메뉴 건너뛰기




Volumn 44, Issue 9, 2014, Pages 2761-2770

c-Cbl regulates MICA-but not ULBP2-induced NKG2D down-modulation in human NK cells

Author keywords

Endocytosis; NK cells; NKG2D ligands; NKG2D receptor

Indexed keywords

CBL PROTEIN; CBL PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HLA ANTIGEN CLASS 1; KLRK1 PROTEIN, HUMAN; MHC CLASS I RELATED CHAIN A; MHC CLASS I-RELATED CHAIN A; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; NATURAL KILLER CELL RECEPTOR NKG2D; SIGNAL PEPTIDE; UBIQUITIN; ULBP2 PROTEIN, HUMAN;

EID: 84907835076     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444512     Document Type: Article
Times cited : (41)

References (55)
  • 1
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier, L. L., NK cell recognition. Annu. Rev. Immunol. 2005. 23: 225-274.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 2
    • 33750743068 scopus 로고    scopus 로고
    • Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse
    • Tassi, I., Klesney-Tait, J. and Colonna, M., Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse. Immunol. Rev. 2006. 214: 92-105.
    • (2006) Immunol. Rev. , vol.214 , pp. 92-105
    • Tassi, I.1    Klesney-Tait, J.2    Colonna, M.3
  • 3
    • 84875528678 scopus 로고    scopus 로고
    • Controlling natural killer cell responses: integration of signals for activation and inhibition
    • Long, E. O., Sik Kim, H., Liu, D., Peterson, M. E. and Rajagopalan, S., Controlling natural killer cell responses: integration of signals for activation and inhibition. Annu. Rev. Immunol. 2013. 31: 227-58.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 227-258
    • Long, E.O.1    Sik Kim, H.2    Liu, D.3    Peterson, M.E.4    Rajagopalan, S.5
  • 4
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • Raulet, D. H., Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 2003. 3: 781-790.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 6
    • 77951683908 scopus 로고    scopus 로고
    • Effect of NKG2D ligand expression on host immune responses
    • Champsaur, M. and Lanier, L. L., Effect of NKG2D ligand expression on host immune responses. Immunol. Rev. 2010. 235: 267-285.
    • (2010) Immunol. Rev. , vol.235 , pp. 267-285
    • Champsaur, M.1    Lanier, L.L.2
  • 8
    • 0035174311 scopus 로고    scopus 로고
    • A renaissance for the tumor immunosurveillance hypothesis
    • Lanier, L. L., A renaissance for the tumor immunosurveillance hypothesis. Nat. Med. 2001. 7: 1178-1180.
    • (2001) Nat. Med. , vol.7 , pp. 1178-1180
    • Lanier, L.L.1
  • 11
    • 41549163195 scopus 로고    scopus 로고
    • NKG2D-deficientmice are defective in tumor surveillance in models of spontaneous malignancy
    • Guerra, N., Tan, Y. X., Joncker, N. T., Choy, A., Gallardo, F., Xiong, N., Knoblaugh, S. et al.,NKG2D-deficientmice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 2008. 28:571-580.
    • (2008) Immunity , vol.28 , pp. 571-580
    • Guerra, N.1    Tan, Y.X.2    Joncker, N.T.3    Choy, A.4    Gallardo, F.5    Xiong, N.6    Knoblaugh, S.7
  • 12
    • 68649112523 scopus 로고    scopus 로고
    • Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice
    • Zafirova, B., Mandarić, S., Antulov, R., Krmpotić, A., Jonsson, H., Yokoyama, W. M., Jonjić, S. et al., Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity 2009. 31: 270-282.
    • (2009) Immunity , vol.31 , pp. 270-282
    • Zafirova, B.1    Mandarić, S.2    Antulov, R.3    Krmpotić, A.4    Jonsson, H.5    Yokoyama, W.M.6    Jonjić, S.7
  • 13
    • 34548247599 scopus 로고    scopus 로고
    • Promiscuity and the single receptor: NKG2D
    • Eagle, R. A. and Trowsdale, J., Promiscuity and the single receptor: NKG2D. Nat. Rev. Immunol. 2007. 7: 737-744.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 737-744
    • Eagle, R.A.1    Trowsdale, J.2
  • 14
    • 53549124398 scopus 로고    scopus 로고
    • NKG2D ligands in tumor immunity
    • Nausch, N. and Cerwenka, A., NKG2D ligands in tumor immunity. Oncogene 2008. 27: 5944-5958.
    • (2008) Oncogene , vol.27 , pp. 5944-5958
    • Nausch, N.1    Cerwenka, A.2
  • 15
    • 68849105814 scopus 로고    scopus 로고
    • Oncogenic stress sensed by the immune system: role of natural killer cell receptors
    • Raulet, D. H. and Guerra, N., Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat. Rev. Immunol. 2009. 9: 568-580.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 568-580
    • Raulet, D.H.1    Guerra, N.2
  • 17
    • 84881413925 scopus 로고    scopus 로고
    • Immunobiology and conflicting roles of the human NKG2D lymphocyte receptor and its ligands in cancer
    • El-Gazzar, A., Groh, V. and Spies, T., Immunobiology and conflicting roles of the human NKG2D lymphocyte receptor and its ligands in cancer. J. Immunol. 2013. 191: 1509-1515.
    • (2013) J. Immunol. , vol.191 , pp. 1509-1515
    • El-Gazzar, A.1    Groh, V.2    Spies, T.3
  • 18
    • 42649119742 scopus 로고    scopus 로고
    • Soluble NKG2D ligands: prevalence, release, and functional impact
    • Salih, H. R., Holdenrieder, S. and Steinle, A., Soluble NKG2D ligands: prevalence, release, and functional impact. Front. Biosci. 2008. 13: 3448- 3456.
    • (2008) Front. Biosci. , vol.13 , pp. 3448- 3456
    • Salih, H.R.1    Holdenrieder, S.2    Steinle, A.3
  • 19
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh, V., Wu, J., Yee, C. and Spies, T., Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 2002. 419: 734-738.
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 20
  • 22
    • 24944500112 scopus 로고    scopus 로고
    • Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
    • Oppenheim, D. E., Roberts, S. J., Clarke, S. L., Filler, R., Lewis, J. M., Tigelaar, R. E., Girardi, M. et al., Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat. Immunol. 2005. 6: 928-937.
    • (2005) Nat. Immunol. , vol.6 , pp. 928-937
    • Oppenheim, D.E.1    Roberts, S.J.2    Clarke, S.L.3    Filler, R.4    Lewis, J.M.5    Tigelaar, R.E.6    Girardi, M.7
  • 24
    • 23944519927 scopus 로고    scopus 로고
    • Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
    • Coudert, J. D., Zimmer, J., Tomasello, E., Cebecauer, M., Colonna, M., Vivier, E. and Held, W., Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood 2005. 106: 1711-1717.
    • (2005) Blood , vol.106 , pp. 1711-1717
    • Coudert, J.D.1    Zimmer, J.2    Tomasello, E.3    Cebecauer, M.4    Colonna, M.5    Vivier, E.6    Held, W.7
  • 25
    • 33645049837 scopus 로고    scopus 로고
    • Proteolytic release of soluble UL16-binding protein 2 from tumor cells
    • Waldhauer, I. and Steinle, A., Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Res. 2006. 66: 2520-2526.
    • (2006) Cancer Res. , vol.66 , pp. 2520-2526
    • Waldhauer, I.1    Steinle, A.2
  • 27
    • 63849308879 scopus 로고    scopus 로고
    • Detuning CD8+ T lymphocytes by down-regulation of the activating receptorNKG2D: role of NKG2D ligands released by activated T cells
    • Cerboni, C., Ardolino, M., Santoni, A. and Zingoni, A., Detuning CD8+ T lymphocytes by down-regulation of the activating receptorNKG2D: role of NKG2D ligands released by activated T cells. Blood 2009. 113: 2955-2964.
    • (2009) Blood , vol.113 , pp. 2955-2964
    • Cerboni, C.1    Ardolino, M.2    Santoni, A.3    Zingoni, A.4
  • 28
    • 33846868891 scopus 로고    scopus 로고
    • Decreased NKG2D expression on CD8+ T cell is involved in immune evasion in patients with gastric cancer
    • Osaki, T., Saito, H., Yoshikawa, T., Matsumoto, S., Tatebe, S., Tsujitani, S. and Ikeguchi, M., Decreased NKG2D expression on CD8+ T cell is involved in immune evasion in patients with gastric cancer. Clin. Cancer Res. 2007. 13: 382-387.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 382-387
    • Osaki, T.1    Saito, H.2    Yoshikawa, T.3    Matsumoto, S.4    Tatebe, S.5    Tsujitani, S.6    Ikeguchi, M.7
  • 29
    • 77953111633 scopus 로고    scopus 로고
    • Reduced immune effector cell NKG2D expression and increased levels of soluble NKG2D ligands in multiple myeloma may not be causally linked
    • von Lilienfeld-Toal, M., Frank, S., Leyendecker, C., Feyler, S., Jarmin, S., Morgan, R., Glasmacher, A. et al., Reduced immune effector cell NKG2D expression and increased levels of soluble NKG2D ligands in multiple myeloma may not be causally linked. Cancer Immunol. Immunother. 2010. 59: 829-839.
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 829-839
    • von Lilienfeld-Toal, M.1    Frank, S.2    Leyendecker, C.3    Feyler, S.4    Jarmin, S.5    Morgan, R.6    Glasmacher, A.7
  • 30
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    • Pende, D., Rivera, P., Marcenaro, S., Chang, C. C., Biassoni, R., Conte, R., Kubin, M. et al., Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res. 2002. 62: 6178-6186.
    • (2002) Cancer Res. , vol.62 , pp. 6178-6186
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3    Chang, C.C.4    Biassoni, R.5    Conte, R.6    Kubin, M.7
  • 31
    • 0035859914 scopus 로고    scopus 로고
    • Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement
    • Paolini, R., Molfetta, R., Piccoli, M., Frati, L. and Santoni, A., Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement. Proc. Natl. Acad. Sci. USA 2001. 98: 9611-9616.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9611-9616
    • Paolini, R.1    Molfetta, R.2    Piccoli, M.3    Frati, L.4    Santoni, A.5
  • 32
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L. and Spies, T., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999. 285: 727-729.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3    Steinle, A.4    Phillips, J.H.5    Lanier, L.L.6    Spies, T.7
  • 34
    • 33645976783 scopus 로고    scopus 로고
    • NKG2D-mediated signaling requires a DAP10-bound Grb2- Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells
    • Upshaw, J. L., Arneson, L. N., Schoon, R. A., Dick, C. J., Billadeau, D. D. and Leibson, P. J., NKG2D-mediated signaling requires a DAP10-bound Grb2- Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat. Immunol. 2006. 7: 524-532.
    • (2006) Nat. Immunol. , vol.7 , pp. 524-532
    • Upshaw, J.L.1    Arneson, L.N.2    Schoon, R.A.3    Dick, C.J.4    Billadeau, D.D.5    Leibson, P.J.6
  • 35
    • 76949100273 scopus 로고    scopus 로고
    • Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase
    • Kim, H. S., Das, A., Gross, C. C., Bryceson, Y. T. and Long, E. O., Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Immunity 2010. 32: 175-186.
    • (2010) Immunity , vol.32 , pp. 175-186
    • Kim, H.S.1    Das, A.2    Gross, C.C.3    Bryceson, Y.T.4    Long, E.O.5
  • 36
    • 3142618052 scopus 로고    scopus 로고
    • Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
    • Kassenbrock, C. K. and Anderson, S. M., Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. J. Biol. Chem. 2004. 279: 28017-28027.
    • (2004) J. Biol. Chem. , vol.279 , pp. 28017-28027
    • Kassenbrock, C.K.1    Anderson, S.M.2
  • 37
    • 49249103760 scopus 로고    scopus 로고
    • Negative regulation of lymphocyte development and function by the Cbl family of proteins
    • Huang, F. and Gu, H., Negative regulation of lymphocyte development and function by the Cbl family of proteins. Immunol. Rev. 2008. 224: 229- 238.
    • (2008) Immunol. Rev. , vol.224 , pp. 229- 238
    • Huang, F.1    Gu, H.2
  • 38
    • 84860420868 scopus 로고    scopus 로고
    • Cbl family proteins: balancing FceRI-mediated mast cell and basophil activation
    • Gasparrini, F., Molfetta, R., Santoni, A. and Paolini, R., Cbl family proteins: balancing FceRI-mediated mast cell and basophil activation. Int. Arch. Allergy Immunol. 2011. 156: 16-26.
    • (2011) Int. Arch. Allergy Immunol. , vol.156 , pp. 16-26
    • Gasparrini, F.1    Molfetta, R.2    Santoni, A.3    Paolini, R.4
  • 39
    • 66049147278 scopus 로고    scopus 로고
    • Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors
    • Molfetta, R., Gasparrini, F., Peruzzi, G., Vian, L., Piccoli, M., Frati, L., Santoni, A. et al., Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors. PLoS One 2009. 4: e5604.
    • (2009) PLoS One , vol.4
    • Molfetta, R.1    Gasparrini, F.2    Peruzzi, G.3    Vian, L.4    Piccoli, M.5    Frati, L.6    Santoni, A.7
  • 40
    • 77956206286 scopus 로고    scopus 로고
    • Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1
    • Champsaur, M., Beilke, J. N., Ogasawara, K., Koszinowski, U. H., Jonjic, S. and Lanier, L. L., Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J. Immunol. 2010. 185: 157-165.
    • (2010) J. Immunol. , vol.185 , pp. 157-165
    • Champsaur, M.1    Beilke, J.N.2    Ogasawara, K.3    Koszinowski, U.H.4    Jonjic, S.5    Lanier, L.L.6
  • 41
    • 78650642570 scopus 로고    scopus 로고
    • NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease
    • Hanaoka, N., Jabri, B., Dai, Z., Ciszewski, C., Stevens, A. M., Yee, C., Nakakuma, H. et al., NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease. J. Immunol. 2010. 185: 5732-5742.
    • (2010) J. Immunol. , vol.185 , pp. 5732-5742
    • Hanaoka, N.1    Jabri, B.2    Dai, Z.3    Ciszewski, C.4    Stevens, A.M.5    Yee, C.6    Nakakuma, H.7
  • 42
    • 33746585232 scopus 로고    scopus 로고
    • Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function
    • Roda-Navarro, P., Vales-Gomez, M., Chisholm, S. E. and Reyburn, H. T., Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. USA 2006. 103: 11258-11263.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 11258-11263
    • Roda-Navarro, P.1    Vales-Gomez, M.2    Chisholm, S.E.3    Reyburn, H.T.4
  • 43
    • 67650239847 scopus 로고    scopus 로고
    • The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation
    • Roda-Navarro, P. and Reyburn, H. T., The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation. J. Biol. Chem. 2009. 284: 16463-16472.
    • (2009) J. Biol. Chem. , vol.284 , pp. 16463-16472
    • Roda-Navarro, P.1    Reyburn, H.T.2
  • 44
  • 45
    • 70649110088 scopus 로고    scopus 로고
    • Endocytosis and intracellular trafficking of human natural killer cell receptors
    • Masilamani, M., Peruzzi, G., Borrego, F. and Coligan, J. E., Endocytosis and intracellular trafficking of human natural killer cell receptors. Traffic. 2009. 10: 1735-1744.
    • (2009) Traffic. , vol.10 , pp. 1735-1744
    • Masilamani, M.1    Peruzzi, G.2    Borrego, F.3    Coligan, J.E.4
  • 46
    • 36248957695 scopus 로고    scopus 로고
    • NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
    • Horng, T., Bezbradica, J. S. and Medzhitov, R.,NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat. Immunol. 2007. 8: 1345-1352.
    • (2007) Nat. Immunol. , vol.8 , pp. 1345-1352
    • Horng, T.1    Bezbradica, J.S.2    Medzhitov, R.3
  • 47
    • 11144357868 scopus 로고    scopus 로고
    • Cell surface organization of stressinducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D
    • Eleme, K., Taner, S. B., Onfelt, B., Collinson, L. M., McCann, F. E., Chalupny, N. J., Cosman, D. et al., Cell surface organization of stressinducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. J. Exp. Med. 2004. 199: 1005-1010.
    • (2004) J. Exp. Med. , vol.199 , pp. 1005-1010
    • Eleme, K.1    Taner, S.B.2    Onfelt, B.3    Collinson, L.M.4    McCann, F.E.5    Chalupny, N.J.6    Cosman, D.7
  • 48
    • 80053130680 scopus 로고    scopus 로고
    • New insights into the T cell synapse from single molecule techniques
    • Dustin, M. L. and Depoil, D., New insights into the T cell synapse from single molecule techniques. Nat. Rev. Immunol. 2011. 11:672-684.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 672-684
    • Dustin, M.L.1    Depoil, D.2
  • 49
    • 80053325995 scopus 로고    scopus 로고
    • Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by superresolution microscopy
    • Brown, A. C., Oddos, S., Dobbie, I. M., Alakoskela, J. M., Parton, R. M., Eissmann, P., Neil, M. A. et al., Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by superresolution microscopy. PLoS Biol. 2011. 9:e1001152.
    • (2011) PLoS Biol. , vol.9
    • Brown, A.C.1    Oddos, S.2    Dobbie, I.M.3    Alakoskela, J.M.4    Parton, R.M.5    Eissmann, P.6    Neil, M.A.7
  • 50
    • 68249149660 scopus 로고    scopus 로고
    • Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses
    • Liu, D., Bryceson, Y. T., Meckel, T., Vasiliver-Shamis, G.,Dustin,M. L.and Long, E. O., Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity 2009. 31: 99-109.
    • (2009) Immunity , vol.31 , pp. 99-109
    • Liu, D.1    Bryceson, Y.T.2    Meckel, T.3    Vasiliver-Shamis, G.4    Dustin, M.L.5    Long, E.O.6
  • 51
    • 4644303421 scopus 로고    scopus 로고
    • Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions
    • Zingoni, A., Sornasse, T., Cocks, B. G., Tanaka, Y., Santoni, A. and Lanier, L. L., Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions. J. Immunol. 2004. 173: 3716-3724.
    • (2004) J. Immunol. , vol.173 , pp. 3716-3724
    • Zingoni, A.1    Sornasse, T.2    Cocks, B.G.3    Tanaka, Y.4    Santoni, A.5    Lanier, L.L.6
  • 52
    • 0347003695 scopus 로고    scopus 로고
    • Efficient gene transfer into the human natural killer cell line, NKL, using the Amaxa nucleofection system
    • Maasho, K., Marusina, A., Reynolds, N. M., Coligan, J. E. and Borrego, F., Efficient gene transfer into the human natural killer cell line, NKL, using the Amaxa nucleofection system. J. Immunol. Methods. 2004. 284: 133-140.
    • (2004) J. Immunol. Methods. , vol.284 , pp. 133-140
    • Maasho, K.1    Marusina, A.2    Reynolds, N.M.3    Coligan, J.E.4    Borrego, F.5
  • 53
    • 84867206422 scopus 로고    scopus 로고
    • Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FceRI engagement: impact on Hrs membrane/cytosol localization
    • Gasparrini, F., Molfetta, R., Quatrini, L., Frati, L., Santoni, A. and Paolini, R., Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FceRI engagement: impact on Hrs membrane/cytosol localization. Eur. J. Immunol. 2012. 42: 2744-2753.
    • (2012) Eur. J. Immunol. , vol.42 , pp. 2744-2753
    • Gasparrini, F.1    Molfetta, R.2    Quatrini, L.3    Frati, L.4    Santoni, A.5    Paolini, R.6
  • 54
    • 34848877450 scopus 로고    scopus 로고
    • The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway
    • Peruzzi, G., Molfetta, R., Gasparrini, F., Vian, L., Morrone, S., Piccoli, M., Frati, L. et al., The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. J. Immunol. 2007. 179: 2089-2096.
    • (2007) J. Immunol. , vol.179 , pp. 2089-2096
    • Peruzzi, G.1    Molfetta, R.2    Gasparrini, F.3    Vian, L.4    Morrone, S.5    Piccoli, M.6    Frati, L.7
  • 55
    • 84858042087 scopus 로고    scopus 로고
    • PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway
    • Capuano, C., Paolini, R., Molfetta, R., Frati, L., Santoni, A. and Galandrini, R., PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway. Blood. 2012. 119: 2252-2262.
    • (2012) Blood. , vol.119 , pp. 2252-2262
    • Capuano, C.1    Paolini, R.2    Molfetta, R.3    Frati, L.4    Santoni, A.5    Galandrini, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.