메뉴 건너뛰기




Volumn 37, Issue 11, 2016, Pages 790-802

Regulation of NKG2D Expression and Signaling by Endocytosis

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K;

EID: 84992731485     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2016.08.015     Document Type: Review
Times cited : (43)

References (77)
  • 1
    • 34548247599 scopus 로고    scopus 로고
    • Promiscuity and the single receptor: NKG2D
    • 1 Eagle, R.A., Trowsdale, J., Promiscuity and the single receptor: NKG2D. Nat. Rev. Immunol. 7 (2007), 737–744.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 737-744
    • Eagle, R.A.1    Trowsdale, J.2
  • 2
    • 84875509728 scopus 로고    scopus 로고
    • Regulation of ligands for the NKG2D activating receptor
    • 2 Raulet, D.H., et al. Regulation of ligands for the NKG2D activating receptor. Annu. Rev. Immunol. 31 (2013), 413–441.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 413-441
    • Raulet, D.H.1
  • 3
    • 84900346239 scopus 로고    scopus 로고
    • New prospects on the NKG2D/NKG2DL system for oncology
    • 3 Ullrich, E., et al. New prospects on the NKG2D/NKG2DL system for oncology. Oncoimmunology, 2, 2013, e26097.
    • (2013) Oncoimmunology , vol.2 , pp. e26097
    • Ullrich, E.1
  • 4
    • 84961879643 scopus 로고    scopus 로고
    • NKG2D receptor and its ligands in host defense
    • 4 Lanier, L.L., NKG2D receptor and its ligands in host defense. Cancer Immunol. Res. 3 (2015), 575–582.
    • (2015) Cancer Immunol. Res. , vol.3 , pp. 575-582
    • Lanier, L.L.1
  • 5
    • 0035949563 scopus 로고    scopus 로고
    • Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    • 5 Cerwenka, A., et al. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. U. S. A. 98 (2001), 11521–11526.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 11521-11526
    • Cerwenka, A.1
  • 6
    • 0035855872 scopus 로고    scopus 로고
    • Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
    • 6 Diefenbach, A., et al. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413 (2001), 165–171.
    • (2001) Nature , vol.413 , pp. 165-171
    • Diefenbach, A.1
  • 7
    • 24344479617 scopus 로고    scopus 로고
    • NKG2D function protects the host from tumor initiation
    • 7 Smyth, M.J., et al. NKG2D function protects the host from tumor initiation. J. Exp. Med. 5 (2005), 583–588.
    • (2005) J. Exp. Med. , vol.5 , pp. 583-588
    • Smyth, M.J.1
  • 8
    • 41549163195 scopus 로고    scopus 로고
    • NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    • 8 Guerra, N., et al. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 28 (2008), 571–580.
    • (2008) Immunity , vol.28 , pp. 571-580
    • Guerra, N.1
  • 9
    • 68649112523 scopus 로고    scopus 로고
    • Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice
    • 9 Zafirova, B., et al. Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity 31 (2009), 270–282.
    • (2009) Immunity , vol.31 , pp. 270-282
    • Zafirova, B.1
  • 10
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • 10 Groh, V., et al. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419 (2002), 734–738.
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1
  • 11
    • 0037241472 scopus 로고    scopus 로고
    • Impairment of NK cell function by NKG2D modulation in NOD mice
    • 11 Ogasawara, K., et al. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18 (2003), 41–51.
    • (2003) Immunity , vol.18 , pp. 41-51
    • Ogasawara, K.1
  • 12
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    • 12 Oppenheim, D.E., et al. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat. Immunol. 6 (2005), 928–937.
    • (2005) Nat. Immunol. , vol.6 , pp. 928-937
    • Oppenheim, D.E.1
  • 13
    • 23244463012 scopus 로고    scopus 로고
    • Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo
    • 13 Wiemann, K., et al. Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J. Immunol. 175 (2005), 720–729.
    • (2005) J. Immunol. , vol.175 , pp. 720-729
    • Wiemann, K.1
  • 14
    • 23944519927 scopus 로고    scopus 로고
    • Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
    • 14 Coudert, J.D., et al. Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood 106 (2005), 1711–1717.
    • (2005) Blood , vol.106 , pp. 1711-1717
    • Coudert, J.D.1
  • 15
    • 33645049837 scopus 로고    scopus 로고
    • Proteolytic release of soluble UL16-binding protein 2 from tumor cells
    • 15 Waldhauer, I., Steinle, A., Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Res. 66 (2006), 2520–2526.
    • (2006) Cancer Res. , vol.66 , pp. 2520-2526
    • Waldhauer, I.1    Steinle, A.2
  • 16
    • 84907835076 scopus 로고    scopus 로고
    • c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells
    • 16 Molfetta, R., et al. c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells. Eur. J. Immunol. 44 (2014), 2761–2770.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 2761-2770
    • Molfetta, R.1
  • 17
    • 84945551002 scopus 로고    scopus 로고
    • Ubiquitin-dependent endocytosis of NKG2D–DAP10 receptor complexes activates signaling and functions in human NK cells
    • 17 Quatrini, L., et al. Ubiquitin-dependent endocytosis of NKG2D–DAP10 receptor complexes activates signaling and functions in human NK cells. Sci. Signal., 8, 2015, ra108.
    • (2015) Sci. Signal. , vol.8 , pp. ra108
    • Quatrini, L.1
  • 18
    • 19644365065 scopus 로고    scopus 로고
    • The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure
    • 18 Garrity, D., et al. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc. Natl. Acad. Sci. U. S. A. 102 (2005), 7641–7646.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 7641-7646
    • Garrity, D.1
  • 19
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • 19 Bauer, S., et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285 (1999), 727–729.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1
  • 20
    • 0033618624 scopus 로고    scopus 로고
    • An activating immunoreceptor complex formed by NKG2D and DAP10
    • 20 Wu, J., et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285 (1999), 730–732.
    • (1999) Science , vol.285 , pp. 730-732
    • Wu, J.1
  • 21
    • 0036915968 scopus 로고    scopus 로고
    • Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    • 21 Diefenbach, A., et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3 (2002), 1142–1149.
    • (2002) Nat. Immunol. , vol.3 , pp. 1142-1149
    • Diefenbach, A.1
  • 22
    • 0036910991 scopus 로고    scopus 로고
    • NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
    • 22 Gilfillan, S., et al. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3 (2002), 1150–1155.
    • (2002) Nat. Immunol. , vol.3 , pp. 1150-1155
    • Gilfillan, S.1
  • 23
    • 0037600740 scopus 로고    scopus 로고
    • NKG2D–DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway
    • 23 Billadeau, D.D., et al. NKG2D–DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. Nat. Immunol. 4 (2003), 557–564.
    • (2003) Nat. Immunol. , vol.4 , pp. 557-564
    • Billadeau, D.D.1
  • 24
    • 36248957695 scopus 로고    scopus 로고
    • NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
    • 24 Horng, T., et al. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat. Immunol. 8 (2007), 1345–1352.
    • (2007) Nat. Immunol. , vol.8 , pp. 1345-1352
    • Horng, T.1
  • 25
    • 33746901647 scopus 로고    scopus 로고
    • Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics
    • 25 Graham, D.B., et al. Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J. Immunol. 177 (2006), 2349–2355.
    • (2006) J. Immunol. , vol.177 , pp. 2349-2355
    • Graham, D.B.1
  • 26
    • 33645976783 scopus 로고    scopus 로고
    • NKG2D-mediated signaling requires a DAP10-bound Grb2–Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells
    • 26 Upshaw, J.L., et al. NKG2D-mediated signaling requires a DAP10-bound Grb2–Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat. Immunol. 7 (2006), 524–532.
    • (2006) Nat. Immunol. , vol.7 , pp. 524-532
    • Upshaw, J.L.1
  • 27
    • 70350497327 scopus 로고    scopus 로고
    • Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
    • 27 Bryceson, Y.T., et al. Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood 114 (2009), 2657–2666.
    • (2009) Blood , vol.114 , pp. 2657-2666
    • Bryceson, Y.T.1
  • 28
    • 77952784625 scopus 로고    scopus 로고
    • Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform
    • 28 Ohashi, M., et al. Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform. J. Biol. Chem. 285 (2010), 16408–16415.
    • (2010) J. Biol. Chem. , vol.285 , pp. 16408-16415
    • Ohashi, M.1
  • 29
    • 79551543929 scopus 로고    scopus 로고
    • The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells
    • 29 Fernández-Messina, L., et al. The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells. J. Cell Sci. 124 (2011), 321–327.
    • (2011) J. Cell Sci. , vol.124 , pp. 321-327
    • Fernández-Messina, L.1
  • 30
    • 84881523460 scopus 로고    scopus 로고
    • A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008
    • 30 Ashiru, O., et al. A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008. Biochem. J. 454 (2013), 295–302.
    • (2013) Biochem. J. , vol.454 , pp. 295-302
    • Ashiru, O.1
  • 31
    • 0029861713 scopus 로고    scopus 로고
    • Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
    • 31 Groh, V., et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U. S. A. 93 (1996), 12445–21250.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 12445-21250
    • Groh, V.1
  • 32
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • 32 Cosman, D., et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14 (2001), 123–133.
    • (2001) Immunity , vol.14 , pp. 123-133
    • Cosman, D.1
  • 33
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • 33 Gasser, S., et al. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436 (2005), 1186–1190.
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1
  • 34
    • 65349131915 scopus 로고    scopus 로고
    • ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype
    • 34 Soriani, A., et al. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood 113 (2009), 3503–3511.
    • (2009) Blood , vol.113 , pp. 3503-3511
    • Soriani, A.1
  • 35
    • 84987776130 scopus 로고    scopus 로고
    • The DNA damage response: a common pathway in the regulation of NKG2D and DNAM-1 kigand expression in normal, infected, and cancer cells
    • 35 Cerboni, C., et al. The DNA damage response: a common pathway in the regulation of NKG2D and DNAM-1 kigand expression in normal, infected, and cancer cells. Front Immunol., 4, 2014, 508.
    • (2014) Front Immunol. , vol.4 , pp. 508
    • Cerboni, C.1
  • 36
    • 0041422233 scopus 로고    scopus 로고
    • Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
    • 36 Groh, V., et al. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Nat. Acad. Sci. U. S. A. 100 (2003), 9452–9457.
    • (2003) Proc. Nat. Acad. Sci. U. S. A. , vol.100 , pp. 9452-9457
    • Groh, V.1
  • 37
    • 4444251461 scopus 로고    scopus 로고
    • A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
    • 37 Hüe, S., et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 21 (2004), 367–377.
    • (2004) Immunity , vol.21 , pp. 367-377
    • Hüe, S.1
  • 38
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    • 38 Meresse, B., et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21 (2004), 357–366.
    • (2004) Immunity , vol.21 , pp. 357-366
    • Meresse, B.1
  • 39
    • 77951683908 scopus 로고    scopus 로고
    • Effect of NKG2D ligand expression on host immune responses
    • 39 Champsaur, M., Lanier, L.L., Effect of NKG2D ligand expression on host immune responses. Immunol. Rev. 235 (2010), 267–285.
    • (2010) Immunol. Rev. , vol.235 , pp. 267-285
    • Champsaur, M.1    Lanier, L.L.2
  • 40
    • 3142781416 scopus 로고    scopus 로고
    • Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D
    • 40 Bacon, L., et al. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. J. Immunol. 173 (2004), 1078–1084.
    • (2004) J. Immunol. , vol.173 , pp. 1078-1084
    • Bacon, L.1
  • 41
    • 34547132338 scopus 로고    scopus 로고
    • RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity
    • 41 Cao, W., et al. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. J. Biol. Chem. 282 (2007), 18922–18928.
    • (2007) J. Biol. Chem. , vol.282 , pp. 18922-18928
    • Cao, W.1
  • 42
    • 0037108517 scopus 로고    scopus 로고
    • Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding
    • 42 Salih, H.R., et al. Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding. J. Immunol. 169 (2002), 4098–4102.
    • (2002) J. Immunol. , vol.169 , pp. 4098-4102
    • Salih, H.R.1
  • 43
    • 59849101423 scopus 로고    scopus 로고
    • Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein
    • 43 Boutet, P., et al. Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. J. Immunol. 182 (2009), 49–53.
    • (2009) J. Immunol. , vol.182 , pp. 49-53
    • Boutet, P.1
  • 44
    • 84936791354 scopus 로고    scopus 로고
    • Genotoxic stress induces senescence-associated ADAM10-dependent release of NKG2D MIC ligands in multiple myeloma cells
    • 44 Zingoni, A., et al. Genotoxic stress induces senescence-associated ADAM10-dependent release of NKG2D MIC ligands in multiple myeloma cells. J. Immunol. 195 (2015), 736–748.
    • (2015) J. Immunol. , vol.195 , pp. 736-748
    • Zingoni, A.1
  • 45
    • 76549099879 scopus 로고    scopus 로고
    • Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
    • 45 Ashiru, O., et al. Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 70 (2010), 481–489.
    • (2010) Cancer Res. , vol.70 , pp. 481-489
    • Ashiru, O.1
  • 46
    • 77950549978 scopus 로고    scopus 로고
    • Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands
    • 46 Fernández-Messina, L., et al. Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands. J. Biol. Chem. 285 (2010), 8543–8551.
    • (2010) J. Biol. Chem. , vol.285 , pp. 8543-8551
    • Fernández-Messina, L.1
  • 47
    • 80052953360 scopus 로고    scopus 로고
    • c cytokines and TGF-β1
    • c cytokines and TGF-β1. Blood 118 (2011), 3019–3027.
    • (2011) Blood , vol.118 , pp. 3019-3027
    • Park, Y.P.1
  • 48
    • 0347627712 scopus 로고    scopus 로고
    • Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma
    • 48 Doubrovina, E.S., et al. Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J. Immunol. 171 (2003), 6891–6899.
    • (2003) J. Immunol. , vol.171 , pp. 6891-6899
    • Doubrovina, E.S.1
  • 49
    • 47249144117 scopus 로고    scopus 로고
    • Human tumor-derived exosomes down-modulate NKG2D expression
    • 49 Clayton, A., et al. Human tumor-derived exosomes down-modulate NKG2D expression. J. Immunol. 180 (2008), 7249–7258.
    • (2008) J. Immunol. , vol.180 , pp. 7249-7258
    • Clayton, A.1
  • 50
    • 77953111633 scopus 로고    scopus 로고
    • Reduced immune effector cell NKG2D expression and increased levels of soluble NKG2D ligands in multiple myeloma may not be causally linked
    • 50 von Lilienfeld-Toal, M., et al. Reduced immune effector cell NKG2D expression and increased levels of soluble NKG2D ligands in multiple myeloma may not be causally linked. Cancer Immunol. Immunother. 59 (2010), 829–839.
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 829-839
    • von Lilienfeld-Toal, M.1
  • 51
    • 33745236078 scopus 로고    scopus 로고
    • Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression
    • 51 Song, H., et al. Soluble ULBP suppresses natural killer cell activity via down-regulating NKG2D expression. Cell. Immunol. 239 (2006), 22–30.
    • (2006) Cell. Immunol. , vol.239 , pp. 22-30
    • Song, H.1
  • 52
    • 63849308879 scopus 로고    scopus 로고
    • + T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells
    • + T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood 113 (2009), 2955–2964.
    • (2009) Blood , vol.113 , pp. 2955-2964
    • Cerboni, C.1
  • 53
    • 84927658788 scopus 로고    scopus 로고
    • A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection
    • 53 Deng, W., et al. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science 348 (2015), 136–139.
    • (2015) Science , vol.348 , pp. 136-139
    • Deng, W.1
  • 54
    • 68949117871 scopus 로고    scopus 로고
    • Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
    • 54 Hedlund, M., et al. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J. Immunol. 183 (2009), 340–351.
    • (2009) J. Immunol. , vol.183 , pp. 340-351
    • Hedlund, M.1
  • 55
    • 78650642570 scopus 로고    scopus 로고
    • NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
    • 55 Hanaoka, N., et al. NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. J. Immunol. 185 (2010), 5732–5742.
    • (2010) J. Immunol. , vol.185 , pp. 5732-5742
    • Hanaoka, N.1
  • 56
    • 43549123826 scopus 로고    scopus 로고
    • Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways
    • 56 Coudert, J.D., et al. Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways. Blood 111 (2008), 3571–3578.
    • (2008) Blood , vol.111 , pp. 3571-3578
    • Coudert, J.D.1
  • 57
    • 77956206286 scopus 로고    scopus 로고
    • Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1
    • 57 Champsaur, M., et al. Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J. Immunol. 185 (2010), 157–165.
    • (2010) J. Immunol. , vol.185 , pp. 157-165
    • Champsaur, M.1
  • 58
    • 33746585232 scopus 로고    scopus 로고
    • Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function
    • 58 Roda-Navarro, P., et al. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. U. S. A. 103 (2006), 11258–11263.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 11258-11263
    • Roda-Navarro, P.1
  • 59
    • 67650239847 scopus 로고    scopus 로고
    • The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation
    • 59 Roda-Navarro, P., Reyburn, H.T., The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation. J. Biol. Chem. 284 (2009), 16463–16472.
    • (2009) J. Biol. Chem. , vol.284 , pp. 16463-16472
    • Roda-Navarro, P.1    Reyburn, H.T.2
  • 60
    • 84890384819 scopus 로고    scopus 로고
    • Activation of lymphocyte cytolytic machinery: where are we?
    • 60 Galandrini, R., et al. Activation of lymphocyte cytolytic machinery: where are we?. Front. Immunol., 4, 2013, 390.
    • (2013) Front. Immunol. , vol.4 , pp. 390
    • Galandrini, R.1
  • 61
    • 84904265813 scopus 로고    scopus 로고
    • Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1
    • 61 Soriani, A., et al. Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. J. Immunol. 193 (2014), 950–960.
    • (2014) J. Immunol. , vol.193 , pp. 950-960
    • Soriani, A.1
  • 62
    • 34447104224 scopus 로고    scopus 로고
    • Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell lysis
    • 62 Cerboni, C., et al. Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell lysis. Blood 110 (2007), 606–615.
    • (2007) Blood , vol.110 , pp. 606-615
    • Cerboni, C.1
  • 63
    • 84871915611 scopus 로고    scopus 로고
    • RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry
    • 63 Jung, H., et al. RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. J. Exp. Med. 209 (2012), 2409–2422.
    • (2012) J. Exp. Med. , vol.209 , pp. 2409-2422
    • Jung, H.1
  • 64
    • 73349122322 scopus 로고    scopus 로고
    • HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response
    • 64 Ward, J., et al. HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. PLoS Pathog., 5, 2009, e1000613.
    • (2009) PLoS Pathog. , vol.5 , pp. e1000613
    • Ward, J.1
  • 65
    • 77949903887 scopus 로고    scopus 로고
    • HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing
    • 65 Richard, J., et al. HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing. Blood 115 (2010), 1354–1363.
    • (2010) Blood , vol.115 , pp. 1354-1363
    • Richard, J.1
  • 66
    • 80053436546 scopus 로고    scopus 로고
    • Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2
    • 66 Li, H., et al. Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2. Cell Cycle 10 (2011), 3346–3358.
    • (2011) Cell Cycle , vol.10 , pp. 3346-3358
    • Li, H.1
  • 67
    • 80052793188 scopus 로고    scopus 로고
    • Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2
    • 67 Textor, S., et al. Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2. Cancer Res. 71 (2011), 5998–6009.
    • (2011) Cancer Res. , vol.71 , pp. 5998-6009
    • Textor, S.1
  • 68
    • 84938685659 scopus 로고    scopus 로고
    • Effects of endocytosis on receptor-mediated signaling
    • 68 Irannejad, R., et al. Effects of endocytosis on receptor-mediated signaling. Curr. Opin. Cell Biol. 35 (2015), 137–143.
    • (2015) Curr. Opin. Cell Biol. , vol.35 , pp. 137-143
    • Irannejad, R.1
  • 69
    • 84974716090 scopus 로고    scopus 로고
    • Spatial and temporal regulation of receptor tyrosine kinase activation and intracellular signal transduction
    • 69 Bergeron, J.J., et al. Spatial and temporal regulation of receptor tyrosine kinase activation and intracellular signal transduction. Annu. Rev. Biochem. 85 (2016), 573–597.
    • (2016) Annu. Rev. Biochem. , vol.85 , pp. 573-597
    • Bergeron, J.J.1
  • 70
    • 70449552889 scopus 로고    scopus 로고
    • Endosomes: a legitimate platform for the signaling train
    • 70 Murphy, J.E., et al. Endosomes: a legitimate platform for the signaling train. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 17615–17622.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 17615-17622
    • Murphy, J.E.1
  • 71
    • 84927639135 scopus 로고    scopus 로고
    • Innate immune pattern recognition: a cell biological perspective
    • 71 Brubaker, S.W., et al. Innate immune pattern recognition: a cell biological perspective. Annu. Rev. Immunol. 33 (2015), 257–290.
    • (2015) Annu. Rev. Immunol. , vol.33 , pp. 257-290
    • Brubaker, S.W.1
  • 72
    • 40949134086 scopus 로고    scopus 로고
    • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    • 72 Kagan, J.C., et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 9 (2008), 361–368.
    • (2008) Nat. Immunol. , vol.9 , pp. 361-368
    • Kagan, J.C.1
  • 73
    • 84946033967 scopus 로고    scopus 로고
    • Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling
    • 73 Kurgonaite, K., et al. Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling. J. Cell Sci. 128 (2015), 3781–3795.
    • (2015) J. Cell Sci. , vol.128 , pp. 3781-3795
    • Kurgonaite, K.1
  • 74
    • 31144460282 scopus 로고    scopus 로고
    • Activation of NK cells by an endocytosed receptor for soluble HLA-G
    • 74 Rajagopalan, S., et al. Activation of NK cells by an endocytosed receptor for soluble HLA-G. PLoS Biol., 4, 2006, e9.
    • (2006) PLoS Biol. , vol.4 , pp. e9
    • Rajagopalan, S.1
  • 75
    • 79952746973 scopus 로고    scopus 로고
    • Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-κB signaling
    • 75 Miah, S.M., et al. Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-κB signaling. J. Immunol. 186 (2011), 2959–2969.
    • (2011) J. Immunol. , vol.186 , pp. 2959-2969
    • Miah, S.M.1
  • 76
    • 80054928885 scopus 로고    scopus 로고
    • Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments
    • 76 Chaturvedi, A., et al. Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat. Immunol. 12 (2011), 1119–1126.
    • (2011) Nat. Immunol. , vol.12 , pp. 1119-1126
    • Chaturvedi, A.1
  • 77
    • 84929658732 scopus 로고    scopus 로고
    • Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes
    • 77 Willinger, T., et al. Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 4423–4428.
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 4423-4428
    • Willinger, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.