Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 14, 2015, Pages 4423-4428

  Willinger, Tim ^a   Staron, Matthew ^a   Ferguson, Shawn M ^a   De Camilli, Pietro ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endocytosis; Metabolism; Proliferation; T cell receptor

Indexed keywords

AMIDOPHOSPHORIBOSYLTRANSFERASE; ASPARTATE AMINOTRANSFERASE ISOENZYME 1; CD5 ANTIGEN; DYNAMIN II; FINGOLIMOD; GLUCOSE TRANSPORTER 1; HEXOKINASE 2; INTERLEUKIN 7; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; OVALBUMIN; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PYRUVATE KINASE; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL GROWTH; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; GLUCOSE TRANSPORT; INTERNALIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CELL MEMBRANE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; IMMUNOTHERAPY; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALIA;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOPHAGY; CELL MEMBRANE; CELL PROLIFERATION; DYNAMIN II; ENDOCYTOSIS; GENE EXPRESSION REGULATION; IMMUNOTHERAPY; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES;

EID: 84929658732     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504279112     Document Type: Article

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