Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis

Toxicology and Applied Pharmacology

Volumn 289, Issue 1, 2015, Pages 20-29

  Liu, Shan Chi ^a   Lee, Hsiang Ping ^a,b   Hung, Chun Yin ^c   Tsai, Chun Hao ^a,b   Li, Te Mao ^a   Tang, Chih Hsin ^a,d,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Anti inflammation; Berberine; CCN2; Osteoarthritis

Indexed keywords

ACETYLCYSTEINE; ALPHA INTEGRIN; APOPTOSIS SIGNAL REGULATING KINASE 1; BERBERINE; BETA INTEGRIN; COLLAGENASE; CONNECTIVE TISSUE GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; ALPHAVBETA5 INTEGRIN; ANTIINFLAMMATORY AGENT; CTGF PROTEIN, HUMAN; RECOMBINANT PROTEIN; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; EXPERIMENTAL MODEL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSTEOARTHRITIS; RAT; ANIMAL; CARTILAGE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FIBROBLAST; GENETICS; HUMAN; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BERBERINE; CARTILAGE; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; MAP KINASE KINASE KINASE 5; NF-KAPPA B; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, VITRONECTIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84945462941     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.08.020     Document Type: Article

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