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Volumn , Issue , 2000, Pages 279-304

Poly(ADP-ribose) polymerase inhibition by genetic and pharmacological means

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EID: 84992606143     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420038897     Document Type: Chapter
Times cited : (12)

References (120)
  • 3
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C., Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE, Nature, 371, 346, 1994.
    • (1994) Nature , vol.371 , pp. 346
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 4
    • 0026601666 scopus 로고
    • Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase
    • Banasik, M., Komura, H., Shimoyama, M., and Ueda, K., Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase, J. Biol. Chem., 267, 1569, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1569
    • Banasik, M.1    Komura, H.2    Shimoyama, M.3    Ueda, K.4
  • 5
    • 0021340281 scopus 로고
    • Inhibitors of poly(adenosine diphosphate-ribose) synthesis: Effect on other metabolic processes
    • Milam, K. M. and Cleaver, J. E., Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes, Science, 223, 589, 1984.
    • (1984) Science , vol.223 , pp. 589
    • Milam, K.M.1    Cleaver, J.E.2
  • 7
    • 0032913438 scopus 로고    scopus 로고
    • PARP inhibition: A novel approach to treat ischaemia/reperfusion and inflammation-related injuries
    • Fitzgerald, J. D., Bowman, W. C., and Taylor, J. B., Eds., Ashley Publication Ltd., London, chap. 10
    • Zhang, J., PARP inhibition: a novel approach to treat ischaemia/reperfusion and inflammation-related injuries, in Emerging Drugs: The Prospect for Improved Medicines, Vol. 4, Fitzgerald, J. D., Bowman, W. C., and Taylor, J. B., Eds., Ashley Publication Ltd., London, 1999, chap. 10.
    • (1999) Emerging Drugs: The Prospect for Improved Medicines , vol.4
    • Zhang, J.1
  • 8
    • 0001091562 scopus 로고    scopus 로고
    • Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats, in 19th Annual Neurotrauma Society Symposium, Miami, Florida
    • (abstract)
    • LaPlaca, M. C., Zhang, J., Li, J.-H., Raghupathi, R., Smith, F., Bareye, F. M., Graham, D. I., and McIntosh, T. K., Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats, in 19th Annual Neurotrauma Society Symposium, Miami, Florida, J. Neurotrauma, 16, 976, 1999 (abstract).
    • (1999) J. Neurotrauma , vol.16 , pp. 976
    • LaPlaca, M.C.1    Zhang, J.2    Li, J.-H.3    Raghupathi, R.4    Smith, F.5    Bareye, F.M.6    Graham, D.I.7    McIntosh, T.K.8
  • 9
    • 0002578948 scopus 로고    scopus 로고
    • GPI 6150, a PARP inhibitor, exhibits strong anti-inflammatory effect in rat models of arthritis, in 6th International Meeting of Biology of Nitric Oxide, Stockholm, Sweden
    • (abstract)
    • Zhang, J., Li, J.-H., Lautar, S., Zhou, Y., Mooney, M. L., and Williams, L. R., GPI 6150, a PARP inhibitor, exhibits strong anti-inflammatory effect in rat models of arthritis, in 6th International Meeting of Biology of Nitric Oxide, Stockholm, Sweden, Acta. Physiol. Scand., 167(Suppl.), 90, 1999 (abstract).
    • (1999) Acta. Physiol. Scand. , vol.167 , pp. 90
    • Zhang, J.1    Li, J.-H.2    Lautar, S.3    Zhou, Y.4    Mooney, M.L.5    Williams, L.R.6
  • 10
    • 0032127666 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
    • Szabó, C. and Dawson, V. L., Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion, Trends Pharmacol. Sci., 19, 287, 1998.
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 287
    • Szabó, C.1    Dawson, V.L.2
  • 12
    • 0032533856 scopus 로고    scopus 로고
    • Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: Covalent poly(ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the Mr 85,000 proteolytic fragment
    • Kumari, S. R., Mendoza-Alvarez, H., and Alvarez-Gonzalez, R., Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly(ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the Mr 85,000 proteolytic fragment, Cancer Res., 58, 5075, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 5075
    • Kumari, S.R.1    Mendoza-Alvarez, H.2    Alvarez-Gonzalez, R.3
  • 13
    • 0033135756 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells
    • Simbulan-Rosenthal, C. M., Rosenthal, D. S., Luo, R., and Smulson, M. E., Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells, Cancer Res., 59, 2190, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 2190
    • Simbulan-Rosenthal, C.M.1    Rosenthal, D.S.2    Luo, R.3    Smulson, M.E.4
  • 14
    • 0028150746 scopus 로고
    • Poly(ADP-ribose) polymerase: Structural conservation among different classes of animals and its implications
    • Uchida, K. and Miwa, M., Poly(ADP-ribose) polymerase: structural conservation among different classes of animals and its implications, Mol. Cell. Biochem., 138, 25, 1994.
    • (1994) Mol. Cell. Biochem. , vol.138 , pp. 25
    • Uchida, K.1    Miwa, M.2
  • 15
    • 0012702917 scopus 로고
    • Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase
    • Tseng, A., Jr., Lee, W. M., Jakobovits, E. B., Kirsten, E., Hakam, A., McLick, J., Buki, K., and Kun, E., Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase, Proc. Natl. Acad. Sci. U.S.A., 84, 1107, 1987.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 1107
    • Tseng, A.1    Lee, W.M.2    Jakobovits, E.B.3    Kirsten, E.4    Hakam, A.5    McLick, J.6    Buki, K.7    Kun, E.8
  • 16
    • 0024993725 scopus 로고
    • Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity
    • Simonin, F., Ménissier-de Murcia, J., Poch, O., Muller, S., Gradwohl, G., Molinete, M., Penning, C., Keith, G., and de Murcia, G., Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity, J. Biol. Chem., 265, 19249, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19249
    • Simonin, F.1    Ménissier-de Murcia, J.2    Poch, O.3    Muller, S.4    Gradwohl, G.5    Molinete, M.6    Penning, C.7    Keith, G.8    de Murcia, G.9
  • 17
    • 0027523401 scopus 로고
    • Identification of potential active-site residues in the human poly(ADP-ribose) polymerase
    • Simonin, F., Poch, O., Delarue, M., and de Murcia, G., Identification of potential active-site residues in the human poly(ADP-ribose) polymerase, J. Biol. Chem., 268, 8529, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8529
    • Simonin, F.1    Poch, O.2    Delarue, M.3    de Murcia, G.4
  • 18
    • 0032539957 scopus 로고    scopus 로고
    • Inhibitor and NAD+ binding to poly(ADPribose) polymerase as derived from crystal structures and homology modeling
    • Ruf, A., de Murcia, G., and Schulz, G. E., Inhibitor and NAD+ binding to poly(ADPribose) polymerase as derived from crystal structures and homology modeling, Biochemistry, 37, 3893, 1998.
    • (1998) Biochemistry , vol.37 , pp. 3893
    • Ruf, A.1    de Murcia, G.2    Schulz, G.E.3
  • 19
    • 0021997074 scopus 로고
    • Poly(ADP-ribose) in the cellular response to DNA damage
    • Berger, N. A., Poly(ADP-ribose) in the cellular response to DNA damage, Radiat. Res., 101, 4, 1985.
    • (1985) Radiat. Res. , vol.101 , pp. 4
    • Berger, N.A.1
  • 20
    • 0019310901 scopus 로고
    • Protection by picolinamide, a novel inhibitor of poly(ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets
    • Yamamoto, H. and Okamoto, H., Protection by picolinamide, a novel inhibitor of poly(ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets, Biochem. Biophys. Res. Commun., 95, 474, 1980.
    • (1980) Biochem. Biophys. Res. Commun. , vol.95 , pp. 474
    • Yamamoto, H.1    Okamoto, H.2
  • 22
    • 0020479802 scopus 로고
    • DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADPribosyl) and poly(ADP-ribosyl) proteins
    • Wielckens, K., Schmidt, A., George, E., Bredehorst, R., and Hilz, H., DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADPribosyl) and poly(ADP-ribosyl) proteins, J. Biol. Chem., 257, 12872, 1983.
    • (1983) J. Biol. Chem. , vol.257 , pp. 12872
    • Wielckens, K.1    Schmidt, A.2    George, E.3    Bredehorst, R.4    Hilz, H.5
  • 23
    • 0026642041 scopus 로고
    • Depletion of poly(ADPribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining
    • Ding, R., Pommier, Y., Kang, V. H., and Smulson, M. E., Depletion of poly(ADPribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining, J. Biol. Chem., 267, 12804, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12804
    • Ding, R.1    Pommier, Y.2    Kang, V.H.3    Smulson, M.E.4
  • 24
    • 0028145365 scopus 로고
    • Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: Influences on genomic stability, chromatin organization, and carcinogen cytotoxicity
    • Ding, R. and Smulson, M. E., Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity, Cancer Res., 54, 4627, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 4627
    • Ding, R.1    Smulson, M.E.2
  • 25
    • 0028168335 scopus 로고
    • Enhancement of interferon-gamma-induced major histocompatibility complex class II gene expression by expressing an antisense RNA of poly(ADP-ribose) synthetase
    • Qu, Z., Fujimoto, S., and Taniguchi, T., Enhancement of interferon-gamma-induced major histocompatibility complex class II gene expression by expressing an antisense RNA of poly(ADP-ribose) synthetase, J. Biol. Chem., 269, 5543, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5543
    • Qu, Z.1    Fujimoto, S.2    Taniguchi, T.3
  • 27
    • 0032938449 scopus 로고    scopus 로고
    • pADPRT-2: A novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans
    • Berghammer, H., Ebner, M., Marksteiner, R., and Auer, B., pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans, FEBS Lett., 449, 259, 1999.
    • (1999) FEBS Lett. , vol.449 , pp. 259
    • Berghammer, H.1    Ebner, M.2    Marksteiner, R.3    Auer, B.4
  • 28
    • 0033135769 scopus 로고    scopus 로고
    • A human poly(ADP-ribose) polymerase gene family (ADPRTL): CDNA cloning of two novel poly(ADP-ribose) polymerase homologues
    • Johansson, M., A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues, Genomics, 57, 442, 1999.
    • (1999) Genomics , vol.57 , pp. 442
    • Johansson, M.1
  • 30
    • 0027979464 scopus 로고
    • Conformational analysis of a 139 basepair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase
    • Le Cam, E., Fack, F., Ménissier-de Murcia, J., Cognet, J. A., Barbin, A., Sarantoglou, V., Revet, B., Delain, E., and de Murcia, G., Conformational analysis of a 139 basepair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase, J. Mol. Biol., 235, 1062, 1994.
    • (1994) J. Mol. Biol. , vol.235 , pp. 1062
    • Le Cam, E.1    Fack, F.2    Ménissier-de Murcia, J.3    Cognet, J.A.4    Barbin, A.5    Sarantoglou, V.6    Revet, B.7    Delain, E.8    de Murcia, G.9
  • 31
    • 0027253141 scopus 로고
    • Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells
    • Molinete, M., Vermeulen, W., Burkle, A., Ménissier-de Murcia, J., Kupper, J. H., Hoeijmakers, J. H., and de Murcia, G., Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells, EMBO J., 12, 2109, 1993.
    • (1993) EMBO J. , vol.12 , pp. 2109
    • Molinete, M.1    Vermeulen, W.2    Burkle, A.3    Ménissier-de Murcia, J.4    Kupper, J.H.5    Hoeijmakers, J.H.6    de Murcia, G.7
  • 32
    • 0029147011 scopus 로고
    • Molecular genetic systems to study the role of poly(ADP-ribosyl)ation in the cellular response to DNA damage
    • Kupper, J. H., van Gool, L., and Burkle, A., Molecular genetic systems to study the role of poly(ADP-ribosyl)ation in the cellular response to DNA damage, Biochimie, 77, 450, 1995.
    • (1995) Biochimie , vol.77 , pp. 450
    • Kupper, J.H.1    van Gool, L.2    Burkle, A.3
  • 33
    • 0028989014 scopus 로고
    • trans-Dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N′-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon
    • Kupper, J. H., Muller, M., Jacobson, M. K., Tatsumi-Miyajima, J., Coyle, D. L., Jacobson, E. L., and Burkle, A., trans-Dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N′-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon, Mol. Cell. Biol., 15, 3154, 1995.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 3154
    • Kupper, J.H.1    Muller, M.2    Jacobson, M.K.3    Tatsumi-Miyajima, J.4    Coyle, D.L.5    Jacobson, E.L.6    Burkle, A.7
  • 34
    • 0029000890 scopus 로고
    • A dominant-negative mutant of human poly(ADPribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage
    • Schreiber, V., Hunting, D., Trucco, C., Gowans, B., Grunwald, D., de Murcia, G., and Ménissier-de Murcia, J., A dominant-negative mutant of human poly(ADPribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage, Proc. Natl. Acad. Sci. U.S.A., 92, 4753, 1995.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 4753
    • Schreiber, V.1    Hunting, D.2    Trucco, C.3    Gowans, B.4    Grunwald, D.5    de Murcia, G.6    Ménissier-de Murcia, J.7
  • 35
    • 0028922462 scopus 로고
    • Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
    • Wang, Z. Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M., and Wagner, E. F., Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease, Genes Dev., 9, 509, 1995.
    • (1995) Genes Dev. , vol.9 , pp. 509
    • Wang, Z.Q.1    Auer, B.2    Stingl, L.3    Berghammer, H.4    Haidacher, D.5    Schweiger, M.6    Wagner, E.F.7
  • 38
    • 0033028043 scopus 로고    scopus 로고
    • The role of p53 in tumour suppression: Lessons from mouse models
    • Attardi, L. D. and Jacks, T., The role of p53 in tumour suppression: lessons from mouse models, Cell. Mol. Life Sci., 55, 48, 1999.
    • (1999) Cell. Mol. Life Sci. , vol.55 , pp. 48
    • Attardi, L.D.1    Jacks, T.2
  • 43
    • 0030752026 scopus 로고    scopus 로고
    • At the scene of ischemic brain injury: Is PARP a perp?
    • Choi, D. W., At the scene of ischemic brain injury: is PARP a perp? Nat. Med., 3, 1073, 1997.
    • (1997) Nat. Med , vol.3 , pp. 1073
    • Choi, D.W.1
  • 45
    • 0033011114 scopus 로고    scopus 로고
    • Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin
    • Burkart, V., Wang, Z. Q., Radons, J., Heller, B., Herceg, Z., Stingl, L., Wagner, E. F., and Kolb, H., Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin, Nat. Med., 5, 314, 1999.
    • (1999) Nat. Med. , vol.5 , pp. 314
    • Burkart, V.1    Wang, Z.Q.2    Radons, J.3    Heller, B.4    Herceg, Z.5    Stingl, L.6    Wagner, E.F.7    Kolb, H.8
  • 47
    • 0015842889 scopus 로고
    • Poly(adenosine diphosphoribose) polymeraae in mammalian nuclei. Characterization of the activity in mouse fibroblasts (LS cells)
    • Stone, P. R. and Shall, S., Poly(adenosine diphosphoribose) polymeraae in mammalian nuclei. Characterization of the activity in mouse fibroblasts (LS cells), Eur. J. Biochem., 38, 146, 1973.
    • (1973) Eur. J. Biochem. , vol.38 , pp. 146
    • Stone, P.R.1    Shall, S.2
  • 48
    • 0018990986 scopus 로고
    • Novel inhibitors of poly(ADP-ribose) synthetase
    • Purnell, M. R. and Whish, W. J. D., Novel inhibitors of poly(ADP-ribose) synthetase, Biochem. J., 185, 775, 1980.
    • (1980) Biochem. J. , vol.185 , pp. 775
    • Purnell, M.R.1    Whish, W.J.D.2
  • 49
    • 0018906390 scopus 로고
    • (ADP-ribose)n participates in DNA excision repair
    • Durkacz, B. W., Omidiji, O., Gray, D. A., and Shall, S., (ADP-ribose)n participates in DNA excision repair, Nature, 283, 593, 1980.
    • (1980) Nature , vol.283 , pp. 593
    • Durkacz, B.W.1    Omidiji, O.2    Gray, D.A.3    Shall, S.4
  • 50
    • 0014403289 scopus 로고
    • Poly adenosine diphosphate ribose synthesis and nicotinamide adenine dinucleotide transglycosidases
    • Nishizuka, Y., Ueda, K., Nakazawa, K., Reeder, R. H., Honjo, T., and Hayaishi, O., Poly adenosine diphosphate ribose synthesis and nicotinamide adenine dinucleotide transglycosidases, J. Vitaminol., 14, 143, 1968.
    • (1968) J. Vitaminol. , vol.14 , pp. 143
    • Nishizuka, Y.1    Ueda, K.2    Nakazawa, K.3    Reeder, R.H.4    Honjo, T.5    Hayaishi, O.6
  • 51
    • 0015244123 scopus 로고
    • Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5-methyl nicotinamide
    • Clark, J. B., Ferns, G. M., and Pinder, S., Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5-methyl nicotinamide, Biochem. Biophys. Acta, 238, 82, 1971.
    • (1971) Biochem. Biophys. Acta , vol.238 , pp. 82
    • Clark, J.B.1    Ferns, G.M.2    Pinder, S.3
  • 52
    • 0000897466 scopus 로고
    • Specific inhibition of poly ADP ribose polymerase by thymidine and nicotinamide in HeLa cells
    • Preiss, I., Schlseger, R., and Hitz, H., Specific inhibition of poly ADP ribose polymerase by thymidine and nicotinamide in HeLa cells, FEBS Lett., 9, 244, 1971.
    • (1971) FEBS Lett. , vol.9 , pp. 244
    • Preiss, I.1    Schlseger, R.2    Hitz, H.3
  • 53
    • 0016754331 scopus 로고
    • Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme
    • Uecia, K., Fukushima, M., Okaysma, H., and Havaishi, O., Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme, J. Biol. Chem., 250, 7541, 1975.
    • (1975) J. Biol. Chem , vol.250 , pp. 7541
    • Uecia, K.1    Fukushima, M.2    Okaysma, H.3    Havaishi, O.4
  • 54
    • 0017306761 scopus 로고
    • Poly(adenosine diphosphate ribose) polymerase activity and nicotinamide adenine dinucleotide in differentiating cardiac muscles
    • Claycomb, W. C., Poly(adenosine diphosphate ribose) polymerase activity and nicotinamide adenine dinucleotide in differentiating cardiac muscles, Biochemistry, 1154, 387, 1976.
    • (1976) Biochemistry , vol.1154 , pp. 387
    • Claycomb, W.C.1
  • 55
    • 0017844942 scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase by methylated xanthines and cytokinins
    • Levi, V., Jacobson, E. L., and Jacobson, M. K., Inhibition of poly(ADP-ribose) polymerase by methylated xanthines and cytokinins, FEBS Lett., 88, 144, 1978.
    • (1978) FEBS Lett. , vol.88 , pp. 144
    • Levi, V.1    Jacobson, E.L.2    Jacobson, M.K.3
  • 56
    • 0018641041 scopus 로고
    • Induction of erythroid differentiation of murine erythraleukernia cells by nicotinamide and related phosphate ribose) polymerase
    • Terada, M., Fujiki, H., Marks, P. A., and Sugimura, T., Induction of erythroid differentiation of murine erythraleukernia cells by nicotinamide and related phosphate ribose) polymerase, Proc. Natl. Acad. Sci. U.S.A., 76, 6411, 1979.
    • (1979) Proc. Natl. Acad. Sci. U.S.A. , vol.76 , pp. 6411
    • Terada, M.1    Fujiki, H.2    Marks, P.A.3    Sugimura, T.4
  • 57
    • 0019310901 scopus 로고
    • Protection by picolinamide, a novel inhibitor of poly(ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets
    • Yaniamoto, H. and Okanioto, H., Protection by picolinamide, a novel inhibitor of poly(ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets, Biochem. Biophys. Res. Commun., 95, 474, 1980.
    • (1980) Biochem. Biophys. Res. Commun. , vol.95 , pp. 474
    • Yaniamoto, H.1    Okanioto, H.2
  • 58
    • 0019270633 scopus 로고
    • Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges
    • Oikawa, A., Tohua, H., Kanai, M., Miwa, M., and Sugimura, T., Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges, Biochem. Biophys. Res. Commun., 97, 1311, 1980.
    • (1980) Biochem. Biophys. Res. Commun , vol.97 , pp. 1311
    • Oikawa, A.1    Tohua, H.2    Kanai, M.3    Miwa, M.4    Sugimura, T.5
  • 59
    • 0025923294 scopus 로고
    • Destabilization of Zn2+ coordination in ADP-ribose transferase (polymerizing) by 6-nitroso 1,2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function
    • Buki, K. G., Bauer, P. L., Mendeleyev, J., Hakam, A., and Kun, E., Destabilization of Zn2+ coordination in ADP-ribose transferase (polymerizing) by 6-nitroso 1,2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function, FEBS Lett., 290 181, 1991.
    • (1991) FEBS Lett. , vol.290 , pp. 181
    • Buki, K.G.1    Bauer, P.L.2    Mendeleyev, J.3    Hakam, A.4    Kun, E.5
  • 60
    • 0028090317 scopus 로고
    • Inhibitors and activators of ADP-ribosylation reactions
    • Banasik, M. and Ueda, K., Inhibitors and activators of ADP-ribosylation reactions, Mol. Cell. Biochem., 138, 185, 1994.
    • (1994) Mol. Cell. Biochem , vol.138 , pp. 185
    • Banasik, M.1    Ueda, K.2
  • 61
    • 84934379256 scopus 로고
    • Mechanism of ethanol stimulation of poly(ADP ribose) synthetase
    • Althaus, F. R., Htlz, H., and Shall, S., Eds., Springer-Verlag, Berlin
    • Sims, J. L. and Benjamin, R. C., Mechanism of ethanol stimulation of poly(ADP ribose) synthetase, in ADP Ribosylation of Proteins, Althaus, F. R., Htlz, H., and Shall, S., Eds., Springer-Verlag, Berlin, 1985, 124-128.
    • (1985) ADP Ribosylation of Proteins , pp. 124-128
    • Sims, J.L.1    Benjamin, R.C.2
  • 62
    • 0032994807 scopus 로고    scopus 로고
    • Dual inhibitory effects of dimethyl sulfoxoide on poly(ADP-ribose) synthetase
    • Banasik, M. and Ueda, K., Dual inhibitory effects of dimethyl sulfoxoide on poly(ADP-ribose) synthetase, J. Enzyme Inhibition, 14, 239, 1999.
    • (1999) J. Enzyme Inhibition , vol.14 , pp. 239
    • Banasik, M.1    Ueda, K.2
  • 63
    • 0024554229 scopus 로고
    • Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo
    • Rankin, P. W., Jacobson, E. L., Benjamin, R. C., Moss, I., and Jacobson, M. K., Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo, J. Biol. Chem., 264, 4312, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 4312
    • Rankin, P.W.1    Jacobson, E.L.2    Benjamin, R.C.3    Moss, I.4    Jacobson, M.K.5
  • 64
    • 0021362948 scopus 로고
    • Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis
    • Borek, C., Morgan, W. F., Ong, A., and Cleaver, J. E., Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis, Proc. Natl. Acad. Sci. U.S.A., 81, 243, 1984.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 243
    • Borek, C.1    Morgan, W.F.2    Ong, A.3    Cleaver, J.E.4
  • 65
    • 0033022355 scopus 로고    scopus 로고
    • Synthesis of thiophenecarboxamides, thieno[3,4-c]pyridin-4(5H)-ones and thieno[3,4-d]pyrimidin-4(3H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)
    • Shinkwin, A. E., Whish, W. J. D., and Threadgill, M. D., Synthesis of thiophenecarboxamides, thieno[3,4-c]pyridin-4(5H)-ones and thieno[3,4-d]pyrimidin-4(3H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP), Bioorg. Med. Chem., 7, 297, 1999.
    • (1999) Bioorg. Med. Chem. , vol.7 , pp. 297
    • Shinkwin, A.E.1    Whish, W.J.D.2    Threadgill, M.D.3
  • 66
    • 0020319078 scopus 로고
    • Poly(adenosine diphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes
    • Sims, J. L., Sikorski, G. W., Catino, D. M., Berger, S. I., and Berger, N. A., Poly(adenosine diphosphoribose) polymerase inhibitors stimulate unscheduled deoxyribonucleic acid synthesis in normal human lymphocytes, Biochemistry, 21, 1813, 1982.
    • (1982) Biochemistry , vol.21 , pp. 1813
    • Sims, J.L.1    Sikorski, G.W.2    Catino, D.M.3    Berger, S.I.4    Berger, N.A.5
  • 67
    • 0031860249 scopus 로고    scopus 로고
    • Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)
    • Watson, C. Y., Whish, W. I. D., and Threadgill, M. D., Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP), Bioog. Med. Chem., 6, 721, 1998.
    • (1998) Bioog. Med. Chem. , vol.6 , pp. 721
    • Watson, C.Y.1    Whish, W.I.D.2    Threadgill, M.D.3
  • 69
    • 0025896731 scopus 로고
    • Dihydroisoquinolinones: The design and synthesis of a new series of potent inhibitors of poly(ADP-ribose)polymerase
    • Suto, M. J., Turner, W. R., Arundel-Suto, C. K., Werbel, L. M., and Sebolt-Leopold, J. S., Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose)polymerase, Anti-Cancer Drug Design, 7, 101, 1991.
    • (1991) Anti-Cancer Drug Design , vol.7 , pp. 101
    • Suto, M.J.1    Turner, W.R.2    Arundel-Suto, C.K.3    Werbel, L.M.4    Sebolt-Leopold, J.S.5
  • 70
    • 0025267542 scopus 로고
    • Inhibition of poly(ADP-ribose) synthetase by fatty acids, vitamins and vitamin-like substances
    • Banasik, M., Kornura, H., and Ueda, K., Inhibition of poly(ADP-ribose) synthetase by fatty acids, vitamins and vitamin-like substances, FEBS Lett., 263, 222, 1990.
    • (1990) FEBS Lett. , vol.263 , pp. 222
    • Banasik, M.1    Kornura, H.2    Ueda, K.3
  • 71
    • 0020595073 scopus 로고
    • Differences in regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type
    • Cleaver, J. E., Bodell, W. I., Morgan, W. E., and Zelle, B., Differences in regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type, J. Biol. Chem., 258, 9059, 1983.
    • (1983) J. Biol. Chem. , vol.258 , pp. 9059
    • Cleaver, J.E.1    Bodell, W.I.2    Morgan, W.E.3    Zelle, B.4
  • 72
    • 0021245843 scopus 로고
    • Differential toxicity of 3-aminobenzamide to wild-type and 6-thioguanine-resistant Chinese hamster cells by interference with pathways of purine biosynthesis
    • Cleaver, J. E., Differential toxicity of 3-aminobenzamide to wild-type and 6-thioguanine-resistant Chinese hamster cells by interference with pathways of purine biosynthesis, Mutat. Res., 131, 123, 1984.
    • (1984) Mutat. Res. , vol.131 , pp. 123
    • Cleaver, J.E.1
  • 73
    • 0021340281 scopus 로고
    • Inhibitors of poly(adenosine diphosphate-ribose) synthesis effect on other metabolic processes
    • Milam, K. M. and Cleaver, J. E., Inhibitors of poly(adenosine diphosphate-ribose) synthesis effect on other metabolic processes, Science, 223, 589, 1984.
    • (1984) Science , vol.223 , pp. 589
    • Milam, K.M.1    Cleaver, J.E.2
  • 74
    • 0026601666 scopus 로고
    • Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase
    • Banasik, M., Komura, H., Shimoyama, M., and Ueda, K., Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase, J. Biol. Chem., 267, 1569, 1992.
    • (1992) J. Biol. Chem , vol.267 , pp. 1569
    • Banasik, M.1    Komura, H.2    Shimoyama, M.3    Ueda, K.4
  • 76
    • 0031762817 scopus 로고    scopus 로고
    • Potentiation of anticancer agent cytotoxicity by the novel poly(ADP-ribose) polymerase inhibitors, NU1025 and NU1064
    • Bowman, K. J., Curtin, N. J., Golding, B. T., Griffn, R. J., and White, A., Potentiation of anticancer agent cytotoxicity by the novel poly(ADP-ribose) polymerase inhibitors, NU1025 and NU1064, Br. J. Cancer, 78, 1269, 1998.
    • (1998) Br. J. Cancer , vol.78 , pp. 1269
    • Bowman, K.J.1    Curtin, N.J.2    Golding, B.T.3    Griffn, R.J.4    White, A.5
  • 78
    • 0032542252 scopus 로고    scopus 로고
    • Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP)
    • Griffin, R. J., Srinivasan, S., Bowman, K., Calvert, A. H., Curtin, N. J., Newell, D. R., Pemberton, L. C., and Golding, B. T., Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP), J. Med. Chem., 41, 5247, 1998.
    • (1998) J. Med. Chem. , vol.41 , pp. 5247
    • Griffin, R.J.1    Srinivasan, S.2    Bowman, K.3    Calvert, A.H.4    Curtin, N.J.5    Newell, D.R.6    Pemberton, L.C.7    Golding, B.T.8
  • 81
    • 0025969644 scopus 로고
    • Production of 2-methyl-4[3H]quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium
    • Yoshida, S., Aoyagi, T., Harada, S., Matuda, N., Ikeda, T., Naganawa, H., Hamada, M., and Takeuchi, T., Production of 2-methyl-4[3H]quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium, J. Antibiot., 44, 111, 1991.
    • (1991) J. Antibiot , vol.44 , pp. 111
    • Yoshida, S.1    Aoyagi, T.2    Harada, S.3    Matuda, N.4    Ikeda, T.5    Naganawa, H.6    Hamada, M.7    Takeuchi, T.8
  • 84
    • 0000371783 scopus 로고    scopus 로고
    • Post-ischemia protection by a potent PARP inhibitor in focal ischemia
    • Zhang, J., Li, J-H., and Lautar, S., Post-ischemia protection by a potent PARP inhibitor in focal ischemia, Soc. Neurosci. Abstr., 24, 1226, 1998.
    • (1998) Soc. Neurosci. Abstr , vol.24 , pp. 1226
    • Zhang, J.1    Li, J.-H.2    Lautar, S.3
  • 85
    • 0019321793 scopus 로고
    • Poly(ADP-ribose)synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks
    • Benjamin, R. C. and Gill, D. M., Poly(ADP-ribose)synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks, J. Biol. Chem., 255, 10502, 1980.
    • (1980) J. Biol. Chem. , vol.255 , pp. 10502
    • Benjamin, R.C.1    Gill, D.M.2
  • 86
    • 0026706539 scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase activity by nucleoside analogs of thymidine
    • Pivazyan, A. D., Birks, E. M., Wood, T. G., Lin, T. S., and Prusoff, W. H., Inhibition of poly(ADP-ribose) polymerase activity by nucleoside analogs of thymidine, Biochem. Pharmacol., 44, 947, 1992.
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 947
    • Pivazyan, A.D.1    Birks, E.M.2    Wood, T.G.3    Lin, T.S.4    Prusoff, W.H.5
  • 88
    • 0031856719 scopus 로고    scopus 로고
    • Protective effects of 5-iodo-6-amino-1,2-benzopyrone, and inhibitor of poly(ADPribose) synthetase against peroxynitrite-induced glial damage and stroke development
    • Endres, M., Scott, G. S., Salzman, A. L., Kun, E., Moskowitz, M. A., and Szabó, C., Protective effects of 5-iodo-6-amino-1,2-benzopyrone, and inhibitor of poly(ADPribose) synthetase against peroxynitrite-induced glial damage and stroke development, Eur. J. Pharmacol., 351, 377, 1998.
    • (1998) Eur. J. Pharmacol. , vol.351 , pp. 377
    • Endres, M.1    Scott, G.S.2    Salzman, A.L.3    Kun, E.4    Moskowitz, M.A.5    Szabó, C.6
  • 90
    • 0025267542 scopus 로고
    • Inhibitions of poly(ADP-ribose) synthetase by unsaturated fatty acids, vitamins and vitamin-like substances
    • Banasik, M., Komura, H., and Ueda, K., Inhibitions of poly(ADP-ribose) synthetase by unsaturated fatty acids, vitamins and vitamin-like substances, FEBS Lett., 263, 222, 1990.
    • (1990) FEBS Lett. , vol.263 , pp. 222
    • Banasik, M.1    Komura, H.2    Ueda, K.3
  • 91
    • 0032486082 scopus 로고    scopus 로고
    • DNA damage and cytotoxicity induced by beta-lapachone: Relation to poly(ADP-ribose) polymerase inhibition
    • Vanni, A., Fiore, M., De Salvia, R., Cundari, E., Ricordy, R., Ceccarelli, R., and Degrassi, F., DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition, Mutat. Res., 401, 55, 1998.
    • (1998) Mutat. Res. , vol.401 , pp. 55
    • Vanni, A.1    Fiore, M.2    De Salvia, R.3    Cundari, E.4    Ricordy, R.5    Ceccarelli, R.6    Degrassi, F.7
  • 92
    • 0030817905 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase by arsenite
    • Yager, J. W. and Wienke, J. K., Inhibition of poly(ADP-ribose) polymerase by arsenite Mutat. Res., 386, 345, 1997.
    • (1997) Mutat. Res. , vol.386 , pp. 345
    • Yager, J.W.1    Wienke, J.K.2
  • 93
    • 0029122925 scopus 로고
    • Cell differentiation induced by poly(ADP-ribose) synthetase inhibitors
    • Ueda, K., Banasik, M., Nakajima, S., Yook, H. Y., and Kido, T., Cell differentiation induced by poly(ADP-ribose) synthetase inhibitors, Biochimie, 77, 368, 1995.
    • (1995) Biochimie , vol.77 , pp. 368
    • Ueda, K.1    Banasik, M.2    Nakajima, S.3    Yook, H.Y.4    Kido, T.5
  • 94
    • 0023802017 scopus 로고    scopus 로고
    • Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination
    • Yoshida, S., Naganawa, H., Aoyagi, T., Takeuchi, T., and Umezawa, H., Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. II. Structure determination, J. Antibiot., 41, 1015, 1998.
    • (1998) J. Antibiot. , vol.41 , pp. 1015
    • Yoshida, S.1    Naganawa, H.2    Aoyagi, T.3    Takeuchi, T.4    Umezawa, H.5
  • 95
    • 0019305788 scopus 로고
    • The enhancement of cytotoxicity of Nmethyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase
    • Nduka, N., Skidmore, C. J., and Shall, S., The enhancement of cytotoxicity of Nmethyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase, Eur. J. Biochem., 105, 525, 1980.
    • (1980) Eur. J. Biochem. , vol.105 , pp. 525
    • Nduka, N.1    Skidmore, C.J.2    Shall, S.3
  • 96
    • 0021179916 scopus 로고
    • Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells
    • Ben-Hur, E., Utsumi, H., and Elkind, M. M., Inhibitors of poly(ADP-ribose) synthesis enhance X-ray killing of log-phase Chinese hamster cells, Radiat. Res., 97, 546, 1984.
    • (1984) Radiat. Res. , vol.97 , pp. 546
    • Ben-Hur, E.1    Utsumi, H.2    Elkind, M.M.3
  • 97
    • 0019812690 scopus 로고
    • Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets
    • Yamamoto, H., Uchigata, Y., and Okamoto, H., Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets, Nature, 294, 284, 1981.
    • (1981) Nature , vol.294 , pp. 284
    • Yamamoto, H.1    Uchigata, Y.2    Okamoto, H.3
  • 98
    • 0022360561 scopus 로고
    • Protective effect of 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase, against streptozotocin-induced diabetes
    • Masiello, P., Cubeddu, T. L., Frosina, G., and Bergamini, E., Protective effect of 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase, against streptozotocin-induced diabetes, Diabetologia, 28, 683, 1985.
    • (1985) Diabetologia , vol.28 , pp. 683
    • Masiello, P.1    Cubeddu, T.L.2    Frosina, G.3    Bergamini, E.4
  • 99
    • 0027732055 scopus 로고    scopus 로고
    • Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation
    • Wallis, R. A., Panizzon, K. L., Henry, D., and Wasterlain, C. G., Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation, Neuroreport, 5, 245, 1999.
    • (1999) Neuroreport , vol.5 , pp. 245
    • Wallis, R.A.1    Panizzon, K.L.2    Henry, D.3    Wasterlain, C.G.4
  • 100
    • 0028294246 scopus 로고
    • Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
    • Zhang, J., Dawson, V. L., Dawson, T. M., and Snyder, S. H., Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity, Science, 263, 687, 1994.
    • (1994) Science , vol.263 , pp. 687
    • Zhang, J.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4
  • 101
    • 0027990790 scopus 로고
    • Poly(ADP-ribose) polymerase: Early involvement in glutamateinduced neurotoxicity in cultured cerebellar granule cells
    • Cosi, C., Suzuki, H., Milani, D., Facci, L., Menegazzi, M., Vantini, G., Kanai, Y., and Skaper, S. D., Poly(ADP-ribose) polymerase: early involvement in glutamateinduced neurotoxicity in cultured cerebellar granule cells, J. Neurosci. Res., 39, 38, 1994.
    • (1994) J. Neurosci. Res. , vol.39 , pp. 38
    • Cosi, C.1    Suzuki, H.2    Milani, D.3    Facci, L.4    Menegazzi, M.5    Vantini, G.6    Kanai, Y.7    Skaper, S.D.8
  • 102
    • 0029100217 scopus 로고
    • Poly(ADP-ribose) synthetase activation: An early indicator of neurotoxic DNA damage
    • Zhang, J., Pieper, A., and Snyder, S. H., Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage, J. Neurochem., 65,1411, 1995.
    • (1995) J. Neurochem , vol.65 , pp. 1411
    • Zhang, J.1    Pieper, A.2    Snyder, S.H.3
  • 103
    • 0030862138 scopus 로고    scopus 로고
    • Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats
    • Takahashi, K., Greenberg, J. H., Jackson, P., Maclin, K., and Zhang, J., Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats, J. Cereb. Blood Flow Metab., 17, 1137, 1997.
    • (1997) J. Cereb. Blood Flow Metab. , vol.17 , pp. 1137
    • Takahashi, K.1    Greenberg, J.H.2    Jackson, P.3    Maclin, K.4    Zhang, J.5
  • 104
    • 0031946532 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase reduction of ischemic injury and attenuation of N-methyl-D-aspartateinduced neurotransmitter dysregulation
    • Lo, E. H., Bosque-Hamilton, P., and Meng, W., Inhibition of poly(ADP-ribose) polymerase reduction of ischemic injury and attenuation of N-methyl-D-aspartateinduced neurotransmitter dysregulation, Stroke, 29, 830, 1997.
    • (1997) Stroke , vol.29 , pp. 830
    • Lo, E.H.1    Bosque-Hamilton, P.2    Meng, W.3
  • 105
    • 0001531095 scopus 로고    scopus 로고
    • Nicotinamide reduces infarct in a permanent model of focal cerebral ischemia in Wistar rats
    • Ayoub, I. A., Ogilvy, C. S., and Maynard, K. I., Nicotinamide reduces infarct in a permanent model of focal cerebral ischemia in Wistar rats, Soc. Neurosci. Abstr., 24, 214, 1998.
    • (1998) Soc. Neurosci. Abstr. , vol.24 , pp. 214
    • Ayoub, I.A.1    Ogilvy, C.S.2    Maynard, K.I.3
  • 107
    • 0001570278 scopus 로고    scopus 로고
    • Neuroprotective effects of poly(ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats
    • Sun, A.-Y. and Cheng, J.-S., Neuroprotective effects of poly(ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats, Acta Pharmacol. Sin., 19, 104, 1998.
    • (1998) Acta Pharmacol. Sin. , vol.19 , pp. 104
    • Sun, A.-Y.1    Cheng, J.-S.2
  • 108
    • 0033594743 scopus 로고    scopus 로고
    • Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
    • Takahashi, K., Pieper, A. A., Croul, S. E., Zhang, J., Snyder, S. H., and Greenberg, J. H., Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia, Brain Res., 829, 46, 1999.
    • (1999) Brain Res. , vol.829 , pp. 46
    • Takahashi, K.1    Pieper, A.A.2    Croul, S.E.3    Zhang, J.4    Snyder, S.H.5    Greenberg, J.H.6
  • 110
    • 0032569674 scopus 로고    scopus 로고
    • Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP): Prevention by the poly(ADPribose) polymerase inhibitor, benzamide
    • Cosi, C. and Marien, M., Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADPribose) polymerase inhibitor, benzamide, Brain Res., 809, 58, 1998.
    • (1998) Brain Res. , vol.809 , pp. 58
    • Cosi, C.1    Marien, M.2
  • 111
    • 0031020434 scopus 로고    scopus 로고
    • Inhibition of the activity of poly(ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle
    • Thiemermann, C., Bowes, J., Myint, F. P., and Vane, J. R., Inhibition of the activity of poly(ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle, Proc. Natl. Acad. Sci. U.S.A., 94, 679, 1997.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 679
    • Thiemermann, C.1    Bowes, J.2    Myint, F.P.3    Vane, J.R.4
  • 112
    • 0031281259 scopus 로고    scopus 로고
    • Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase
    • Zingarelli, B., Cuzzocrea, S., Zsengeller, Z., Salzman, A. L., and Szabó, C., Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly(ADP-ribose) synthetase, Cardiovasc. Res., 36, 205, 1997.
    • (1997) Cardiovasc. Res. , vol.36 , pp. 205
    • Zingarelli, B.1    Cuzzocrea, S.2    Zsengeller, Z.3    Salzman, A.L.4    Szabó, C.5
  • 113
    • 0032514225 scopus 로고    scopus 로고
    • Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury
    • Zingarelli, B., Salzman, A. L., and Szabó, C., Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury, Circ. Res., 83, 85, 1998.
    • (1998) Circ. Res. , vol.83 , pp. 85
    • Zingarelli, B.1    Salzman, A.L.2    Szabó, C.3
  • 114
    • 0032990891 scopus 로고    scopus 로고
    • Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts
    • Grupp, I. L., Jackson, T. M., Hake, P., Grupp, G., and Szabó, C., Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts, J. Mol. Cell. Cardiol., 31, 297, 1999.
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 297
    • Grupp, I.L.1    Jackson, T.M.2    Hake, P.3    Grupp, G.4    Szabó, C.5
  • 115
    • 0000819046 scopus 로고    scopus 로고
    • Mice lacking poly(ADP-ribose) polymerase gene show attenuated cellular energy depletion and improved recovery of myocardial function following global ischemia
    • Walles, T., Wang, P., Pieper, A., Li, J.-H., Zhang, J., Snyder, S. H., and Zweier, J. L., Mice lacking poly(ADP-ribose) polymerase gene show attenuated cellular energy depletion and improved recovery of myocardial function following global ischemia, Circ. Suppl., 98, I-260, 1998.
    • (1998) Circ. Suppl. , vol.98 , pp. I-260
    • Walles, T.1    Wang, P.2    Pieper, A.3    Li, J.-H.4    Zhang, J.5    Snyder, S.H.6    Zweier, J.L.7
  • 117
    • 0032926291 scopus 로고    scopus 로고
    • Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis
    • Zingarelli, B., Szabó, C., and Salzman, A. L., Blockade of poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis, Gastroenterology, 116, 335, 1999.
    • (1999) Gastroenterology , vol.116 , pp. 335
    • Zingarelli, B.1    Szabó, C.2    Salzman, A.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.