Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 13-27

  Börgeling, Yvonne ^a   Schmolke, Mirco ^a,b   Viemann, Dorothee ^a,c   Nordhoff, Carolin ^a   Roth, Johannes ^a   Ludwig, Stephan ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Cells in Motion Cluster of Excellence University of Muenster ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENDOTHELIAL CELLS; ENZYMES; MAMMALS; VIRUSES;

CONDITIONED MEDIAS; CYTOKINE EXPRESSION; GENE EXPRESSION PROFILING; HIGHLY PATHOGENIC AVIAN INFLUENZAS; HUMAN ENDOTHELIAL CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASE; PROMOTER ACTIVITIES; SPECIFIC INHIBITORS;

GENE EXPRESSION;

BETA INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE P38; SERINE; STAT1 PROTEIN; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; CYTOKINE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; STAT1 PROTEIN, HUMAN; STAT1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VIVO STUDY; INFECTION RESISTANCE; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS A H7N7; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHLOROCEBUS AETHIOPS; DOG; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; MDCK CELL LINE; METABOLISM; ORTHOMYXOVIRIDAE INFECTIONS; PATHOLOGY; PHOSPHORYLATION; PROMOTER REGION; VERO CELL LINE;

ANIMALS; CERCOPITHECUS AETHIOPS; CYTOKINES; DOGS; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA A VIRUS, H7N7 SUBTYPE; INTERFERON-BETA; MADIN DARBY CANINE KIDNEY CELLS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PYRIDINES; STAT1 TRANSCRIPTION FACTOR; VERO CELLS;

EID: 84891706700     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.469239     Document Type: Article

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