballerie X., Raoult D. Chikungunya outbreaks-the globalization of vectorborne diseases. N. Engl. J. Med. 2007, 356:769-771.
22. Clarke D.H., Casals J. Techniques for haemagglutination and haemagglutination-inhibition with arthropod-borne viruses. Am. J. Trop. Med. Hyg. 1958, 7:561-573.
23. Coombs K., Mann E., Edwards J., Brown D.T. Effects of chloroquine and cytochalasin B on the infection of cells by Sindbis virus and vesicular stomatitis virus. J. Virol. 1981, 37:1060-1065.
24. Couderc T., Chrétien F., Schilte C., Disson O., Brigitte M., Guivel-Benhassine F., Touret Y., Barau G., Cayet N., Schuffenecker I., Desprès P., Arenzana-Seisdedos F., Michault A., Albert M.L., Lecuit M. A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog. 2008, 4(2):e29.
25. Coutard B., Gorbalenya A.E., Snijder E.J., Leontovich A.M., Poupon A., De Lamballerie X., Charrel R., Gould E.A., Gunther S., Norder H., Klempag B., Bourhy H., Rohayemj J., L'hermite E., Nordlund P., Stuart D.I., Owens R.J., Grimes J.M., Tuckerm P.A., Bolognesi M., Mattevi A., Coll M., Jones T.A., Åqvist J., Unger T., Hilgenfeld R., Bricogne G., Neyts J., La Colla P., Puerstinger G., Gonzalez J.P., Leroy E., Cambillau C., Romette J.L., Canard B. The VIZIER project: preparedness against pathogenic RNA viruses. Antiviral Res. 2008, 78:37-46.
26. Crotty S., Cameron C.E., Andino R. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc. Natl. Acad. Sci. 2001, 89:6895-6900.
27. Davis N.L., Brown K.W., Greenwald G.F., Zajac A.J., Zacny V.L., Smith J.F., Johnston R.E. Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. Virology 1995, 212:102-110.
28. de Clercq E., Bernaerts R., Shealy Y.F., Montgomery J.A. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. Biochem. Pharmacol. 1990, 39:319-325.
29. de Groot R.J., Hardy W.R., Shirako Y., Strauss J.H. Cleavage-site preferences of Sindbis virus polyproteins containing the non-structural proteinase. Evidence for temporal regulation of polyprotein processing in vivo. EMBO J. 1990, 9:2632-2638.
30. Dé I., Fata-Hartley C., Sawicki S.G., Sawicki D.L. Functional analysis of nsP3 phosphoprotein mutants of Sindbis virus. J. Virol. 2003, 77:13106-13116.
31. de Lamballerie X., Boisson V., Reynier J.C., Enault S., Charrel R.N., Flahault A., Roques P., Le Grand R. On Chikungunya acute infection and chloroquine treatment. Vector Borne Zoonotic Dis. 2008, 8:837-840.
32. de Lamballerie X., Leroy E., Charrel R.N., Ttsetsarkin K., Higgs S., Gould E.A. Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?. Virol. J. 2008, 5:33.
33. De Palma A.M., Vliegen I., De Clercq E., Neyts J. Selective inhibitors of picornavirus replication. Med. Res. Rev. 2008, 28:823-824.
34. Diaz L.A., Cardenas V.M., Daza E., Bruzon L., Alcala A., De la Hoz O., Caceres F.M.G., Aristizabal G., Martinez J.W., Revelo D.F., De la Hoz F., Boshell J., Camacho T., Calderon L., Olano V.A., Villarreal L.I., Roselli D., Alvarez G., Ludwig G., Tsai T. Epidemic Venezuelan equine encephalitis in La Guajira, Colombia, 1995. J. Infect. Dis. 1997, 175:828-832.
35. Eckels K., Harrison V.R., Hetrick F.M. Chikungunya virus vaccine prepared by Tween-Ether extraction. Appl. Microbiol. 1970, 19:321-325.
36. Edelman R., Tacket C.O., Wasserman S.S., Bodison S.A., Perry J.G., Mangiafico J.A. Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218. Am. J. Trop. Med. Hyg. 2000, 62:681-685.
37. Feder M., Pas J., Wyrwicz L.S., Bujnicki J.M. Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. Gene 2003, 302.
38. Galbraith S.E., Sheahan B.J., Atkins G.J. Deletions in the hypervariable domain of the nsP3 gene attenuate Semliki Forest virus virulence. J. Gen. Virol. 2005, 87:937-947.
39. Garmashova N., Gorchakov R., Frolova E., Frolov I. Sindbis Virus non-structural protein nsP2 is cytotoxic and inhibits cellular transcription. J. Virol. 2006, 80:5686-5696.
40. Gomez de Cedrón M., Ehsani N., Mikkola M.L., García J.A., Kääriäinen L. RNA helicase activity of Semliki Forest virus replicase protein nsP2. FEBS Lett. 1999, 448:19-22.
41. Goodell J.R., Puig-Basagoiti F., Forshey B.M., Shi P.-Y., Ferguson D.M. Identification of compounds with anti-West Nile virus activity. J. Med. Chem. 2006, 49:2127-2137.
42. Gorbalenya A.E., Koonin E.V. Helicases: amino acid sequence comparisons and structure-function relationships. Curr. Opin. Struct. Biol. 1993, 3:419-429.
43. Gorbalenya A.E., Koonin E.V., Donchenko A.P., Blinov V.M.F.L.A. A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination. FEBS Lett. 1988, 235:16-24.
44. Gorbalenya A.E., Koonin E.V., Lai M.M. Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses. FEBS Lett. 1991, 288:201-205.
45. Gorchakov R., Elena Frolova E., Sawicki S., Atasheva S., Sawicki D., Ilya Frolov I. A new role for ns polyprotein cleavage in Sindbis virus replication. J. Virol. 2008, 82:6218-6231.
46. Gould E.A., de Lamballerie X., Zanotto P.M., Holmes E.C. Origins, evolution, and vector/host coadaptations within the genus Flavivirus. Adv. Virus Res. 2003, 59:277-314.
47. Gould E.A., de Lamballerie X., Zanotto P.M.A., Holmes E.C. Evolution, epidemiology and dispersal of flaviviruses revealed by molecular phylogenies. Adv. Virus Res. 2001, 57:71-103.
48. Gould E.A., Higgs S. Impact of climate change and other factors on emerging arbovirus diseases. Trans. R. Soc. Trop. Med. Hyg. 2009, 103:109-121.
49. Gumina G., Chong Y., Choo H., Song G.Y., Chu C.K. L-Nucleosides: antiviral activity and molecular mechanism. Curr. Top. Med. Chem. 2002, 2:1056-1086.
50. Hahn C.S., Lustig S., Strauss E.G., Strauss J.H. Western equine encephalitis virus is a recombinant virus. Proc. Natl. Acad. Sci. U.S.A. 1988, 85:5997-6001.
51. Hart M.K., Caswell-Stephan K., Bakken R., Tammariello R., Pratt W., Davis N., Johnston R.E., Smith J.K.S. Improved mucosal protection against Venezuelan equine encephalitis virus is induced by the molecularly defined, live-attenuated V3526 vaccine candidate. Vaccine 2000, 18:3067-3075.
52. Helenius A., Marsh M., White J. Inhibition of Semliki Forest virus penetration by lysosomotropic weak bases. J. Gen. Virol. 1982, 58:47-61.
53. Hodgman T.G. A new superfamily of replicative proteins. Nature 1988, 333:22-23.
54. Inglot A.D. Comparison of the antiviral activity in vitro of some non-steroidal anti-inflammatory drugs. J. Gen. Virol. 1969, 4:203-214.
55. Johnson K.M., Martin D.M. Venezuelan equine encephalitis. Adv. Vet. Sci. Comp. Med. 1974, 18:79-116.
56. Josseran L., Paquet C., Zehgnoun A., Caillere N., Le Tertre A., Solet J.L., Ledrans M. Chikungunya disease outbreak, Reunion Island. Emerg. Infect. Dis. 2006, 12:1994-1995.
57. Julandera J.G., Bowen R.A., Raoc J.R., Daya C., Shafera K., Smeea D.F., Morreya J.D., Chuc C.K. Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine. Antiviral Res. 2008, 80:309-315.
58. Kamer G., Argos P. Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses. Nucleic Acids Res. 1984, 12:7269-7282.
59. Karabatsos N. Antigenic relationships of group A arboviruses by plaque reduction neutralization testing. Am. J. Trop. Med. Hyg. 1975, 24:527-532.
60. Keyaerts E., Vijgen L., Maes P., Neyts J., Van Ranst M. In vitro inhibition of severe syndrome coronavirus by chloroquine. Biochem. Biophys. Res. Commun. 2004, 323:264-268.
61. Kumaran D., Eswaramoorthy S., Studier F.W., Swaminathan S. Structure and mechanism of ADP-ribose-1″-monophosphatase (Appr-1″-pase), a ubiquitous cellular processing enzyme. Protein Sci. 2005, 14:719-726.
62. Laakkonen P., Ahola T., Kääriäinen L. The effects of palmitoylation on membrane association of Semliki Forest virus RNA capping enzyme. J. Biol. Chem. 1996, 271:28567-28571.
63. Laakkonen P., Hyvönen M., Peränen J., Kääriäinen L. Expression of Semliki Forest virus nsP1-specific methyltransferase in insect cells and in Escherichia coli. J. Virol. 1994, 68:7418-7425.
64. Lampio A., Ahola T., Darzynkiewicz E., Stepinski J., Jankowska-Anyszka M., Kääriäinen L. Guanosine nucleotide analogs as inhibitors of alphavirus mRNA caping enzyme. Antiviral Res. 1999, 42:35-46.
65. Lampio A., Kilpeläinen I., Pesonen S., Karhi K., Auvinen P., Somerharju P., Kääriäinen L. Membrane-binding of Semliki Forest virus mRNA capping enzyme-solution structure of the binding peptide and interaction with liposomes. J. Biol. Chem. 2000, 275:37853-37859.
66. LaStarza M.W., Grakoui A., Rice C.M. Deletion and duplication mutations in the C-terminal non-conserved region of Sindbis virus nsP3: effects on phosphorylation and on virus replication in vertebrate and invertebrate cells. Virology 1994, 202:224-232.
67. Lavergne A., de Thoisy B., Lacoste V., Pascalis H., Pouliquen J.-F., Mercier V., Tolou H., Dussart P., Morvan J., Talarmin A., Kazanji M. Mayaro virus: complete nucleotide sequence and phylogenetic relationships with other alphaviruses. Virus Res. 2006, 117:283-290.
68. Lemm J.A., Bergqvist A., Read C.M., Rice C.M. Template-dependent initiation of Sindbis virus RNA replication in vitro. J. Virol. 1998, 72:6546-6553.
69. Lemm J.A., Rümenapf T., Strauss E.G., Strauss J.H., Rice C.M. Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesis. EMBO J. 1994, 13:2925-2934.
70. Leon C.A. Sequelae of Venezuelan equine encephalitis in humans: a four year follow-up. Int. J. Epidemiol. 1975, 4:131-140.
71. Lescar J., Roussel A., Wien M.W., Navaza J., Fuller S.D., Wengler G., Rey F.A. The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH. Cell 2001, 105:137-148.
72. Levinson R.S., Strauss J.H., Strauss E.G. Complete sequence of the genomic RNA of o'nyong-nyong virus and its use in the construction of alphavirus phylogenetic trees. Virology 1990, 174:110-123.
73. Lewthwaite P., Vasanthapuram R., Osborne J.C., Begum A., Plank J.L.M., Shankar M.V., Hewson R., Desai A., Beeching N.J., Ravikumar R., Solomon T. Chikungunya virus and central nervous system infections in children, India. Emerg. Infect. Dis. 2009, 15:329-331.
74. Leyssen P., Balzarini J., De Clercq E., Neyts J. The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J. Virol. 2005, 79:1943-1947.
75. Leyssen P., De Clercq E., Neyts J. The anti-yellow fever virus activity of ribavirin is independent of error-prone replication. Mol. Pharmacol. 2006, 69:1461-1467.
76. Leyssen P., De Clercq E., Neyts J. Molecular strategies to inhibit the replication of RNA viruses. Antiviral Res. 2008, 78:9-25.
77. Li G.P., La Starza M.W., Hardy W.R., Strauss J.H., Rice C.M. Phosphorylation of Sindbis virus nsP3 in vivo and in vitro. Virology 1990, 179:416-427.
78. Li G.P., Rice C.M. Mutagenesis of the in-frame opal termination codon preceding nsP4 of Sindbis virus: studies of translational readthrough and its effect on virus replication. J. Virol. 1989, 63:1326-1337.
79. Li M.L., Lin Y.H., Simmonds H.A., Stollar V. A mutant of Sindbis virus which is able to replicate in cells with reduced CTP makes a replicase/transcriptase with a decreased Km for CTP. J. Virol. 2004, 78:9645-9651.
80. Li Y., Wang L., Li S., Chen X., Shen Y., Zhang Z., He H., Xu W., Shu Y., Liang G., Fang R., Hao X. Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses. Proc. Natl. Acad. Sci. 2007, 104:8083-8088.
81. Lounibos L.P. Invasions by insect vectors of human disease. Annu. Rev. Entomol. 2002, 47:233-266.
82. Lukaszewski R.A., Brooks T.J. Pegylated alpha interferon is an effective treatment for virulent Venezuelan equine encephalitis virus and has profound effects on the host immune response to infection. J. Virol. 2000, 74:5006-5015.
83. Maheshwari R.K., Srikantan V., Bhartiya D. Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice. J. Virol. 1991, 65:992-995.
84. Malet H., Jamal S., Coutard B., Dutartre H., Papageorgiou N., Heinonen M., Ahola T., Forrester N., Gould E.A., Laffitte D., Ferron F., Lescar J., de Lamballerie X., Canard B. The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket. J. Virol. 2009, 83:6534-6545.
85. Mavalankar D., Shastri P., Bandyopadhyay T., Parmar J., Ramani K.V. Increased mortality rate associated with chikungunya epidemic, ahmedabad, India. Emerg. Infect. Dis. 2008, 14:412-415.
86. Mayuri, Todd W.G., Smith J.L., Kuhn R.J. Role for conserved residues of Sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection. J. Virol. 2008, 82:7284-7297.
87. Mi S., Durbin R., Huang H.V., Rice C.M., Stollar V. Association of the Sindbis virus RNA methyltransferase activity with the nonstructural protein nsP1. Virology 1989, 170:385-391.
88. Mi S., Stollar V. Expression of Sindbis virus nsP1 and methyltransferase activity in Escherichia coli. Virology 1991, 184:423-427.
89. Mukhopadhyay S., Zhang W., Gabler S., Chipman P.R., Strauss E.G., Strauss J.H., Baker T.S., Kuhn R.J., Rossmann M.G. Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses. Structure 2006, 14:63-73.
90. Muthumani K., Lankaraman K.M., Laddy D.J., Sundaram S.G., Chung C.W., Sako E., Wu L., Khan A., Sardesai N., Kim J.J., Vijayachari P., Weiner D.B. Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus. Vaccine 2008, 26:5128.
91. Neyts J., Meerbach A., McKenna P., De Clercq E. Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections. Antiviral Res. 1996, 30:125-132.
92. O'Brien L. Inhibition of multiple strains of Venezuelan equine encephalitis virus by a pool of four short interfering RNAs. Antiviral Res. 2007, 75:20-29.
93. Ozden S., Lucas-Hourani M., Ceccaldi P.E., Basak A., Valentine M., Benjannet S., Hamelin J., Jacob Y., Mamchaoui K., Mouly V., Desprès P., Gessain A., Butler-Browne G., Chretien M., Tangy F., Vidalain P.O., Seidah N.G. Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein. J. Biol. Chem. 2008, 283:21899-21908.
94. Paessler S., Ni H., Petrakova O., Fayzulin R.Z., Yun N., Anishchenko M., Weaver S.C., Frolov I. Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses. J. Virol. 2006, 80:2784-2796.
95. Paessler S., Rijnbrand R., Stein D.A., Ni H., Yun N.E., Dziuba N., Borisevich V., Seregin A., Ma Y., Blouch R., Iversen P.L., Zacks M.A. Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oliogmers. Virology 2008, 376:357-370.
96. Park E., Griffin D.E. The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice. Virology 2009, (April). (Epub ahead of print).
97. Pastorino B.A.M., Peyrefitte C.N., Almeras L., Grandadam M., Rolland D., Tolou H.J., Bessaud M. Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus. Virus Res. 2008, 131:293-298.
98. Pavlova B.G., Loew-Baselli A., Fritsch S., Poellabauer E.-M., Vartian N., Rinke I., Ehrlich H.J. Tolerability of modified tick-borne encephalitis vaccine FSME-IMMUN " NEW" in children: results of post-marketing surveillance. Vaccine 2003, 21:742-745.
99. Perhson J.H., Fuji R.N. Evolutionary conservation of histone macroH2A subtypes and domains. Nucleic Acids Res. 1998, 26:2837-2842.
100. Pialoux G., Gaüzère B.A., Jauréguiberry S., Strobel M. Chikungunya, an epidemic arbovirosis. Lancet Infect. Dis. 2007, 7:633.
101. Piotrowski Y., Hansen G., Boomaars-van der Zanden A.L., Snijder E.J., Gorbalenya A.E., Hilgenfeld R. Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property. Protein Sci. 2009, 18:6-16.
102. Pittman P.R., Makuch R.S., Mangiafico J.A., Cannon T.L., Gibbs P.H.C.J., Peters C.J. Long-term duration of detectable neutralizing antibodies after administration of live-attenuated VEE vaccine and following booster vaccination with inactivated VEE vaccine. Vaccine 1996, 14:337-343.
103. Poidinger M., Roy S., Hall R.A., Turley P.J., Scherret J.H., Lindsay M.D., Broom A.K., Mackenzie J.S. Genetic stability among temporally and geographically diverse isolates of Barmah Forest virus. Am. J. Trop. Med. Hyg. 1997, 57:230-234.
104. Porterfield J.S. Cross-neutralization studies with group A arthropod-borne viruses. Bull. World Health Org. 1961, 24:735-741.
105. Powers A.M., Brault A.C., Shirako Y., Strauss E.G., Kang W., Strauss J.H., Weaver S.C. Evolutionary relationships and systematics of the alphaviruses. J. Virol. 2001, 75:10118-10131.
106. Powers A.M., Logue C.H. Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J. Gen. Virol. 2007, 88:2363-2377.
107. Reiskind M.H., Pesko K., Westbrook C.J., Mores C.N. Susceptibility of Florida mosquitoes to Chikungunya virus. Am. J. Trop. Med. Hyg. 2008, 78:422-425.
108. Rezza G., Nicoletti L., Angelini R., Romi R., Finarelli A.C., Panning M., Cordioli P., Fortuna C., Boros S., Magurano F., Silvi G., Angelini P., Dottori M., Ciufolini M.G., Majori G.C., Cassone A. Infection with Chikungunya virus in Italy: an outbreak in a temperate region. Lancet 2007, 1840-1846.
109. Rikkonen M., Peränen J., Kääriäinen L. ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2. J. Virol. 1994, 68:5804-5810.
110. Robin S., Ramful D., Le Seach F., Jaffar-Bandjee M.C., Rigou G., Alessandri J.L. Neurologic manifestations of pediatric Chikungunya infection. J. Child Neurol. 2008.
111. Roques, P., Joubert, C., Malleret, B., Delache, B., Brochard, P., Calvo, J., Morin, J., Mannioui, A., Martinon, F., Lebon, P., Verrier, B., Lotteau, V., de Lamballerie, X., Cherel, Y., Larcher, T., Aumont, G., Le Grand, R., 2007. Chikungunya et autres arboviroses émergentes en milieu tropical. Reunion Island http://www.invs.sante.fr/agenda/colloque_chikungunya/.
112. Rozanov M.N., Koonin E.V., Gorbalenya A.E. Conservation of the putative methyltransferase domain: a hallmark of the 'Sindbis-like' supergroup of positive-strand RNA viruses. J. Gen. Virol. 1992, 73:2129-2134.
113. Rubak J.K., Wasik B.R., Rupp J.C., Kuhn R.J., Hardy R.W., Smith J.L. Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro. Virology 2009, 384:201-208.
114. Rumenapf T., Strauss E.G., Strauss J.H. Aura virus is a New World Representative of Sindbis-like viruses. Virology 1995, 208:621-633.
115. Russell R.C. Vectors vs. humans in Australia-who is on top down under? An update on vector-borne disease and research on vectors in Australia. J. Vector Ecol. 1998, 23:1-46.
116. Russo A.T., White M.A., Watowich S.J. The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease. Structure 2006, 14:1449-1458.
117. Savarino A., Cauda R., Cassone A. On the use of chloroquine for Chikungunya. Lancet Infect. Dis. 2007, 7:633.
118. Sawicki D.L., Sawicki S.G. Alphavirus positive and negative strand RNA synthesis and the role of polyproteins in formation of viral replication complexes. Arch. Virol. 1994, 9(Suppl.):393-405.
119. Scheidel L.M., Durbin R., Stollar V. Sindbis virus mutants resistant to mycophenolic acid and ribavirin. Virology 1987, 158:1-7.
120. Scheidel L.M., Durbin R., Stollar V. SVLM21, a Sindbis virus mutant resistant to methionine deprivation, encodes an altered methyltransferase. Virology 1989, 173:408-414.
121. Scheidel L.M., Stollar V. Mutations that confer resistance to mycophenolic acid and ribavirin on Sindbis virus map to the nonstructural protein nsP1. Virology 1991, 181:490-499.
122. Schuffenecker I., Iteman I., Michault A., Murri S., Frangeul L., Vaney M.C., Lavenir R., Pardigon N., Reynes J.M., Pettinelli F., Biscornet L., Diancourt L., Michel S., Duquerroy S., Guigon G., Frenkiel M.P., Brehin A.C., Cubito N., Despres P., Kunst F., Rey F.A., Zeller H., Brisse S. Genome microevolution of chikungunya viruses causing the Indian ocean outbreak. PLoS Med. 2006, 3:e263.
123. Severson W.E., Schmaljohn C.S., Javadian A., Jonsson C.B. Ribavirin causes error catastrophe during Hantaan virus replication. J. Virol. 2003, 77:481-488.
124. Shimizu Y., Yamamoto S., Homma, Ishida M. Effect of chloroquine on the growth of animal viruses. Arch. Gesamte Virusforsch. 1972, 36:93-104.
125. Shirako Y., Strauss E.G., Strauss J.H. Modification of the 5' terminus of Sindbis virus genomic RNA allows nsP4 RNA polymerases with nonaromatic amino acids at the N terminus to function in RNA replication. J. Virol. 2003, 77:2301-2309.
126. Shirako Y., Strauss J.H. Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis. J. Virol. 1994, 68:1874-1885.
127. Shull N.P., Spinelli S.L., Phizicky E.M. A highly specific phosphatase that acts on ADP-ribose 1″-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae. Nucleic Acids Res. 2005, 33:650-660.
128. Singleton M.R., Dillingham M.S., Wigley D.B. Structure and mechanism of helicases and nucleic acid translocases. Annu. Rev. Biochem. 2007, 76:23-50.
129. Smith C.E., Gibson M.E. Yellow fever in South Wales. Med. Hist. 1986, 30:322-340.
130. Spuul P., Salonen A., Merits A., Jokitalo E., Kääriäinen L., Ahola T. Role of the amphipathic peptide of Semliki Forest virus replicase protein nsP1 in membrane association and virus replication. J. Virol. 2007, 81:872-883.
131. Stadler K., Allison S.L., Schalich J., Heinz F.X. Proteolytic activation of tick-borne encephalitis virus by furin. J. Virol. 1997, 71:8475-8481.
132. Strauss E.G., deGroot R.J., Levinson R., Strauss J.H. Identification of the active site residues in the nsP2 proteinase of Sindbis virus. Virology 1992, 191:932-940.
133. Strauss J.H., Strauss E.G. The alphaviruses: gene expression, replication, and evolution. Microbiol. Rev. 1994, 58:491-562.
134. Strode G.K. Yellow Fever 1951, McGraw-Hill, New York.
135. Sun Y., Chung D.H., Chu Y.K., Jonsson C.B., Parker W.B. Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase. Antimicrob. Agents Chemother. 2007, 51:84-88.
136. Swofford D.L. PAUP*. Phylogenetic Analysis Using Parsimony (* and Other Methods), version 4 1998, Sinauer Associates, Sunderland, MA.
137. Tabachnick W.J. Evolutionary genetics and arthropod-borne diseases. The yellow fever mosquito, Aedes aegypti. Am. J. Entomol. 1991, 37:14-24.
138. Tani H., Akimitsu N., Fujita O., Matsuda Y., Miyata R., Tsuneda S., Igarashi M., Sekiguchi Y., Noda N. High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon. Biochem. Biophys. Res. Commun. 2009, 379:1054-1059.
139. Tatem A.J., Hay S.I., Rogers D.J. Global traffic and disease vector dispersal. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:6242-6247.
140. Tomar S., Hardy R.W., Smith J.L., Kuhn R.J. Catalytic core of alphavirus nonstructural protein nsP4 possesses terminal adenylyltransferase activity. J. Virol. 2006, 80:9962-9969.
141. Tsetsarkin K.A., Vanlandingham D.L., McGee C.E., Higgs S. A single mutation in Chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog. 2007, 3:e201.
142. Tuittila M.T., Santagati M.G., Röyttä M., Määttä J.A., Hinkkanen A.E. Replicase complex genes of Semliki Forest virus confer lethal neurovirulence. J. Virol. 2000, 74:4579-4589.
143. Vasiljeva L., Merits A., Golubtsov A., Sizemskaja V., Kääriäinen L., Ahola T. Regulation of the sequential processing of Semliki Forest virus replicase polyprotein. J. Biol. Chem. 2003, 278:41636-41645.
144. Vasiljeva L., Merits A., Auvinen P., Kääriäinen L. Identification of a novel function of the alphavirus capping apparatus: RNA 5'-triphosphatase activity of nsP2. J. Biol. Chem. 2000, 275:17281-17287.
145. Vasiljeva L., Valmu L., Kääriäinen L., Merits A. Site-specific protease activity of the carboxyl-terminal domain of Semliki Forest virus replicase protein nsP2. J. Biol. Chem. 2001, 276:30786-30793.
146. Vihinen H., Ahola T., Tuittila M., Merits A., Kääriäinen L. Elimination of phosphorylation sites of Semliki Forest virus replicase protein nsP3. J. Biol. Chem. 2001, 276:5745-5752.
147. Walton T.E., Grayson M.A. Venezuelan equine encephalomyelitis. The Arboviruses: Epidemiology and Ecology 1988, 203-231. CRC Press, Boca Raton, FL. T.P. Monath (Ed.).
148. Wang E., Volkova E., Adams A.P., Forrester N., Xiao S.Y., Frolov I., Weaver S.C. Chimeric alphavirus vaccine candidates for chikungunya. Vaccine 2008, 26:5030-5039.
149. Wang H.L., O'Rear J., Stollar V. Mutagenesis of the Sindbis virus nsP1 protein: effects on methyltransferase activity and viral infectivity. Virology 1996, 217:527-531.
150. Wang Y.F., Sawicki S.G., Sawicki D.L. Alphavirus nsP3 functions to form replication complexes transcribing negative-strand RNA. J. Virol. 1994, 68:6466-6475.
151. Weaver S.C. Host range, amplification and arboviral disease emergence. Arch. Virol. Suppl. 2005, 33-44.
152. Weaver S.C., Barrett A.D. Transmission cycles, host range, evolution and emergence of arboviral disease. Nat. Rev. Microbiol. 2004, 2:789-801.
153. Weaver S.C., Ferro C., Barrera R., Boshell J., Navarro J.-C. Venezuelan equine encephalitis. Annu. Rev. Entomol. 2004, 49:141-174.
154. Weaver S.C., Frey T.K., Huang H.V., Kinney R.M., Rice C.M., Roehrig J.T., Shope R.E., Strauss E.G. Togaviridae. Virus Taxonomy VIIIth Report of the ICTV 2005, 999-1008. Elsevier/Academic Press, London. C.M. Fauquet, M.A. Mayo, J. Maniloff, U. Desselberger, L.A. Ball (Eds.).
155. Weaver S.C., Hagenbaugh A., Bellew L.A., Netesov S.V., Volchkov V.E., Chang G.-J.J., Clarke D.K., Gousset L., Scott T.W., Trent D.W., Holland J.J. A comparison of the nucleotide sequences of eastern and western equine encephalomyelitis viruses with those of other alphaviruses and related RNA viruses. Virology 1993, 197:375-390.
156. Weaver S.C., Kang W., Shirako Y., Rumenapf T., Strauss E.G., Strauss J.H. Recombinational history and molecular evolution of western equine encephalomyelitis complex alphaviruses. J. Virol. 1997, 71:613-623.
157. Weaver S.C., Salas R., Rico-Hesse R., Ludwig G.V., Oberste M.S., Boshell J., Tesh R.B. Re-emergence of epidemic Venezuelan equine encephalomyelitis in South America. Lancet 1996, 348:436-440.
158. Young K.C., Lindsay K.L., Lee K.J., Liu W.C., Jian-Wen H.J., Milstein S.L., Lai M.M. Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy. Hepatology 2003, 38:869-878.
159. Young N.A. Serologic differentiation of viruses of the Venezuelan encephalitis (VE) complex. Proceedings of the workshop-symposium on Venezuelan encephalitis virus, scientific publication 243 1972, 84-89. Pan American Health Organization, Washington, DC.
160. Young N.A., Johnson K.M. Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance. Am. J. Epidemiol. 1969, 89:286-307.
161. Zhang D., Tozser J., Waugh D.S. Molecular cloning, overproduction, purification and biochemical characterization of the p39 nsp2 protease domains encoded by three alphaviruses. Protein Expr. Purif. 2009, 64:89-97.
162. Zhou S., Liu R., Baroudy B.M., Malcolm B.A., Reyes G.R. The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA. Virology 2003, 310:332-342.
163. Zhu W.-Y., Yang Y.-L., Fu S.-H., Wang L.-H., Zai Y.-G., Tang Q., Liang G.-D. Substitutions of 169Lys and 173Thr in nonstructural protein 1 influence the infectivity and pathogenicity of XJ-160 virus. Arch. Virol. 2009, 154:245-253.
164. Ziegler S.A., Lu L., da Rosa A.P., Xiao S.Y., Tesh R.B. An animal model for studying the pathogenesis of chikungunya virus infection. Am. J. Trop. Med. Hyg. 2008, 79:133-139.